Page last updated: 2024-10-24

chloroquine and Dry Eye

chloroquine has been researched along with Dry Eye in 3 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Research Excerpts

ExcerptRelevanceReference
"Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy."5.51The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model. ( Cheon, EJ; Chung, SH; Lee, HJ; Shin, S; Yoon, SG, 2019)
"Inflammation has been associated with dry eye and anti-inflammatory drugs are now being targeted as the alternate therapeutic approach for dry eye condition."5.48Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux. ( Ghosh, A; Jeyabalan, N; Panigrahi, T; Shetty, R; Shivakumar, S; Subramani, M, 2018)
"Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy."1.51The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model. ( Cheon, EJ; Chung, SH; Lee, HJ; Shin, S; Yoon, SG, 2019)
"Inflammation has been associated with dry eye and anti-inflammatory drugs are now being targeted as the alternate therapeutic approach for dry eye condition."1.48Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux. ( Ghosh, A; Jeyabalan, N; Panigrahi, T; Shetty, R; Shivakumar, S; Subramani, M, 2018)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, HJ1
Shin, S1
Yoon, SG1
Cheon, EJ1
Chung, SH1
Shivakumar, S1
Panigrahi, T1
Shetty, R1
Subramani, M1
Ghosh, A1
Jeyabalan, N1
Titiyal, JS1
Kaur, M1
Falera, R1
Bharghava, A1
Sah, R1
Sen, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression (the ACLR8-LR Study)"[NCT05947812]Phase 2148 participants (Anticipated)Interventional2023-08-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

3 other studies available for chloroquine and Dry Eye

ArticleYear
The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model.
    Investigative ophthalmology & visual science, 2019, 09-03, Volume: 60, Issue:12

    Topics: Animals; Antirheumatic Agents; Autophagy; Autophagy-Related Protein 5; Biomarkers; Chloroquine; Corn

2019
Chloroquine Protects Human Corneal Epithelial Cells from Desiccation Stress Induced Inflammation without Altering the Autophagy Flux.
    BioMed research international, 2018, Volume: 2018

    Topics: Autophagy; Chloroquine; Cornea; Dry Eye Syndromes; Epithelium, Corneal; Humans; Inflammation; Matrix

2018
Efficacy and Safety of Topical Chloroquine in Mild to Moderate Dry Eye Disease.
    Current eye research, 2019, Volume: 44, Issue:12

    Topics: Antirheumatic Agents; Chloroquine; Conjunctiva; Dose-Response Relationship, Drug; Dry Eye Syndromes;

2019