chloroquine has been researched along with Gaucher Disease in 1 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doebber, TW | 1 |
| Wu, MS | 1 |
| Bugianesi, RL | 1 |
| Ponpipom, MM | 1 |
| Furbish, FS | 1 |
| Barranger, JA | 1 |
| Brady, RO | 1 |
| Shen, TY | 1 |
1 other study available for chloroquine and Gaucher Disease
| Article | Year |
|---|---|
Enhanced macrophage uptake of synthetically glycosylated human placental beta-glucocerebrosidase.
Topics: Animals; Chloroquine; Endocytosis; Female; Gaucher Disease; Glucosidases; Glucosylceramidase; Glycop | 1982 |