chloroquine has been researched along with Electrocardiogram QT Prolonged in 24 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In fact, two of the actually used drugs against SARS-CoV2, such as chloroquine and the combination lopinavir/ritonavir, might determine a QT (the time from the start of the Q wave to the end of the T wave) interval prolongation and they show several interactions with antiarrhythmic drugs and antipsychotic medications, making them prone to an increased risk of developing arrhythmias." | 5.12 | COVID-19 and the burning issue of drug interaction: never forget the ECG. ( Cameli, M; Cameli, P; Franchi, F; Mandoli, GE; Menci, D; Mondillo, S; Sciaccaluga, C; Sisti, N; Valente, S, 2021) |
| "Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment." | 3.96 | Concentration-dependent mortality of chloroquine in overdose. ( Baud, FJ; Clemessy, JL; Hoglund, RM; Megarbane, B; Tarning, J; Watson, JA; White, NJ, 2020) |
| " The choice of (typically subtherapeutic) dosing regimens, influenced partly by "QT-phobia," varied widely and seems anecdotal without any pharmacologically reliable supporting clinical evidence." | 2.72 | Chloroquine and hydroxychloroquine for COVID-19: Perspectives on their failure in repurposing. ( Shah, RR, 2021) |
| " Food and Drug Administration's Adverse Event Reporting System (FAERS) (>13 million total reports) were used." | 1.62 | Safety signals for QT prolongation or Torsades de Pointes associated with azithromycin with or without chloroquine or hydroxychloroquine. ( Brown, JD; Cicali, B; Henriksen, CH; Sarayani, A, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 21 (87.50) | 2.80 |
| Authors | Studies |
|---|---|
| Chotsiri, P | 1 |
| Tarning, J | 2 |
| Hoglund, RM | 2 |
| Watson, JA | 2 |
| White, NJ | 2 |
| Sarayani, A | 1 |
| Cicali, B | 1 |
| Henriksen, CH | 1 |
| Brown, JD | 1 |
| Javelot, H | 1 |
| El-Hage, W | 1 |
| Meyer, G | 1 |
| Becker, G | 1 |
| Michel, B | 1 |
| Hingray, C | 1 |
| Monzani, A | 1 |
| Genoni, G | 1 |
| Scopinaro, A | 1 |
| Pistis, G | 1 |
| Kozel, D | 1 |
| Secco, GG | 1 |
| Asensio, E | 1 |
| Acunzo, R | 1 |
| Uribe, W | 1 |
| Saad, EB | 1 |
| Sáenz, LC | 1 |
| Yahya, AS | 1 |
| Khawaja, S | 1 |
| Chukwuma, J | 1 |
| Weehuizen, JM | 1 |
| Hoepelman, AIM | 1 |
| Sun, J | 1 |
| Chen, Y | 1 |
| Fan, X | 1 |
| Wang, X | 2 |
| Han, Q | 1 |
| Liu, Z | 1 |
| Baud, FJ | 1 |
| Megarbane, B | 1 |
| Clemessy, JL | 1 |
| Hsia, BC | 1 |
| Greige, N | 1 |
| Quiroz, JA | 1 |
| Khokhar, AS | 1 |
| Daily, J | 1 |
| Di Biase, L | 1 |
| Ferrick, KJ | 1 |
| Fisher, JD | 1 |
| Krumerman, A | 1 |
| Sciaccaluga, C | 1 |
| Cameli, M | 1 |
| Menci, D | 1 |
| Mandoli, GE | 1 |
| Sisti, N | 1 |
| Cameli, P | 1 |
| Franchi, F | 1 |
| Mondillo, S | 1 |
| Valente, S | 1 |
| Danjuma, MI | 1 |
| Sinha, U | 1 |
| Fatima, H | 1 |
| Mohamed, MFH | 1 |
| Nathoe, H | 1 |
| Zekarias, A | 1 |
| Watson, S | 1 |
| Vidlin, SH | 1 |
| Grundmark, B | 1 |
| Shah, RR | 1 |
| Alkasir, A | 1 |
| Lippmann, S | 1 |
| Zequn, Z | 1 |
| Yujia, W | 1 |
| Dingding, Q | 1 |
| Jiangfang, L | 1 |
| Becker, ML | 1 |
| Snijders, D | 1 |
| van Gemeren, CW | 1 |
| Kingma, HJ | 1 |
| van Lelyveld, SFL | 1 |
| Giezen, TJ | 1 |
| Brüggemann, RJ | 1 |
| Moes, DJAR | 1 |
| van Rhee, KP | 1 |
| van 't Veer, NE | 1 |
| Koch, BCP | 1 |
| van Rossum, M | 1 |
| Windsant-van den Tweel, AV | 1 |
| Reijers, MHE | 1 |
| van Kimmenade, RRJ | 1 |
| Rahamat-Langedoen, JC | 1 |
| Rettig, TCD | 1 |
| van Raalte, R | 1 |
| van Paassen, J | 1 |
| Polderman, FN | 1 |
| van der Linden, PD | 1 |
| Frenzel, T | 1 |
| de Mast, Q | 1 |
| Burger, DM | 1 |
| Schouten, J | 1 |
| van de Veerdonk, FL | 1 |
| Pickkers, P | 1 |
| Ter Heine, R | 1 |
| Ehrlich, H | 1 |
| Elkbuli, A | 1 |
| Diaz-Arocutipa, C | 1 |
| Brañez-Condorena, A | 1 |
| Hernandez, AV | 1 |
| Ding, J | 1 |
| Liu, W | 1 |
| Guan, H | 1 |
| Feng, Y | 1 |
| Bao, Y | 1 |
| Li, H | 1 |
| Zhou, Z | 1 |
| Chen, Z | 1 |
| Yelve, K | 1 |
| Phatak, S | 1 |
| Patil, MA | 1 |
| Pazare, AR | 1 |
| Stas, P | 1 |
| Faes, D | 1 |
| Noyens, P | 1 |
| Mansfield, RJ | 1 |
| Thomas, RD | 1 |
6 reviews available for chloroquine and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Recommendations for the measurement of the QT interval during the use of drugs for COVID-19 infection treatment. Updatable in accordance with the availability of new evidence.
Topics: Adult; Aged; Antimalarials; Arrhythmias, Cardiac; Azithromycin; Chloroquine; Coronavirus Infections; | 2020 |
Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19.
Topics: Angiotensin-Converting Enzyme 2; Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus 229E, H | 2020 |
COVID-19 and the burning issue of drug interaction: never forget the ECG.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antiviral | 2021 |
Chloroquine and hydroxychloroquine for COVID-19: Perspectives on their failure in repurposing.
Topics: Antiviral Agents; Azithromycin; Chloroquine; COVID-19; COVID-19 Drug Treatment; Dose-Response Relati | 2021 |
Off-label use of chloroquine, hydroxychloroquine, azithromycin and lopinavir/ritonavir in COVID-19 risks prolonging the QT interval by targeting the hERG channel.
Topics: Azithromycin; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Combinations; ERG1 Potassium Chan | 2021 |
QTc prolongation in COVID-19 patients treated with hydroxychloroquine, chloroquine, azithromycin, or lopinavir/ritonavir: A systematic review and meta-analysis.
Topics: Azithromycin; Chloroquine; COVID-19; COVID-19 Drug Treatment; Humans; Hydroxychloroquine; Long QT Sy | 2021 |
1 trial available for chloroquine and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
An open-label cluster-randomized controlled trial of chloroquine, hydroxychloroquine or only supportive care in patients admitted with moderate to severe COVID-19 (ARCHAIC)-Protocol publication.
Topics: Antiviral Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Trea | 2020 |
17 other studies available for chloroquine and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Pharmacometric and Electrocardiographic Evaluation of Chloroquine and Azithromycin in Healthy Volunteers.
Topics: Adult; Antimalarials; Azithromycin; Chloroquine; Coronavirus Infections; COVID-19 Drug Treatment; DN | 2022 |
Safety signals for QT prolongation or Torsades de Pointes associated with azithromycin with or without chloroquine or hydroxychloroquine.
Topics: Antiviral Agents; Azithromycin; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Interactions; D | 2021 |
COVID-19 and (hydroxy)chloroquine-azithromycin combination: Should we take the risk for our patients?
Topics: Azithromycin; Chloroquine; Coronavirus Infections; COVID-19; Drug Therapy, Combination; Humans; Hydr | 2020 |
QTc evaluation in COVID-19 patients treated with chloroquine/hydroxychloroquine.
Topics: Antiviral Agents; Arrhythmias, Cardiac; Azithromycin; Cardiotoxicity; Chloroquine; Coronavirus Infec | 2020 |
The Use of "Novel Pharmacology" in the Treatment of COVID-19 and Potential Psychiatric Risks.
Topics: Adrenal Cortex Hormones; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; Humans; Hyd | 2020 |
Concentration-dependent mortality of chloroquine in overdose.
Topics: Adult; Antimalarials; Biotransformation; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Dru | 2020 |
QT prolongation in a diverse, urban population of COVID-19 patients treated with hydroxychloroquine, chloroquine, or azithromycin.
Topics: Age Distribution; Aged; Aged, 80 and over; Antimalarials; Azithromycin; Chloroquine; Coronavirus Inf | 2020 |
QTc evaluation in COVID-19 patients treated with chloroquine/hydroxychloroquine: A letter to the editor.
Topics: Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Electrocardiography; Humans; | 2020 |
Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.
Topics: Abdominal Pain; Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agent | 2020 |
COVID-19 and Cardiac Concerns for Psychiatric Patients.
Topics: Antidepressive Agents; Antiviral Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrioventricular | 2020 |
QTc Prolongation in COVID-19 Patients Using Chloroquine.
Topics: Aged; Chloroquine; Cohort Studies; COVID-19; COVID-19 Drug Treatment; Electrocardiography; Female; H | 2021 |
Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals.
Topics: Aged; Chloroquine; COVID-19 Drug Treatment; Electrocardiography; Female; Humans; Long QT Syndrome; M | 2021 |
Cardiac arrhythmias in COVID-19 patients: A combination of viral comorbidities and pro-arrhythmic drug interactions.
Topics: Angiotensin-Converting Enzyme 2; Anti-Bacterial Agents; Antimalarials; Arrhythmias, Cardiac; Azithro | 2021 |
Corrected QT interval in hospitalized patients with coronavirus disease 2019: Focus on drugs therapy.
Topics: Aged; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; D | 2021 |
Syncope in a patient being treated for hepatic and intestinal amoebiasis.
Topics: Amebicides; Antiprotozoal Agents; Chloroquine; Dysentery, Amebic; Furans; Humans; Hypokalemia; Liver | 2012 |
Conduction disorder and QT prolongation secondary to long-term treatment with chloroquine.
Topics: Adult; Antimalarials; Chloroquine; Defibrillators, Implantable; Echocardiography; Electrocardiograph | 2008 |
Recurrent syncope. Drug induced long QT syndrome.
Topics: Adult; Anti-Allergic Agents; Antimalarials; Astemizole; Chloroquine; Electrocardiography; Humans; Lo | 2001 |