chloroquine has been researched along with Hypercholesterolemia in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine is an effective inhibitor of cholesterol synthesis in freshly isolated rat hepatocytes, cultured mouse L cells and 20,000 X g supernatants of mouse liver homogenates." | 5.27 | Could chloroquine be of value in the treatment of hypercholesterolemia? ( Beynen, AC, 1986) |
| "Chloroquine is an effective inhibitor of cholesterol synthesis in freshly isolated rat hepatocytes, cultured mouse L cells and 20,000 X g supernatants of mouse liver homogenates." | 1.27 | Could chloroquine be of value in the treatment of hypercholesterolemia? ( Beynen, AC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SHEARN, MA | 1 |
| Rahman, P | 1 |
| Gladman, DD | 1 |
| Urowitz, MB | 1 |
| Yuen, K | 1 |
| Hallett, D | 1 |
| Bruce, IN | 1 |
| Wu, JD | 1 |
| Butler, J | 1 |
| Bailey, JM | 1 |
| Stein, O | 1 |
| Stein, Y | 1 |
| Brown, MS | 1 |
| Dana, SE | 1 |
| Goldstein, JL | 1 |
| Beynen, AC | 1 |
1 review available for chloroquine and Hypercholesterolemia
| Article | Year |
|---|---|
Catabolism of serum lipoproteins.
Topics: Animals; Arteriosclerosis; Cells, Cultured; Chloroquine; Cholesterol; Chylomicrons; Humans; Hypercho | 1979 |
5 other studies available for chloroquine and Hypercholesterolemia
| Article | Year |
|---|---|
NORMOCHOLESTEROLEMIC NEPHROTIC SYNDROME OF SYSTEMIC LUPUS ERYTHEMATOSUS.
Topics: Adolescent; Body Weight; Chloroquine; Cholesterol; Humans; Hypercholesterolemia; Lupus Erythematosus | 1964 |
The cholesterol lowering effect of antimalarial drugs is enhanced in patients with lupus taking corticosteroid drugs.
Topics: Antimalarials; Antirheumatic Agents; Chloroquine; Cholesterol; Dose-Response Relationship, Drug; Dru | 1999 |
Lipid metabolism in cultured cells. XVIII. Comparative uptake of low density and high density lipoproteins by normal, hypercholesterolemic and tumor virus-transformed human fibroblasts.
Topics: Animals; Biological Transport; Cell Line; Cell Transformation, Viral; Chloroquine; Cycloheximide; He | 1979 |
Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.
Topics: Adult; Carboxylic Ester Hydrolases; Cells, Cultured; Child; Child, Preschool; Chloroquine; Cholester | 1975 |
Could chloroquine be of value in the treatment of hypercholesterolemia?
Topics: Animals; Chloroquine; Cholesterol; Fatty Acids; Humans; Hypercholesterolemia; Lysosomes; Mice; Rats | 1986 |