chloroquine has been researched along with Hypoxia in 24 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to investigate whether chloroquine induced relaxation in the pulmonary artery (PA) and attenuates hypoxia-induced pulmonary hypertension (HPH)." | 7.85 | Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. ( Ayon, RJ; Balistrieri, A; Black, SM; Garcia, JGN; Gu, Y; Liang, Z; Lu, W; Makino, A; McDermott, KM; Song, S; Tang, H; Wang, C; Wang, J; Wang, Z; Wu, K; Wu, X; Yuan, JX; Zhang, Q, 2017) |
| "MiaPaCa2 (non-metastatic) and S2VP10 (metastatic) cell lines were treated with 25 and 50 µM chloroquine for 24 and 48 hours in normoxia and hypoxia (5-10% O₂)." | 7.80 | Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. ( Frieboes, HB; Huang, JS; McNally, LR; Yin, WC, 2014) |
| "Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia." | 7.79 | Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013) |
| "Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug." | 5.91 | Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023) |
| "Chloroquine (CLQ) has been observed to inhibit calcium influx." | 5.62 | The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension. ( Akin, AT; Başaran, KE; Kaymak, E; Özdamar, S; Taheri, S; Tufan, E; Yakan, B, 2021) |
| " In fact, two of the actually used drugs against SARS-CoV2, such as chloroquine and the combination lopinavir/ritonavir, might determine a QT (the time from the start of the Q wave to the end of the T wave) interval prolongation and they show several interactions with antiarrhythmic drugs and antipsychotic medications, making them prone to an increased risk of developing arrhythmias." | 5.12 | COVID-19 and the burning issue of drug interaction: never forget the ECG. ( Cameli, M; Cameli, P; Franchi, F; Mandoli, GE; Menci, D; Mondillo, S; Sciaccaluga, C; Sisti, N; Valente, S, 2021) |
| " The purpose of this study was to investigate whether chloroquine induced relaxation in the pulmonary artery (PA) and attenuates hypoxia-induced pulmonary hypertension (HPH)." | 3.85 | Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. ( Ayon, RJ; Balistrieri, A; Black, SM; Garcia, JGN; Gu, Y; Liang, Z; Lu, W; Makino, A; McDermott, KM; Song, S; Tang, H; Wang, C; Wang, J; Wang, Z; Wu, K; Wu, X; Yuan, JX; Zhang, Q, 2017) |
| "MiaPaCa2 (non-metastatic) and S2VP10 (metastatic) cell lines were treated with 25 and 50 µM chloroquine for 24 and 48 hours in normoxia and hypoxia (5-10% O₂)." | 3.80 | Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. ( Frieboes, HB; Huang, JS; McNally, LR; Yin, WC, 2014) |
| "Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia." | 3.79 | Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013) |
| " Inhibition of autophagy by chloroquine and 3-methyladenine worsened renal ischemia/reperfusion injury, as indicated by renal function, histology, and tubular apoptosis." | 3.76 | Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. ( Dong, Z; Jiang, M; Liu, K; Luo, J, 2010) |
| "The anti-hypoxic effect of drugs that inhibit different steps of arachidonic acid metabolism was studied using an experimental model of acute hypobaric hypoxia in mice." | 3.67 | Arachidonic acid cascade and anti-hypoxic drugs. ( Nikolov, R, 1984) |
| "Although coronavirus disease 2019 (COVID-19) predominantly disrupts the respiratory system, there is accumulating experience that the disease, particularly in its more severe manifestations, also affects the cardiovascular system." | 2.66 | A current review of COVID-19 for the cardiovascular specialist. ( Bohula, EA; Lang, JP; Morrow, DA; Moura, FA; Siddiqi, HK; Wang, X, 2020) |
| "Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug." | 1.91 | Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023) |
| "Chloroquine (CLQ) has been observed to inhibit calcium influx." | 1.62 | The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension. ( Akin, AT; Başaran, KE; Kaymak, E; Özdamar, S; Taheri, S; Tufan, E; Yakan, B, 2021) |
| "These stressors included anoxia, hyperthermia, polycyclic aromatic hydrocarbons, copper and a combination of copper+nutritional deprivation." | 1.34 | Autophagic and lysosomal reactions to stress in the hepatopancreas of blue mussels. ( Donkin, P; Hawkins, AJ; Moore, MN; Viarengo, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (29.17) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, C | 2 |
| Ju, S | 2 |
| Kim, J | 2 |
| Jung, Y | 2 |
| Lang, JP | 1 |
| Wang, X | 1 |
| Moura, FA | 1 |
| Siddiqi, HK | 1 |
| Morrow, DA | 1 |
| Bohula, EA | 1 |
| Sciaccaluga, C | 1 |
| Cameli, M | 1 |
| Menci, D | 1 |
| Mandoli, GE | 1 |
| Sisti, N | 1 |
| Cameli, P | 1 |
| Franchi, F | 1 |
| Mondillo, S | 1 |
| Valente, S | 1 |
| Kaymak, E | 1 |
| Akin, AT | 1 |
| Tufan, E | 1 |
| Başaran, KE | 1 |
| Taheri, S | 1 |
| Özdamar, S | 1 |
| Yakan, B | 1 |
| Wu, K | 1 |
| Zhang, Q | 1 |
| Wu, X | 1 |
| Lu, W | 1 |
| Tang, H | 1 |
| Liang, Z | 1 |
| Gu, Y | 1 |
| Song, S | 1 |
| Ayon, RJ | 1 |
| Wang, Z | 1 |
| McDermott, KM | 1 |
| Balistrieri, A | 1 |
| Wang, C | 1 |
| Black, SM | 1 |
| Garcia, JGN | 1 |
| Makino, A | 1 |
| Yuan, JX | 1 |
| Wang, J | 1 |
| Maeda, H | 1 |
| Nagai, H | 1 |
| Takemura, G | 1 |
| Shintani-Ishida, K | 1 |
| Komatsu, M | 1 |
| Ogura, S | 1 |
| Aki, T | 1 |
| Shirai, M | 1 |
| Kuwahira, I | 1 |
| Yoshida, K | 1 |
| Egger, ME | 1 |
| Huang, JS | 2 |
| Yin, W | 1 |
| McMasters, KM | 1 |
| McNally, LR | 2 |
| Frieboes, HB | 1 |
| Yin, WC | 1 |
| Maes, H | 1 |
| Kuchnio, A | 1 |
| Carmeliet, P | 1 |
| Agostinis, P | 1 |
| Wu, H | 1 |
| Huang, S | 1 |
| Chen, Z | 1 |
| Liu, W | 1 |
| Zhou, X | 1 |
| Zhang, D | 1 |
| Bae, D | 1 |
| Lu, S | 1 |
| Taglienti, CA | 1 |
| Mercurio, AM | 1 |
| JAILER, JW | 1 |
| ZUBROD, CG | 1 |
| Rouschop, KM | 1 |
| Ramaekers, CH | 1 |
| Schaaf, MB | 1 |
| Keulers, TG | 1 |
| Savelkouls, KG | 1 |
| Lambin, P | 1 |
| Koritzinsky, M | 1 |
| Wouters, BG | 1 |
| Jiang, M | 1 |
| Liu, K | 1 |
| Luo, J | 1 |
| Dong, Z | 1 |
| KURACHI, Y | 1 |
| YONEMURA, D | 1 |
| Moore, MN | 1 |
| Viarengo, A | 1 |
| Donkin, P | 1 |
| Hawkins, AJ | 1 |
| Abraham, R | 1 |
| Goldberg, L | 1 |
| Grasso, P | 1 |
| Nikolov, R | 1 |
| Papadopoulou, MV | 1 |
| Ji, M | 1 |
| Rao, MK | 1 |
| Bloomer, WD | 1 |
| Welman, E | 1 |
| Peters, TJ | 1 |
| Taegtmeyer, H | 1 |
| Ferguson, AG | 1 |
| Lesch, M | 1 |
| Kempf, J | 2 |
| Saissy, JM | 2 |
| Ridout, RM | 1 |
| Wildenthal, K | 1 |
| Decker, RS | 1 |
3 reviews available for chloroquine and Hypoxia
| Article | Year |
|---|---|
A current review of COVID-19 for the cardiovascular specialist.
Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; Betacoronavirus; Biomarkers; Card | 2020 |
COVID-19 and the burning issue of drug interaction: never forget the ECG.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antiviral | 2021 |
[Effects of diazepam and incidence of hypoxemia during acute chloroquine poisoning].
Topics: Acute Disease; Adolescent; Adult; Blood Gas Analysis; Chloroquine; Diazepam; Female; Humans; Hypoxia | 1992 |
21 other studies available for chloroquine and Hypoxia
| Article | Year |
|---|---|
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension.
Topics: Animals; Arterioles; Body Weight; Cell Line; Chloroquine; Disease Models, Animal; Hypoxia; Lung; Mal | 2021 |
Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.
Topics: Animals; Calcium Channels; Cell Proliferation; Cell Survival; Cells, Cultured; Chloroquine; Humans; | 2017 |
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.
Topics: Adenine; Animals; Autophagy; Chloroquine; Heart Diseases; Heart Failure; Hypoxia; Lysosomes; Male; M | 2013 |
Inhibition of autophagy with chloroquine is effective in melanoma.
Topics: Antibiotics, Antineoplastic; Antimalarials; Autophagy; Benzoquinones; Cell Line, Tumor; Chloroquine; | 2013 |
Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy.
Topics: Adenocarcinoma; Apoptosis; Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; Chloroquine; Dose | 2014 |
How to teach an old dog new tricks: autophagy-independent action of chloroquine on the tumor vasculature.
Topics: Animals; Antimalarials; Autophagy; Chloroquine; Endosomes; Gene Deletion; Humans; Hypoxia; Mice; Neo | 2014 |
Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway.
Topics: Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cel | 2015 |
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Membrane; Chloroquine; Culture Media; Endothelium, Vascul | 2008 |
Effect of acidosis and anoxia on the concentration of quinacrine and chloroquine in blood.
Topics: Acidosis; Chloroquine; Hypoxia; Quinacrine | 1948 |
Autophagy is required during cycling hypoxia to lower production of reactive oxygen species.
Topics: Analysis of Variance; Autophagy; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Survival; Chl | 2009 |
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; | 2010 |
[ERG, WITH SPECIAL REFERENCE TO ITS CORRELATION WITH INTERNAL DISEASES].
Topics: Anesthesia; Anesthesiology; Behcet Syndrome; Blood Circulation; Chloroquine; Diabetic Retinopathy; E | 1964 |
Autophagic and lysosomal reactions to stress in the hepatopancreas of blue mussels.
Topics: Animals; Autophagy; Chloroquine; Copper; Food Deprivation; Hepatopancreas; Hot Temperature; Hypoxia; | 2007 |
Hepatic response to lysosomal effects of hypoxia, neutral red and chloroquine.
Topics: Acid Phosphatase; Animals; Chloroquine; Coloring Agents; Glucuronidase; Histocytochemistry; Hypoxia; | 1967 |
Arachidonic acid cascade and anti-hypoxic drugs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Betamethasone; Chloroquine; Chlorpromazine; Cyclooxyge | 1984 |
4-[3-(2-Nitro-1-imidazolyl)propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin.
Topics: Aminoquinolines; Animals; Antineoplastic Agents; Cell Survival; Chloroquine; Chromatography, Thin La | 2000 |
Prevention of lysosome disruption in anoxic myocardium by chloroquine and methyl prednisolone.
Topics: Aerobiosis; Animals; Chloroquine; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Lysosomes; Male; | 1977 |
Thermoregulation of myocardial protein synthesis.
Topics: Animals; Chloroquine; Extracellular Space; Glucose; Hot Temperature; Hypoxia; In Vitro Techniques; M | 1975 |
[Hypoxemia in acute benign chloroquine intoxication].
Topics: Acute Disease; Chloroquine; Gastric Lavage; Humans; Hyperbaric Oxygenation; Hypoxia | 1991 |
Influence of agents that alter lysosomal function on fetal mouse hearts recovering from anoxia and substrate depletion.
Topics: Animals; Chloroquine; Female; Fetus; Hydrocortisone; Hypoxia; Kinetics; Leupeptins; Lysosomes; Mice; | 1986 |