chloroquine has been researched along with Dry Eye in 3 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy." | 5.51 | The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model. ( Cheon, EJ; Chung, SH; Lee, HJ; Shin, S; Yoon, SG, 2019) |
| "Inflammation has been associated with dry eye and anti-inflammatory drugs are now being targeted as the alternate therapeutic approach for dry eye condition." | 5.48 | Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux. ( Ghosh, A; Jeyabalan, N; Panigrahi, T; Shetty, R; Shivakumar, S; Subramani, M, 2018) |
| "Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy." | 1.51 | The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model. ( Cheon, EJ; Chung, SH; Lee, HJ; Shin, S; Yoon, SG, 2019) |
| "Inflammation has been associated with dry eye and anti-inflammatory drugs are now being targeted as the alternate therapeutic approach for dry eye condition." | 1.48 | Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux. ( Ghosh, A; Jeyabalan, N; Panigrahi, T; Shetty, R; Shivakumar, S; Subramani, M, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, HJ | 1 |
| Shin, S | 1 |
| Yoon, SG | 1 |
| Cheon, EJ | 1 |
| Chung, SH | 1 |
| Shivakumar, S | 1 |
| Panigrahi, T | 1 |
| Shetty, R | 1 |
| Subramani, M | 1 |
| Ghosh, A | 1 |
| Jeyabalan, N | 1 |
| Titiyal, JS | 1 |
| Kaur, M | 1 |
| Falera, R | 1 |
| Bharghava, A | 1 |
| Sah, R | 1 |
| Sen, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression (the ACLR8-LR Study)"[NCT05947812] | Phase 2 | 148 participants (Anticipated) | Interventional | 2023-08-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for chloroquine and Dry Eye
| Article | Year |
|---|---|
The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model.
Topics: Animals; Antirheumatic Agents; Autophagy; Autophagy-Related Protein 5; Biomarkers; Chloroquine; Corn | 2019 |
Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux.
Topics: Autophagy; Chloroquine; Cornea; Dry Eye Syndromes; Epithelium, Corneal; Humans; Inflammation; Matrix | 2018 |
Efficacy and Safety of Topical Chloroquine in Mild to Moderate Dry Eye Disease.
Topics: Antirheumatic Agents; Chloroquine; Conjunctiva; Dose-Response Relationship, Drug; Dry Eye Syndromes; | 2019 |