chloroquine has been researched along with Hemolysis in 69 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure')." | 8.98 | Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. ( Ashley, EA; Recht, J; White, NJ, 2018) |
| "Plasmodium vivax malaria elimination requires radical cure with chloroquine/primaquine." | 8.12 | Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India. ( Ahmed, N; Anvikar, AR; Duparc, S; Grewal Daumerie, P; Pradhan, MM; Pradhan, S; Sahu, P; Sharma, S; Valecha, N; Yadav, CP, 2022) |
| "Primaquine has the potential to reduce malaria-related anaemia at day 42 and beyond by preventing recurrent parasitaemia." | 6.61 | The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis. ( Abreha, T; Alemu, SG; Añez, A; Anstey, NM; Aseffa, A; Assefa, A; Awab, GR; Baird, JK; Barber, BE; Borghini-Fuhrer, I; Chu, CS; Commons, RJ; D'Alessandro, U; Dahal, P; Daher, A; de Vries, PJ; Douglas, NM; Erhart, A; Gomes, MSM; Grigg, MJ; Guerin, PJ; Hien, TT; Hwang, J; Kager, PA; Ketema, T; Khan, WA; Lacerda, MVG; Leslie, T; Ley, B; Lidia, K; Monteiro, WM; Nosten, F; Pereira, DB; Phan, GT; Phyo, AP; Price, RN; Rowland, M; Saravu, K; Sibley, CH; Simpson, JA; Siqueira, AM; Stepniewska, K; Taylor, WRJ; Thriemer, K; Thwaites, G; Tran, BQ; Vieira, JLF; Wangchuk, S; Watson, J; White, NJ; William, T; Woodrow, CJ, 2019) |
| " A sigmoidal dose-response curve is followed with 50% hemolysis being produced by 4 microM FP." | 5.26 | Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications. ( Chou, AC; Fitch, CD, 1980) |
| "Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure')." | 4.98 | Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. ( Ashley, EA; Recht, J; White, NJ, 2018) |
| "Plasmodium vivax malaria elimination requires radical cure with chloroquine/primaquine." | 4.12 | Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India. ( Ahmed, N; Anvikar, AR; Duparc, S; Grewal Daumerie, P; Pradhan, MM; Pradhan, S; Sahu, P; Sharma, S; Valecha, N; Yadav, CP, 2022) |
| "Since their first use in the 1920s, 8-aminoquinolines have been known to have important toxicities such as methemoglobinemia and hemolysis." | 4.12 | Historical 8-Aminoquinoline Combinations: Not All Antimalarial Drugs Work Well Together. ( Shanks, GD, 2022) |
| "Chloroquine (CQ) has been the main treatment for malaria in regions where there are no resistant strains." | 4.02 | In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization. ( Abramo, C; David da Silva, A; de Almeida Pimentel, G; de Pilla Varotti, F; Glanzmann, N; Gualberto Pereira, HM; Karine da Costa Nunes, I; Marinho, JA; Martins Guimarães, DS; Navarro, M, 2021) |
| " We now demonstrate the ability of 2-tert-butylprimaquine to inhibit in vitro beta-hematin formation, to form a complex with heme with a stoichiometry of 1:1, and to enhance heme-induced hemolysis." | 3.74 | 2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization. ( Harada, S; Huy, NT; Jain, M; Jain, R; Kamei, K; Kaur, K; Mizunuma, K; Nhien, NT; Uyen, DT, 2007) |
| " Since hydrogen peroxide can decompose FP, its effect on hemolysis induced by FP and by the complex of FP with chloroquine was investigated." | 3.67 | Ferriprotoporphyrin IX and cell lysis: a protective role for hydrogen peroxide. ( Fitch, CD; Kanjananggulpan, P; Orjih, AU, 1988) |
| " Therefore, standard dosages of MB appear to be safe in G6PD-deficient African populations with predominantly class III G6PD deficiency." | 2.71 | Safety of the combination of chloroquine and methylene blue in healthy adult men with G6PD deficiency from rural Burkina Faso. ( Burhenne, J; Coulibaly, B; Jahn, A; Kouyaté, B; Mandi, G; Mansmann, U; Meissner, P; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Sanon, M; Schiek, W; Schirmer, H; Walter-Sack, I; Witte, S; Wüst, K, 2005) |
| "Primaquine has the potential to reduce malaria-related anaemia at day 42 and beyond by preventing recurrent parasitaemia." | 2.61 | The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis. ( Abreha, T; Alemu, SG; Añez, A; Anstey, NM; Aseffa, A; Assefa, A; Awab, GR; Baird, JK; Barber, BE; Borghini-Fuhrer, I; Chu, CS; Commons, RJ; D'Alessandro, U; Dahal, P; Daher, A; de Vries, PJ; Douglas, NM; Erhart, A; Gomes, MSM; Grigg, MJ; Guerin, PJ; Hien, TT; Hwang, J; Kager, PA; Ketema, T; Khan, WA; Lacerda, MVG; Leslie, T; Ley, B; Lidia, K; Monteiro, WM; Nosten, F; Pereira, DB; Phan, GT; Phyo, AP; Price, RN; Rowland, M; Saravu, K; Sibley, CH; Simpson, JA; Siqueira, AM; Stepniewska, K; Taylor, WRJ; Thriemer, K; Thwaites, G; Tran, BQ; Vieira, JLF; Wangchuk, S; Watson, J; White, NJ; William, T; Woodrow, CJ, 2019) |
| "Primaquine was officially licensed as an anti-malarial drug by the FDA in 1952." | 2.47 | Primaquine in vivax malaria: an update and review on management issues. ( Fernando, D; Rajapakse, S; Rodrigo, C, 2011) |
| "The current available treatment for P." | 1.40 | Evaluation of antimalarial activity and toxicity of a new primaquine prodrug. ( Aguiar, AC; Campos, ML; Chin, CM; da Fonseca, LM; Davanço, MG; de Andrade, CR; Dos Santos, JL; Dos Santos, LA; Krettli, AU; Padilha, EC; Peccinini, RG, 2014) |
| " A few potent chalcones were selected for their antimalarial interaction in combination with artemisinin in vitro." | 1.35 | Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro. ( Awasthi, SK; Bhasin, VK; Bhattacharya, A; Mishra, LC; Sharma, M, 2009) |
| " A sigmoidal dose-response curve is followed with 50% hemolysis being produced by 4 microM FP." | 1.26 | Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications. ( Chou, AC; Fitch, CD, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (56.52) | 18.7374 |
| 1990's | 4 (5.80) | 18.2507 |
| 2000's | 8 (11.59) | 29.6817 |
| 2010's | 12 (17.39) | 24.3611 |
| 2020's | 6 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Huy, NT | 1 |
| Mizunuma, K | 1 |
| Kaur, K | 1 |
| Nhien, NT | 1 |
| Jain, M | 1 |
| Uyen, DT | 1 |
| Harada, S | 1 |
| Jain, R | 1 |
| Kamei, K | 1 |
| Bhattacharya, A | 1 |
| Mishra, LC | 1 |
| Sharma, M | 1 |
| Awasthi, SK | 1 |
| Bhasin, VK | 1 |
| Marinho, JA | 1 |
| Martins Guimarães, DS | 1 |
| Glanzmann, N | 1 |
| de Almeida Pimentel, G | 1 |
| Karine da Costa Nunes, I | 1 |
| Gualberto Pereira, HM | 1 |
| Navarro, M | 1 |
| de Pilla Varotti, F | 1 |
| David da Silva, A | 1 |
| Abramo, C | 1 |
| Anvikar, AR | 1 |
| Sahu, P | 1 |
| Pradhan, MM | 1 |
| Sharma, S | 1 |
| Ahmed, N | 1 |
| Yadav, CP | 1 |
| Pradhan, S | 1 |
| Duparc, S | 1 |
| Grewal Daumerie, P | 1 |
| Valecha, N | 1 |
| Shanks, GD | 1 |
| Kuipers, MT | 1 |
| van Zwieten, R | 1 |
| Heijmans, J | 1 |
| Rutten, CE | 1 |
| de Heer, K | 1 |
| Kater, AP | 1 |
| Nur, E | 1 |
| De Franceschi, L | 1 |
| Costa, E | 1 |
| Dima, F | 1 |
| Morandi, M | 1 |
| Olivieri, O | 1 |
| Schilling, WHK | 1 |
| Bancone, G | 2 |
| White, NJ | 3 |
| Recht, J | 1 |
| Ashley, EA | 1 |
| Commons, RJ | 1 |
| Simpson, JA | 1 |
| Thriemer, K | 1 |
| Chu, CS | 1 |
| Douglas, NM | 1 |
| Abreha, T | 1 |
| Alemu, SG | 1 |
| Añez, A | 1 |
| Anstey, NM | 1 |
| Aseffa, A | 1 |
| Assefa, A | 1 |
| Awab, GR | 1 |
| Baird, JK | 1 |
| Barber, BE | 1 |
| Borghini-Fuhrer, I | 1 |
| D'Alessandro, U | 1 |
| Dahal, P | 1 |
| Daher, A | 1 |
| de Vries, PJ | 1 |
| Erhart, A | 1 |
| Gomes, MSM | 1 |
| Grigg, MJ | 1 |
| Hwang, J | 1 |
| Kager, PA | 1 |
| Ketema, T | 1 |
| Khan, WA | 1 |
| Lacerda, MVG | 1 |
| Leslie, T | 1 |
| Ley, B | 1 |
| Lidia, K | 1 |
| Monteiro, WM | 1 |
| Pereira, DB | 1 |
| Phan, GT | 1 |
| Phyo, AP | 1 |
| Rowland, M | 1 |
| Saravu, K | 1 |
| Sibley, CH | 1 |
| Siqueira, AM | 1 |
| Stepniewska, K | 1 |
| Taylor, WRJ | 1 |
| Thwaites, G | 1 |
| Tran, BQ | 1 |
| Hien, TT | 1 |
| Vieira, JLF | 1 |
| Wangchuk, S | 1 |
| Watson, J | 1 |
| William, T | 1 |
| Woodrow, CJ | 1 |
| Nosten, F | 2 |
| Guerin, PJ | 1 |
| Price, RN | 1 |
| Salahuddin, A | 1 |
| Inam, A | 1 |
| van Zyl, RL | 1 |
| Heslop, DC | 1 |
| Chen, CT | 1 |
| Avecilla, F | 1 |
| Agarwal, SM | 1 |
| Azam, A | 1 |
| Iribhogbe, OI | 1 |
| Agbaje, EO | 1 |
| Oreagba, IA | 1 |
| Aina, OO | 1 |
| Ota, AD | 1 |
| Laothamatas, J | 1 |
| Sammet, CL | 1 |
| Golay, X | 1 |
| Van Cauteren, M | 1 |
| Lekprasert, V | 1 |
| Tangpukdee, N | 1 |
| Krudsood, S | 1 |
| Leowattana, W | 1 |
| Wilairatana, P | 1 |
| Swaminathan, SV | 1 |
| DeLaPaz, RL | 1 |
| Brown, TR | 1 |
| Looareesuwan, S | 1 |
| Brittenham, GM | 1 |
| Davanço, MG | 1 |
| Aguiar, AC | 1 |
| Dos Santos, LA | 1 |
| Padilha, EC | 1 |
| Campos, ML | 1 |
| de Andrade, CR | 1 |
| da Fonseca, LM | 1 |
| Dos Santos, JL | 1 |
| Chin, CM | 1 |
| Krettli, AU | 1 |
| Peccinini, RG | 1 |
| Shi, C | 1 |
| Zhang, Z | 1 |
| Shi, J | 1 |
| Wang, F | 1 |
| Luan, Y | 1 |
| Wang, H | 1 |
| Zhong, CY | 1 |
| Wu, JF | 1 |
| Huang, YB | 1 |
| Liu, CB | 1 |
| Burgoine, KL | 1 |
| Fernando, D | 1 |
| Rodrigo, C | 1 |
| Rajapakse, S | 1 |
| Sadeghian, F | 1 |
| Hosseinkhani, S | 1 |
| Alizadeh, A | 1 |
| Hatefi, A | 1 |
| Sun, XD | 1 |
| Wang, J | 1 |
| Wei, C | 1 |
| ALVING, AS | 1 |
| JOHNSON, CF | 1 |
| TARLOV, AR | 1 |
| BREWER, GJ | 1 |
| KELLERMEYER, RW | 1 |
| CARSON, PE | 2 |
| MOLENAAR, JC | 1 |
| VOORS, AW | 1 |
| COHEN, G | 1 |
| HOCHSTEIN, P | 1 |
| Auparakkitanon, S | 2 |
| Noonpakdee, W | 1 |
| Ralph, RK | 1 |
| Denny, WA | 1 |
| Wilairat, P | 2 |
| Mandi, G | 1 |
| Witte, S | 1 |
| Meissner, P | 1 |
| Coulibaly, B | 1 |
| Mansmann, U | 1 |
| Rengelshausen, J | 1 |
| Schiek, W | 1 |
| Jahn, A | 1 |
| Sanon, M | 1 |
| Wüst, K | 1 |
| Walter-Sack, I | 1 |
| Mikus, G | 1 |
| Burhenne, J | 1 |
| Riedel, KD | 1 |
| Schirmer, H | 1 |
| Kouyaté, B | 1 |
| Müller, O | 1 |
| Chapoy, P | 1 |
| Vovan, L | 1 |
| Theveniau, D | 1 |
| Garnier, JM | 1 |
| Perrimond, H | 1 |
| Louchet, E | 1 |
| Bhadra, D | 1 |
| Bhadra, S | 1 |
| Jain, NK | 1 |
| Chapoomram, S | 1 |
| Kuaha, K | 1 |
| Chirachariyavej, T | 1 |
| Rebholz, CE | 1 |
| Michel, AJ | 1 |
| Maselli, DA | 1 |
| Saipphudin, K | 1 |
| Wyss, K | 1 |
| Fitch, CD | 6 |
| Russell, NV | 1 |
| Dutta, P | 2 |
| Kanjananggulpan, P | 2 |
| Chevli, R | 1 |
| Reilly, Q | 1 |
| Yuthavong, Y | 1 |
| Chou, AC | 1 |
| Schrier, SL | 1 |
| Martínez-Rueda, JO | 1 |
| Arce-Salinas, CA | 1 |
| Kraus, A | 1 |
| Alcocer-Varela, J | 1 |
| Alarcón-Segovia, D | 1 |
| Handa, R | 1 |
| Wig, N | 1 |
| Aggarwal, P | 1 |
| Suresh, V | 1 |
| Biswas, A | 1 |
| Wali, JP | 1 |
| Depasse, J | 1 |
| Choudhry, VP | 1 |
| Madan, N | 1 |
| Sood, SK | 1 |
| Ghai, OP | 1 |
| Gaetani, GD | 1 |
| Mareni, C | 1 |
| Ravazzolo, R | 1 |
| Salvidio, E | 2 |
| Kashyap, A | 1 |
| Saha, K | 1 |
| Sehgal, VN | 1 |
| Ni, YC | 1 |
| Xu, YQ | 1 |
| Ginsburg, H | 1 |
| Krugliak, M | 1 |
| Zhang, Y | 1 |
| Hempelmann, E | 1 |
| Orjih, AU | 1 |
| Stein, CM | 1 |
| Germany, FM | 1 |
| Bhatia, A | 1 |
| Charet, P | 1 |
| Janney, SK | 1 |
| Joist, JJ | 1 |
| Ramanathan, VD | 1 |
| Sengupta, U | 1 |
| Roubal, Z | 1 |
| Grimová, J | 1 |
| Nĕmecek, O | 1 |
| Cepelák, V | 1 |
| Levy, MR | 1 |
| Chou, SC | 1 |
| Cucinell, SA | 1 |
| Rebert, C | 1 |
| Clyde, D | 1 |
| Seeler, RA | 1 |
| Miller, RA | 1 |
| Lin, CH | 1 |
| Lin, SK | 1 |
| Charoenlarp, P | 1 |
| Harinasuta, T | 1 |
| Lowe, JS | 1 |
| Turner, EH | 1 |
| Waller, HD | 1 |
| Lüer, S | 1 |
| Benöhr, HC | 1 |
| Dukes, DC | 1 |
| Sealey, BJ | 1 |
| Forbes, JI | 1 |
| Eppes, RB | 1 |
| McNamara, JV | 1 |
| DeGowin, RL | 1 |
| Powell, RD | 1 |
| Fujihira, E | 3 |
| Otomo, S | 3 |
| Sota, K | 1 |
| Nakazawa, M | 1 |
| Rey, M | 1 |
| Camerlynck, P | 1 |
| Oudart, JL | 1 |
| Zucker, JM | 1 |
| Plassart, M | 1 |
| Alihonou, E | 1 |
| Lafaix, C | 1 |
| Kramer, PA | 1 |
| Matusik, JE | 1 |
| Neblett, TR | 1 |
| Burnham, TK | 1 |
| Kay, N | 1 |
| Sheppard, H | 1 |
| Tsien, WH | 1 |
| Burghardt, C | 1 |
| Jobin, F | 1 |
| Gagnon, FT | 1 |
| Thiel, N | 1 |
| L'age-Stehr, J | 1 |
| Wacker, A | 1 |
| Pannacciulli, I | 1 |
| Tizianello, A | 1 |
| Parravidino, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Artemisinin Combination Treatment Reduce the Radical Curative Efficacy of High Dose Tafenoquine for Plasmodium Vivax Malaria?[NCT05788094] | Phase 4 | 388 participants (Anticipated) | Interventional | 2023-06-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for chloroquine and Hemolysis
| Article | Year |
|---|---|
Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries.
Topics: Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Ma | 2018 |
The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis.
Topics: Adult; Anemia, Hemolytic; Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficie | 2019 |
Primaquine in vivax malaria: an update and review on management issues.
Topics: Aminoquinolines; Antimalarials; Artemisinins; Chloroquine; Clinical Trials as Topic; Drug Resistance | 2011 |
1 trial available for chloroquine and Hemolysis
| Article | Year |
|---|---|
Safety of the combination of chloroquine and methylene blue in healthy adult men with G6PD deficiency from rural Burkina Faso.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Glucosephosphate Dehydroge | 2005 |
65 other studies available for chloroquine and Hemolysis
| Article | Year |
|---|---|
2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization.
Topics: Animals; Antimalarials; Erythrocytes; Hemeproteins; Hemolysis; Humans; Malaria, Falciparum; Parasiti | 2007 |
Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Artemisinins; Chalcone; Drug Combinations; Drug Synergism; Erythrocytes; Hem | 2009 |
In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization.
Topics: Animals; Antimalarials; Cell Line; Erythrocytes; Female; Hemeproteins; Hemin; Hemolysis; Humans; Mal | 2021 |
Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India.
Topics: Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Hemolysi | 2022 |
Historical 8-Aminoquinoline Combinations: Not All Antimalarial Drugs Work Well Together.
Topics: Aminoquinolines; Antimalarials; Chloroquine; Hemolysis; Humans; Primaquine; Quinine | 2022 |
Glucose-6-phosphate dehydrogenase deficiency-associated hemolysis and methemoglobinemia in a COVID-19 patient treated with chloroquine.
Topics: Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Glucosephos | 2020 |
Glucose-6-phosphate dehydrogenase deficiency associated hemolysis in COVID-19 patients treated with hydroxychloroquine/chloroquine: New case reports coming out.
Topics: Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Glucosephos | 2020 |
No evidence that chloroquine or hydroxychloroquine induce hemolysis in G6PD deficiency.
Topics: Antimalarials; Chloroquine; COVID-19 Drug Treatment; Enzyme Inhibitors; Glucosephosphate Dehydrogena | 2020 |
Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl)quinoline-sulfonamide as hybrid antiprotozoal agents.
Topics: Amino Acid Sequence; Antiprotozoal Agents; Cell Survival; Chloroquine; Crystallography, X-Ray; Dihyd | 2013 |
Oxidative stress and micronutrient therapy in malaria: an in vivo study in Plasmodium berghei infected mice.
Topics: Animals; Antioxidants; Artemisinins; Artesunate; Chloroquine; Dose-Response Relationship, Drug; Fema | 2013 |
Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria.
Topics: Acute Disease; Adult; Antimalarials; Artemisinins; Chloroquine; Corpus Callosum; Drug Therapy, Combi | 2014 |
Evaluation of antimalarial activity and toxicity of a new primaquine prodrug.
Topics: Aedes; Animals; Antimalarials; Cell Line; Chloroquine; Dipeptides; Glucosephosphate Dehydrogenase; H | 2014 |
Co-delivery of docetaxel and chloroquine via PEO-PPO-PCL/TPGS micelles for overcoming multidrug resistance.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Chloroquine; Docetaxel; Drug Combinations; Drug | 2015 |
Enhancement of TAT cell membrane penetration efficiency by dimethyl sulphoxide.
Topics: Active Transport, Cell Nucleus; Ammonium Chloride; Animals; Apoptosis; Capsid Proteins; Cell Membran | 2010 |
The reality of using primaquine.
Topics: Adult; Antimalarials; Chloroquine; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Mal | 2010 |
Design, engineering and preparation of a multi-domain fusion vector for gene delivery.
Topics: Animals; Chloroquine; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Deoxyribonucleases; DNA | 2012 |
[A case of vivax malaria with acute hemolysis from treatment of chloroquine combined with primaquine].
Topics: Antimalarials; Chloroquine; Hemolysis; Humans; Malaria, Vivax; Male; Primaquine; Young Adult | 2012 |
Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Piasmodium vivax by intermittent regimens of drug administration: a preliminary report.
Topics: Adult; Aminoquinolines; Antimalarials; Chloroquine; Hemolysis; Humans; Malaria, Vivax; Male; Primaqu | 1960 |
BLACKWATER FEVER AFTER THE USE OF CHLOROQUINE-PYRIMETHAMINE.
Topics: Blackwater Fever; Chloroquine; Hemolysis; Humans; Malaria; New Guinea; Pyrimethamine; Quinine; Toxic | 1963 |
GENERATION OF HYDROGEN PEROXIDE IN ERYTHROCYTES BY HEMOLYTIC AGENTS.
Topics: Antimalarials; Catalase; Chloroquine; Erythrocytes; Ethanol; Glucosephosphate Dehydrogenase Deficien | 1964 |
Antimalarial 9-anilinoacridine compounds directed at hematin.
Topics: Amsacrine; Animals; Antimalarials; Chloroquine; Erythrocytes; Hemin; Hemolysis; Humans; In Vitro Tec | 2003 |
[Malaria in childhood and G6PD deficiency. Report of three cases].
Topics: Adolescent; Antimalarials; Black People; Blood Transfusion; Child; Chloroquine; Comoros; Emergency T | 1978 |
PEGylated peptide dendrimeric carriers for the delivery of antimalarial drug chloroquine phosphate.
Topics: Animals; Antimalarials; Biological Availability; Chloroquine; Chondroitin Sulfates; Delayed-Action P | 2006 |
Targeting of hematin by the antimalarial pyronaridine.
Topics: Animals; Antimalarials; Chloroquine; Drug Delivery Systems; Erythrocytes; Glutathione; Hemeproteins; | 2006 |
Frequency of malaria and glucose-6-phosphate dehydrogenase deficiency in Tajikistan.
Topics: Adult; Chloroquine; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria; Malaria, Vivax; Mal | 2006 |
Accelerated denaturation of hemoglobin and the antimalarial action of chloroquine.
Topics: Animals; Antimalarials; Chloroquine; Erythrocytes; Hemin; Hemoglobins; Hemolysis; Hydrogen-Ion Conce | 2006 |
Ferriprotoporphyrin IX: a mediator of the antimalarial action of oxidants and 4-aminoquinoline drugs.
Topics: Aminoquinolines; Animals; Antimalarials; Cell Membrane; Chloroquine; Erythrocytes; Heme; Hemin; Hemo | 1984 |
Diverse membrane-active agents modify the hemolytic response to ferriprotoporphyrin IX.
Topics: Adult; Antimalarials; Calcium; Chloroquine; Drug Synergism; Erythrocytes; Female; Heme; Hemin; Hemol | 1983 |
Danger of haemolysis from primaquine use.
Topics: Chloroquine; Drug Therapy, Combination; Hemolysis; Humans; Malaria; Primaquine | 1982 |
Distribution of chloroquine in normal, pronase-treated and malaria-infected red cells.
Topics: Animals; Binding Sites; Chloroquine; Erythrocyte Membrane; Erythrocytes; Hemolysis; Malaria; Mice; P | 1980 |
Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications.
Topics: Animals; Chloroquine; Drug Interactions; Erythrocytes; Heme; Hemin; Hemolysis; In Vitro Techniques; | 1980 |
Human erythrocyte G6PD deficiency: pathophysiology, prevalence, diagnosis, and management.
Topics: Black People; Blood Transfusion; Chloroquine; Female; Genetic Counseling; Glucosephosphate Dehydroge | 1980 |
Factors associated with fetal losses in severe systemic lupus erythematosus.
Topics: Adult; Analysis of Variance; Azathioprine; Case-Control Studies; Chloroquine; Cohort Studies; Congen | 1996 |
Halofantrine in G-6 PD deficiency.
Topics: Aged; Antimalarials; Chloroquine; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria, Falci | 1997 |
Interaction between silica and hydrophobic cations.
Topics: Adsorption; Cations; Chloroquine; Hemolysis; Silicon Dioxide | 1978 |
Chloroquine induced haemolysis and acute renal failure in subjects with G-6-PD deficiency.
Topics: Acute Kidney Injury; Child; Chloroquine; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Human | 1978 |
Haemolytic effect of two sulphonamides evaluated by a new method.
Topics: Chloroquine; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; In Vitro Te | 1976 |
Reconstruction of anti-leprosy drug depleted complement haemolytic activity by addition of zymosan-treated sera (a source of C142) and CratEDTA (a source of C3-C9).
Topics: Animals; Chloroquine; Clofazimine; Complement Activation; Complement System Proteins; Dapsone; Edeti | 1992 |
[In vitro assay for detecting hemolytic toxicity of antimalarials incorporated with microsomal metabolic system].
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Hemolysis; Male; Microsomes, Liver; Primaquine | 1990 |
Effects of quinoline-containing antimalarials on the erythrocyte membrane and their significance to drug action on Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Erythrocyte Membrane; Hemolysis; Humans; Hydrogen-Ion Concentra | 1988 |
Lysis of malarial parasites and erythrocytes by ferriprotoporphyrin IX-chloroquine and the inhibition of this effect by proteins.
Topics: Chloroquine; Erythrocytes; Heme; Hemin; Hemolysis; Humans; Plasmodium falciparum; Proteins | 1987 |
Ferriprotoporphyrin IX and cell lysis: a protective role for hydrogen peroxide.
Topics: Chloroquine; Heme; Hemin; Hemolysis; Humans; Hydrogen Peroxide; In Vitro Techniques; Inactivation, M | 1988 |
Drug-induced haemolysis masquerading as blackwater fever.
Topics: Adult; Blackwater Fever; Chloroquine; Diagnosis, Differential; Female; Glucosephosphate Dehydrogenas | 1987 |
Chloroquine induces oxidative lysis of Plasmodium berghei parasitized red blood cells.
Topics: Animals; Chloroquine; Erythrocytes; Hemolysis; Malaria; Mice; Plasmodium berghei | 1985 |
Excess release of ferriheme in G6PD-deficient erythrocytes: possible cause of hemolysis and resistance to malaria.
Topics: Chloroquine; Erythrocyte Membrane; Ferric Compounds; Glucosephosphate Dehydrogenase Deficiency; Heme | 1986 |
In vitro inhibition of the activation of the human complement and coagulation systems by chloroquine.
Topics: Animals; Antigen-Antibody Complex; Blood Coagulation; Chloroquine; Complement Activation; Dose-Respo | 1985 |
Effects of nonsteroid anti-inflammatory agents and some dicoumarol derivatives on platelet aggregation, fibrinolysis and stabilization of cell membrane in vitro.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Platelets; Cell Membrane; Chloroquine; Coumarins; Depressio | 1972 |
Activity and some properties of an acid proteinase from normal and Plasmodium berghei-infected red cells.
Topics: Acid Phosphatase; Animals; Cell-Free System; Chloroquine; Dithiothreitol; Edetic Acid; Erythrocytes; | 1973 |
Clinical pharmacology of diformyldapsone.
Topics: Chloroquine; Dapsone; Drug Therapy, Combination; Erythrocytes; Formaldehyde; Glucosephosphate Dehydr | 1974 |
Transfusion-induced malaria. Plasmodium vivax in a 5-month-old child.
Topics: Chloroquine; Fever; Hemolysis; Hepatomegaly; Humans; Infant; Malaria; Male; Plasmodium vivax; Primaq | 1973 |
Relapses of vivax malaria after a conventional course of primaquine and chloroquine: report of 2 cases.
Topics: Adult; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Glucosephosphate Dehydrogenase; | 1973 |
The effect of adjuvant arthritis and drugs on the ability of rat plasma to inhibit the triton X-100 induced lysis of rabbit polymorphonuclear leucocyte granules.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Chlorobenzenes; Chloroquine; C | 1973 |
[Influence of chloroquine and primaquine on red cell metabolism (author's transl)].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Chloroquine; Erythroc | 1973 |
Oliguric renal failure in blackwater fever.
Topics: Acute Kidney Injury; Adolescent; Adult; Anuria; Biopsy; Black People; Chloroquine; Glucosephosphate | 1968 |
Chloroquine-resistant Plasmodium falciparum: protective and hemolytic effects of 4,4'-diaminodiphenylsulfone (DDS) administered daily together with weekly chloroquine and primaquine.
Topics: Adult; Black or African American; Chloroquine; Dapsone; Hemolysis; Humans; Malaria; Male; Plasmodium | 1967 |
[Anti-inflammatory activities of compounds related to anthranilic acid. II. On acridine mono- and dicarboxylic, and oxo-acridan monocarboxylic acid derivatives].
Topics: Acridines; Aminopyrine; Animals; Anti-Inflammatory Agents; Carboxylic Acids; Carrageenan; Cattle; Ch | 1971 |
[Clinical aspects of G 6 PD deficiency in African children (apropos of 50 cases in Dakars)].
Topics: Adolescent; Anemia, Hemolytic; Child; Child, Preschool; Chloramphenicol; Chloroquine; Erythrocyte Co | 1971 |
Location of chloroquine binding sites in Plasmodium berghei.
Topics: Animals; Binding Sites; Carbon Isotopes; Carbon Radioisotopes; Cell Membrane; Chloroquine; Chromatog | 1971 |
Chloroquine: its mechanism of action upon immune phenomena.
Topics: Animals; Antibody Formation; Antigen-Antibody Reactions; Chloroquine; Complement System Proteins; Fl | 1965 |
Effect of drugs on the hemolysis of rat erythrocytes.
Topics: Animals; Aspirin; Bile Acids and Salts; Chlordiazepoxide; Chloroquine; Chlorpromazine; Chlorprothixe | 1969 |
Platelet reactions and immune processes. IV. The inhibition of complement by pyrazole compounds and other inhibitors of platelet reactions.
Topics: Animals; Blood Coagulation; Blood Platelets; Chloroquine; Complement Inactivator Proteins; Erythrocy | 1970 |
[Stabilizing effect of anti-inflammatory drugs on erythrocyte membrane. II. On UV-induced canine erythrocyte hemolysisand lipid peroxidation, on UV-induced peroxide formation in extracted lipid, and on irradiated lipid-induced hemolysis].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Betamethasone; Capillary Permeability; Chloroquine; Dogs | 1970 |
[Stabilizing effect of anti-inflammatory drugs on erythrocyte membrane. I. On hemolysis and lipid peroxidation induced by H202 in canine erythrocyte].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Betamethasone; Cell Membrane; Chloroquine; Dogs; Erythro | 1970 |
[Studies on the influence of protein synthesis inhibitors on the formation of antibodies].
Topics: Animals; Anti-Infective Agents; Antibody Formation; Antimetabolites; Chloroquine; Dactinomycin; Depr | 1967 |
Hemolytic effects of standard single dosages of primaquine and chloroquine on G-6-PD-deficient caucasians.
Topics: Anemia, Hemolytic; Black or African American; Chloroquine; Chromium Isotopes; Female; Glucosephospha | 1969 |