chloroquine has been researched along with Enlarged Spleen in 38 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " At present, under the National guidelines; all fevers are presumed to be due to malaria and chloroquine is given as presumptive treatment." | 3.70 | Clinical case definition of malaria at a secondary level hospital in northern India. ( Anand, K; Kant, S; Kapoor, SK; Kumar, G, 1999) |
| " There was a decrease in spleen rate and a fall in average enlarged spleen size with increasing gestational age for women attending on a first clinic visit and before receiving chloroquine prophylaxis." | 3.67 | A longitudinal study of splenomegaly in pregnancy in a malaria endemic area in Papua New Guinea. ( Alpers, MP; Brabin, BJ; Brabin, LR; Sapau, J, 1988) |
| "A village-based programme of presumptive treatment of fever, using voluntary village aides to dispense oral chloroquine or amodiaquine, was established in 1982 by the Papua New Guinea Institute of Medical Research (PNG IMR) in 35 rural villages or hamlets near Madang, on the north coast of PNG." | 3.67 | The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health. ( Alpers, MP; Heywood, PF; Jolley, DJ; Moir, JS; Tulloch, JL; Vrbova, H, 1985) |
| "Self-reported CQ treatment of fever episodes at home as well as referrals to health centres increased over the study period." | 2.73 | Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial. ( Becher, H; Coulibaly, B; Eriksen, J; Gustafsson, L; Jahn, A; Kouyaté, B; Mueller, O; Sauerborn, R; Somé, F; Tomson, G, 2008) |
| "Children with deep coma (scoring 0-2) had significantly longer duration of coma before presentation (P = 0." | 2.68 | Predictors of severity of illness on presentation in children with cerebral malaria. ( Biemba, G; Gordeuk, VR; Khumalo, H; Mabeza, GF; Moyo, VM; Nyarugwe, P; Parry, D; Thuma, PE; Zulu, S, 1995) |
| "Chloroquine was once the most widely used antimalarial for nearly eight decades for its safety, efficiency, stability, low cost and finally for its less toxic nature." | 1.48 | Optimisation of chloroquine phosphate loaded nanostructured lipid carriers using Box-Behnken design and its antimalarial efficacy. ( Baruah, UK; Gowthamarajan, K; Karri, VVSR; Ravisankar, V; Simhadri, PK; Singh, V, 2018) |
| "Chloroquine was initiated for therapy and the patient was successfully treated." | 1.33 | [A transfusion-transmitted malaria case]. ( Altoparlak, U; Erol, S; Kadanali, A; Ozkurt, Z; Taşyaran, MA, 2005) |
| "Chloroquine resistance was seen in 23% of the cases." | 1.32 | Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal community. ( Chand, SK; Mishra, AK; Shukla, MM; Singh, N, 2003) |
| "The prevalence of enlarged spleen was 57% in children and 10% in adults and closely matched the corresponding age-related parasite rate." | 1.29 | The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity. ( al-Yaman, F; Alpers, MP; Beck, HP; Genton, B; Gibson, N; Hii, J; Mellor, S; Narara, A; Smith, T, 1995) |
| "Chloroquine was effective in 75% cases despite of existence of resistant falciparum strain." | 1.29 | Epidemiological observations on malaria in villages of Buhari PHC, Surat, Gujarat. ( Bhatt, RM; Kant, R; Sharma, SK; Sharma, VP; Srivastava, HC, 1995) |
| "Malaria is an increasing hazard of tropical travel." | 1.26 | Imported malaria in adults in Auckland. ( Ellis-Pegler, RB; Palmer, CW, 1982) |
| "In general tertian malaria is rarely fatal to adults, but in children the primary attack can be life threatening." | 1.26 | [Tertiary malaria with acute lung edema in a Turkish child]. ( Sauer, O, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (55.26) | 18.7374 |
| 1990's | 9 (23.68) | 18.2507 |
| 2000's | 6 (15.79) | 29.6817 |
| 2010's | 2 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baruah, UK | 1 |
| Gowthamarajan, K | 1 |
| Ravisankar, V | 1 |
| Karri, VVSR | 1 |
| Simhadri, PK | 1 |
| Singh, V | 1 |
| Kim, EM | 1 |
| Cho, HJ | 1 |
| Cho, CR | 1 |
| Kwak, YG | 1 |
| Kim, MY | 1 |
| Cho, YK | 1 |
| Singh, N | 1 |
| Mishra, AK | 1 |
| Shukla, MM | 1 |
| Chand, SK | 1 |
| Ozkurt, Z | 1 |
| Erol, S | 1 |
| Kadanali, A | 1 |
| Altoparlak, U | 1 |
| Taşyaran, MA | 1 |
| Singh, RK | 1 |
| Mothe, B | 1 |
| Lopez-Contreras, J | 1 |
| Torres, OH | 1 |
| Muñoz, C | 1 |
| Domingo, P | 1 |
| Gurgui, M | 1 |
| BERBERIAN, DA | 1 |
| DENNIS, EW | 1 |
| Kouyaté, B | 1 |
| Somé, F | 1 |
| Jahn, A | 1 |
| Coulibaly, B | 1 |
| Eriksen, J | 1 |
| Sauerborn, R | 1 |
| Gustafsson, L | 1 |
| Tomson, G | 1 |
| Becher, H | 1 |
| Mueller, O | 1 |
| Hoffman, SL | 1 |
| Piessens, WF | 1 |
| Ratiwayanto, S | 1 |
| Hussein, PR | 1 |
| Kurniawan, L | 1 |
| Piessens, PW | 1 |
| Campbell, JR | 1 |
| Marwoto, HA | 1 |
| Palmer, CW | 1 |
| Ellis-Pegler, RB | 1 |
| Bhattacharya, DN | 1 |
| Harries, JR | 1 |
| Emerson, PA | 1 |
| Genton, B | 1 |
| al-Yaman, F | 1 |
| Beck, HP | 1 |
| Hii, J | 1 |
| Mellor, S | 1 |
| Narara, A | 1 |
| Gibson, N | 1 |
| Smith, T | 1 |
| Alpers, MP | 3 |
| Mabeza, GF | 1 |
| Moyo, VM | 1 |
| Thuma, PE | 1 |
| Biemba, G | 1 |
| Parry, D | 1 |
| Khumalo, H | 1 |
| Nyarugwe, P | 1 |
| Zulu, S | 1 |
| Gordeuk, VR | 1 |
| Hogh, B | 1 |
| Marbiah, NT | 1 |
| Petersen, E | 1 |
| Dolopaye, E | 1 |
| Willcox, M | 1 |
| Björkman, A | 1 |
| Hanson, AP | 1 |
| Gottschau, A | 1 |
| Wolde, B | 1 |
| Pickering, J | 1 |
| Wotton, K | 1 |
| Barnish, G | 1 |
| Maude, GH | 1 |
| Bockarie, MJ | 1 |
| Eggelte, TA | 1 |
| Greenwood, BM | 1 |
| Srivastava, HC | 1 |
| Kant, R | 1 |
| Bhatt, RM | 1 |
| Sharma, SK | 1 |
| Sharma, VP | 1 |
| Anand, K | 1 |
| Kant, S | 1 |
| Kumar, G | 1 |
| Kapoor, SK | 1 |
| Van den Ende, J | 1 |
| van Gompel, A | 1 |
| van den Enden, E | 1 |
| Taelman, H | 1 |
| Vanham, G | 1 |
| Vervoort, T | 1 |
| Sauer, O | 1 |
| Hedman, P | 1 |
| Brohult, J | 1 |
| Forslund, J | 1 |
| Sirleaf, V | 1 |
| Bengtsson, E | 1 |
| Martet, G | 1 |
| Da Conceicao, S | 1 |
| Cordoliani, G | 1 |
| Delolme, H | 1 |
| Raphenon, G | 1 |
| Hovette, P | 1 |
| Doury, JC | 1 |
| Baudon, D | 1 |
| Touze, JE | 1 |
| Lecamus, JL | 1 |
| Betticher, DC | 1 |
| Nicole, A | 1 |
| Pugin, P | 1 |
| Regamey, C | 1 |
| Gupta, OP | 1 |
| Bajaj, S | 1 |
| Gupta, SC | 1 |
| Brabin, BJ | 1 |
| Brabin, LR | 1 |
| Sapau, J | 1 |
| Gupta, HL | 1 |
| Vankataswar, N | 1 |
| Aggarwal, A | 1 |
| Bhutani, P | 1 |
| Moir, JS | 1 |
| Tulloch, JL | 1 |
| Vrbova, H | 1 |
| Jolley, DJ | 1 |
| Heywood, PF | 1 |
| Pazmiño, NH | 1 |
| Yuhas, JM | 1 |
| Tennant, RW | 1 |
| Seeler, RA | 1 |
| Miller, RA | 1 |
| Lin, CH | 1 |
| Lin, SK | 1 |
| MacLennan, R | 1 |
| Walsh, RJ | 1 |
| Mallin, WS | 1 |
| Alter, AA | 1 |
| Ritz, ND | 1 |
| Dempsey, L | 1 |
| Powell, RJ | 1 |
| Vanier, TM | 1 |
| Hutt, MS | 2 |
| Cook, GC | 1 |
| Lapierre, J | 1 |
| Schneider, MD | 1 |
| Zeleznick, LD | 1 |
| Crim, JA | 1 |
| Gray, GD | 1 |
| Hamilton, PJ | 1 |
| Gebbie, DA | 1 |
| Lothe, F | 1 |
| Wilks, NE | 1 |
4 trials available for chloroquine and Enlarged Spleen
| Article | Year |
|---|---|
Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial.
Topics: Anemia; Animals; Burkina Faso; Child, Preschool; Chloroquine; Female; Fever; Humans; Infant; Malaria | 2008 |
Predictors of severity of illness on presentation in children with cerebral malaria.
Topics: Age of Onset; Anemia; Child, Preschool; Chloroquine; Coma; Double-Blind Method; Drug Resistance; Fem | 1995 |
Classification of clinical falciparum malaria and its use for the evaluation of chemosuppression in children under six years of age in Liberia, west Africa.
Topics: Anemia; Body Temperature; Child, Preschool; Chloroquine; Cohort Studies; Female; Humans; Infant; Lib | 1993 |
Chloroquine chemoprophylaxis in children during peak transmission period in Ethiopia.
Topics: Adolescent; Age Distribution; Child; Child, Preschool; Chloroquine; Drug Resistance; Ethiopia; Follo | 1994 |
34 other studies available for chloroquine and Enlarged Spleen
| Article | Year |
|---|---|
Optimisation of chloroquine phosphate loaded nanostructured lipid carriers using Box-Behnken design and its antimalarial efficacy.
Topics: Animals; Antimalarials; Calorimetry, Differential Scanning; Chloroquine; Chromatography, High Pressu | 2018 |
Abdominal computed tomography findings of malaria infection with Plasmodium vivax.
Topics: Abdomen; Antimalarials; Chloroquine; Female; Humans; Malaria, Vivax; Male; Middle Aged; Plasmodium v | 2010 |
Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal community.
Topics: Adolescent; Adult; Age Factors; Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroqu | 2003 |
[A transfusion-transmitted malaria case].
Topics: Animals; Antimalarials; Blood Donors; Chills; Chloroquine; Diarrhea; Female; Fever; Humans; Jaundice | 2005 |
Tinospora cordifolia as an adjuvant drug in the treatment of hyper-reactive malarious splenomegaly--case reports.
Topics: Adult; Chemotherapy, Adjuvant; Chloroquine; Drug Therapy, Combination; Female; Hemoglobins; Humans; | 2005 |
A case of hyper-reactive malarial splenomegaly. The role of rapid antigen-detecting and PCR-based tests.
Topics: Aged; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Chloroquine; Humans; Malar | 2008 |
The effect of chloroquine diphosphate on malaria splenomegaly.
Topics: Chloroquine; Malaria; Splenomegaly | 1949 |
Reduction of suppressor T lymphocytes in the tropical splenomegaly syndrome.
Topics: Adolescent; Adult; Antibodies; Chloroquine; Female; Humans; Immunoglobulin G; Immunoglobulin M; Indo | 1984 |
Imported malaria in adults in Auckland.
Topics: Adolescent; Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Kenya; Malaria; Male; Mi | 1982 |
Tropical splenomegaly syndrome (T.S.S.) in a European.
Topics: Aged; Chloroquine; Humans; Malaria; Male; Proguanil; Splenomegaly | 1983 |
The World Health Organisation North Fly clinico-epidemilogical pilot study.
Topics: Anemia; Child; Child, Preschool; Chloroquine; Cysticercosis; Elephantiasis; Epidemiologic Methods; F | 1980 |
The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity.
Topics: Adolescent; Adult; Age Factors; Antibodies, Protozoan; Child; Child, Preschool; Chloroquine; Female; | 1995 |
The epidemiology of malaria in southern Sierra Leone.
Topics: Child; Child, Preschool; Chloroquine; Comorbidity; Cross-Sectional Studies; Female; Fever; Hematocri | 1993 |
Epidemiological observations on malaria in villages of Buhari PHC, Surat, Gujarat.
Topics: Adolescent; Adult; Animals; Anopheles; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Res | 1995 |
Clinical case definition of malaria at a secondary level hospital in northern India.
Topics: Analysis of Variance; Antimalarials; Case-Control Studies; Child; Chloroquine; Female; Fever; Humans | 1999 |
Hyperreactive malaria in expatriates returning from sub-Saharan Africa.
Topics: Adolescent; Adult; Africa South of the Sahara; Aged; Animals; Antibodies, Protozoan; Antimalarials; | 2000 |
[Tertiary malaria with acute lung edema in a Turkish child].
Topics: Blood Transfusion; Child, Preschool; Chloroquine; Erythrocytes; Germany, West; Humans; Malaria; Male | 1977 |
A pocket of controlled malaria in a holoendemic region of West Africa.
Topics: Amodiaquine; Anopheles; Child; Child, Preschool; Chloroquine; Costs and Cost Analysis; Humans; Liber | 1979 |
[Malaria in the republic of São Tomé and Principe. Epidemiologic evaluation and chemoresistance of P. falciparum].
Topics: Age Factors; Animals; Antimalarials; Atlantic Islands; Child; Child, Preschool; Chloroquine; Drug Re | 1991 |
The hyperreactive malarial splenomegaly syndrome in a European: has the treatment a modulatory effect on the immune system?
Topics: Chloroquine; Humans; Immune System; Malaria; Male; Middle Aged; Splenomegaly; Syndrome | 1990 |
A study on tropical splenomegaly syndrome and chloroquine prophylaxis.
Topics: Adolescent; Adult; Animals; Chloroquine; Female; Humans; India; Malaria; Male; Middle Aged; Plasmodi | 1989 |
A longitudinal study of splenomegaly in pregnancy in a malaria endemic area in Papua New Guinea.
Topics: Adolescent; Adult; Chloroquine; Female; Humans; Longitudinal Studies; Malaria; Papua New Guinea; Pre | 1988 |
Tropical splenomegaly syndrome and the role of chloroquine prophylaxis.
Topics: Adult; Chloroquine; Female; Humans; Splenomegaly; Syndrome; Tropical Medicine | 1987 |
The role of voluntary village aides in the control of malaria by presumptive treatment of fever. 2. Impact on village health.
Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Community Health Workers; Fever; Huma | 1985 |
Inhibition of murine RNA tumor virus replication and oncogenesis by chloroquine.
Topics: Animals; Antiviral Agents; Cells, Cultured; Chloroquine; Depression, Chemical; DNA Replication; Fibr | 1974 |
Transfusion-induced malaria. Plasmodium vivax in a 5-month-old child.
Topics: Chloroquine; Fever; Hemolysis; Hepatomegaly; Humans; Infant; Malaria; Male; Plasmodium vivax; Primaq | 1973 |
Some haematological and biochemical effects of a malaria control programme in New Guinea.
Topics: Adolescent; Adult; Antimalarials; Blood Group Antigens; Blood Proteins; Child; Child, Preschool; Chl | 1973 |
Posttransfusion malaria in a newborn.
Topics: Anemia; Antigens; Blood Donors; Chloroquine; Exchange Transfusion, Whole Blood; Female; Fluorescent | 1973 |
Systemic lupus erythematosus with widespread subcutaneous fat calcification.
Topics: Adipose Tissue; Adult; Calcinosis; Chloroquine; Female; Fever; Humans; Lupus Erythematosus, Systemic | 1974 |
Childhood splenomegaly in Uganda, and its relation to malaria.
Topics: Biopsy; Child; Child, Preschool; Chloroquine; Female; Fluorescent Antibody Technique; Hemoglobinomet | 1968 |
[Leishmaniasis].
Topics: Amidines; Amphotericin B; Anemia; Animals; Antimony; Blood Protein Electrophoresis; Child, Preschool | 1969 |
Characteristics and cross-resistance patterns of chloroquine-resistant Plasmodium berghei infections in mice.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Female; Hemat | 1968 |
Immunosuppression by compounds which complex with deoxyribonucleic acid.
Topics: Acridines; Alcohols; Animals; Antibody Formation; Chloroquine; Coloring Agents; DNA; Erythrocytes; F | 1969 |
Anaemia in pregnancy associated with "big spleen disease".
Topics: Adolescent; Adult; Anemia, Hypochromic; Chloroquine; Female; Humans; Liver; Malaria; Pregnancy; Preg | 1966 |