Page last updated: 2024-10-24

chloroquine and Hypoxia

chloroquine has been researched along with Hypoxia in 24 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
" The purpose of this study was to investigate whether chloroquine induced relaxation in the pulmonary artery (PA) and attenuates hypoxia-induced pulmonary hypertension (HPH)."7.85Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. ( Ayon, RJ; Balistrieri, A; Black, SM; Garcia, JGN; Gu, Y; Liang, Z; Lu, W; Makino, A; McDermott, KM; Song, S; Tang, H; Wang, C; Wang, J; Wang, Z; Wu, K; Wu, X; Yuan, JX; Zhang, Q, 2017)
"MiaPaCa2 (non-metastatic) and S2VP10 (metastatic) cell lines were treated with 25 and 50 µM chloroquine for 24 and 48 hours in normoxia and hypoxia (5-10% O₂)."7.80Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. ( Frieboes, HB; Huang, JS; McNally, LR; Yin, WC, 2014)
"Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia."7.79Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013)
"Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug."5.91Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023)
"Chloroquine (CLQ) has been observed to inhibit calcium influx."5.62The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension. ( Akin, AT; Başaran, KE; Kaymak, E; Özdamar, S; Taheri, S; Tufan, E; Yakan, B, 2021)
" In fact, two of the actually used drugs against SARS-CoV2, such as chloroquine and the combination lopinavir/ritonavir, might determine a QT (the time from the start of the Q wave to the end of the T wave) interval prolongation and they show several interactions with antiarrhythmic drugs and antipsychotic medications, making them prone to an increased risk of developing arrhythmias."5.12COVID-19 and the burning issue of drug interaction: never forget the ECG. ( Cameli, M; Cameli, P; Franchi, F; Mandoli, GE; Menci, D; Mondillo, S; Sciaccaluga, C; Sisti, N; Valente, S, 2021)
" The purpose of this study was to investigate whether chloroquine induced relaxation in the pulmonary artery (PA) and attenuates hypoxia-induced pulmonary hypertension (HPH)."3.85Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. ( Ayon, RJ; Balistrieri, A; Black, SM; Garcia, JGN; Gu, Y; Liang, Z; Lu, W; Makino, A; McDermott, KM; Song, S; Tang, H; Wang, C; Wang, J; Wang, Z; Wu, K; Wu, X; Yuan, JX; Zhang, Q, 2017)
"MiaPaCa2 (non-metastatic) and S2VP10 (metastatic) cell lines were treated with 25 and 50 µM chloroquine for 24 and 48 hours in normoxia and hypoxia (5-10% O₂)."3.80Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. ( Frieboes, HB; Huang, JS; McNally, LR; Yin, WC, 2014)
"Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia."3.79Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013)
" Inhibition of autophagy by chloroquine and 3-methyladenine worsened renal ischemia/reperfusion injury, as indicated by renal function, histology, and tubular apoptosis."3.76Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. ( Dong, Z; Jiang, M; Liu, K; Luo, J, 2010)
"The anti-hypoxic effect of drugs that inhibit different steps of arachidonic acid metabolism was studied using an experimental model of acute hypobaric hypoxia in mice."3.67Arachidonic acid cascade and anti-hypoxic drugs. ( Nikolov, R, 1984)
"Although coronavirus disease 2019 (COVID-19) predominantly disrupts the respiratory system, there is accumulating experience that the disease, particularly in its more severe manifestations, also affects the cardiovascular system."2.66A current review of COVID-19 for the cardiovascular specialist. ( Bohula, EA; Lang, JP; Morrow, DA; Moura, FA; Siddiqi, HK; Wang, X, 2020)
"Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug."1.91Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023)
"Chloroquine (CLQ) has been observed to inhibit calcium influx."1.62The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension. ( Akin, AT; Başaran, KE; Kaymak, E; Özdamar, S; Taheri, S; Tufan, E; Yakan, B, 2021)
"These stressors included anoxia, hyperthermia, polycyclic aromatic hydrocarbons, copper and a combination of copper+nutritional deprivation."1.34Autophagic and lysosomal reactions to stress in the hepatopancreas of blue mussels. ( Donkin, P; Hawkins, AJ; Moore, MN; Viarengo, A, 2007)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19907 (29.17)18.7374
1990's2 (8.33)18.2507
2000's4 (16.67)29.6817
2010's7 (29.17)24.3611
2020's4 (16.67)2.80

Authors

AuthorsStudies
Kang, C2
Ju, S2
Kim, J2
Jung, Y2
Lang, JP1
Wang, X1
Moura, FA1
Siddiqi, HK1
Morrow, DA1
Bohula, EA1
Sciaccaluga, C1
Cameli, M1
Menci, D1
Mandoli, GE1
Sisti, N1
Cameli, P1
Franchi, F1
Mondillo, S1
Valente, S1
Kaymak, E1
Akin, AT1
Tufan, E1
Başaran, KE1
Taheri, S1
Özdamar, S1
Yakan, B1
Wu, K1
Zhang, Q1
Wu, X1
Lu, W1
Tang, H1
Liang, Z1
Gu, Y1
Song, S1
Ayon, RJ1
Wang, Z1
McDermott, KM1
Balistrieri, A1
Wang, C1
Black, SM1
Garcia, JGN1
Makino, A1
Yuan, JX1
Wang, J1
Maeda, H1
Nagai, H1
Takemura, G1
Shintani-Ishida, K1
Komatsu, M1
Ogura, S1
Aki, T1
Shirai, M1
Kuwahira, I1
Yoshida, K1
Egger, ME1
Huang, JS2
Yin, W1
McMasters, KM1
McNally, LR2
Frieboes, HB1
Yin, WC1
Maes, H1
Kuchnio, A1
Carmeliet, P1
Agostinis, P1
Wu, H1
Huang, S1
Chen, Z1
Liu, W1
Zhou, X1
Zhang, D1
Bae, D1
Lu, S1
Taglienti, CA1
Mercurio, AM1
JAILER, JW1
ZUBROD, CG1
Rouschop, KM1
Ramaekers, CH1
Schaaf, MB1
Keulers, TG1
Savelkouls, KG1
Lambin, P1
Koritzinsky, M1
Wouters, BG1
Jiang, M1
Liu, K1
Luo, J1
Dong, Z1
KURACHI, Y1
YONEMURA, D1
Moore, MN1
Viarengo, A1
Donkin, P1
Hawkins, AJ1
Abraham, R1
Goldberg, L1
Grasso, P1
Nikolov, R1
Papadopoulou, MV1
Ji, M1
Rao, MK1
Bloomer, WD1
Welman, E1
Peters, TJ1
Taegtmeyer, H1
Ferguson, AG1
Lesch, M1
Kempf, J2
Saissy, JM2
Ridout, RM1
Wildenthal, K1
Decker, RS1

Reviews

3 reviews available for chloroquine and Hypoxia

ArticleYear
A current review of COVID-19 for the cardiovascular specialist.
    American heart journal, 2020, Volume: 226

    Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; Betacoronavirus; Biomarkers; Card

2020
COVID-19 and the burning issue of drug interaction: never forget the ECG.
    Postgraduate medical journal, 2021, Volume: 97, Issue:1145

    Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antiviral

2021
[Effects of diazepam and incidence of hypoxemia during acute chloroquine poisoning].
    Annales francaises d'anesthesie et de reanimation, 1992, Volume: 11, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Blood Gas Analysis; Chloroquine; Diazepam; Female; Humans; Hypoxia

1992

Other Studies

21 other studies available for chloroquine and Hypoxia

ArticleYear
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo

2023
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo

2023
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo

2023
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo

2023
The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension.
    Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:2

    Topics: Animals; Arterioles; Body Weight; Cell Line; Chloroquine; Disease Models, Animal; Hypoxia; Lung; Mal

2021
Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.
    British journal of pharmacology, 2017, Volume: 174, Issue:22

    Topics: Animals; Calcium Channels; Cell Proliferation; Cell Survival; Cells, Cultured; Chloroquine; Humans;

2017
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.
    Biochimica et biophysica acta, 2013, Volume: 1832, Issue:8

    Topics: Adenine; Animals; Autophagy; Chloroquine; Heart Diseases; Heart Failure; Hypoxia; Lysosomes; Male; M

2013
Inhibition of autophagy with chloroquine is effective in melanoma.
    The Journal of surgical research, 2013, Volume: 184, Issue:1

    Topics: Antibiotics, Antineoplastic; Antimalarials; Autophagy; Benzoquinones; Cell Line, Tumor; Chloroquine;

2013
Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy.
    JOP : Journal of the pancreas, 2014, Mar-10, Volume: 15, Issue:2

    Topics: Adenocarcinoma; Apoptosis; Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; Chloroquine; Dose

2014
How to teach an old dog new tricks: autophagy-independent action of chloroquine on the tumor vasculature.
    Autophagy, 2014, Volume: 10, Issue:11

    Topics: Animals; Antimalarials; Autophagy; Chloroquine; Endosomes; Gene Deletion; Humans; Hypoxia; Mice; Neo

2014
Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway.
    Molecular medicine reports, 2015, Volume: 12, Issue:5

    Topics: Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cel

2015
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
    The Journal of biological chemistry, 2008, Oct-17, Volume: 283, Issue:42

    Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Membrane; Chloroquine; Culture Media; Endothelium, Vascul

2008
Effect of acidosis and anoxia on the concentration of quinacrine and chloroquine in blood.
    The Journal of pharmacology and experimental therapeutics, 1948, Volume: 92, Issue:3

    Topics: Acidosis; Chloroquine; Hypoxia; Quinacrine

1948
Autophagy is required during cycling hypoxia to lower production of reactive oxygen species.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2009, Volume: 92, Issue:3

    Topics: Analysis of Variance; Autophagy; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Survival; Chl

2009
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.
    The American journal of pathology, 2010, Volume: 176, Issue:3

    Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5;

2010
[ERG, WITH SPECIAL REFERENCE TO ITS CORRELATION WITH INTERNAL DISEASES].
    [Sogo rinsho] Clinic all-round, 1964, Volume: 13

    Topics: Anesthesia; Anesthesiology; Behcet Syndrome; Blood Circulation; Chloroquine; Diabetic Retinopathy; E

1964
Autophagic and lysosomal reactions to stress in the hepatopancreas of blue mussels.
    Aquatic toxicology (Amsterdam, Netherlands), 2007, Aug-15, Volume: 84, Issue:1

    Topics: Animals; Autophagy; Chloroquine; Copper; Food Deprivation; Hepatopancreas; Hot Temperature; Hypoxia;

2007
Hepatic response to lysosomal effects of hypoxia, neutral red and chloroquine.
    Nature, 1967, Jul-08, Volume: 215, Issue:5097

    Topics: Acid Phosphatase; Animals; Chloroquine; Coloring Agents; Glucuronidase; Histocytochemistry; Hypoxia;

1967
Arachidonic acid cascade and anti-hypoxic drugs.
    Methods and findings in experimental and clinical pharmacology, 1984, Volume: 6, Issue:5

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Betamethasone; Chloroquine; Chlorpromazine; Cyclooxyge

1984
4-[3-(2-Nitro-1-imidazolyl)propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin.
    Oncology research, 2000, Volume: 12, Issue:4

    Topics: Aminoquinolines; Animals; Antineoplastic Agents; Cell Survival; Chloroquine; Chromatography, Thin La

2000
Prevention of lysosome disruption in anoxic myocardium by chloroquine and methyl prednisolone.
    Pharmacological research communications, 1977, Volume: 9, Issue:1

    Topics: Aerobiosis; Animals; Chloroquine; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Lysosomes; Male;

1977
Thermoregulation of myocardial protein synthesis.
    The American journal of physiology, 1975, Volume: 228, Issue:3

    Topics: Animals; Chloroquine; Extracellular Space; Glucose; Hot Temperature; Hypoxia; In Vitro Techniques; M

1975
[Hypoxemia in acute benign chloroquine intoxication].
    Presse medicale (Paris, France : 1983), 1991, Mar-16, Volume: 20, Issue:10

    Topics: Acute Disease; Chloroquine; Gastric Lavage; Humans; Hyperbaric Oxygenation; Hypoxia

1991
Influence of agents that alter lysosomal function on fetal mouse hearts recovering from anoxia and substrate depletion.
    Journal of molecular and cellular cardiology, 1986, Volume: 18, Issue:8

    Topics: Animals; Chloroquine; Female; Fetus; Hydrocortisone; Hypoxia; Kinetics; Leupeptins; Lysosomes; Mice;

1986