chloroquine has been researched along with Experimental Neoplasms in 40 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53 tumor-suppressor pathway, preferentially enhances the death of Myc oncogene-overexpressing primary mouse B cells and mouse embryonic fibroblasts (MEFs) and impairs Myc-induced lymphomagenesis in a transgenic mouse model of human Burkitt lymphoma." | 3.74 | Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. ( Cleveland, JL; Dorsey, FC; Kastan, MB; Maclean, KH, 2008) |
| "Chloroquine-treated animals showed a statistically significant (6 weeks) shorter latent period of tumour development." | 1.27 | [Effect of khingamin on the development of SV40 virus-induced and transplantable tumors in hamsters]. ( Gamburg, LIu, 1986) |
| "Verapamil may enhance the cytotoxicity of EGF-PE by blocking lysosomal degradation of EGF-PE." | 1.27 | [The effect of calcium antagonists on intracellular transport of epidermal growth factor and the conjugate of epidermal growth factor with pseudomonas exotoxin]. ( Akiyama, S, 1985) |
| "The induction of skin cancer in mice of the Swiss (Carshalton) strain, by repeated irradiation with UV-light, was strikingly reduced by the local application of caffeine prior to each exposure." | 1.26 | Inhibition of skin carcinogenesis in vivo by caffeine and other agents. ( Latarjet, R; Zajdela, F, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (80.00) | 18.7374 |
| 1990's | 1 (2.50) | 18.2507 |
| 2000's | 2 (5.00) | 29.6817 |
| 2010's | 4 (10.00) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 1 |
| Liu, S | 1 |
| Liu, H | 1 |
| Yang, C | 1 |
| Jiang, A | 1 |
| Wei, H | 1 |
| Sun, D | 1 |
| Cai, Z | 1 |
| Zheng, Y | 1 |
| Qin, L | 1 |
| Xu, T | 1 |
| Xia, L | 1 |
| Wang, X | 1 |
| Zhang, X | 3 |
| Zhu, Z | 1 |
| Zhong, S | 1 |
| Wang, C | 2 |
| Shen, Z | 1 |
| Gao, M | 1 |
| Xu, Y | 1 |
| Qiu, L | 1 |
| Liang, X | 1 |
| Gu, J | 1 |
| Chang, D | 1 |
| Zhang, J | 1 |
| Chen, Z | 1 |
| Ye, Y | 1 |
| Tao, W | 1 |
| Zeng, X | 1 |
| Liu, G | 1 |
| Zhang, Y | 1 |
| Mei, L | 1 |
| Gu, Z | 1 |
| Loehberg, CR | 1 |
| Strissel, PL | 1 |
| Dittrich, R | 1 |
| Strick, R | 1 |
| Dittmer, J | 1 |
| Dittmer, A | 1 |
| Fabry, B | 1 |
| Kalender, WA | 1 |
| Koch, T | 1 |
| Wachter, DL | 1 |
| Groh, N | 1 |
| Polier, A | 1 |
| Brandt, I | 1 |
| Lotz, L | 1 |
| Hoffmann, I | 1 |
| Koppitz, F | 1 |
| Oeser, S | 1 |
| Mueller, A | 1 |
| Fasching, PA | 1 |
| Lux, MP | 1 |
| Beckmann, MW | 1 |
| Schrauder, MG | 1 |
| KIMURA, I | 3 |
| HIRAKI, K | 2 |
| DAMRON, MH | 1 |
| CLARK, RB | 1 |
| CZADO, L | 1 |
| POWERS, CC | 1 |
| RUTMAN, RJ | 1 |
| STEELE, WJ | 1 |
| PRICE, CC | 1 |
| Dang, CV | 1 |
| Maclean, KH | 1 |
| Dorsey, FC | 1 |
| Cleveland, JL | 1 |
| Kastan, MB | 1 |
| Kageyama, H | 1 |
| Kawanishi, K | 1 |
| Moritani, Y | 1 |
| Asano, K | 1 |
| Fukudome, M | 1 |
| Takayasu, M | 1 |
| Wake, Y | 1 |
| Halpern, J | 1 |
| Hinkle, PM | 1 |
| Westendorf, JM | 1 |
| Schonbrunn, A | 1 |
| Arnold, AM | 1 |
| Whitehouse, JM | 1 |
| Biller, H | 1 |
| Schachtschabel, DO | 1 |
| Leising, HB | 1 |
| Pfab, R | 1 |
| Hess, F | 1 |
| Chu, BC | 1 |
| Howell, SB | 1 |
| Giraldi, T | 1 |
| Sava, G | 1 |
| Kopitar, M | 1 |
| Brzin, J | 1 |
| Turk, V | 1 |
| Zajdela, F | 1 |
| Latarjet, R | 1 |
| Tebo, JM | 1 |
| Mortensen, RF | 1 |
| Gamburg, LIu | 1 |
| Sakamoto, K | 1 |
| Yoshioka, T | 1 |
| Shimizu, J | 1 |
| Sato, S | 1 |
| Nakajima, H | 1 |
| Fujiwara, H | 1 |
| Hamaoka, T | 1 |
| Ghoneum, M | 1 |
| Cooper, EL | 1 |
| Smith, C | 1 |
| Mørland, B | 1 |
| Akiyama, S | 1 |
| Tanneberger, S | 1 |
| Bacigalupo, G | 1 |
| Bliznakov, EG | 1 |
| Adler, AD | 1 |
| Van Woert, MH | 2 |
| Korb, F | 2 |
| Kim, SH | 1 |
| Kim, JH | 1 |
| Fried, J | 1 |
| Prasad, KN | 1 |
| Shamberger, RJ | 1 |
| Bedoya, V | 1 |
| Cenedella, RJ | 1 |
| Saxe, LH | 1 |
| Van Dyke, K | 1 |
| Nieper, HA | 1 |
| Kowalewski, K | 1 |
| Van Duuren, BL | 1 |
| Sivak, A | 1 |
| Katz, C | 1 |
| Melchionne, S | 1 |
| Gaudin, D | 1 |
| Yielding, KL | 1 |
| Yamaguchi, I | 1 |
| Takahashi, T | 1 |
| Narisawa, T | 1 |
| Karube, K | 1 |
| Majima, S | 1 |
40 other studies available for chloroquine and Experimental Neoplasms
| Article | Year |
|---|---|
Versatile cationic liposomes for RIP3 overexpression in colon cancer therapy and RIP3 downregulation in acute pancreatitis therapy.
Topics: Animals; Antimalarials; Arginine; Cell Line; Chemotherapy, Adjuvant; Chloroquine; Colonic Neoplasms; | 2020 |
Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Animals; Antineoplastic Agents; Aut | 2016 |
Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Do | 2017 |
Investigation and intervention of autophagy to guide cancer treatment with nanogels.
Topics: Animals; Autophagy; Chloroquine; Doxorubicin; Drug Delivery Systems; Endocytosis; Endosomes; Exocyto | 2017 |
Akt and p53 are potential mediators of reduced mammary tumor growth by cloroquine and the mTOR inhibitor RAD001.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; | 2012 |
BASIC AND CLINICAL STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH A FIBROBLAST-INHIBITING AGENT, CHLOROQUINE.
Topics: Animals; Biomedical Research; Carcinoma, Brown-Pearce; Carcinoma, Ehrlich Tumor; Chloroquine; Fibrob | 1963 |
STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. II. EFFECTS OF CHLOROQUINE ON ANIMAL TUMORS.
Topics: Animals; Antineoplastic Agents; Carcinoma, Brown-Pearce; Carcinoma, Ehrlich Tumor; Chloroquine; Fibr | 1963 |
A PROBLEM IN RESEARCH.
Topics: Antineoplastic Agents; Chloroquine; Electron Transport Complex IV; Mice; Neoplasms; Neoplasms, Exper | 1965 |
Experimental chemotherapy studies. I. Chemical and metabolic investigations of chloroquine mustard.
Topics: Animals; Chloroquine; Mechlorethamine; Mustard Plant; Neoplasms, Experimental; Nitrogen Mustard Comp | 1961 |
Antimalarial therapy prevents Myc-induced lymphoma.
Topics: Animals; Antimalarials; Apoptosis; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Au | 2008 |
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
Topics: Animals; Antirheumatic Agents; Apoptosis; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Prote | 2008 |
[Studies on the treatment of malignant tumor with fibroblast-inhibiting agents].
Topics: Aged; Animals; Antineoplastic Agents; Chloroquine; Female; Fibroblasts; Humans; Male; Mice; Middle A | 1966 |
[Effects of a few anti-neoplastic agents on transplanted tumor and significance of serum lactate dehydrogenase activity as its evaluation standard].
Topics: Animals; Antineoplastic Agents; Chloroquine; L-Lactate Dehydrogenase; Mice; Mitomycins; Neoplasm Tra | 1966 |
Evidence for an active step in thyroid hormone transport to nuclei: drug inhibition of L-125I-triiodothyronine binding to nuclear receptors in rat pituitary tumor cells.
Topics: Animals; Antineoplastic Agents; Biological Transport, Active; Cadaverine; Cell Line; Cell Nucleus; C | 1982 |
Characterization of bombesin receptors in a rat pituitary cell line.
Topics: Animals; Binding, Competitive; Bombesin; Cell Line; Chloroquine; Kinetics; Neoplasms, Experimental; | 1983 |
Interaction of VP16-213 with the DNA repair antagonist chloroquine.
Topics: Animals; Chloroquine; DNA Repair; Drug Interactions; Etoposide; Female; Lymphoma; Mice; Mice, Inbred | 1982 |
[Influence of x-rays and quinacrine (atebrine) or chloroquine (resochine)--alone or in combination--on growth and melanin formation of Harding-Passey melanoma cells in monolayer culture].
Topics: Cell Survival; Cells, Cultured; Chloroquine; Dose-Response Relationship, Radiation; Melanins; Melano | 1982 |
Differential toxicity of carrier-bound methotrexate toward human lymphocytes, marrow and tumor cells.
Topics: Astrocytoma; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chloroquine; Deoxyuridine; Humans; In | 1981 |
Neutral proteinase inhibitors and antimetastatic effects in mice.
Topics: Animals; Aurintricarboxylic Acid; Chloroquine; Indomethacin; Lung Neoplasms; Mice; Mice, Inbred C57B | 1980 |
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: some miscellaneous pharmaceutical substances.
Topics: Acriflavine; Animals; Anthralin; Aurothioglucose; Carcinogens; Chloroquine; Diazepam; Ethanolamines; | 1977 |
Inhibition of skin carcinogenesis in vivo by caffeine and other agents.
Topics: Animals; Caffeine; Cell Line; Chloroquine; DNA; DNA Repair; Female; Malondialdehyde; Mice; Neoplasms | 1978 |
Internalization and degradation of receptor bound C-reactive protein by U-937 cells: induction of H2O2 production and tumoricidal activity.
Topics: Ammonium Chloride; C-Reactive Protein; Cell Compartmentation; Cell Death; Cell Differentiation; Cell | 1991 |
[Effect of khingamin on the development of SV40 virus-induced and transplantable tumors in hamsters].
Topics: Animals; Animals, Newborn; Antineoplastic Agents; Chloroquine; Cricetinae; Drug Evaluation, Preclini | 1986 |
Mechanisms for recognition of tumor antigens and mediation of anti-tumor effect by noncytolytic Lyt-2+ T cell subset.
Topics: Animals; Antigens, Ly; Antigens, Neoplasm; Chloroquine; Female; Formaldehyde; Histocompatibility Ant | 1988 |
Inhibition of SK cell activity in frogs by certain drugs and sugars.
Topics: Animals; Carbohydrates; Cell Line; Chloroquine; Colchicine; Cycloheximide; Cytotoxicity, Immunologic | 1987 |
Cytotoxic activity of stimulated mouse macrophages exposed to various inhibitors.
Topics: Animals; Carbon Radioisotopes; Cell Line; Chloroquine; Colchicine; Cytotoxicity, Immunologic; Lysoso | 1986 |
[The effect of calcium antagonists on intracellular transport of epidermal growth factor and the conjugate of epidermal growth factor with pseudomonas exotoxin].
Topics: Biological Transport; Calcium Channel Blockers; Cathepsin B; Cathepsins; Cell Line; Cell Survival; C | 1985 |
[On the value of chloroquine in the treatment of malignant tumor diseases].
Topics: Adenocarcinoma, Scirrhous; Adult; Aged; Animals; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, E | 1967 |
Nonlinear response of the reticuloendothelial system upon stimulation.
Topics: Animals; Avian Sarcoma Viruses; Bacterial Infections; Chickens; Chloroquine; Dose-Response Relations | 1972 |
Effect of x-irradiation on melanosomal tyrosinase activity.
Topics: Animals; Catechol Oxidase; Chloroquine; Melanocytes; Melanoma; Mice; Neoplasm Transplantation; Neopl | 1973 |
Enhancement of the radiation response of cultured tumor cells by chloroquine.
Topics: Carbon Isotopes; Cell Line; Chloroquine; Female; HeLa Cells; Humans; Lung; Melanoma; Neoplasms, Expe | 1973 |
Regulation of tyrosinase activity in mouse melanoma and skin by changes in melanosomal membrane permeability.
Topics: Animals; Bile Acids and Salts; Catechol Oxidase; Cell Membrane Permeability; Chloroquine; Chlorproma | 1971 |
Inhibitory effect of vitamin A on carcinogenesis.
Topics: Acid Phosphatase; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Benz(a)Anthracenes; B | 1971 |
Effect of chloroquine on malignant lymphoreticular and pigmented cells in vitro.
Topics: Animals; Burkitt Lymphoma; Cell Nucleolus; Cell Nucleus; Chloroquine; Culture Techniques; Cytoplasm; | 1970 |
An automated method of mass drug testing applied to screening for antimalarial activity.
Topics: Animals; Antimalarials; Automation; Chloroquine; Erythrocytes; Glucose; Glycolysis; Lactates; Male; | 1970 |
[Cytostatic effect of resochin and atebrin (compare same journal 20 (N.F.) 28: 1591 (1969))].
Topics: Animals; Antineoplastic Agents; Chloroquine; Humans; Neoplasms; Neoplasms, Experimental; Quinacrine | 1970 |
Effect of chloroquine on tissue hydroxyproline and hexosamine in mice bearing Bashford carcinoma.
Topics: Animals; Carcinoma; Chloroquine; Hexosamines; Hydroxyproline; Male; Mice; Neoplasms, Connective Tiss | 1967 |
Inhibition of tumor induction in two-stage carcinogenesis on mouse skin.
Topics: Aflatoxins; Animals; Antineoplastic Agents; Benz(a)Anthracenes; Chloroquine; Cyclohexanes; Cytarabin | 1969 |
Response of a "resistant" plasmacytoma to alkylating agents and x-ray in combination with the "excision" repair inhibitors caffeine and chloroquine.
Topics: Animals; Caffeine; Chloroquine; Cricetinae; Cyclophosphamide; Depression, Chemical; DNA, Neoplasm; M | 1969 |
Influence of host conditions upon the growth pattern of transplanted tumors.
Topics: Animals; Carcinoma, Ehrlich Tumor; Chloroquine; Female; Male; Mammary Neoplasms, Experimental; Mice; | 1966 |