chloroquine has been researched along with Experimental Mammary Neoplasms in 10 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In two separate experiments, treatment of C3H/He mice bearing transplantable mammary adenocarcinomas (C3HBA) with a regimen of 6-propylthiouracil (PTUra) and 5-fluorouracil (FUra) plus chloroquine phosphate (CP) resulted in complete remissions of 77 and 65%, respectively." | 7.66 | Remissions of mammary adenocarcinoma in hypothyroid mice given 5-fluorouracil and chloroquine phosphate. ( Dagher, RK; Shoemaker, JP, 1979) |
| "Metastatic breast cancers are hard to treat and almost always fatal." | 5.36 | Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. ( Deng, XQ; Jiang, PD; Li, ZG; Mao, YQ; Shi, W; Tang, QQ; Wei, YQ; Yang, SY; Zhao, YL; Zheng, YZ, 2010) |
| "In two separate experiments, treatment of C3H/He mice bearing transplantable mammary adenocarcinomas (C3HBA) with a regimen of 6-propylthiouracil (PTUra) and 5-fluorouracil (FUra) plus chloroquine phosphate (CP) resulted in complete remissions of 77 and 65%, respectively." | 3.66 | Remissions of mammary adenocarcinoma in hypothyroid mice given 5-fluorouracil and chloroquine phosphate. ( Dagher, RK; Shoemaker, JP, 1979) |
| "Human mammary cancer cells and derived xenografts were used to examine whether hypoxia could exacerbate autophagy-mediated resistance to the mTOR inhibitor rapamycin." | 1.39 | Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours. ( Boidot, R; Bouzin, C; Feron, O; Gallez, B; Jordan, BF; Karroum, O; Machiels, JP; Seront, E, 2013) |
| "Metastatic breast cancers are hard to treat and almost always fatal." | 1.36 | Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. ( Deng, XQ; Jiang, PD; Li, ZG; Mao, YQ; Shi, W; Tang, QQ; Wei, YQ; Yang, SY; Zhao, YL; Zheng, YZ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hirai, S | 1 |
| Kikuchi, H | 1 |
| Kim, HS | 1 |
| Begum, K | 1 |
| Wataya, Y | 1 |
| Tasaka, H | 1 |
| Miyazawa, Y | 1 |
| Yamamoto, K | 1 |
| Oshima, Y | 1 |
| Chiang, CF | 1 |
| Hsu, YH | 1 |
| Liu, CC | 1 |
| Liang, PC | 1 |
| Miaw, SC | 1 |
| Lin, WL | 1 |
| Seront, E | 1 |
| Boidot, R | 1 |
| Bouzin, C | 1 |
| Karroum, O | 1 |
| Jordan, BF | 1 |
| Gallez, B | 1 |
| Machiels, JP | 1 |
| Feron, O | 1 |
| Jiang, PD | 1 |
| Zhao, YL | 1 |
| Deng, XQ | 1 |
| Mao, YQ | 1 |
| Shi, W | 1 |
| Tang, QQ | 1 |
| Li, ZG | 1 |
| Zheng, YZ | 1 |
| Yang, SY | 1 |
| Wei, YQ | 1 |
| Costlow, M | 1 |
| Hample, A | 1 |
| Gandilhon, P | 1 |
| Melancon, R | 1 |
| Gandilhon, F | 1 |
| Djiane, J | 1 |
| Kelly, PA | 1 |
| Dutta, P | 1 |
| Karmali, R | 1 |
| Pinto, JT | 1 |
| Rivlin, RS | 1 |
| Shoemaker, JP | 2 |
| Dagher, RK | 1 |
| Yamaguchi, I | 1 |
| Takahashi, T | 1 |
| Narisawa, T | 1 |
| Karube, K | 1 |
| Majima, S | 1 |
10 other studies available for chloroquine and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite.
Topics: Administration, Oral; Animals; Antimalarials; Antineoplastic Agents; Dose-Response Relationship, Dru | 2003 |
Pulsed-wave Ultrasound Hyperthermia Enhanced Nanodrug Delivery Combined with Chloroquine Exerts Effective Antitumor Response and Postpones Recurrence.
Topics: Animals; Cell Line, Tumor; Chloroquine; Doxorubicin; Drug Delivery Systems; Female; Hyperthermia, In | 2019 |
Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Breast Neoplasms; Cell Hypoxia; | 2013 |
Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 9; Cell Cycle; Cell | 2010 |
Metabolic inhibitors increase prolactin binding to cultured mammary tumor cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bacitracin; Cells, Cultured; Chloroquine; Dinitrophenols; | 1980 |
Prolactin receptors in explant cultures of carcinogen-induced rat mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chloroquine; Colchicine; Cycloheximide; Cytochalasin B; F | 1983 |
Enhanced growth of mammary adenocarcinoma in rats by chloroquine and quinacrine.
Topics: Adenocarcinoma; Animals; Body Weight; Cell Division; Chloroquine; Dinoprostone; Erythrocytes; Female | 1994 |
Remissions of mammary adenocarcinoma in hypothyroid mice given 5-fluorouracil and chloroquine phosphate.
Topics: Adenocarcinoma; Animals; Chloroquine; Drug Therapy, Combination; Female; Fluorouracil; Hypothyroidis | 1979 |
Fifty-five percent complete remission of mammary carcinoma in mice with 5-fluorouracil and chloroquine.
Topics: Animals; Chloroquine; Drug Therapy, Combination; Female; Fluorouracil; Mammary Neoplasms, Experiment | 1978 |
Influence of host conditions upon the growth pattern of transplanted tumors.
Topics: Animals; Carcinoma, Ehrlich Tumor; Chloroquine; Female; Male; Mammary Neoplasms, Experimental; Mice; | 1966 |