chloroquine has been researched along with Hypoxia in 24 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
Excerpt | Relevance | Reference |
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" The purpose of this study was to investigate whether chloroquine induced relaxation in the pulmonary artery (PA) and attenuates hypoxia-induced pulmonary hypertension (HPH)." | 7.85 | Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. ( Ayon, RJ; Balistrieri, A; Black, SM; Garcia, JGN; Gu, Y; Liang, Z; Lu, W; Makino, A; McDermott, KM; Song, S; Tang, H; Wang, C; Wang, J; Wang, Z; Wu, K; Wu, X; Yuan, JX; Zhang, Q, 2017) |
"MiaPaCa2 (non-metastatic) and S2VP10 (metastatic) cell lines were treated with 25 and 50 µM chloroquine for 24 and 48 hours in normoxia and hypoxia (5-10% O₂)." | 7.80 | Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. ( Frieboes, HB; Huang, JS; McNally, LR; Yin, WC, 2014) |
"Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia." | 7.79 | Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013) |
"Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug." | 5.91 | Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023) |
"Chloroquine (CLQ) has been observed to inhibit calcium influx." | 5.62 | The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension. ( Akin, AT; Başaran, KE; Kaymak, E; Özdamar, S; Taheri, S; Tufan, E; Yakan, B, 2021) |
" In fact, two of the actually used drugs against SARS-CoV2, such as chloroquine and the combination lopinavir/ritonavir, might determine a QT (the time from the start of the Q wave to the end of the T wave) interval prolongation and they show several interactions with antiarrhythmic drugs and antipsychotic medications, making them prone to an increased risk of developing arrhythmias." | 5.12 | COVID-19 and the burning issue of drug interaction: never forget the ECG. ( Cameli, M; Cameli, P; Franchi, F; Mandoli, GE; Menci, D; Mondillo, S; Sciaccaluga, C; Sisti, N; Valente, S, 2021) |
" The purpose of this study was to investigate whether chloroquine induced relaxation in the pulmonary artery (PA) and attenuates hypoxia-induced pulmonary hypertension (HPH)." | 3.85 | Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. ( Ayon, RJ; Balistrieri, A; Black, SM; Garcia, JGN; Gu, Y; Liang, Z; Lu, W; Makino, A; McDermott, KM; Song, S; Tang, H; Wang, C; Wang, J; Wang, Z; Wu, K; Wu, X; Yuan, JX; Zhang, Q, 2017) |
"MiaPaCa2 (non-metastatic) and S2VP10 (metastatic) cell lines were treated with 25 and 50 µM chloroquine for 24 and 48 hours in normoxia and hypoxia (5-10% O₂)." | 3.80 | Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. ( Frieboes, HB; Huang, JS; McNally, LR; Yin, WC, 2014) |
"Chloroquine, echinomycin, and 17-DMAG each induced cytotoxicity in multiple human melanoma cell lines, in both normoxia and hypoxia." | 3.79 | Inhibition of autophagy with chloroquine is effective in melanoma. ( Egger, ME; Huang, JS; McMasters, KM; McNally, LR; Yin, W, 2013) |
" Inhibition of autophagy by chloroquine and 3-methyladenine worsened renal ischemia/reperfusion injury, as indicated by renal function, histology, and tubular apoptosis." | 3.76 | Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. ( Dong, Z; Jiang, M; Liu, K; Luo, J, 2010) |
"The anti-hypoxic effect of drugs that inhibit different steps of arachidonic acid metabolism was studied using an experimental model of acute hypobaric hypoxia in mice." | 3.67 | Arachidonic acid cascade and anti-hypoxic drugs. ( Nikolov, R, 1984) |
"Although coronavirus disease 2019 (COVID-19) predominantly disrupts the respiratory system, there is accumulating experience that the disease, particularly in its more severe manifestations, also affects the cardiovascular system." | 2.66 | A current review of COVID-19 for the cardiovascular specialist. ( Bohula, EA; Lang, JP; Morrow, DA; Moura, FA; Siddiqi, HK; Wang, X, 2020) |
"Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug." | 1.91 | Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023) |
"Chloroquine (CLQ) has been observed to inhibit calcium influx." | 1.62 | The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension. ( Akin, AT; Başaran, KE; Kaymak, E; Özdamar, S; Taheri, S; Tufan, E; Yakan, B, 2021) |
"These stressors included anoxia, hyperthermia, polycyclic aromatic hydrocarbons, copper and a combination of copper+nutritional deprivation." | 1.34 | Autophagic and lysosomal reactions to stress in the hepatopancreas of blue mussels. ( Donkin, P; Hawkins, AJ; Moore, MN; Viarengo, A, 2007) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (29.17) | 18.7374 |
1990's | 2 (8.33) | 18.2507 |
2000's | 4 (16.67) | 29.6817 |
2010's | 7 (29.17) | 24.3611 |
2020's | 4 (16.67) | 2.80 |
Authors | Studies |
---|---|
Kang, C | 2 |
Ju, S | 2 |
Kim, J | 2 |
Jung, Y | 2 |
Lang, JP | 1 |
Wang, X | 1 |
Moura, FA | 1 |
Siddiqi, HK | 1 |
Morrow, DA | 1 |
Bohula, EA | 1 |
Sciaccaluga, C | 1 |
Cameli, M | 1 |
Menci, D | 1 |
Mandoli, GE | 1 |
Sisti, N | 1 |
Cameli, P | 1 |
Franchi, F | 1 |
Mondillo, S | 1 |
Valente, S | 1 |
Kaymak, E | 1 |
Akin, AT | 1 |
Tufan, E | 1 |
Başaran, KE | 1 |
Taheri, S | 1 |
Özdamar, S | 1 |
Yakan, B | 1 |
Wu, K | 1 |
Zhang, Q | 1 |
Wu, X | 1 |
Lu, W | 1 |
Tang, H | 1 |
Liang, Z | 1 |
Gu, Y | 1 |
Song, S | 1 |
Ayon, RJ | 1 |
Wang, Z | 1 |
McDermott, KM | 1 |
Balistrieri, A | 1 |
Wang, C | 1 |
Black, SM | 1 |
Garcia, JGN | 1 |
Makino, A | 1 |
Yuan, JX | 1 |
Wang, J | 1 |
Maeda, H | 1 |
Nagai, H | 1 |
Takemura, G | 1 |
Shintani-Ishida, K | 1 |
Komatsu, M | 1 |
Ogura, S | 1 |
Aki, T | 1 |
Shirai, M | 1 |
Kuwahira, I | 1 |
Yoshida, K | 1 |
Egger, ME | 1 |
Huang, JS | 2 |
Yin, W | 1 |
McMasters, KM | 1 |
McNally, LR | 2 |
Frieboes, HB | 1 |
Yin, WC | 1 |
Maes, H | 1 |
Kuchnio, A | 1 |
Carmeliet, P | 1 |
Agostinis, P | 1 |
Wu, H | 1 |
Huang, S | 1 |
Chen, Z | 1 |
Liu, W | 1 |
Zhou, X | 1 |
Zhang, D | 1 |
Bae, D | 1 |
Lu, S | 1 |
Taglienti, CA | 1 |
Mercurio, AM | 1 |
JAILER, JW | 1 |
ZUBROD, CG | 1 |
Rouschop, KM | 1 |
Ramaekers, CH | 1 |
Schaaf, MB | 1 |
Keulers, TG | 1 |
Savelkouls, KG | 1 |
Lambin, P | 1 |
Koritzinsky, M | 1 |
Wouters, BG | 1 |
Jiang, M | 1 |
Liu, K | 1 |
Luo, J | 1 |
Dong, Z | 1 |
KURACHI, Y | 1 |
YONEMURA, D | 1 |
Moore, MN | 1 |
Viarengo, A | 1 |
Donkin, P | 1 |
Hawkins, AJ | 1 |
Abraham, R | 1 |
Goldberg, L | 1 |
Grasso, P | 1 |
Nikolov, R | 1 |
Papadopoulou, MV | 1 |
Ji, M | 1 |
Rao, MK | 1 |
Bloomer, WD | 1 |
Welman, E | 1 |
Peters, TJ | 1 |
Taegtmeyer, H | 1 |
Ferguson, AG | 1 |
Lesch, M | 1 |
Kempf, J | 2 |
Saissy, JM | 2 |
Ridout, RM | 1 |
Wildenthal, K | 1 |
Decker, RS | 1 |
3 reviews available for chloroquine and Hypoxia
Article | Year |
---|---|
A current review of COVID-19 for the cardiovascular specialist.
Topics: Adenosine Monophosphate; Alanine; Antimalarials; Antiviral Agents; Betacoronavirus; Biomarkers; Card | 2020 |
COVID-19 and the burning issue of drug interaction: never forget the ECG.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antiviral | 2021 |
[Effects of diazepam and incidence of hypoxemia during acute chloroquine poisoning].
Topics: Acute Disease; Adolescent; Adult; Blood Gas Analysis; Chloroquine; Diazepam; Female; Humans; Hypoxia | 1992 |
21 other studies available for chloroquine and Hypoxia
Article | Year |
---|---|
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension.
Topics: Animals; Arterioles; Body Weight; Cell Line; Chloroquine; Disease Models, Animal; Hypoxia; Lung; Mal | 2021 |
Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.
Topics: Animals; Calcium Channels; Cell Proliferation; Cell Survival; Cells, Cultured; Chloroquine; Humans; | 2017 |
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.
Topics: Adenine; Animals; Autophagy; Chloroquine; Heart Diseases; Heart Failure; Hypoxia; Lysosomes; Male; M | 2013 |
Inhibition of autophagy with chloroquine is effective in melanoma.
Topics: Antibiotics, Antineoplastic; Antimalarials; Autophagy; Benzoquinones; Cell Line, Tumor; Chloroquine; | 2013 |
Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy.
Topics: Adenocarcinoma; Apoptosis; Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; Chloroquine; Dose | 2014 |
How to teach an old dog new tricks: autophagy-independent action of chloroquine on the tumor vasculature.
Topics: Animals; Antimalarials; Autophagy; Chloroquine; Endosomes; Gene Deletion; Humans; Hypoxia; Mice; Neo | 2014 |
Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway.
Topics: Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cel | 2015 |
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Membrane; Chloroquine; Culture Media; Endothelium, Vascul | 2008 |
Effect of acidosis and anoxia on the concentration of quinacrine and chloroquine in blood.
Topics: Acidosis; Chloroquine; Hypoxia; Quinacrine | 1948 |
Autophagy is required during cycling hypoxia to lower production of reactive oxygen species.
Topics: Analysis of Variance; Autophagy; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Survival; Chl | 2009 |
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; | 2010 |
[ERG, WITH SPECIAL REFERENCE TO ITS CORRELATION WITH INTERNAL DISEASES].
Topics: Anesthesia; Anesthesiology; Behcet Syndrome; Blood Circulation; Chloroquine; Diabetic Retinopathy; E | 1964 |
Autophagic and lysosomal reactions to stress in the hepatopancreas of blue mussels.
Topics: Animals; Autophagy; Chloroquine; Copper; Food Deprivation; Hepatopancreas; Hot Temperature; Hypoxia; | 2007 |
Hepatic response to lysosomal effects of hypoxia, neutral red and chloroquine.
Topics: Acid Phosphatase; Animals; Chloroquine; Coloring Agents; Glucuronidase; Histocytochemistry; Hypoxia; | 1967 |
Arachidonic acid cascade and anti-hypoxic drugs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Betamethasone; Chloroquine; Chlorpromazine; Cyclooxyge | 1984 |
4-[3-(2-Nitro-1-imidazolyl)propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin.
Topics: Aminoquinolines; Animals; Antineoplastic Agents; Cell Survival; Chloroquine; Chromatography, Thin La | 2000 |
Prevention of lysosome disruption in anoxic myocardium by chloroquine and methyl prednisolone.
Topics: Aerobiosis; Animals; Chloroquine; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Lysosomes; Male; | 1977 |
Thermoregulation of myocardial protein synthesis.
Topics: Animals; Chloroquine; Extracellular Space; Glucose; Hot Temperature; Hypoxia; In Vitro Techniques; M | 1975 |
[Hypoxemia in acute benign chloroquine intoxication].
Topics: Acute Disease; Chloroquine; Gastric Lavage; Humans; Hyperbaric Oxygenation; Hypoxia | 1991 |
Influence of agents that alter lysosomal function on fetal mouse hearts recovering from anoxia and substrate depletion.
Topics: Animals; Chloroquine; Female; Fetus; Hydrocortisone; Hypoxia; Kinetics; Leupeptins; Lysosomes; Mice; | 1986 |