chloroquine has been researched along with Head and Neck Neoplasms in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study tested the anti-HNSCC cell activity by a mTOR kinase inhibitor CZ415." | 1.48 | Targeting mTOR by CZ415 Inhibits Head and Neck Squamous Cell Carcinoma Cells. ( Ding, X; Gao, Y; Li, Q; Xie, J, 2018) |
| "Notably, when HNSCC cells were cocultured with normal fibroblasts, they upregulated autophagy through IL6, IL8, and basic fibroblast growth factor." | 1.46 | Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target. ( Alvi, S; Anant, S; Ananth, M; Arnold, L; Dai, H; Ding, WX; Girod, DA; Kakarala, K; New, J; Shnayder, Y; Tawfik, O; Thomas, SM; Thornton, M; Tsue, TT; Werner, L, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, L | 1 |
| Gong, X | 1 |
| Xiong, P | 1 |
| New, J | 1 |
| Arnold, L | 1 |
| Ananth, M | 1 |
| Alvi, S | 1 |
| Thornton, M | 1 |
| Werner, L | 1 |
| Tawfik, O | 1 |
| Dai, H | 1 |
| Shnayder, Y | 1 |
| Kakarala, K | 1 |
| Tsue, TT | 1 |
| Girod, DA | 1 |
| Ding, WX | 1 |
| Anant, S | 1 |
| Thomas, SM | 1 |
| Xie, J | 1 |
| Li, Q | 1 |
| Ding, X | 1 |
| Gao, Y | 1 |
| Chaachouay, H | 1 |
| Fehrenbacher, B | 1 |
| Toulany, M | 1 |
| Schaller, M | 1 |
| Multhoff, G | 1 |
| Rodemann, HP | 1 |
| Sobhakumari, A | 1 |
| Orcutt, KP | 1 |
| Love-Homan, L | 1 |
| Kowalski, CE | 1 |
| Parsons, AD | 1 |
| Knudson, CM | 1 |
| Simons, AL | 1 |
| Pazmiño, NH | 1 |
| Yuhas, JM | 1 |
6 other studies available for chloroquine and Head and Neck Neoplasms
| Article | Year |
|---|---|
[Gefitinib/chloroquine-liposome-microbubble complexes as ultrasound-triggered therapeutic particles for head and neck squamous cell carcinoma in vitro].
Topics: Cell Line, Tumor; Chloroquine; Gefitinib; Head and Neck Neoplasms; Humans; Liposomes; Microbubbles; | 2020 |
Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target.
Topics: Animals; Autophagy; Cancer-Associated Fibroblasts; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell | 2017 |
Targeting mTOR by CZ415 Inhibits Head and Neck Squamous Cell Carcinoma Cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Carcinoma, Squamous Cell; Cell Proliferation; Cell | 2018 |
AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cel | 2015 |
2-Deoxy-d-glucose Suppresses the In Vivo Antitumor Efficacy of Erlotinib in Head and Neck Squamous Cell Carcinoma Cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Carcinoma, Squamous Cell; Carrier Proteins; Cell Line, Tu | 2016 |
Chloroquine: nonselective inhibition of recovery from radiation injury in tumors and normal tissues.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Chloroquine; DNA; DNA Damage; DNA Repair; DNA, Neoplas | 1974 |