chloroquine has been researched along with Hypermelanosis in 10 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Due to historic of rheumatoid arthritis and use of chloroquine phosphate for 3 years, exogenous hyperpigmentation associated with the drug was included among the possible diagnoses." | 7.96 | Extensive hard palate hyperpigmentation associated with chloroquine use. ( de Araújo Gomes, EPA; Garcia, CL; Godinho, GV; Paz, ALLM; Volpato, LER, 2020) |
| " The antimalarial chloroquine diphosphate may be associated with a bluish-gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate." | 7.79 | Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases. ( de Almeida, OP; de Andrade, BA; Dos Santos Silva, AR; Falci, SG; Fonseca, FP; Jorge, J; Mesquita, AT; Pires, FR; Vargas, PA, 2013) |
| " Due to historic of rheumatoid arthritis and use of chloroquine phosphate for 3 years, exogenous hyperpigmentation associated with the drug was included among the possible diagnoses." | 3.96 | Extensive hard palate hyperpigmentation associated with chloroquine use. ( de Araújo Gomes, EPA; Garcia, CL; Godinho, GV; Paz, ALLM; Volpato, LER, 2020) |
| " The prolonged use of chloroquine and hydroxychloroquine can cause hyperpigmentation in the skin, oral mucosa and retinal pigment epithelium, which in turn can trigger toxicity in this epithelium, which in some cases causes vision loss." | 3.96 | Oral manifestations associated with antimalarial therapy in patients with systemic lupus erythematosus. ( Chacón-Dulcey, V; Frías, J; González, N; López-Labady, J; Pérez Alfonzo, R; Tirado, W; Villarroel-Dorrego, M, 2020) |
| " The antimalarial chloroquine diphosphate may be associated with a bluish-gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate." | 3.79 | Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases. ( de Almeida, OP; de Andrade, BA; Dos Santos Silva, AR; Falci, SG; Fonseca, FP; Jorge, J; Mesquita, AT; Pires, FR; Vargas, PA, 2013) |
| "9 years, and the mean drug dosage was 244 mg." | 2.82 | Oral pigmentation as an adverse effect of chloroquine and hydroxychloroquine use: A scoping review. ( Blumenberg, C; Cardoso, SV; Franco, A; Oliveira, MB; Paranhos, LR; Silva, PUJ; Siqueira, WL; Vieira, W, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Silva, PUJ | 1 |
| Oliveira, MB | 1 |
| Vieira, W | 1 |
| Cardoso, SV | 1 |
| Blumenberg, C | 1 |
| Franco, A | 1 |
| Siqueira, WL | 1 |
| Paranhos, LR | 1 |
| Godinho, GV | 1 |
| Paz, ALLM | 1 |
| de Araújo Gomes, EPA | 1 |
| Garcia, CL | 1 |
| Volpato, LER | 1 |
| Chacón-Dulcey, V | 1 |
| López-Labady, J | 1 |
| Villarroel-Dorrego, M | 1 |
| Frías, J | 1 |
| Tirado, W | 1 |
| González, N | 1 |
| Pérez Alfonzo, R | 1 |
| Manger, K | 1 |
| von Streitberg, U | 1 |
| Seitz, G | 1 |
| Kleyer, A | 1 |
| Manger, B | 1 |
| de Andrade, BA | 1 |
| Fonseca, FP | 1 |
| Pires, FR | 1 |
| Mesquita, AT | 1 |
| Falci, SG | 1 |
| Dos Santos Silva, AR | 1 |
| Vargas, PA | 1 |
| Jorge, J | 1 |
| de Almeida, OP | 1 |
| Ocampo-Garza, J | 1 |
| Herz-Ruelas, ME | 1 |
| Ocampo-Candiani, J | 1 |
| Gallo, CB | 1 |
| Luiz, AC | 1 |
| Ferrazzo, KL | 1 |
| Migliari, DA | 1 |
| Sugaya, NN | 1 |
| de Melo Filho, MR | 1 |
| da Silva, CA | 1 |
| da Rocha Dourado, M | 1 |
| de Oliveira Pires, MB | 1 |
| Pêgo, SP | 1 |
| de Freitas, EM | 1 |
| LANGHOF, H | 1 |
| GEYER, G | 1 |
| BARTHELMES, H | 1 |
| Anders, HJ | 1 |
| Sperling, JH | 1 |
| Schewe, S | 1 |
1 review available for chloroquine and Hypermelanosis
| Article | Year |
|---|---|
Oral pigmentation as an adverse effect of chloroquine and hydroxychloroquine use: A scoping review.
Topics: Chloroquine; Cross-Sectional Studies; Humans; Hydroxychloroquine; Hyperpigmentation; Pigmentation | 2022 |
9 other studies available for chloroquine and Hypermelanosis
| Article | Year |
|---|---|
Extensive hard palate hyperpigmentation associated with chloroquine use.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Chloroquine; Female; Humans; Hyperpigmentation; Palate, Hard | 2020 |
Oral manifestations associated with antimalarial therapy in patients with systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Female; Humans; Hydroxychloroquine; Hyperpigmen | 2020 |
Hard palate hyperpigmentation-a rare side effect of antimalarials.
Topics: Antimalarials; Chloroquine; Female; Humans; Hyperpigmentation; Middle Aged; Palate, Hard | 2018 |
Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases.
Topics: Aged, 80 and over; Antimalarials; Chloroquine; Female; Humans; Hyperpigmentation; Male; Middle Aged; | 2013 |
Acquired Hyperpigmentation and Cicatricial Alopecia.
Topics: Aged; Alopecia; Chloroquine; Diagnosis, Differential; Female; Humans; Hyperpigmentation; Lichen Plan | 2016 |
Drug-induced pigmentation of hard palate and skin due to chronic chloroquine therapy: report of two cases.
Topics: Aged; Antirheumatic Agents; Chloroquine; Drug Eruptions; Female; Humans; Hyperpigmentation; Mouth Di | 2009 |
Palate hyperpigmentation caused by prolonged use of the anti-malarial chloroquine.
Topics: Antimalarials; Chloroquine; Female; Humans; Hyperpigmentation; Middle Aged; Mouth Mucosa; Palate, Ha | 2012 |
[HYPERPIGMENTATION AND RETINOPATHY CAUSED BY CHLOROQUINE DIPHOSPHATE].
Topics: Chloroquine; Humans; Hyperpigmentation; Pigmentation Disorders; Retinal Diseases; Toxicology | 1965 |
[Chloroquine-induced cutaneous hyperpigmentation].
Topics: Antirheumatic Agents; Chloroquine; Drug Eruptions; Female; Forearm; Humans; Hyperpigmentation; Lupus | 2006 |