chloroquine has been researched along with Inflammation in 81 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of chloroquine on airway hyperresponsiveness in asthmatic mice and explore the possible mechanism." | 7.81 | [Inhibitory effect of chloroquine on airway hyperresponsiveness in asthmatic mice]. ( Fu, Z; Hu, XY; Liu, EM; Sun, XC; Wang, LJ, 2015) |
| "Chloroquine (CQ) is a prototypical systemic and intradermal pruritogen for histamine-independent (nonhistaminergic) itch in mice and humans." | 5.56 | Characterization of a chloroquine-induced canine model of pruritus and skin inflammation. ( Banovic, F; Blubaugh, A; Denley, T, 2020) |
| "Inflammation has been associated with dry eye and anti-inflammatory drugs are now being targeted as the alternate therapeutic approach for dry eye condition." | 5.48 | Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux. ( Ghosh, A; Jeyabalan, N; Panigrahi, T; Shetty, R; Shivakumar, S; Subramani, M, 2018) |
| " In fact, two of the actually used drugs against SARS-CoV2, such as chloroquine and the combination lopinavir/ritonavir, might determine a QT (the time from the start of the Q wave to the end of the T wave) interval prolongation and they show several interactions with antiarrhythmic drugs and antipsychotic medications, making them prone to an increased risk of developing arrhythmias." | 5.12 | COVID-19 and the burning issue of drug interaction: never forget the ECG. ( Cameli, M; Cameli, P; Franchi, F; Mandoli, GE; Menci, D; Mondillo, S; Sciaccaluga, C; Sisti, N; Valente, S, 2021) |
| "Although anti-malarial agents, chloroquine (CQ) and hydroxychloroquine (HCQ) are currently used for the treatment of systemic lupus erythematosus, their efficacy for lupus nephritis (LN) remains unclear." | 4.02 | Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells. ( Aizawa, T; Imaizumi, T; Kawaguchi, S; Matsumiya, T; Sato, R; Seya, K; Tanaka, H; Tsugawa, K; Watanabe, S, 2021) |
| "To investigate the effect of chloroquine on airway hyperresponsiveness in asthmatic mice and explore the possible mechanism." | 3.81 | [Inhibitory effect of chloroquine on airway hyperresponsiveness in asthmatic mice]. ( Fu, Z; Hu, XY; Liu, EM; Sun, XC; Wang, LJ, 2015) |
| "The pandemic outbreak of coronavirus disease 2019 (COVID-19) is rapidly spreading all over the world." | 2.66 | The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China. ( Li, T; Liu, Z; Qin, Y; Wang, J; Wang, Q; Yan, X; Zeng, X; Zhang, F; Zhang, S; Zhang, W; Zhang, X; Zhao, Y, 2020) |
| " The dosing regimen used in preclinical models of nephrotoxicity may impact the success of therapeutic candidates in clinical trials." | 1.72 | Pharmacological inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury. ( Beverly, LJ; Doll, MA; Feng, JL; Krueger, AM; Orwick, A; Sears, SM; Shah, PP; Siskind, LJ; Vega, AA, 2022) |
| "Chloroquine (CQ) is a prototypical systemic and intradermal pruritogen for histamine-independent (nonhistaminergic) itch in mice and humans." | 1.56 | Characterization of a chloroquine-induced canine model of pruritus and skin inflammation. ( Banovic, F; Blubaugh, A; Denley, T, 2020) |
| " The author here is proposing to test 5-FU in combination with a number of deoxynucleosides on animal models infected with this Covid-19." | 1.56 | 5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection. ( Ahmad, SI, 2020) |
| "We studied RT4 schwannoma cells to investigate the regulation of Fpr2 and TLR9 after stimulation with fMLF as a prototypical formylated peptide." | 1.56 | ( Dubový, P; Korimová, A, 2020) |
| "Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal." | 1.51 | Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria. ( Azevedo-Quintanilha, IG; Bozza, PT; Campbell, RA; Castro-Faria-Neto, HC; Estato, V; Ferreira, AC; Nascimento, DO; Reis, PA; Silva, TI; Vieira-de-Abreu, A; Weyrich, AS; Zimmerman, GA, 2019) |
| "Inflammation has been associated with dry eye and anti-inflammatory drugs are now being targeted as the alternate therapeutic approach for dry eye condition." | 1.48 | Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux. ( Ghosh, A; Jeyabalan, N; Panigrahi, T; Shetty, R; Shivakumar, S; Subramani, M, 2018) |
| "TAS2R agonists attenuated features of airway remodeling including smooth muscle mass, extracellular matrix deposition and pro-fibrotic signaling, and also prevented mucus accumulation and development of AHR in mice." | 1.46 | Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice. ( Deshpande, DA; Knight, MJ; Nayak, AP; Oliver, B; Pan, S; Sharma, P; Tang, F; Wang, N; Yi, R, 2017) |
| "Chloroquine (CQ) has been shown to affect LPS-TLR4 colocalization and inhibit both MyD88-dependent and TRAM/TRIF-dependent pathways, though the mechanism involved is still poorly understood." | 1.46 | Chloroquine attenuates lipopolysaccharide-induced inflammatory responses through upregulation of USP25. ( Ding, C; Li, F; Long, Y; Zheng, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (34.57) | 18.7374 |
| 1990's | 2 (2.47) | 18.2507 |
| 2000's | 10 (12.35) | 29.6817 |
| 2010's | 18 (22.22) | 24.3611 |
| 2020's | 23 (28.40) | 2.80 |
| Authors | Studies |
|---|---|
| Ukani, R | 1 |
| Lewis, TC | 1 |
| Day, TP | 1 |
| Wu, W | 2 |
| Malladi, SS | 1 |
| Warshakoon, HJ | 1 |
| David, SA | 1 |
| Hamel, Y | 1 |
| Mauvais, FX | 1 |
| Madrange, M | 1 |
| Renard, P | 1 |
| Lebreton, C | 1 |
| Nemazanyy, I | 1 |
| Pellé, O | 1 |
| Goudin, N | 1 |
| Tang, X | 3 |
| Rodero, MP | 1 |
| Tuchmann-Durand, C | 1 |
| Nusbaum, P | 1 |
| Brindley, DN | 1 |
| van Endert, P | 1 |
| de Lonlay, P | 1 |
| Banga, R | 1 |
| Banga, V | 1 |
| Eltalla, A | 1 |
| Shahin, L | 1 |
| Parag, S | 1 |
| Naim, M | 1 |
| Iyer, E | 1 |
| Kumrah, N | 1 |
| Zacharias, B | 1 |
| Nathanson, L | 1 |
| Beljanski, V | 1 |
| Gamea, GA | 1 |
| Elmehy, DA | 1 |
| Salama, AM | 1 |
| Soliman, NA | 1 |
| Afifi, OK | 1 |
| Elkaliny, HH | 1 |
| Abo El Gheit, RE | 1 |
| El-Ebiary, AA | 1 |
| Tahoon, DM | 1 |
| Elkholy, RA | 1 |
| Shoeib, SM | 1 |
| Eleryan, MA | 1 |
| Younis, SS | 1 |
| Sears, SM | 1 |
| Feng, JL | 1 |
| Orwick, A | 1 |
| Vega, AA | 1 |
| Krueger, AM | 1 |
| Shah, PP | 1 |
| Doll, MA | 1 |
| Beverly, LJ | 1 |
| Siskind, LJ | 1 |
| Wang, J | 6 |
| Zhao, Y | 4 |
| Zhang, X | 8 |
| Tu, W | 1 |
| Wan, R | 1 |
| Shen, Y | 1 |
| Zhang, Y | 5 |
| Trivedi, R | 1 |
| Gao, P | 1 |
| Kartik, S | 1 |
| Pal, R | 1 |
| Chaudhary, MJ | 1 |
| Nath, R | 1 |
| Kumar, M | 1 |
| Binwal, M | 1 |
| Bawankule, DU | 1 |
| Tan, H | 2 |
| Cao, L | 1 |
| Sadeghi, A | 1 |
| Shabani, M | 1 |
| Alizadeh, S | 1 |
| Meshkani, R | 1 |
| Park, TY | 1 |
| Jang, Y | 1 |
| Kim, W | 1 |
| Shin, J | 1 |
| Toh, HT | 1 |
| Kim, CH | 1 |
| Yoon, HS | 1 |
| Leblanc, P | 1 |
| Kim, KS | 1 |
| Blubaugh, A | 1 |
| Denley, T | 1 |
| Banovic, F | 1 |
| Azevedo-Quintanilha, IG | 1 |
| Vieira-de-Abreu, A | 1 |
| Ferreira, AC | 1 |
| Reis, PA | 2 |
| Silva, TI | 1 |
| Nascimento, DO | 1 |
| Campbell, RA | 1 |
| Estato, V | 2 |
| Weyrich, AS | 1 |
| Bozza, PT | 2 |
| Zimmerman, GA | 2 |
| Castro-Faria-Neto, HC | 2 |
| Lübow, C | 1 |
| Bockstiegel, J | 1 |
| Weindl, G | 1 |
| Hu, TY | 1 |
| Frieman, M | 1 |
| Wolfram, J | 1 |
| Zhang, W | 1 |
| Zhang, F | 2 |
| Wang, Q | 3 |
| Li, T | 2 |
| Liu, Z | 3 |
| Qin, Y | 1 |
| Yan, X | 1 |
| Zeng, X | 1 |
| Zhang, S | 3 |
| Ahmad, SI | 1 |
| Liao, S | 1 |
| Tang, S | 2 |
| Tan, B | 1 |
| Li, J | 8 |
| Qi, M | 1 |
| Cui, Z | 1 |
| Zha, A | 1 |
| Wang, Y | 4 |
| Yin, Y | 1 |
| Sun, P | 1 |
| Tang, Y | 1 |
| Sciaccaluga, C | 1 |
| Cameli, M | 1 |
| Menci, D | 1 |
| Mandoli, GE | 1 |
| Sisti, N | 1 |
| Cameli, P | 1 |
| Franchi, F | 1 |
| Mondillo, S | 1 |
| Valente, S | 1 |
| Podlasin, RB | 1 |
| Kowalska, JD | 1 |
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| Thompson, M | 1 |
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| Liu, ZM | 1 |
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| Chen, MA | 1 |
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| Wu, XT | 1 |
| Zhang, D | 2 |
| Huang, W | 1 |
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| Yang, QQ | 1 |
| Li, HW | 1 |
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| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
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| Ghazimirsaeed, SM | 1 |
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| Silvani, Y | 1 |
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| Lemin, AS | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency[NCT04007562] | 0 participants (Actual) | Observational | 2019-07-31 | Withdrawn (stopped due to The study never started) | |||
| Efficacy and Safety of the Use of Hydroxychloroquine, Favipiravir or Hydroxychloroquine + Favipiravir in Early SARS-CoV-2 (COVID-19) Treatment[NCT04981379] | Phase 3 | 1,120 participants (Actual) | Interventional | 2020-11-16 | Completed | ||
| Nutritional Habits, Does it Affect Coronavirus Disease 2019 (COVID-19) Infection Outcome? An Egyptian Experience[NCT04447144] | 200 participants (Anticipated) | Observational | 2020-06-01 | Recruiting | |||
| Evaluation of Independent Clinical- Laboratory Predictors of Clinical Outcomes in Hospitalized Positive SARS-CoV2 Patients (Outcomes SARS-CoV2)[NCT05162534] | 1,800 participants (Actual) | Observational | 2020-05-29 | Completed | |||
| Comparison of Cytokine Hemadsorption as an Immunomodulator Therapy in Covid 19 Patients With and Without Bacterial Sepsis[NCT04920851] | 23 participants (Anticipated) | Observational | 2021-06-10 | Recruiting | |||
| "A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression (the ACLR8-LR Study)"[NCT05947812] | Phase 2 | 148 participants (Anticipated) | Interventional | 2023-08-01 | Not yet recruiting | ||
| Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury[NCT02530359] | Phase 4 | 90 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting | ||
| Effects of Early Atorvastatin Treatment During the Acute Phase of Stroke on Immunoinflammatory Markers and Outcome in Patients With Acute Ischemic Stroke Classified as LAAS According TOAST Classification[NCT02225834] | Phase 4 | 50 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for chloroquine and Inflammation
| Article | Year |
|---|---|
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Betacoronavirus; Chloroquine; Coronavir | 2020 |
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Betacoronavirus; Chloroquine; Coronavir | 2020 |
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Betacoronavirus; Chloroquine; Coronavir | 2020 |
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Betacoronavirus; Chloroquine; Coronavir | 2020 |
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Betacoronavirus; Chloroquine; Coronavir | 2020 |
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Betacoronavirus; Chloroquine; Coronavir | 2020 |
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Betacoronavirus; Chloroquine; Coronavir | 2020 |
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Betacoronavirus; Chloroquine; Coronavir | 2020 |
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Betacoronavirus; Chloroquine; Coronavir | 2020 |
COVID-19 and the burning issue of drug interaction: never forget the ECG.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antiviral | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
SARS-CoV 2 Infection (Covid-19) and Cardiovascular Disease in Africa: Health Care and Socio-Economic Implications.
Topics: Acute Coronary Syndrome; Africa; Antimalarials; Arrhythmias, Cardiac; Cardiovascular Diseases; Chlor | 2021 |
Antiplatelet and antileukocyte effects of cardiovascular, immunomodulatory and chemotherapeutic drugs.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Blood Platelets; Cardiovascular Agents; Chlo | 2006 |
Antimalarial therapy in SLE.
Topics: Antimalarials; Binding Sites; Chloroquine; Corneal Diseases; Dose-Response Relationship, Drug; Femal | 1982 |
Ocular manifestations of connective tissue disease.
Topics: Adrenal Cortex Hormones; Child; Chloroquine; Connective Tissue Diseases; Eye Diseases; Female; Giant | 1985 |
[Mechanism of action of non-steroid anti-inflammatory agents].
Topics: Acid-Base Equilibrium; Adenosine Triphosphatases; Anti-Inflammatory Agents; Ascorbic Acid; Autacoids | 1971 |
1 trial available for chloroquine and Inflammation
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
73 other studies available for chloroquine and Inflammation
| Article | Year |
|---|---|
Potent adjuvantic activity of a CCR1-agonistic bis-quinoline.
Topics: Animals; Cattle; Chloroquine; Dose-Response Relationship, Drug; Humans; Immunoglobulin G; Inflammati | 2012 |
Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.
Topics: Autophagosomes; Child; Child, Preschool; Chloroquine; DNA, Mitochondrial; Endosomes; Female; Follow- | 2021 |
Effects of autophagy modulators tamoxifen and chloroquine on the expression profiles of long non-coding RNAs in MIAMI cells exposed to IFNγ.
Topics: Autophagy; Chloroquine; Humans; Inflammation; Interferon-gamma; RNA, Long Noncoding; Tamoxifen | 2022 |
Direct and indirect antiparasitic effects of chloroquine against the virulent RH strain of Toxoplasma gondii: An experimental study.
Topics: Alanine Transaminase; Animals; Antiparasitic Agents; Aspartate Aminotransferases; Caspase 3; Chloroq | 2022 |
Pharmacological inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Autophagy; Chloroquine; Cisplatin; Fibrosis; In | 2022 |
Type II alveolar epithelial cell aryl hydrocarbon receptor protects against allergic airway inflammation through controlling cell autophagy.
Topics: Allergens; Alveolar Epithelial Cells; Animals; Asthma; Autophagy; Basic Helix-Loop-Helix Transcripti | 2022 |
Neuroprotective role of chloroquine via modulation of autophagy and neuroinflammation in MPTP-induced Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autophagy; Chloroquine; Disease Models, Anima | 2023 |
Acinetobacter baumannii outer membrane protein A induces autophagy in bone marrow-derived dendritic cells involving the PI3K/mTOR pathway.
Topics: Acinetobacter baumannii; Animals; Autophagy; Beclin-1; Bone Marrow; Chloroquine; Dendritic Cells; In | 2023 |
Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chloroquine; Cytokines; Free Radical Scaveng | 2020 |
Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases.
Topics: Autoimmune Diseases; Autoimmunity; Cell Differentiation; Chloroquine; Cyclic AMP Response Element-Bi | 2019 |
Characterization of a chloroquine-induced canine model of pruritus and skin inflammation.
Topics: Administration, Intravenous; Animals; Chloroquine; Cross-Over Studies; Disease Models, Animal; Dogs; | 2020 |
Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; CD11 Antigens; Chloroquine; Disease Models, Animal | 2019 |
Lysosomotropic drugs enhance pro-inflammatory responses to IL-1β in macrophages by inhibiting internalization of the IL-1 receptor.
Topics: Autophagy; Cell Culture Techniques; Cell Survival; Chloroquine; Chlorpromazine; Endocytosis; Fluoxet | 2020 |
Insights from nanomedicine into chloroquine efficacy against COVID-19.
Topics: Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Trea | 2020 |
5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronaviru | 2020 |
Chloroquine Improves Deoxynivalenol-Induced Inflammatory Response and Intestinal Mucosal Damage in Piglets.
Topics: Amine Oxidase (Copper-Containing); Animals; Antioxidants; Autophagy; Cadherins; Chloroquine; Cytokin | 2020 |
How to follow-up a patient who received tocilizumab in severe COVID-19: a case report.
Topics: Adult; Antibodies, Monoclonal, Humanized; Azithromycin; Betacoronavirus; Chloroquine; Coronavirus In | 2020 |
Autophagy inhibition protects from alveolar barrier dysfunction in LPS-induced ALI mice by targeting alveolar epithelial cells.
Topics: Acute Lung Injury; Adenine; Alveolar Epithelial Cells; Animals; Autophagy; Bronchoalveolar Lavage Fl | 2021 |
Topics: Animals; Cell Line, Tumor; Chloroquine; Inflammation; N-Formylmethionine Leucyl-Phenylalanine; Neuri | 2020 |
Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study.
Topics: Adult; Aged; Blood Coagulation; Chloroquine; Coinfection; Comorbidity; Cough; COVID-19; COVID-19 Dru | 2020 |
Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells.
Topics: Antimalarials; Cell Line; Cells, Cultured; Chemokine CCL5; Chemokines; Chloroquine; Endothelial Cell | 2021 |
A novel nano-anti-malarial induces redox damage and elicits cytokine response to the parasite.
Topics: Animals; Antimalarials; Cells, Cultured; Chitosan; Chloroquine; Cytokines; Drug Resistance; Humans; | 2021 |
Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu | 2017 |
Plasma-derived exosomes contribute to inflammation via the TLR9-NF-κB pathway in chronic heart failure patients.
Topics: Base Sequence; Cells, Cultured; Chloroquine; DNA, Mitochondrial; Exosomes; Gene Dosage; Heart Failur | 2017 |
Chloroquine Promotes the Recovery of Acute Spinal Cord Injury by Inhibiting Autophagy-Associated Inflammation and Endoplasmic Reticulum Stress.
Topics: Animals; Autophagy; Chloroquine; Endoplasmic Reticulum Stress; Female; Inflammation; Neuroprotective | 2018 |
Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux.
Topics: Autophagy; Chloroquine; Cornea; Dry Eye Syndromes; Epithelium, Corneal; Humans; Inflammation; Matrix | 2018 |
The release and activity of HMGB1 in ferroptosis.
Topics: Animals; Autophagy; Carbolines; Cell Death; Cell Line, Tumor; Chloroquine; Ferritins; Fibroblasts; H | 2019 |
HIV-derived ssRNA binds to TLR8 to induce inflammation-driven macrophage foam cell formation.
Topics: Antibodies, Neutralizing; Bronchoalveolar Lavage Fluid; Chloroquine; Endocytosis; Endosomes; Foam Ce | 2014 |
Exacerbation of autoimmune neuro-inflammation in mice cured from blood-stage Plasmodium berghei infection.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chloroquine; Encephalomyelitis, Aut | 2014 |
[Inhibitory effect of chloroquine on airway hyperresponsiveness in asthmatic mice].
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Chloroquine; Dexamethasone; Dinoprost; Disease Models | 2015 |
Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic death.
Topics: Animals; Antigens, Nuclear; Autophagy; Biomarkers; Brain Edema; Brain Injuries; Chloroquine; Disease | 2015 |
BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neopla | 2015 |
Chloroquine attenuates lipopolysaccharide-induced inflammatory responses through upregulation of USP25.
Topics: Active Transport, Cell Nucleus; Animals; Cell Nucleus; Chloroquine; Gene Knockout Techniques; Gene S | 2017 |
Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis.
Topics: Actins; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Chloroquine; Cytokines; Humans; Inflam | 2017 |
Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice.
Topics: Acrylates; Animals; Cecum; Chloroquine; Inflammation; Kidney; Kidney Function Tests; Kinetics; Ligat | 2008 |
SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; alpha Karyopherins; Apoptosis | 2008 |
Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chloroqui | 2009 |
Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Chloroquine; Cytokines; Glucocorticoids; Inf | 2011 |
Could chloroquine conquer autoimmune disorders and inflammation?
Topics: Animals; Autoimmune Diseases; Chloroquine; Humans; Inflammation | 2011 |
Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria.
Topics: Animals; Brain; CD11b Antigen; Chemokines; Chloroquine; Cognition Disorders; Cytokines; Edema; Endot | 2012 |
Chloroquine induces activation of nuclear factor-kappaB and subsequent expression of pro-inflammatory cytokines by human astroglial cells.
Topics: Ammonium Chloride; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Astrocytes; Cells, Cult | 2003 |
[Influence of chloroquine on reactive phlogosis caused by turpentine in guinea pigs].
Topics: Animals; Chloroquine; Guinea Pigs; Inflammation; Turpentine | 1960 |
[The effect of resochin on biochemical changes in inflamed tissue].
Topics: Chloroquine; Granuloma; Humans; Inflammation | 1961 |
BIOCHEMICAL PROPERTIES OF ANTI-INFLAMMATORY DRUGS-II. SOME EFFECTS ON SULPHATE-35S METABOLISM IN VIVO.
Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antipyrine; Autoradio | 1964 |
[EFFECT OF RESOCHIN ON STERILE AND INFECTIOUS EXPERIMENTAL INFLAMMATION].
Topics: Anti-Infective Agents; Chloroquine; Edema; Granuloma; Inflammation; Neisseria; Penicillins; Rats; Re | 1964 |
CHEMOPROPHYLAXIS OF HOMOZYGOUS SICKLERS WITH ANTIMALARIALS AND LONG-ACTING PENICILLIN.
Topics: Adolescent; Anemia; Anemia, Sickle Cell; Antimalarials; Biomedical Research; Chemoprevention; Child; | 1965 |
[ANTIBACTERIAL ACTION OF RESOCHIN AND EXPERIMENTAL INFLAMMATION].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Chloroquine; Inflammation; Pharmacology; Rats; Rese | 1964 |
Effect of a gold-chloroquine complex on inflammation-related leukocyte functions and cell viability. Comparison with auranofin.
Topics: Animals; Antirheumatic Agents; Auranofin; Cell Proliferation; Cell Survival; Chloroquine; Female; Go | 2006 |
Role of RIG-I, MDA-5, and PKR on the expression of inflammatory chemokines induced by synthetic dsRNA in airway epithelial cells.
Topics: Bronchi; Cell Line, Transformed; Chemokine CCL5; Chemokine CXCL10; Chemokines, CXC; Chloroquine; DEA | 2007 |
Improving the risk-benefit relationship and informed consent for patients treated with hydroxychloroquine.
Topics: Arthritis, Rheumatoid; Chloroquine; Humans; Hydroxychloroquine; Inflammation; Informed Consent; Lupu | 2007 |
A new anti-inflammatory test, utilizing the chorio-allantoic membrane of the chick embryo.
Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Anti-Inflammatory Agents; Betamethaso | 1967 |
The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Chloroquine; Chronic Disease; Concanavalin A; Female; Go | 1982 |
The liver in Ethiopians with porphyria cutanea tarda.
Topics: Adult; Aged; Alcohol Drinking; Biopsy; Chloroquine; Ethiopia; Female; Humans; Inflammation; Liver; L | 1982 |
Factors associated with fetal losses in severe systemic lupus erythematosus.
Topics: Adult; Analysis of Variance; Azathioprine; Case-Control Studies; Chloroquine; Cohort Studies; Congen | 1996 |
Mechanisms of action of antimalarials in inflammation: induction of apoptosis in human endothelial cells.
Topics: Antimalarials; Apoptosis; Cell Division; Cells, Cultured; Chloroquine; Endothelium, Vascular; Fibrob | 1997 |
Temporal profile of release of interleukin-1beta in neurotrauma.
Topics: Animals; Brain; Brain Injuries; Chloroquine; Colchicine; Immunohistochemistry; Inflammation; Interfe | 2000 |
Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs.
Topics: Administration, Intranasal; Animals; Antimalarials; Bronchoalveolar Lavage Fluid; Chloroquine; CpG I | 2000 |
Studies on the effect of lysosomotropic agents on the release of Gal beta 1-4GlcNAc alpha-2,6-sialytransferase from rat liver slices during the acute-phase response.
Topics: Acute-Phase Reaction; Ammonium Chloride; Animals; beta-D-Galactoside alpha 2-6-Sialyltransferase; Ch | 1989 |
The management of reaction in leprosy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Aspirin; Benzenesulfonates; Chloroquine | 1989 |
The mechanism of the inhibitory effects of antimalarials on UV-induced skin inflammation in mice.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chloroquine; Ear, External; Edema; Female; Inflammatio | 1988 |
Alteration of interleukin-1 activity and the acute phase response in adjuvant arthritic rats treated with disease modifying antirheumatic drugs.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experi | 1988 |
Alteration of chloroquine accumulation in human polymorphonuclear leucocytes under inflammatory conditions.
Topics: Chloroquine; Exocytosis; Humans; Hydrogen-Ion Concentration; Inflammation; Kinetics; Lysosomes; Neut | 1987 |
Effects of nonsteroid anti-inflammatory agents and some dicoumarol derivatives on platelet aggregation, fibrinolysis and stabilization of cell membrane in vitro.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Platelets; Cell Membrane; Chloroquine; Coumarins; Depressio | 1972 |
Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation.
Topics: Animals; Bucladesine; Carrageenan; Chemotaxis; Chloroquine; Chlorpromazine; Chromium Radioisotopes; | 1974 |
[Tests of antiphlogistics in an immunological inflammation in chickens].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chickens; Chloroquine; Histamine H1 Antagonists; Immu | 1967 |
A modification of rat adjuvant arthritis for testing antirheumatic drugs.
Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthr | 1972 |
[What is assured in the treatment of chronic inflammatory joint disease?].
Topics: Chloroquine; Chronic Disease; Gold; Humans; Immunosuppressive Agents; Inflammation; Joint Diseases; | 1972 |
Mediators and nonsteroid antiinflammatory drugs in immunologically specific and nonspecific inflammatory processes.
Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis; Bradykinin; Chlor | 1971 |
Inflammatory hemobilia.
Topics: Adult; Aspartate Aminotransferases; Biliary Tract; Biliary Tract Diseases; Chloroquine; Cholangiogra | 1969 |
Platelet reactions and immune processes. IV. The inhibition of complement by pyrazole compounds and other inhibitors of platelet reactions.
Topics: Animals; Blood Coagulation; Blood Platelets; Chloroquine; Complement Inactivator Proteins; Erythrocy | 1970 |
Interaction between "sensitized lymphocytes" and antigen in vitro. II. Mitogen-induced release of skin reactive and macrophage migration inhibitory factors.
Topics: Animals; Antigens; Ascitic Fluid; Cell Migration Inhibition; Cells, Cultured; Chloramphenicol; Chlor | 1970 |
Chloroquine enhancement of inflammation.
Topics: Animals; Chloroquine; Dimethyl Sulfoxide; Inflammation; Phosphates; Pyridoxine; Rabbits; Skin | 1968 |
Early cellular inflammation and neoplasia control.
Topics: Arsenic; Carcinogens; Chloroquine; Folliculitis; Infections; Inflammation; Neoplasms; Psoriasis; Ski | 1968 |