chloroquine has been researched along with Drug Overdose in 36 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neither diazepam nor other ligands for benzodiazepine binding sites protect against or attenuate chloroquine cardiotoxicity." | 3.96 | Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam. ( Hughes, DA, 2020) |
| "Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment." | 3.96 | Concentration-dependent mortality of chloroquine in overdose. ( Baud, FJ; Clemessy, JL; Hoglund, RM; Megarbane, B; Tarning, J; Watson, JA; White, NJ, 2020) |
| "A case of hair depigmentation induced by chloroquine diphosphate subacute overdosage in an 11-year-old patient with dermatomyositis is presented." | 3.75 | Chloroquine -induced hair depigmentation. ( Di Giacomo, TB; Nico, MM; Valente, NY, 2009) |
| "A child with malaria from a chloroquine-resistant area received an accidental overdose of chloroquine administered by a parent." | 3.71 | Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity. ( Corry, A; Fitzmaurice, L; Jackson, MA; Kearns, GL; Lowry, JA, 2001) |
| "Chloroquine is a derivative of 4-aminoquinoline, which is used in the malaria prophylaxis and treatment and the therapy of some connective tissue diseases." | 2.43 | [Acute chloroquine intoxication--rare, but always serious: case reports and literature review]. ( Ciszowski, K; Groszek, B; Kołodziej, J; Kłys, M; Winnik, L, 2005) |
| " Food and Drug Administration Adverse Events Reporting System (FAERS) database to assess HCQ/CQ-associated cardiovascular adverse events (CVAEs) in pre-COVID-19 reports." | 1.62 | Cardiovascular adverse events associated with hydroxychloroquine and chloroquine: A comprehensive pharmacovigilance analysis of pre-COVID-19 reports. ( Bomze, D; Boursi, B; Dankner, R; Goldman, A; Hod, H; Maor, E; Meirson, T, 2021) |
| "The patient was given chloroquine by his captain in a dosage regimen appropriate for quinine (2 tablets 3 times daily for 7 d)." | 1.32 | Toxicity related to chloroquine treatment of resistant vivax malaria. ( Barrett, PH; Davis, TM; Ilett, KF; Syed, DA, 2003) |
| "Refractory seizures not responding to benzodiazepine may require an antiepileptic drug." | 1.31 | Chloroquine poisoning: report of two cases. ( Reddy, VG; Sinna, S, 2000) |
| " In 5 patients it was demonstrated that the amount of uptake of chloroquine into the hair varied proportionally with the dosage (from 500 mg/week to 10 g single dose) and with the time of administration." | 1.28 | Sequential concentration of chloroquine in human hair correlates with ingested dose and duration of therapy. ( Ochsendorf, FR; Raudonat, HW; Runne, U; Schmidt, K, 1992) |
| "Chloroquine poisoning has profound effects, chiefly on contractility and conduction of the heart." | 1.28 | [Chloroquine poisoning]. ( Aakhus, S; Aasarød, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.33) | 18.7374 |
| 1990's | 18 (50.00) | 18.2507 |
| 2000's | 7 (19.44) | 29.6817 |
| 2010's | 2 (5.56) | 24.3611 |
| 2020's | 6 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Griswold, MK | 1 |
| Chai, PR | 1 |
| Brent, J | 1 |
| Weiss, S | 1 |
| Askman, N | 1 |
| Wax, PM | 1 |
| Farrugia, LA | 1 |
| Hughes, DA | 1 |
| Watson, JA | 1 |
| Tarning, J | 1 |
| Hoglund, RM | 1 |
| Baud, FJ | 2 |
| Megarbane, B | 1 |
| Clemessy, JL | 2 |
| White, NJ | 1 |
| Goldman, A | 1 |
| Bomze, D | 1 |
| Dankner, R | 1 |
| Hod, H | 1 |
| Meirson, T | 1 |
| Boursi, B | 1 |
| Maor, E | 1 |
| Della Porta, A | 1 |
| Bornstein, K | 1 |
| Coye, A | 1 |
| Montrief, T | 1 |
| Long, B | 1 |
| Parris, MA | 1 |
| Lee, SH | 1 |
| Sohn, JT | 1 |
| Bethlehem, C | 1 |
| Jongsma, M | 1 |
| Korporaal-Heijman, J | 1 |
| Yska, JP | 1 |
| Di Giacomo, TB | 1 |
| Valente, NY | 1 |
| Nico, MM | 1 |
| Zaki, SA | 1 |
| Mauskar, A | 1 |
| Shanbag, P | 1 |
| Phipps, C | 1 |
| Chan, K | 1 |
| Teo, F | 1 |
| Ponampalam, R | 1 |
| Davis, TM | 1 |
| Syed, DA | 1 |
| Ilett, KF | 1 |
| Barrett, PH | 1 |
| GRAHAM, JD | 1 |
| HELWIG, H | 1 |
| KJAER, K | 1 |
| Smith, ER | 1 |
| Klein-Schwartz, W | 1 |
| Ciszowski, K | 1 |
| Winnik, L | 1 |
| Groszek, B | 1 |
| Kłys, M | 1 |
| Kołodziej, J | 1 |
| Nwobodo, EO | 1 |
| Obi, J | 1 |
| Henderson, A | 1 |
| Adamson, M | 1 |
| Pond, SM | 1 |
| Wilkinson, R | 1 |
| Mahatane, J | 1 |
| Wade, P | 1 |
| Pasvol, G | 1 |
| Flaurenson, I | 1 |
| Naraqi, S | 2 |
| Lalloo, DG | 1 |
| Trevett, AJ | 1 |
| Kevau, IH | 1 |
| Semb, SO | 1 |
| Jacobsen, D | 1 |
| Taboulet, P | 1 |
| Hoffman, JR | 1 |
| Hantson, P | 1 |
| Barriot, P | 1 |
| Bismuth, C | 1 |
| Altrock, G | 1 |
| Lange, A | 1 |
| Münster, P | 1 |
| Queen, HF | 1 |
| Tapfumaneyi, C | 1 |
| Lewis, RJ | 1 |
| Personne, M | 1 |
| Rombo, L | 1 |
| Sandler, H | 1 |
| Wegener, T | 1 |
| Reddy, VG | 1 |
| Sinna, S | 1 |
| Lowry, JA | 1 |
| Corry, A | 1 |
| Fitzmaurice, L | 1 |
| Jackson, MA | 1 |
| Kearns, GL | 1 |
| Korinihona, A | 1 |
| Laurenson, IF | 1 |
| Runne, U | 2 |
| Ochsendorf, FR | 2 |
| Schmidt, K | 1 |
| Raudonat, HW | 1 |
| Collee, GG | 1 |
| Samra, GS | 1 |
| Hanson, GC | 1 |
| Stiff, G | 1 |
| Robinson, D | 1 |
| Cugnoni, HL | 1 |
| Touquet, R | 1 |
| Dalton, AM | 1 |
| Kuhlman, JJ | 1 |
| Mayes, RW | 1 |
| Levine, B | 1 |
| Jones, R | 1 |
| Wagner, GN | 1 |
| Smith, ML | 1 |
| Easterbrook, M | 1 |
| Rajah, A | 1 |
| Aasarød, K | 1 |
| Aakhus, S | 1 |
4 reviews available for chloroquine and Drug Overdose
| Article | Year |
|---|---|
Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians.
Topics: Chloroquine; COVID-19 Drug Treatment; Drug Overdose; Emergency Service, Hospital; Humans; Hydroxychl | 2020 |
Are 1-2 dangerous? Chloroquine and hydroxychloroquine exposure in toddlers.
Topics: Animals; Child, Preschool; Chloroquine; Drug Overdose; Emergency Treatment; Humans; Hydroxychloroqui | 2005 |
[Acute chloroquine intoxication--rare, but always serious: case reports and literature review].
Topics: Adolescent; Antimalarials; Chloroquine; Drug Overdose; Fatal Outcome; Female; Heart Arrest; Heart Co | 2005 |
Chloroquine overdose in adults: a practical approach to management.
Topics: Adult; Child; Chloroquine; Clinical Protocols; Diazepam; Drug Overdose; Epinephrine; Female; Humans; | 1992 |
32 other studies available for chloroquine and Drug Overdose
| Article | Year |
|---|---|
Hydroxychloroquine and Chloroquine Toxicity as Reported by Medical Toxicologists to the Toxicology Investigators Consortium (ToxIC) Registry.
Topics: Chloroquine; Drug Overdose; Humans; Hydroxychloroquine; Registries; Research Personnel | 2022 |
Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam.
Topics: Animals; Arrhythmias, Cardiac; Benzodiazepinones; Cardiotoxicity; Chloroquine; Clonazepam; Coronavir | 2020 |
Concentration-dependent mortality of chloroquine in overdose.
Topics: Adult; Antimalarials; Biotransformation; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Dru | 2020 |
Cardiovascular adverse events associated with hydroxychloroquine and chloroquine: A comprehensive pharmacovigilance analysis of pre-COVID-19 reports.
Topics: Adult; Aged; Antimalarials; Cardiovascular Diseases; Chloroquine; COVID-19; COVID-19 Drug Treatment; | 2021 |
Lipid emulsion treatment as an antidote for chloroquine and hydroxychloroquine toxicity.
Topics: Antidotes; Chloroquine; Drug Overdose; Fat Emulsions, Intravenous; Humans; Hydroxychloroquine | 2021 |
Cardiac arrest following chloroquine overdose treated with bicarbonate and lipid emulsion.
Topics: Adult; Antimalarials; Buffers; Calcium Gluconate; Cardiovascular Agents; Chloroquine; Critical Care; | 2019 |
Chloroquine -induced hair depigmentation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Chloroquine; Dermatomyositis; Drug Overdose; Hair Co | 2009 |
Toxic psychosis due to chloroquine overdose: a case report.
Topics: Antimalarials; Child; Chloroquine; Drug Overdose; Female; Humans; Psychoses, Substance-Induced | 2009 |
Fatal chloroquine poisoning: a rare cause of sudden cardiac arrest.
Topics: Acute Disease; Adult; Antimalarials; Arrhythmias, Cardiac; Chloroquine; Death, Sudden, Cardiac; Drug | 2011 |
Toxicity related to chloroquine treatment of resistant vivax malaria.
Topics: Adult; Animals; Antimalarials; Atovaquone; Chloroquine; Drug Overdose; Humans; Malaria, Vivax; Male; | 2003 |
An overdose of "plaquenil".
Topics: Chloroquine; Drug Overdose; Humans; Hydroxychloroquine | 1960 |
[Nil nocere'. Prolonged overdosage of chloroquine. Desirable and undesirable effects].
Topics: Chloroquine; Drug Overdose; Malaria; Motivation | 1962 |
Effects of an overdose of chloroquine in a pregnant woman.
Topics: Chloroquine; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Pregnan | 1955 |
Chloroquine overdose and leucopenia in Nigerians.
Topics: Chloroquine; Drug Overdose; Humans; Leukopenia; Neutropenia; Nigeria | 1993 |
Death from inadvertent chloroquine overdose.
Topics: Adult; Chloroquine; Drug Overdose; Fatal Outcome; Female; Humans | 1994 |
Chloroquine poisoning.
Topics: Adult; Charcoal; Chloroquine; Drug Overdose; Female; Humans | 1993 |
Chloroquine overdose in Papua New Guinea.
Topics: Chloroquine; Drug Overdose; Humans; Papua New Guinea | 1993 |
[Chloroquine poisoning].
Topics: Adolescent; Antimalarials; Chloroquine; Drug Overdose; Female; Humans; Suicide, Attempted | 1996 |
Treatment of acute chloroquine poisoning: a 5-year experience.
Topics: Acute Disease; Adult; Chloroquine; Combined Modality Therapy; Diazepam; Drug Overdose; Drug Therapy, | 1996 |
[Acute chloroquine poisoning].
Topics: Anticonvulsants; Antidotes; Antimalarials; Chloroquine; Diazepam; Drug Overdose; Epilepsy, Tonic-Clo | 1997 |
The rising incidence of serious chloroquine overdose in Harare, Zimbabwe: emergency department surveillance in the developing world.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Developing Countries; Drug Overdose; Emergency Servic | 1999 |
[Serious effects of chloroquine overdose. Prescribe the smallest possible dosage-packages and inform about the risks].
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Drug Information Services; Drug Overdose; Drug | 1999 |
Chloroquine poisoning: report of two cases.
Topics: Adult; Anticonvulsants; Antidotes; Antimalarials; Charcoal; Chloroquine; Coma; Diazepam; Drug Overdo | 2000 |
Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity.
Topics: Antimalarials; Child; Chloroquine; Drug Overdose; Drug Synergism; Drug Therapy, Combination; Humans; | 2001 |
Sequential concentration of chloroquine in human hair correlates with ingested dose and duration of therapy.
Topics: Adult; Aged; Chloroquine; Chromatography, Gas; Drug Overdose; Female; Hair; Humans; Lupus Erythemato | 1992 |
Chloroquine poisoning: ventricular fibrillation following 'trivial' overdose in a child.
Topics: Adolescent; Cardiopulmonary Resuscitation; Chloroquine; Drug Overdose; Electrocardiography; Gastric | 1992 |
[Subacute chloroquine overdosage].
Topics: Accommodation, Ocular; Acute Disease; Adult; Chloroquine; Drug Overdose; Hair Color; Heliotherapy; H | 1991 |
Massive chloroquine overdose--a survivor.
Topics: Adult; Chloroquine; Diazepam; Drug Overdose; Female; Humans; Suicide, Attempted | 1991 |
Chloroquine distribution in postmortem cases.
Topics: Accidents, Aviation; Brain; Chloroquine; Chromatography, Gas; Drug Overdose; Humans; Liver; Military | 1991 |
Is corneal deposition of antimalarial any indication of retinal toxicity?
Topics: Adult; Aged; Chloroquine; Cornea; Drug Overdose; Female; Fluorescein Angiography; Fundus Oculi; Huma | 1990 |
The use of diazepam in chloroquine poisoning.
Topics: Adult; Chloroquine; Diazepam; Drug Overdose; Female; Gastric Lavage; Humans; Poisoning | 1990 |
[Chloroquine poisoning].
Topics: Adult; Africa; Antimalarials; Asia; Chloroquine; Drug Overdose; Humans; Malaria; Male; Norway; South | 1990 |