chloroquine has been researched along with Idiopathic Parkinson Disease in 7 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The autophagy-lysosome pathway (ALP) regulates intracellular homeostasis of the cytosolic protein SNCA/alpha-synuclein and is impaired in synucleinopathies, including Parkinson disease and dementia with Lewy bodies (DLB)." | 3.88 | Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype. ( Adame, A; Barkovits, K; Bergmann, A; Buzás, EI; Emmanouilidou, E; Galasko, D; Kittel, A; Klucken, J; Lie, DC; Marcus, K; Marxreiter, F; Masliah, E; Menges, S; Minakaki, G; Mollenhauer, B; Rockenstein, E; Schaeffner, I; Schlötzer-Schrehardt, U; Vekrellis, K; Winkler, J; Xiang, W, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, DT | 1 |
| Iqbal, J | 1 |
| Han, J | 1 |
| Pierens, GK | 1 |
| Wood, SA | 1 |
| Mellick, GD | 1 |
| Feng, Y | 1 |
| Kartik, S | 1 |
| Pal, R | 1 |
| Chaudhary, MJ | 1 |
| Nath, R | 1 |
| Kumar, M | 1 |
| Binwal, M | 1 |
| Bawankule, DU | 1 |
| Aguilar, JI | 1 |
| Cheng, MH | 1 |
| Font, J | 1 |
| Schwartz, AC | 1 |
| Ledwitch, K | 1 |
| Duran, A | 1 |
| Mabry, SJ | 1 |
| Belovich, AN | 1 |
| Zhu, Y | 1 |
| Carter, AM | 1 |
| Shi, L | 1 |
| Kurian, MA | 1 |
| Fenollar-Ferrer, C | 1 |
| Meiler, J | 1 |
| Ryan, RM | 1 |
| Mchaourab, HS | 1 |
| Bahar, I | 1 |
| Matthies, HJ | 1 |
| Galli, A | 1 |
| Minakaki, G | 1 |
| Menges, S | 1 |
| Kittel, A | 1 |
| Emmanouilidou, E | 1 |
| Schaeffner, I | 1 |
| Barkovits, K | 1 |
| Bergmann, A | 1 |
| Rockenstein, E | 1 |
| Adame, A | 1 |
| Marxreiter, F | 1 |
| Mollenhauer, B | 1 |
| Galasko, D | 1 |
| Buzás, EI | 1 |
| Schlötzer-Schrehardt, U | 1 |
| Marcus, K | 1 |
| Xiang, W | 1 |
| Lie, DC | 1 |
| Vekrellis, K | 1 |
| Masliah, E | 1 |
| Winkler, J | 1 |
| Klucken, J | 1 |
| Kim, CH | 1 |
| Han, BS | 1 |
| Moon, J | 1 |
| Kim, DJ | 1 |
| Shin, J | 1 |
| Rajan, S | 1 |
| Nguyen, QT | 1 |
| Sohn, M | 1 |
| Kim, WG | 1 |
| Han, M | 1 |
| Jeong, I | 1 |
| Kim, KS | 2 |
| Lee, EH | 1 |
| Tu, Y | 1 |
| Naffin-Olivos, JL | 1 |
| Park, CH | 1 |
| Ringe, D | 1 |
| Yoon, HS | 1 |
| Petsko, GA | 1 |
| Ohta, E | 1 |
| Kubo, M | 1 |
| Obata, F | 1 |
| Vaĭnshtok, AB | 1 |
7 other studies available for chloroquine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson's disease patient-derived cell line.
Topics: Alkaloids; Cell Line; Circular Dichroism; Density Functional Theory; Humans; Lysosomes; Magnetic Res | 2020 |
Neuroprotective role of chloroquine via modulation of autophagy and neuroinflammation in MPTP-induced Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autophagy; Chloroquine; Disease Models, Anima | 2023 |
Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Topics: Animals; Chloroquine; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; | 2021 |
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.
Topics: alpha-Synuclein; Animals; Autophagosomes; Autophagy; Biomarkers; Cells, Cultured; Chloroquine; Exoso | 2018 |
Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.
Topics: Amodiaquine; Animals; Behavior, Animal; Chloroquine; Disease Models, Animal; Ligands; Neurogenesis; | 2015 |
Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.
Topics: Acetylcysteine; Apoptosis; Chloroquine; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Leucin | 2010 |
[Treatment of parkinsonism with delagil].
Topics: Adult; Aged; Chloroquine; Female; Humans; Male; Middle Aged; Parkinson Disease | 1972 |