chloroquine has been researched along with Invasiveness, Neoplasm in 20 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "CAFs contribute to metastasis process through direct or indirect interaction with tumor cells; however, the underlying mechanism is largely unknown." | 1.62 | Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling. ( Cao, L; Chen, M; Furlong, F; Guo, X; Li, X; Meng, Z; Ren, Y; Wang, L; Wu, X; Xu, K; Zhang, Q; Zheng, S, 2021) |
| "Notably, when HNSCC cells were cocultured with normal fibroblasts, they upregulated autophagy through IL6, IL8, and basic fibroblast growth factor." | 1.46 | Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target. ( Alvi, S; Anant, S; Ananth, M; Arnold, L; Dai, H; Ding, WX; Girod, DA; Kakarala, K; New, J; Shnayder, Y; Tawfik, O; Thomas, SM; Thornton, M; Tsue, TT; Werner, L, 2017) |
| "Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy." | 1.40 | Tumor vessel normalization by chloroquine independent of autophagy. ( Agostinis, P; Annaert, W; Boulanger, C; Carmeliet, P; De Bock, K; Dejana, E; Dewerchin, M; Garmyn, M; Georgiadou, M; Gerhardt, H; Ghesquière, B; Kuchnio, A; Maes, H; Moens, S; Nys, K; Peric, A; Quaegebeur, A; Radtke, F; Schoors, S; Vankelecom, H; Vinckier, S; Vion, AC; Wouters, J, 2014) |
| "Invasion of hepatocellular carcinoma (HCC) cells is a leading cause of intrahepatic dissemination and metastasis." | 1.39 | Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition. ( Guo, Y; Li, J; Shang, D; Song, Z; Wu, Y; Xiong, J; Yang, B; Zheng, Q; Zhou, Q, 2013) |
| "Moreover, pancreatic cancer aggressiveness is closely related to high levels of pro-survival mediators, which can ultimately lead to rapid disease progression, resistance and metastasis." | 1.39 | Calix[6]arene bypasses human pancreatic cancer aggressiveness: downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy. ( de Fátima, A; de Jesus, MB; Ferreira-Halder, CV; Nakamura, CV; Pelizzaro-Rocha, KJ; Reis, FS; Ruela-de-Sousa, RR, 2013) |
| "Cathepsin D secretion by the breast cancer cell lines MDA-MB-231, MDA-MB-435, MDA-MB-435s, MDA-MB-468, SK-Br-3, and MCF-7-ADRr was also measured." | 1.29 | The role of cathepsin D in the invasiveness of human breast cancer cells. ( Dickson, RB; Johnson, MD; Lippman, ME; Torri, JA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 14 (70.00) | 24.3611 |
| 2020's | 4 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, Y | 1 |
| Cao, L | 1 |
| Wang, L | 1 |
| Zheng, S | 1 |
| Zhang, Q | 1 |
| Guo, X | 1 |
| Li, X | 1 |
| Chen, M | 1 |
| Wu, X | 1 |
| Furlong, F | 1 |
| Meng, Z | 1 |
| Xu, K | 1 |
| Holm, TM | 1 |
| Bian, ZC | 1 |
| Manupati, K | 1 |
| Guan, JL | 1 |
| Gil, D | 1 |
| Zarzycka, M | 1 |
| Ciołczyk-Wierzbicka, D | 1 |
| Laidler, P | 1 |
| Chen, C | 1 |
| Zhang, H | 1 |
| Yu, Y | 1 |
| Huang, Q | 1 |
| Wang, W | 1 |
| Niu, J | 1 |
| Lou, J | 1 |
| Ren, T | 1 |
| Huang, Y | 1 |
| Guo, W | 1 |
| Sleightholm, R | 1 |
| Yang, B | 2 |
| Yu, F | 1 |
| Xie, Y | 1 |
| Oupický, D | 1 |
| New, J | 1 |
| Arnold, L | 1 |
| Ananth, M | 1 |
| Alvi, S | 1 |
| Thornton, M | 1 |
| Werner, L | 1 |
| Tawfik, O | 1 |
| Dai, H | 1 |
| Shnayder, Y | 1 |
| Kakarala, K | 1 |
| Tsue, TT | 1 |
| Girod, DA | 1 |
| Ding, WX | 1 |
| Anant, S | 1 |
| Thomas, SM | 1 |
| Zhang, C | 1 |
| Zhang, X | 1 |
| Xu, R | 1 |
| Huang, B | 1 |
| Chen, AJ | 1 |
| Li, C | 1 |
| Wang, J | 1 |
| Li, XG | 1 |
| Li, J | 1 |
| Zhou, Q | 1 |
| Wu, Y | 1 |
| Shang, D | 1 |
| Guo, Y | 1 |
| Song, Z | 1 |
| Zheng, Q | 1 |
| Xiong, J | 1 |
| Pelizzaro-Rocha, KJ | 1 |
| de Jesus, MB | 1 |
| Ruela-de-Sousa, RR | 1 |
| Nakamura, CV | 1 |
| Reis, FS | 1 |
| de Fátima, A | 1 |
| Ferreira-Halder, CV | 1 |
| Zhang, Y | 1 |
| Wang, Q | 1 |
| Ma, A | 1 |
| Li, Y | 1 |
| Li, R | 1 |
| Wang, Y | 1 |
| Maes, H | 2 |
| Kuchnio, A | 2 |
| Peric, A | 1 |
| Moens, S | 1 |
| Nys, K | 1 |
| De Bock, K | 1 |
| Quaegebeur, A | 1 |
| Schoors, S | 1 |
| Georgiadou, M | 1 |
| Wouters, J | 1 |
| Vinckier, S | 1 |
| Vankelecom, H | 1 |
| Garmyn, M | 1 |
| Vion, AC | 1 |
| Radtke, F | 1 |
| Boulanger, C | 1 |
| Gerhardt, H | 1 |
| Dejana, E | 1 |
| Dewerchin, M | 1 |
| Ghesquière, B | 1 |
| Annaert, W | 1 |
| Agostinis, P | 2 |
| Carmeliet, P | 2 |
| Catalano, M | 1 |
| D'Alessandro, G | 1 |
| Lepore, F | 1 |
| Corazzari, M | 1 |
| Caldarola, S | 1 |
| Valacca, C | 1 |
| Faienza, F | 1 |
| Esposito, V | 1 |
| Limatola, C | 1 |
| Cecconi, F | 1 |
| Di Bartolomeo, S | 1 |
| Wu, H | 1 |
| Huang, S | 2 |
| Chen, Z | 1 |
| Liu, W | 1 |
| Zhou, X | 1 |
| Zhang, D | 1 |
| Long, Z | 1 |
| Chen, B | 1 |
| Liu, Q | 1 |
| Zhao, J | 1 |
| Yang, Z | 1 |
| Dong, X | 1 |
| Xia, L | 1 |
| Hu, X | 1 |
| Song, B | 1 |
| Li, L | 1 |
| Endo, S | 1 |
| Nakata, K | 1 |
| Ohuchida, K | 1 |
| Takesue, S | 1 |
| Nakayama, H | 1 |
| Abe, T | 1 |
| Koikawa, K | 1 |
| Okumura, T | 1 |
| Sada, M | 1 |
| Horioka, K | 1 |
| Zheng, B | 1 |
| Mizuuchi, Y | 1 |
| Iwamoto, C | 1 |
| Murata, M | 1 |
| Moriyama, T | 1 |
| Miyasaka, Y | 1 |
| Ohtsuka, T | 1 |
| Mizumoto, K | 1 |
| Oda, Y | 1 |
| Hashizume, M | 1 |
| Nakamura, M | 1 |
| Saka, M | 1 |
| Amano, T | 1 |
| Kajiwara, K | 1 |
| Yoshikawa, K | 1 |
| Ideguchi, M | 1 |
| Nomura, S | 1 |
| Fujisawa, H | 1 |
| Kato, S | 1 |
| Fujii, M | 1 |
| Ueno, K | 1 |
| Hinoda, Y | 1 |
| Suzuki, M | 1 |
| Kauppila, JH | 1 |
| Karttunen, TJ | 1 |
| Saarnio, J | 1 |
| Nyberg, P | 1 |
| Salo, T | 1 |
| Graves, DE | 1 |
| Lehenkari, PP | 1 |
| Selander, KS | 2 |
| Ilvesaro, JM | 1 |
| Merrell, MA | 1 |
| Swain, TM | 1 |
| Davidson, J | 1 |
| Zayzafoon, M | 1 |
| Harris, KW | 1 |
| Johnson, MD | 1 |
| Torri, JA | 1 |
| Lippman, ME | 1 |
| Dickson, RB | 1 |
20 other studies available for chloroquine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling.
Topics: Adenine; Autophagy; Autophagy-Related Protein 5; Cancer-Associated Fibroblasts; Carcinoma, Non-Small | 2021 |
Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer.
Topics: Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Humans; Macrolides; Neoplasm Invasiveness; | 2022 |
Integrin linked kinase regulates endosomal recycling of N-cadherin in melanoma cells.
Topics: Cadherins; Cell Line, Tumor; Cell Membrane; Cell Survival; Chloroquine; Endocytosis; Endosomes; Huma | 2020 |
Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3.
Topics: Adult; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Bone Neoplasms; Cell Proliferation; Ch | 2021 |
Chloroquine-Modified Hydroxyethyl Starch as a Polymeric Drug for Cancer Therapy.
Topics: Cell Line, Tumor; Cell Movement; Chloroquine; Drug Screening Assays, Antitumor; Humans; Hydroxyethyl | 2017 |
Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target.
Topics: Animals; Autophagy; Cancer-Associated Fibroblasts; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell | 2017 |
TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells' invasion.
Topics: Animals; Autophagy; Brain Neoplasms; Cell Line, Tumor; Chloroquine; Epithelial-Mesenchymal Transitio | 2017 |
Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition.
Topics: Autophagy; Autophagy-Related Protein 7; Autophagy-Related Proteins; Carcinoma, Hepatocellular; Cell | 2013 |
Calix[6]arene bypasses human pancreatic cancer aggressiveness: downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy.
Topics: Apoptosis; Autophagy; Calixarenes; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cel | 2013 |
Functional expression of TLR9 in esophageal cancer.
Topics: Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2014 |
Tumor vessel normalization by chloroquine independent of autophagy.
Topics: Angiogenesis Inhibitors; Animals; Autophagy; Autophagy-Related Protein 5; Camptothecin; Cell Line, T | 2014 |
How to teach an old dog new tricks: autophagy-independent action of chloroquine on the tumor vasculature.
Topics: Animals; Antimalarials; Autophagy; Chloroquine; Endosomes; Gene Deletion; Humans; Hypoxia; Mice; Neo | 2014 |
Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells.
Topics: Animals; Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Culture Media, Serum-Free; Epithel | 2015 |
Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway.
Topics: Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cel | 2015 |
The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux.
Topics: Animals; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Survival; Chloroqui | 2016 |
Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.
Topics: Animals; Autophagy; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chloroquine; Disease Progre | 2017 |
Vaccine therapy with dendritic cells transfected with Il13ra2 mRNA for glioma in mice.
Topics: Animals; Bone Marrow Cells; Brain Neoplasms; Cancer Vaccines; Cell Line, Tumor; Chloroquine; Dendrit | 2010 |
Short DNA sequences and bacterial DNA induce esophageal, gastric, and colorectal cancer cell invasion.
Topics: Base Sequence; Caco-2 Cells; Chloroquine; Colorectal Neoplasms; Dipeptides; DNA, Bacterial; Enzyme A | 2013 |
Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro.
Topics: Adjuvants, Immunologic; Antimalarials; Cell Line, Tumor; Chloroquine; DNA, Bacterial; Estradiol; Gen | 2007 |
The role of cathepsin D in the invasiveness of human breast cancer cells.
Topics: Breast Neoplasms; Cathepsin D; Chloroquine; Diffusion Chambers, Culture; Female; Humans; Molecular W | 1993 |