Compounds > chloroquine
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chloroquine and Disease Models, Animal

chloroquine has been researched along with Disease Models, Animal in 298 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
" Asiatic acid suppressed parasitaemia while oral chloroquine (30 mg/kg) did not influence malaria induction."9.22Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats. ( Mabandla, MV; Mavondo, GA; Mkhwananzi, BN, 2016)
" Pretreatment with perampanel dose-dependently attenuated the induction of scratching, a behavior typically associated with pruritus, by intradermal administration of the pruritogen chloroquine."7.96Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice. ( Funahashi, H; Haruta-Tsukamoto, A; Ishida, Y; Miyahara, Y; Nishimori, T, 2020)
"Co-administration of amodiaquine with MAMA decoction (MD), an herbal antimalarial drug comprising the leaves of Mangifera indica L."7.83Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model. ( Adepiti, AO; Bolaji, OO; Elujoba, AA, 2016)
"Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyrazine series led to the identification of highly potent compounds against the blood life-cycle stage of the human malaria parasite Plasmodium falciparum."7.83Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle. ( Angulo-Barturen, I; Antonova-Koch, Y; Bashyam, S; Birkholtz, LM; Botha, ME; Charman, SA; Chibale, K; Ferrer, S; Gonzàlez Cabrera, D; Han, Z; Jiménez-Díaz, MB; Lawrence, N; Le Manach, C; Martínez, MS; Meister, S; Nchinda, AT; Nondaba, SH; Paquet, T; Reader, J; Street, LJ; Taylor, D; Waterson, D; White, KL; Winzeler, EA; Wittlin, S; Witty, MJ; Younis, Y; Zabiulla, M, 2016)
"To investigate the effect of chloroquine on airway hyperresponsiveness in asthmatic mice and explore the possible mechanism."7.81[Inhibitory effect of chloroquine on airway hyperresponsiveness in asthmatic mice]. ( Fu, Z; Hu, XY; Liu, EM; Sun, XC; Wang, LJ, 2015)
"Plumbagin exhibited promising antimalarial activity with in vitro IC50 (concentration that inhibits parasite growth to 50%) against 3D7 chloroquine-sensitive P."7.80Antimalarial activity of plumbagin in vitro and in animal models. ( Chaijaroenkul, W; Karbwang, J; Na-Bangchang, K; Plengsuriyakarn, T; Sumsakul, W; Viyanant, V, 2014)
"An alternative antimalarial pathway of an 'outdated' drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials."7.80Validation of a chloroquine-induced cell death mechanism for clinical use against malaria. ( Batty, KT; Ch'ng, JH; Chang, ZW; Chia, WN; Gun, SY; Lee, YQ; Nosten, F; Renia, L; Russell, B; Tan, KS; Wong, LK, 2014)
"Results indicate prominent anti-malarial action of tigecycline in vitro and in vivo in combination with CQ and support further evaluation of tigecycline as a potential combination candidate for treatment of drug-resistant cases of malaria."7.80In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine. ( Sahu, R; Tekwani, BL; Walker, LA, 2014)
"Blockade of inward-rectifier K+ channels by chloroquine terminates reentry in cholinergic atrial fibrillation (AF)."7.78Chloroquine terminates stretch-induced atrial fibrillation more effectively than flecainide in the sheep heart. ( Bandaru, K; Berenfeld, O; Calvo, CJ; Ennis, SR; Filgueiras-Rama, D; Jalife, J; Kalifa, J; Martins, RP; Mironov, S; Noujaim, SF; Yamazaki, M, 2012)
"Previously reported studies identified analogues of propafenone that had potent antimalarial activity, reduced cardiac ion channel activity, and properties that suggested the potential for clinical development for malaria."7.78Lead optimization of antimalarial propafenone analogues. ( Clark, JA; Connelly, MC; Derisi, JL; Furimsky, A; Gow, J; Guiguemde, WA; Guy, RK; Iyer, LV; Kyle, DE; Lemoff, A; Lowes, D; Mirsalis, J; Parman, T; Pradhan, A; Sigal, M; Tang, L; Wilson, E; Zhu, F, 2012)
"The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei."7.78The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. ( Aldana, I; Bertani, S; Deharo, E; Garavito, G; Quiliano, M; Valentin, A, 2012)
"Chloroquine (CQ) is an important antimalarial drug for the treatment of special patient groups and as a comparator for preclinical testing of new drugs."7.77Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model. ( Batty, KT; Ilett, KF; Jago, JD; Moore, BR; Page-Sharp, M; Stoney, JR, 2011)
"The emergence and spread of Plasmodium falciparum with resistance to chloroquine (CQ), the safest and cheapest antimalarial drug coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the need to optimize antimalarial actions of plant extracts and restore chloroquine efficacy."7.74Enhanced antimalarial effects of chloroquine by aqueous Vernonia amygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasmodium berghei strains. ( Iwalokun, BA, 2008)
"To study the antimalarial effect of agmatine (Agm) on chloroquine-susceptible Plasmodium berghei K173 strain (S strain) and the P berghei K173 resistant strain (R strain)."7.72Antimalarial effect of agmatine on Plasmodium berghei K173 strain. ( Li, J; Liu, Y; Su, RB; Wei, XL, 2003)
"Chloroquine has been shown to increase the cellular retention and nuclear incorporation of 125I-labeled monoclonal antibody (MAb) 425, a murine anti-epidermal growth factor receptor monoclonal antibody, in human high-grade glioma cells in vitro."7.69Biodistribution of 125I-MAb 425 in a human glioma xenograft model: effect of chloroquine. ( Bender, H; Brady, LW; Class, R; Dilling, TJ; Emrich, JG; Hand, CM, 1997)
"The antimalarial activity of beta-artemether and beta-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P."7.68Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. ( Ager, AL; Canfield, CJ; Heiffer, MH; Klayman, DL; Kyle, DE; Milhous, WK; Rossan, RN; Schuster, BG; Shmuklarsky, MJ; Tang, DB, 1993)
" A model-informed strategy based on preclinical data, which incorporates pharmacokinetic-pharmacodynamic (PK-PD) properties with physiologically based pharmacokinetic (PBPK) modeling, is proposed to optimally predict an efficacious human dose and dosage regimen for the treatment of Plasmodium falciparum malaria."5.91Integrating Pharmacokinetic-Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study. ( Chibale, K; Gibhard, L; Mulubwa, M; Redhi, D, 2023)
"pylori-related gastric cancer, but the treatment should simultaneously remove H."5.91Chloroquine inhibited Helicobacter pylori-related gastric carcinogenesis by YAP-β-catenin-autophagy axis. ( Du, Y; He, J; Li, B; Liu, S; Lv, X; Zhang, X; Zhang, Y, 2023)
"Seizures were induced by pentylenetetrazol and maximal electroshock."5.72Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022)
"Chloroquine (CLQ) has been observed to inhibit calcium influx."5.62The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension. ( Akin, AT; Başaran, KE; Kaymak, E; Özdamar, S; Taheri, S; Tufan, E; Yakan, B, 2021)
"Periodontitis is an inflammation characterized by alveolar bone resorption caused by imbalance in bone homeostasis."5.56Chloroquine and 3-Methyladenine Attenuates Periodontal Inflammation and Bone Loss in Experimental Periodontitis. ( Chen, B; He, S; Li, L; Luo, B; Yan, F; Zhou, Q, 2020)
"Chloroquine (CQ) is a prototypical systemic and intradermal pruritogen for histamine-independent (nonhistaminergic) itch in mice and humans."5.56Characterization of a chloroquine-induced canine model of pruritus and skin inflammation. ( Banovic, F; Blubaugh, A; Denley, T, 2020)
"Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy."5.51The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model. ( Cheon, EJ; Chung, SH; Lee, HJ; Shin, S; Yoon, SG, 2019)
"Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available."5.46Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017)
"Chloroquine treatment increased whole lung and PASMC p62 protein levels consistent with inhibition of autophagy, and increased levels of BMPR-II protein."5.39Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. ( Dunmore, BJ; Long, L; Lu, J; Marciniak, SJ; Morrell, NW; Southwood, M; Yang, X, 2013)
"The chloroquine was treated by the actual drug content of effective nanochloroquine and the nanodrug was charged with its effective dose for fifteen days, after successive infection development in Swiss mice."5.39A novel chitosan based antimalarial drug delivery against Plasmodium berghei infection. ( Chattopadhyay, S; Das, S; Dash, SK; Mahapatra, SK; Majumder, S; Pramanik, P; Roy, S; Tripathy, S, 2013)
"Parasitemia was 4% on day 8 when compared to that on day 0, whereas it was 9% on day 9."5.38Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis. ( Abolghasemi, E; Davoudi, M; Moosa-Kazemi, SH; Reisi, A; Satvat, MT, 2012)
"Fluconazole alone was not found significantly effective against C."5.32Prophylactic role of liposomized chloroquine against murine cryptococcosis less susceptible to fluconazole. ( Jabeen, R; Khan, MA; Mohammad, O, 2004)
" To reduce the side effects, another test was carried out in 3 monkeys and the dosage regimen was modified to pyronaridine 6 mg/kg-artemether 10 mg/kg-chloroquine 20 mg/kg (PAC-2) once daily for 3 days."5.29[Studies on the establishment of malarial animal model of short-term relapse. III. Combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance]. ( Fang, Y; Lin, BY; Pan, YR; Zhang, JX; Zheng, H, 1993)
" Asiatic acid suppressed parasitaemia while oral chloroquine (30 mg/kg) did not influence malaria induction."5.22Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats. ( Mabandla, MV; Mavondo, GA; Mkhwananzi, BN, 2016)
"To assess the relationship between the genetic and phenotypic factors linked to the cytochrome P-450 enzyme system and the response to the antimalarial drugs chloroquine, amodiaquine, mefloquine, and proguanil, as well as to determine how certain biological and social factors of the host influence the behavior of this enzymatic complex."4.83[Cytochrome P-450 and the response to antimalarial drugs]. ( Carmona-Fonseca, J; Guzmán, V, 2006)
"Hence, this study was therefore aimed at evaluating the antimalarial activity of a probiotic bacterium Lactobacillus sakei isolated from traditionally fermented milk in mice infected with chloroquine sensitive Plasmodium berghei ANKA."4.02In vivo antimalarial activity of a probiotic bacterium Lactobacillus sakei isolated from traditionally fermented milk in BALB/c mice infected with Plasmodium berghei ANKA. ( Achidi, EA; Bila, RB; Feugaing Sofeu, DD; Ivo, EP; Taiwe, GS; Tatsinkou Fossi, B; Toukam, LL, 2021)
" Pretreatment with perampanel dose-dependently attenuated the induction of scratching, a behavior typically associated with pruritus, by intradermal administration of the pruritogen chloroquine."3.96Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice. ( Funahashi, H; Haruta-Tsukamoto, A; Ishida, Y; Miyahara, Y; Nishimori, T, 2020)
"Phenyl- and bioisosteric ferrocenyl-derived aminoquinoline-benzimidazole hybrid compounds were synthesised and evaluated for their in vitro antiplasmodial activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human malaria parasite, Plasmodium falciparum."3.91Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights. ( Baartzes, N; Chibale, K; Seldon, R; Smith, GS; Stringer, T; Taylor, D; Warner, DF; Wittlin, S, 2019)
" Itch responses were evoked by histamine, chloroquine, and dinitrochlorobenzene-induced contact dermatitis (CD)."3.88GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way. ( Han, MK; Im, SY; Im, YN; Kim, HK; Lee, HK; Lee, YD; Park, JS; Song, HR, 2018)
"The Wolrd Health Organization (WHO) encourages all countries to investigate antimalarial drug substances derived from herbal sources with the slogan "Hunt of the Next Artemisinin" due to the emergence of resistant strains of Plasmodium species to artemisinin."3.85In vivo and in vitro Models for Scanning Drug Substances in Malaria: Prestudy. ( Çavuş, İ; Kaya, T; Nuraydın, A; Özbilgin, A, 2017)
" An acetone-ether-water (AEW) model as a histamine-independent itch model is often used in the study of chronic pruritus."3.85MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model. ( Geng, X; Gu, L; Hu, D; Lan, L; Shi, H; Tang, Z; Wang, C; Wu, G; Yang, N; Yang, Y; Yu, G; Yu, L; Yuan, X; Zhu, C, 2017)
"Co-administration of amodiaquine with MAMA decoction (MD), an herbal antimalarial drug comprising the leaves of Mangifera indica L."3.83Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model. ( Adepiti, AO; Bolaji, OO; Elujoba, AA, 2016)
"Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyrazine series led to the identification of highly potent compounds against the blood life-cycle stage of the human malaria parasite Plasmodium falciparum."3.83Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle. ( Angulo-Barturen, I; Antonova-Koch, Y; Bashyam, S; Birkholtz, LM; Botha, ME; Charman, SA; Chibale, K; Ferrer, S; Gonzàlez Cabrera, D; Han, Z; Jiménez-Díaz, MB; Lawrence, N; Le Manach, C; Martínez, MS; Meister, S; Nchinda, AT; Nondaba, SH; Paquet, T; Reader, J; Street, LJ; Taylor, D; Waterson, D; White, KL; Winzeler, EA; Wittlin, S; Witty, MJ; Younis, Y; Zabiulla, M, 2016)
"To investigate the effect of chloroquine on airway hyperresponsiveness in asthmatic mice and explore the possible mechanism."3.81[Inhibitory effect of chloroquine on airway hyperresponsiveness in asthmatic mice]. ( Fu, Z; Hu, XY; Liu, EM; Sun, XC; Wang, LJ, 2015)
"Plumbagin exhibited promising antimalarial activity with in vitro IC50 (concentration that inhibits parasite growth to 50%) against 3D7 chloroquine-sensitive P."3.80Antimalarial activity of plumbagin in vitro and in animal models. ( Chaijaroenkul, W; Karbwang, J; Na-Bangchang, K; Plengsuriyakarn, T; Sumsakul, W; Viyanant, V, 2014)
"An alternative antimalarial pathway of an 'outdated' drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials."3.80Validation of a chloroquine-induced cell death mechanism for clinical use against malaria. ( Batty, KT; Ch'ng, JH; Chang, ZW; Chia, WN; Gun, SY; Lee, YQ; Nosten, F; Renia, L; Russell, B; Tan, KS; Wong, LK, 2014)
"Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure."3.80Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta). ( Gettyacamin, M; Imerbsin, R; Khemawoot, P; Lanteri, C; Nanayakkara, NP; Ohrt, C; Sampath, A; Saunders, D; Siripokasupkul, R; Teja-Isavadharm, P; Tekwani, BL; Vanachayangkul, P; Walker, L, 2014)
"Results indicate prominent anti-malarial action of tigecycline in vitro and in vivo in combination with CQ and support further evaluation of tigecycline as a potential combination candidate for treatment of drug-resistant cases of malaria."3.80In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine. ( Sahu, R; Tekwani, BL; Walker, LA, 2014)
"Chloroquine (CQ), a well-known anti-malarial drug, has long been used for the treatment of autoimmune diseases because of its profound immunomodulatory effects."3.80Early treatment with chloroquine inhibits the immune response against Plasmodium yoelii infection in mice. ( Cao, Y; Chen, G; Du, Y; Feng, Y; Pang, W; Qi, Z; Qin, X; Zhu, X, 2014)
" Moreover, similar to wild-type littermates, Nf1± mice developed inflammation-induced heat and mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia."3.79Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. ( Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE, 2013)
"The increasing spread of chloroquine resistant malaria has intensified the search for new antimalarial treatment, especially drugs that can be used in combination."3.78Interaction between ciprofloxacin and chloroquine in mice infected with chloroquine resistant Plasmodium berghei: interaction between ciprofloxacin and chloroqune. ( Abiodun, OO; Gbotosho, GO; Happi, CT; Oduola, AM; Sowunmi, A; Woranola, O, 2012)
"Blockade of inward-rectifier K+ channels by chloroquine terminates reentry in cholinergic atrial fibrillation (AF)."3.78Chloroquine terminates stretch-induced atrial fibrillation more effectively than flecainide in the sheep heart. ( Bandaru, K; Berenfeld, O; Calvo, CJ; Ennis, SR; Filgueiras-Rama, D; Jalife, J; Kalifa, J; Martins, RP; Mironov, S; Noujaim, SF; Yamazaki, M, 2012)
" After sporozoite inoculation and blood-stage cure of initial parasitemia with chloroquine, rhesus macaques were treated on subsequent relapses with chloroquine in conjunction with test regimens of approved drugs."3.78Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances. ( Bennett, K; Deye, GA; Fracisco, S; Gettayacamin, M; Hansukjariya, P; Im-erbsin, R; Macareo, L; Magill, AJ; Ohrt, C; Rothstein, Y; Sattabongkot, J, 2012)
"Previously reported studies identified analogues of propafenone that had potent antimalarial activity, reduced cardiac ion channel activity, and properties that suggested the potential for clinical development for malaria."3.78Lead optimization of antimalarial propafenone analogues. ( Clark, JA; Connelly, MC; Derisi, JL; Furimsky, A; Gow, J; Guiguemde, WA; Guy, RK; Iyer, LV; Kyle, DE; Lemoff, A; Lowes, D; Mirsalis, J; Parman, T; Pradhan, A; Sigal, M; Tang, L; Wilson, E; Zhu, F, 2012)
"The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei."3.78The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. ( Aldana, I; Bertani, S; Deharo, E; Garavito, G; Quiliano, M; Valentin, A, 2012)
"Resistance of the human malarial parasite Plasmodium falciparum to the antimalarial drug chloroquine has rapidly spread from several independent origins and is now widely prevalent throughout the majority of malaria-endemic areas."3.77Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes. ( Coppens, I; Ecker, A; Fidock, DA; Lakshmanan, V; Sinnis, P, 2011)
" In this study, a new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride (1), showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leishmaniasis model."3.77Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. ( Anklin, C; Bahar, M; Deng, Y; Doskotch, RW; Drew, ME; Gil, RR; He, S; Kinghorn, AD; Navarro-Vázquez, A; Pandharkar, T; Werbovetz, KA; Zhu, X, 2011)
"Chloroquine (CQ) is an important antimalarial drug for the treatment of special patient groups and as a comparator for preclinical testing of new drugs."3.77Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model. ( Batty, KT; Ilett, KF; Jago, JD; Moore, BR; Page-Sharp, M; Stoney, JR, 2011)
"Primaquine is the drug of choice for the radical cure of Plasmodium vivax malaria, but possesses serious side effects."3.74Synthesis and evaluation of naphthyridine compounds as antimalarial agents. ( Gudise, C; Kong, Y; Meng, L; Smith, E; Wei, L; Zhang, Q; Zhu, S, 2007)
"The emergence and spread of Plasmodium falciparum with resistance to chloroquine (CQ), the safest and cheapest antimalarial drug coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the need to optimize antimalarial actions of plant extracts and restore chloroquine efficacy."3.74Enhanced antimalarial effects of chloroquine by aqueous Vernonia amygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasmodium berghei strains. ( Iwalokun, BA, 2008)
"The influence of combinations containing the blood schizontocides chloroquine (CQ) or mefloquine (MEF), together with the 8-aminoquinolines (8AQ) primaquine (PQ) or the new, long-acting compound, tafenoquine (TAF), on the rate of selection of resistance to the individual compounds was examined using the asexual, intra-erythrocytic stages in rodent malaria models."3.72The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines. ( Peters, W; Robinson, BL; Stewart, LB, 2003)
"To study the antimalarial effect of agmatine (Agm) on chloroquine-susceptible Plasmodium berghei K173 strain (S strain) and the P berghei K173 resistant strain (R strain)."3.72Antimalarial effect of agmatine on Plasmodium berghei K173 strain. ( Li, J; Liu, Y; Su, RB; Wei, XL, 2003)
"Chloroquine has been shown to increase the cellular retention and nuclear incorporation of 125I-labeled monoclonal antibody (MAb) 425, a murine anti-epidermal growth factor receptor monoclonal antibody, in human high-grade glioma cells in vitro."3.69Biodistribution of 125I-MAb 425 in a human glioma xenograft model: effect of chloroquine. ( Bender, H; Brady, LW; Class, R; Dilling, TJ; Emrich, JG; Hand, CM, 1997)
"The antimalarial activity of beta-artemether and beta-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P."3.68Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. ( Ager, AL; Canfield, CJ; Heiffer, MH; Klayman, DL; Kyle, DE; Milhous, WK; Rossan, RN; Schuster, BG; Shmuklarsky, MJ; Tang, DB, 1993)
"Rats were treated with the well-known porphyrogen hexachlorobenzene (HCB) to induce experimental porphyria."3.67Influence of chloroquine on the porphyrin metabolism. ( Bolsen, K; Goerz, G; Merk, H, 1985)
" A model-informed strategy based on preclinical data, which incorporates pharmacokinetic-pharmacodynamic (PK-PD) properties with physiologically based pharmacokinetic (PBPK) modeling, is proposed to optimally predict an efficacious human dose and dosage regimen for the treatment of Plasmodium falciparum malaria."1.91Integrating Pharmacokinetic-Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study. ( Chibale, K; Gibhard, L; Mulubwa, M; Redhi, D, 2023)
"Atopic dermatitis is often associated with increased pain."1.91Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis. ( Akiyama, T; Bystrom, L; Ishida, H; Markan, A; Pavlenko, D; Todurga Seven, Z; Verpile, R, 2023)
"pylori-related gastric cancer, but the treatment should simultaneously remove H."1.91Chloroquine inhibited Helicobacter pylori-related gastric carcinogenesis by YAP-β-catenin-autophagy axis. ( Du, Y; He, J; Li, B; Liu, S; Lv, X; Zhang, X; Zhang, Y, 2023)
"Apalutamide (APA) is a next-generation androgen receptor antagonist for the treatment of advanced prostate cancer."1.72Apalutamide and autophagy inhibition in a xenograft mouse model of human prostate cancer. ( Baumgartner, V; Eberli, D; Kranzbühler, B; Lehner, F; Prause, L; Preda, S; Salemi, S; Sousa, R, 2022)
"Seizures were induced by pentylenetetrazol and maximal electroshock."1.72Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022)
"Chloroquine (CLQ) has been observed to inhibit calcium influx."1.62The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension. ( Akin, AT; Başaran, KE; Kaymak, E; Özdamar, S; Taheri, S; Tufan, E; Yakan, B, 2021)
"Chloroquine is a traditional medicine to treat malaria."1.56Chloroquine differentially modulates coronary vasodilation in control and diabetic mice. ( Lai, N; Makino, A; Si, R; Tsuji-Hosokawa, A; Wang, J; Wang, Z; Watanabe, M; Willson, C; Yuan, JX; Zhang, Q, 2020)
"Periodontitis is an inflammation characterized by alveolar bone resorption caused by imbalance in bone homeostasis."1.56Chloroquine and 3-Methyladenine Attenuates Periodontal Inflammation and Bone Loss in Experimental Periodontitis. ( Chen, B; He, S; Li, L; Luo, B; Yan, F; Zhou, Q, 2020)
"Chloroquine (CQ) is a prototypical systemic and intradermal pruritogen for histamine-independent (nonhistaminergic) itch in mice and humans."1.56Characterization of a chloroquine-induced canine model of pruritus and skin inflammation. ( Banovic, F; Blubaugh, A; Denley, T, 2020)
" However, its adverse effect has been limiting its long-term use in clinic."1.56Chloroquine attenuates lithium-induced NDI and proliferation of renal collecting duct cells. ( Cao, W; Chen, S; Du, Y; Guo, Y; Huang, S; Jia, Z; Jiang, M; Qian, Y; Tang, X; Yang, B; Zhang, A; Zhang, Y, 2020)
"Current asthma therapies fail to target airway remodeling that correlates with asthma severity driving disease progression that ultimately leads to loss of lung function."1.51Autophagy Activation in Asthma Airways Remodeling. ( Deshpande, DA; Ghavami, S; Haghi, M; McAlinden, KD; Oliver, BG; Sharma, P; Sohal, SS; Xenaki, D, 2019)
"Chloroquine is a drug used for the treatment of lupus; chloroquine has a quinoline ring and two positive charges that interact with conic anionic lipids and prevent or revert the formation of NPA."1.51Lupresan, a new drug that prevents or reverts the formation of nonbilayer phospholipid arrangements that trigger a murine lupus resembling human lupus. ( Baeza, I; Landa, C; Meza-Toledo, S; Reséndiz-Mora, A; Sánchez-Barbosa, S; Santiago-Hernández, JC; Wong, C; Wong-Baeza, C, 2019)
"Malaria is a serious disease and is one of the most alarming public health issues."1.51Efficacy of TLR7 agonistic imidazoquinoline as immunochemotherapeutic agent against P. Berghei ANKA infected rodent host. ( Bagai, U; Kaur, S; Kaushik, D; Salunke, DB; Saroa, R, 2019)
"Honokiol (HKL) is a natural low-molecular-weight biphenolic compound derived from the bark of magnolia trees."1.51Honokiol post-treatment ameliorates myocardial ischemia/reperfusion injury by enhancing autophagic flux and reducing intracellular ROS production. ( Chen, A; He, S; Ling, Y; Liu, H; Song, X; Tan, Z; Wang, S; Wang, X; Yan, J; Yan, Y, 2019)
"Chloroquine treatment significantly improved the survival of ZIKV-infected 1-day old suckling SCID Beige mice and reduced viremia in adult SCID Beige mice."1.51Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus. ( Chen, L; Feng, L; Guo, W; Li, C; Li, P; Liu, X; Niu, X; Pan, W; Peng, J; Qu, L; Wang, Q; Wu, M; Yan, Q; Ye, X; Yi, C; Zhang, F; Zhang, S, 2019)
"Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive deposition of droplets in hepatocytes."1.51Immunohistochemical expression of autophagosome markers LC3 and p62 in preneoplastic liver foci in high fat diet-fed rats. ( Eguchi, A; Ichikawa, R; Masuda, S; Mizukami, S; Nakamura, K; Nakamura, M; Okada, R; Shibutani, M; Tanaka, T; Yoshida, T, 2019)
"Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy."1.51The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model. ( Cheon, EJ; Chung, SH; Lee, HJ; Shin, S; Yoon, SG, 2019)
"Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal."1.51Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria. ( Azevedo-Quintanilha, IG; Bozza, PT; Campbell, RA; Castro-Faria-Neto, HC; Estato, V; Ferreira, AC; Nascimento, DO; Reis, PA; Silva, TI; Vieira-de-Abreu, A; Weyrich, AS; Zimmerman, GA, 2019)
"Chloroquine was injected intradermally into the rostral back of NMRI mice, and the scratching behavior was evaluated by measuring the number of bouts over 30 min."1.48Pharmacological evidence of involvement of nitric oxide pathway in anti-pruritic effects of sumatriptan in chloroquine-induced scratching in mice. ( Afshari, K; Dehpour, AR; Foroutan, A; Haddadi, NS; Ostadhadi, S; Rahimi, N; Shakiba, S, 2018)
" This work describes the optimization of the pharmacokinetic properties of a previously published family of triazine lead compounds."1.48Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives. ( Augustyns, K; Baán, A; Caljon, G; Kiekens, F; Maes, L; Matheeussen, A; Salado, IG; Van der Veken, P; Verdeyen, T, 2018)
"This will promote the research and treatment of pruritus and depression."1.48The behavioral study on the interactive aggravation between pruritus and depression. ( Bai, Y; Feng, YP; Li, H; Wang, XD; Yang, G, 2018)
" Single-dose pharmacokinetic and biodistribution studies performed in the colitis model indicated negligible systemic absorption (p ≤ 0."1.48Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. ( Ahmad, R; Chen, Y; Chhonker, YS; Jaramillo, L; Kanvinde, S; Li, J; Murry, DJ; Oupický, D; Sheinin, Y; Singh, AB; Sleightholm, R; Tang, W; Yu, F, 2018)
"TAS2R agonists attenuated features of airway remodeling including smooth muscle mass, extracellular matrix deposition and pro-fibrotic signaling, and also prevented mucus accumulation and development of AHR in mice."1.46Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice. ( Deshpande, DA; Knight, MJ; Nayak, AP; Oliver, B; Pan, S; Sharma, P; Tang, F; Wang, N; Yi, R, 2017)
"Anal carcinogenesis can be inhibited or induced via pharmacologic modulation of autophagy."1.46The role of pharmacologic modulation of autophagy on anal cancer development in an HPV mouse model of carcinogenesis. ( Carchman, EH; Matkowskyj, KA; Meske, LM; Rademacher, BL; Romero, A; Sleiman, H, 2017)
"Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available."1.46Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017)
"Calcitriol treatment activated VDR protein expression and attenuated neurological deficits in this rat TBI model."1.46Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury. ( Cui, C; Cui, J; Cui, Y; Gao, J; Jiang, P; Jiang, X; Jin, F; Li, R; Tian, Y; Wang, K, 2017)
"During SC dedifferentiation-associated demyelination (SAD) in Wallerian degeneration (WD) after axonal injury, SCs exhibit myelin and junctional instability, down-regulation of myelin gene expression and autophagic myelin breakdown."1.46Schwann cell dedifferentiation-associated demyelination leads to exocytotic myelin clearance in inflammatory segmental demyelination. ( Ahn, M; Choi, YY; Jang, SY; Jo, YR; Kim, JK; Park, HT; Park, JI; Shin, T; Shin, YK; Yoon, BA; Yun, SH, 2017)
"Serum samples of thirty patients with dengue hemorrhagic fever (DHF) were analysed for different biochemical parameters."1.46Potential of Nigella sativa seed aqueous extract in ameliorating quinine-induced thrombocytopenia in rats. ( Khan, MA; Rehman, S; Robin, S; Ruby, T; Saadia, M; Sher, M; Siddiqui, WA, 2017)
"Chloroquine has long been used for the treatment of malaria and rheumatological disorders."1.43Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. ( Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A, 2016)
" Compounds with halogen substitutions displayed sustained plasma levels after oral dosing in rodents leading to efficacy in the P."1.43Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. ( Angulo-Barturen, I; Bazaga, SF; Burrows, JN; Charman, SA; Chen, G; Coteron, JM; de Las Heras, L; Deng, X; El Mazouni, F; Jimenez-Diaz, MB; Kaminsky, W; Kokkonda, S; Leroy, D; Manjalanagara, K; Marco, M; Martínez-Martínez, MS; Matthews, D; Morizzi, J; Phillips, MA; Rathod, PK; Rudra, KR; Ryan, E; Tomchick, DR; Waterson, D; White, J; White, KL, 2016)
"Penfluridol treatment induced apoptosis and inhibited the growth of Panc-1, BxPC-3 and AsPC-1, pancreatic cancer cells with IC50 ranging between 6-7 μM after 24 h of treatment."1.43Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis. ( Ranjan, A; Srivastava, SK, 2016)
"The drug has been used successfully to treat malaria patients in clinical studies, thus validating IspC as an antimalarial target."1.42Prodrugs of reverse fosmidomycin analogues. ( Bacher, A; Behrendt, C; Brücher, K; Fischer, M; Gräwert, T; Held, J; Illarionov, B; Konzuch, S; Kurz, T; Lienau, C; Maes, L; Mordmüller, B; Wittlin, S, 2015)
"Treatment with vildagliptin (10 mg/kg/day s."1.42Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats. ( Ishikawa, S; Kouzu, H; Kuno, A; Miki, T; Miura, T; Murase, H; Nishizawa, K; Ogasawara, M; Tanno, M; Tobisawa, T; Yano, T, 2015)
" In previous studies we reported on the ability of Pheroid vesicles to improve the bioavailability of poorly soluble drugs."1.42In vivo efficacy and bioavailability of lumefantrine: Evaluating the application of Pheroid technology. ( Denti, P; du Plessis, LH; Govender, K; Wiesner, L, 2015)
" The pharmacokinetic properties of active compounds were determined using a mouse model and blood samples were collected at different time intervals and analysed using LC-MS/MS."1.42Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model. ( Andayi, A; Chibale, K; Dambuza, NS; Egan, T; Evans, A; Norman, J; Smith, P; Taylor, D; Wiesner, L, 2015)
"Ellipticine has been shown previously to exhibit excellent in vitro antiplasmodial activity and in vivo antimalarial properties that are comparable to those of the control drug chloroquine in a mouse malaria model."1.40Antiplasmodial activity of synthetic ellipticine derivatives and an isolated analog. ( Amorim, RC; Costa, DS; Costa, MR; Eberlin, MN; Grafov, A; Grafova, I; Henrique, MC; Lima, ES; Montoia, A; Pohlit, AM; Rocha E Silva, LF; Souza, RC; Tadei, WP; Torres, ZE; Vasconcellos, MC, 2014)
"Chloroquine treatment increased whole lung and PASMC p62 protein levels consistent with inhibition of autophagy, and increased levels of BMPR-II protein."1.39Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. ( Dunmore, BJ; Long, L; Lu, J; Marciniak, SJ; Morrell, NW; Southwood, M; Yang, X, 2013)
"The chloroquine was treated by the actual drug content of effective nanochloroquine and the nanodrug was charged with its effective dose for fifteen days, after successive infection development in Swiss mice."1.39A novel chitosan based antimalarial drug delivery against Plasmodium berghei infection. ( Chattopadhyay, S; Das, S; Dash, SK; Mahapatra, SK; Majumder, S; Pramanik, P; Roy, S; Tripathy, S, 2013)
" We reasoned that, akin to antibacterials, antimalarials might have an essential pharmacokinetic requirement for efficacy: action governed either by total exposure or peak concentration (AUC/CMAX), or by duration above a defined minimum concentration [time above minimum inhibitory concentration (TMIC)]."1.39Model system to define pharmacokinetic requirements for antimalarial drug efficacy. ( Bakshi, RP; Nenortas, E; Shapiro, TA; Sullivan, DJ; Tripathi, AK, 2013)
"Fagaronine was found to have very good antimalarial activity in vivo, comparable to the activity of the reference compound chloroquine."1.38Short synthesis and antimalarial activity of fagaronine. ( Jullian, V; Mendoza, A; Rivaud, M; Sauvain, M; Valentin, A, 2012)
"Parasitemia was 4% on day 8 when compared to that on day 0, whereas it was 9% on day 9."1.38Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis. ( Abolghasemi, E; Davoudi, M; Moosa-Kazemi, SH; Reisi, A; Satvat, MT, 2012)
"Malaria is one of the leading causes of severe infectious disease worldwide; yet, our ability to maintain effective therapy to combat the illness is continually challenged by the emergence of drug resistance."1.37Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. ( Bathurst, I; Buckner, FS; Burrows, J; Charman, SA; Charman, WN; Creason, S; Deng, X; El Mazouni, F; Floyd, DM; Gujjar, R; Matthews, D; Phillips, MA; Rathod, PK; Shackleford, DM; White, J; White, KL, 2011)
"Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax."1.37Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta). ( Cozens, S; Dow, GS; Gettayacamin, M; Hansukjariya, P; Imerbsin, R; Kenworthy, D; Komcharoen, S; Kyle, D; Milhous, W; Miller, A; Ohrt, C; Sattabongkot, J; Veazey, J, 2011)
"Human cerebral malaria causes neurological and behavioral deficits which persist long after resolution of infection and clearance of parasites with antimalarial drugs."1.36Persistent cognitive and motor deficits after successful antimalarial treatment in murine cerebral malaria. ( Dai, M; Desruisseaux, MS; Gulinello, M; Reznik, SE; Spray, DC; Tanowitz, HB; Weiss, LM, 2010)
" It is thought that variability in the presentation of chloroquine retinopathy may be the result of perturbations in drug bioavailability subsequent to oral ingestion."1.35Retinal toxicity of chloroquine hydrochloride administered by intraperitoneal injection. ( Gaynes, BI; Grostern, R; Perlman, J; Torczynski, E; Varro, Z, 2008)
"Tetrahydrocurcumin is an antioxidative substance, which is derived from curcumin, the component of turmeric."1.33Tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney. ( Murugan, P; Pari, L, 2006)
"Chloroquine has marked effects on the normal kidney and stimulates an increase in plasma vasopressin via nitric oxide."1.32Renal function in a rat model of analgesic nephropathy: effect of chloroquine. ( Ahmed, MH; Ashton, N; Balment, RJ, 2003)
"Fluconazole alone was not found significantly effective against C."1.32Prophylactic role of liposomized chloroquine against murine cryptococcosis less susceptible to fluconazole. ( Jabeen, R; Khan, MA; Mohammad, O, 2004)
"Methemoglobin, a toxic ferric form of hemoglobin, is continuously formed in normal erythrocytes, but during abnormal situations in situ, the level is enhanced."1.31A simple and rapid evaluation of methemoglobin toxicity of 8-aminoquinolines and related compounds. ( Jain, GK; Pandey, VC; Puri, SK; Singh, S; Srivastava, P, 2000)
"With chloroquine treatment, muscle atrophy occurred predominantly in soleus muscle and unusual autophagosomes were accumulated."1.31The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy. ( Ishiura, S; Nakagawa, M; Nishino, I; Nonaka, I; Ohsumi, Y; Sasagawa, N; Suzuki, T; Yoshikawa, A; Yoshimori, T, 2002)
"Cyproheptadine has been shown to produce dose-dependent inhibition of haem polymerization activity both in vitro and in vivo."1.31Haem polymerase as a novel target of antimalarial action of cyproheptadine. ( Agrawal, R; Dutta, GP; Jain, SK; Shukla, OP; Tekwani, BL; Tripathi, R, 2002)
"Chloroquine (CQ) is a widely used drug and its administration has been reported to increase surfactant- associated phospholipids in lungs."1.29Chloroquine-induced retardation of foetal lung maturation in rats. ( Ashiru, OA; Dada, MO; Ejiwunmi, AB; Okanlawon, AO, 1993)
" To reduce the side effects, another test was carried out in 3 monkeys and the dosage regimen was modified to pyronaridine 6 mg/kg-artemether 10 mg/kg-chloroquine 20 mg/kg (PAC-2) once daily for 3 days."1.29[Studies on the establishment of malarial animal model of short-term relapse. III. Combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance]. ( Fang, Y; Lin, BY; Pan, YR; Zhang, JX; Zheng, H, 1993)
"Cyproheptadine and verapamil were not effective in reversing chloroquine resistance and probable drug toxicity was observed with these drugs in combination with chloroquine."1.29Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys. ( Kyle, DE; Milhous, WK; Rossan, RN, 1993)
"Chloroquine resistance was induced in Plasmodium yoelii nigeriensis by the method of drug pressure."1.29Induction of chloroquine resistance in Plasmodium yoelii nigeriensis. ( Fagbenro-Beyioku, AF; Kimbi, HK, 1996)
" Chronic administration of chloroquine (20 days) caused an overall lengthening of the duration of the ERG b-wave, together with delayed peaking."1.28Effect of Gingko biloba extract (EGb 761) on chloroquine induced retinal alterations. ( Besse, G; Doly, M; Droy-Lefaix, MT; Vennat, JC, 1992)
"A drug-induced lipidosis of the central nervous system of chickens is reported."1.25A drug-induced cerebrospinal lipodystrophy in the domestic chicken (Gallus domesticus). ( Bay, WW; Dukes, TW; Gleiser, CA; Read, WK, 1971)

Research

Studies (298)

TimeframeStudies, this research(%)All Research%
pre-199021 (7.05)18.7374
1990's29 (9.73)18.2507
2000's50 (16.78)29.6817
2010's155 (52.01)24.3611
2020's43 (14.43)2.80

Authors

AuthorsStudies
Gonzalez, JL1
Stephens, CE1
Wenzler, T3
Brun, R9
Tanious, FA1
Wilson, WD1
Barszcz, T2
Werbovetz, KA4
Boykin, DW1
Zhu, S1
Zhang, Q5
Gudise, C1
Meng, L1
Wei, L2
Smith, E1
Kong, Y1
Ellis, GL1
Amewu, R1
Sabbani, S1
Stocks, PA1
Shone, A1
Stanford, D1
Gibbons, P1
Davies, J1
Vivas, L1
Charnaud, S1
Bongard, E1
Hall, C1
Rimmer, K1
Lozanom, S1
Jesús, M1
Gargallo, D1
Ward, SA1
O'Neill, PM1
Downey, AS1
Chong, CR2
Graczyk, TK1
Sullivan, DJ3
Shilabin, AG1
Kasanah, N1
Tekwani, BL5
Hamann, MT1
Opsenica, I1
Opsenica, D1
Lanteri, CA1
Anova, L1
Milhous, WK5
Smith, KS1
Solaja, BA1
Bakunov, SA2
Bakunova, SM2
Tidwell, RR2
Höfle, G1
Bööhlendorf, B1
Fecker, T1
Sasse, F1
Kunze, B1
Musonda, CC1
Whitlock, GA1
Witty, MJ3
Kaiser, M7
Samoylenko, V1
Ashfaq, MK1
Jacob, MR1
Khan, SI1
Manly, SP1
Joshi, VC1
Walker, LA2
Muhammad, I1
Jiménez-Díaz, MB4
Mulet, T1
Viera, S1
Gómez, V1
Garuti, H1
Ibáñez, J1
Alvarez-Doval, A1
Shultz, LD1
Martínez, A1
Gargallo-Viola, D1
Angulo-Barturen, I4
Ghebru, M1
Faist, J4
Seebacher, W4
Saf, R4
Weis, R4
Bahar, M1
Deng, Y1
Zhu, X4
He, S3
Pandharkar, T1
Drew, ME1
Navarro-Vázquez, A1
Anklin, C1
Gil, RR1
Doskotch, RW1
Kinghorn, AD1
Gujjar, R1
El Mazouni, F2
White, KL4
White, J2
Creason, S1
Shackleford, DM1
Deng, X2
Charman, WN1
Bathurst, I1
Burrows, J2
Floyd, DM1
Matthews, D2
Buckner, FS1
Charman, SA4
Phillips, MA2
Rathod, PK2
Vlahakis, JZ1
Mitu, S1
Roman, G1
Patricia Rodriguez, E1
Crandall, IE1
Szarek, WA1
Lowes, D1
Pradhan, A1
Iyer, LV1
Parman, T1
Gow, J1
Zhu, F1
Furimsky, A1
Lemoff, A1
Guiguemde, WA1
Sigal, M1
Clark, JA1
Wilson, E1
Tang, L1
Connelly, MC1
Derisi, JL1
Kyle, DE5
Mirsalis, J1
Guy, RK1
Rivaud, M1
Mendoza, A1
Sauvain, M1
Valentin, A2
Jullian, V1
Younis, Y2
Douelle, F1
González Cabrera, D3
Le Manach, C4
Nchinda, AT4
Paquet, T4
Street, LJ4
Zabiulla, KM1
Joseph, JT1
Bashyam, S2
Waterson, D3
Wittlin, S8
Chibale, K8
Ríos Martínez, CH1
Lagartera, L1
Dardonville, C1
Giannini, G2
Battistuzzi, G2
Vignola, D1
Brücher, K1
Gräwert, T1
Konzuch, S1
Held, J1
Lienau, C1
Behrendt, C1
Illarionov, B1
Maes, L2
Bacher, A1
Mordmüller, B1
Fischer, M1
Kurz, T1
Wolkinger, V1
Bucar, F1
Gröblacher, B1
Brantner, A1
Merino, V1
Kalia, Y1
Scapozza, L1
Perozzo, R1
Mendoza-Martínez, C1
Correa-Basurto, J1
Nieto-Meneses, R1
Márquez-Navarro, A1
Aguilar-Suárez, R1
Montero-Cortes, MD1
Nogueda-Torres, B1
Suárez-Contreras, E1
Galindo-Sevilla, N1
Rojas-Rojas, Á1
Rodriguez-Lezama, A1
Hernández-Luis, F1
Mital, A1
Murugesan, D1
Yeates, C2
Gilbert, IH1
Kokkonda, S1
Coteron, JM1
Marco, M1
de Las Heras, L1
Tomchick, DR1
Manjalanagara, K1
Rudra, KR1
Chen, G4
Morizzi, J1
Ryan, E1
Kaminsky, W1
Leroy, D1
Martínez-Martínez, MS1
Bazaga, SF1
Burrows, JN1
Han, Z1
Zabiulla, M1
Taylor, D5
Lawrence, N3
Botha, ME1
Nondaba, SH1
Reader, J3
Birkholtz, LM3
Martínez, MS1
Ferrer, S2
Meister, S1
Antonova-Koch, Y1
Winzeler, EA1
Gilson, PR1
Tan, C1
Jarman, KE1
Lowes, KN1
Curtis, JM1
Nguyen, W1
Di Rago, AE1
Bullen, HE1
Prinz, B1
Duffy, S1
Baell, JB1
Hutton, CA1
Jousset Subroux, H1
Crabb, BS1
Avery, VM1
Cowman, AF1
Sleebs, BE1
Gopalsamy, A1
Narayanan, A1
Liu, S2
Parikh, MD1
Kyne, RE1
Fadeyi, O1
Tones, MA1
Cherry, JJ1
Nabhan, JF1
LaRosa, G1
Petersen, DN1
Menard, C1
Foley, TL1
Noell, S1
Ren, Y2
Loria, PM1
Maglich-Goodwin, J1
Rong, H1
Jones, LH1
Salado, IG1
Baán, A1
Verdeyen, T1
Matheeussen, A1
Caljon, G1
Van der Veken, P1
Kiekens, F1
Augustyns, K1
Wicht, KJ1
Brunschwig, C2
Njoroge, M3
Abay, E1
Santos Martínez, M1
Lafuente-Monasterio, MJ1
Duffy, J2
Mayoka, G1
Okombo, J2
Gibhard, L3
Sanches-Vaz, M1
Fontinha, D1
van der Watt, M2
Coetzer, TL1
Lauterbach, S1
Churchyard, A1
Bezuidenhout, B1
Egan, TJ2
Prudêncio, M2
Saroa, R1
Kaushik, D1
Bagai, U1
Kaur, S1
Salunke, DB1
Dodean, RA2
Kancharla, P2
Li, Y8
Melendez, V2
Read, L2
Bane, CE2
Vesely, B2
Kreishman-Deitrick, M2
Black, C2
Li, Q4
Sciotti, RJ2
Olmeda, R2
Luong, TL2
Gaona, H2
Potter, B2
Sousa, J2
Marcsisin, S2
Caridha, D3
Xie, L2
Vuong, C2
Zeng, Q2
Zhang, J6
Zhang, P4
Lin, H2
Butler, K2
Roncal, N2
Gaynor-Ohnstad, L2
Leed, SE2
Nolan, C2
Huezo, SJ1
Rasmussen, SA2
Stephens, MT1
Tan, JC1
Cooper, RA2
Smilkstein, MJ2
Pou, S2
Winter, RW1
Riscoe, MK2
Kelly, JX2
Meyers, MJ1
Liu, J1
Xu, J3
Leng, F1
Guan, J1
Liu, Z4
McNitt, SA1
Qin, L1
Dai, L1
Ma, H2
Adah, D1
Zhao, S3
Li, X13
Polino, AJ1
Nasamu, AS1
Goldberg, DE1
Liu, X3
Lu, Y2
Tu, Z1
Chen, X5
Tortorella, MD1
Hochegger, P1
Mäser, P1
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X2
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Baartzes, N1
Stringer, T1
Seldon, R1
Warner, DF1
Smith, GS1
Pybus, B1
Ceja, FG1
Tumwebaze, PK1
Rosenthal, PJ1
Mu, J2
Bayles, BR1
Reynolds, KA1
Horatscheck, A1
Andrijevic, A1
Khonde, LP1
Dam, J1
Pawar, K1
Wicht, K1
de Sousa, ACC1
Maepa, K1
Basarab, GS1
Fish, PV1
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
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Pinkas-Kramarski, R1
Adepiti, AO1
Elujoba, AA1
Bolaji, OO1
Mavondo, GA1
Mkhwananzi, BN1
Mabandla, MV1
Ranjan, A1
Srivastava, SK1
Lobo, L1
Sousa, Bd1
Cabral, L1
Cristiano, ML1
Nogueira, F1
Macedo, TS1
Colina-Vegas, L1
DA Paixão, M1
Navarro, M1
Barreto, BC1
Oliveira, PC1
Macambira, SG1
Machado, M1
D'Alessandro, S1
Basilico, N1
Moreira, DR1
Batista, AA1
Soares, MB1
McCarthy, CG1
Wenceslau, CF1
Goulopoulou, S1
Baban, B1
Matsumoto, T1
Webb, RC1
Chukwuocha, UM1
Fernández-Rivera, O1
Legorreta-Herrera, M1
Azimi, E1
Nateghpour, M1
Lerner, EA1
Yeo, SJ1
Liu, DX1
Kim, HS1
Wilmot, D1
Ameyaw, EO1
Amoako-Sakyi, D1
Boampong, JN1
Quashie, NB1
Koutakis, P1
Pipinos, I1
Tzeng, E1
Sachdev, U1
Kamitsuji, Y1
Kuroda, J1
Kimura, S1
Toyokuni, S1
Watanabe, K1
Ashihara, E1
Tanaka, H1
Yui, Y1
Matsubara, H1
Mizushima, Y2
Hiraumi, Y1
Kawata, E1
Yoshikawa, T1
Maekawa, T1
Nakahata, T1
Adachi, S1
Kiboi, DM1
Irungu, BN1
Langat, B1
Chollet, J1
Abiodun, O1
Nganga, JK1
Nyambati, VC1
Rukunga, GM1
Bell, A1
Nzila, A1
Iwalokun, BA1
Vashist, U1
Carvalhaes, R1
D'agosto, M1
da Silva, AD1
Freiberg, AN1
Worthy, MN1
Lee, B1
Holbrook, MR1
Ju, JS1
Fuentealba, RA1
Miller, SE1
Jackson, E1
Piwnica-Worms, D1
Baloh, RH1
Weihl, CC1
Dai, M1
Reznik, SE1
Spray, DC1
Weiss, LM1
Tanowitz, HB1
Gulinello, M1
Desruisseaux, MS1
Ecker, A1
Lakshmanan, V1
Sinnis, P1
Coppens, I1
Fidock, DA1
Nurul Aiezzah, Z1
Noor, E1
Hasidah, MS1
Wilson, SR1
Gerhold, KA1
Bifolck-Fisher, A1
Patel, KN1
Bautista, DM1
Moore, BR1
Page-Sharp, M1
Stoney, JR1
Ilett, KF1
Jago, JD1
Dow, GS4
Gettayacamin, M2
Hansukjariya, P2
Komcharoen, S1
Sattabongkot, J2
Kyle, D1
Milhous, W1
Cozens, S1
Kenworthy, D1
Miller, A1
Veazey, J1
Gbotosho, GO1
Happi, CT1
Woranola, O1
Abiodun, OO1
Sowunmi, A2
Oduola, AM2
Mbah, CC1
Akuodor, GC1
Anyalewechi, NA1
Iwuanyanwu, TC1
Osunkwo, UA1
Collins, WE9
Sullivan, JS6
Jeffery, GM1
Nace, D2
Williams, T2
Galland, GG6
Williams, A2
Barnwell, JW2
Ganfon, H1
Bero, J1
Tchinda, AT1
Gbaguidi, F1
Gbenou, J1
Moudachirou, M1
Frédérich, M1
Quetin-Leclercq, J1
Filgueiras-Rama, D1
Martins, RP1
Mironov, S1
Yamazaki, M1
Calvo, CJ1
Ennis, SR1
Bandaru, K1
Noujaim, SF1
Kalifa, J1
Berenfeld, O1
Jalife, J1
Pan, Y1
Shang, H1
Gowda, DC1
Cui, L1
Chakraborty, SP1
Sahu, SK1
Deye, GA1
Im-erbsin, R1
Rothstein, Y1
Macareo, L1
Fracisco, S1
Bennett, K1
Dong, G1
Komatsu, M1
Su, Y1
Garavito, G1
Bertani, S1
Quiliano, M1
Aldana, I1
Deharo, E1
Nganou-Makamdop, K1
Ploemen, I1
Behet, M1
Van Gemert, GJ1
Hermsen, C1
Roestenberg, M1
Sauerwein, RW1
Zou, Z1
Xu, KF1
Jin, N1
Jiang, C1
Bristol, ML1
Emery, SM1
Maycotte, P1
Thorburn, A1
Chakradeo, S1
Xiong, X1
Dong, XC1
Yin, XM1
Armson, A1
Boddy, MR1
Itenge, T1
McCarthy, D1
Parkin, JE1
Thompson, RC2
Reynoldson, JA3
Agrawal, R1
Tripathi, R1
Jain, SK1
Dutta, GP2
Shukla, OP1
Leadbetter, EA1
Rifkin, IR1
Marshak-Rothstein, A1
Nwabuisi, C1
Ahmed, MH1
Ashton, N1
Balment, RJ1
Bendiske, J1
Bahr, BA1
Peters, W1
Stewart, LB1
Robinson, BL1
Su, RB1
Wei, XL1
Dommergues, MA1
Plaisant, F1
Verney, C1
Gressens, P1
Reece, SE1
Duncan, AB1
West, SA1
Read, AF1
Hong, Z1
Jiang, Z1
Liangxi, W1
Guofu, D1
Ping, L1
Yongling, L1
Wendong, P1
Minghai, W1
Oliveira, MF1
d'Avila, JC1
Tempone, AJ1
Soares, JB1
Rumjanek, FD1
Ferreira-Pereira, A1
Ferreira, ST1
Oliveira, PL1
Artenstein, AW1
Opal, SM1
Cristofaro, P1
Palardy, JE1
Parejo, NA1
Green, MD1
Jhung, JW1
Okpako, LC1
Ajaiyeoba, EO1
Jabeen, R2
Nasti, TH1
Mohammad, O2
Martinelli, A1
Hunt, P2
Fawcett, R1
Cravo, PV1
Walliker, D2
Carter, R1
Tamez, PA1
Lantvit, D1
Lim, E1
Pezzuto, JM1
Pedroni, HC1
Bettoni, CC1
Spalding, SM1
Dalla Costa, T1
Guzmán, V1
Carmona-Fonseca, J1
Martin, FC1
Handforth, A1
Liu, JO1
Pari, L1
Murugan, P1
Okokon, JE1
Udokpoh, AE1
Antia, BS1
Dias-Melicio, LA1
Calvi, SA1
Bordon, AP1
Golim, MA1
Peraçoli, MT1
Soares, AM1
Kimura, N1
Kumamoto, T1
Kawamura, Y1
Himeno, T1
Nakamura, KI1
Ueyama, H1
Arakawa, R1
Hall, P1
Ruebush, TK1
Grady, KK1
Bounngaseng, A1
Huber, C1
Sullivan, JJ1
Gaynes, BI1
Torczynski, E1
Varro, Z1
Grostern, R1
Perlman, J1
Cashin, CH1
Doherty, NS1
Jeffries, BL1
Buckland-Wright, JC1
Cooper, RD2
Murakami, N1
Ihara, Y1
Nonaka, I2
Okanlawon, AO1
Ejiwunmi, AB1
Dada, MO1
Ashiru, OA1
Zhang, JX2
Lin, BY2
Pan, YR2
Zheng, H2
Tang, WZ1
Chen, YD1
Xu, B1
Fang, Y1
Weglicki, WB1
Stafford, RE1
Freedman, AM1
Cassidy, MM1
Phillips, TM1
Shmuklarsky, MJ1
Klayman, DL1
Ager, AL1
Tang, DB1
Heiffer, MH1
Canfield, CJ1
Schuster, BG2
Tsuzuki, K3
Fukatsu, R3
Takamaru, Y3
Mafune, N1
Kobayashi, K2
Fujii, N3
Takahata, N3
Curry, SC1
Connor, DA1
Clark, RF1
Holland, D1
Carrol, L1
Raschke, R1
Hayashi, Y2
Yamaguchi, H1
Kimbi, HK2
Fagbenro-Beyioku, AF2
Emrich, JG1
Hand, CM1
Dilling, TJ1
Class, R1
Bender, H1
Brady, LW1
Cambie, G2
Verdier, F1
Gaudebout, C1
Clavier, F1
Ginsburg, H2
Nayar, JK1
Baker, RH1
Knight, JW1
Morris, CL4
Richardson, BB3
Brewer, TG1
Gerena, L1
Salako, LA1
Nguyen-Dinh, P1
Nesby, S1
Mohan, K1
Sam, H1
Stevenson, MM1
Jennings, VM1
Kendall, J2
Andrew Thompson, RC1
Srivastava, P1
Jain, GK1
Puri, SK2
Pandey, VC1
Rafatro, H1
Ramanitrahasimbola, D1
Rasoanaivo, P1
Ratsimamanga-Urverg, S1
Rakoto-Ratsimamanga, A1
Frappier, F1
Fryauff, DJ1
Jennings, V1
Van Horssen, PJ1
Preijers, FW1
Van Oosterhout, YV1
Eling, WM1
De Witte, T1
Cravo, P1
Culleton, R1
Mackinnon, MJ1
Suzuki, T1
Nakagawa, M1
Yoshikawa, A1
Sasagawa, N1
Yoshimori, T1
Ohsumi, Y1
Nishino, I1
Ishiura, S1
Schmidt, LH2
Chin, W1
Skinner, JC1
Young, MD1
Baerg, DC1
Droy-Lefaix, MT1
Vennat, JC1
Besse, G1
Doly, M1
el-Mofty, MM1
Khudoley, VV1
Sakr, SA1
Abdel-Gawad, HS1
Blasi, E1
Barluzzi, R1
Mazzolla, R1
Mosci, P1
Bistoni, F1
Caillard, V1
Beauté-Lafitte, A1
Chabaud, A1
Landau, I1
Riou, B1
Rimailho, A1
Galliot, M1
Bourdon, R1
Huet, Y1
Sweeney, GD1
Campbell, CC1
Roberts, JM1
Armstead, A1
Goerz, G1
Bolsen, K1
Merk, H1
Ehrlich, GE1
Sano, M1
Klinghardt, GW2
Dukes, TW1
Read, WK1
Bay, WW1
Gleiser, CA1
Tsukada, W1
Akimoto, T1
Scholnick, PL1
Epstein, J1
Marver, HS1
Graham, HA1
Stauber, LA1
Palczuk, NC1
Barnes, WD1
Vischer, WA1
Fitch, CD1
Contacos, PG1

Clinical Trials (9)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 1, Randomized, Double-Blind, Vehicle-Controlled Ascending Doses Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ASN008 Topical Gel in Healthy Volunteers and Subjects With Atopic Dermatitis[NCT03798561]Phase 124 participants (Actual)Interventional2019-01-14Completed
Using Hydroxychloroquine to Treat Nonalcoholic Steatohepatitis[NCT05733897]150 participants (Anticipated)Observational2022-06-10Recruiting
Hydroxychloroquine Post-Exposure Prophylaxis for Coronavirus Disease (COVID-19) Among Health-Care Workers: A Randomized-Controlled Trial[NCT04438837]582 participants (Anticipated)Interventional2020-07-31Not yet recruiting
Development of Safer Drugs for Malaria in U.S. Troops, Civilian Personnel, and Travelers: Clinical Evaluation of Primaquine Enantiomer[NCT02898779]Phase 136 participants (Actual)Interventional2017-05-01Completed
Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study[NCT02932007]Phase 240 participants (Anticipated)Interventional2017-03-28Recruiting
Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia: A Pragmatic Randomized Controlled Trial[NCT04359095]Phase 2/Phase 3650 participants (Actual)Interventional2020-08-18Completed
Prophylaxis With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19)[NCT04627467]Phase 23,217 participants (Actual)Interventional2020-03-28Completed
Prevention of COVID19 Infection by the Administration of Hydroxychloroquine to Institutionalized Older People and Nursing Home Staff. Controlled Clinical Trial, Randomized Triple Blind by Clusters (PREVICHARM Study)[NCT04400019]Phase 2/Phase 31,930 participants (Anticipated)Interventional2020-09-30Not yet recruiting
Randomized Double-Blind Placebo-Controlled Trial on the Safety and Efficacy of Imatinib for Hospitalized Adults With COVID-19[NCT04394416]Phase 3204 participants (Anticipated)Interventional2020-06-02Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for chloroquine and Disease Models, Animal

ArticleYear
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Hydroxychloroquine/Chloroquine as Therapeutics for COVID-19: Truth under the Mystery.
    International journal of biological sciences, 2021, Volume: 17, Issue:6

    Topics: Animals; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; E

2021
Repurposing New Use for Old Drug Chloroquine against Metabolic Syndrome: A Review on Animal and Human Evidence.
    International journal of medical sciences, 2021, Volume: 18, Issue:12

    Topics: Animals; Apoptosis; Autophagy; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclinical; Dr

2021
Autophagy in glioma cells: An identity crisis with a clinical perspective.
    Cancer letters, 2018, 08-01, Volume: 428

    Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Proteins; Brain Neoplasms; Cell Survival; Chloroqui

2018
Toll-like receptors and activation of autoreactive B cells.
    Current directions in autoimmunity, 2003, Volume: 6

    Topics: Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Autoimmune Diseases; B-Lymphocyte Subset

2003
[Cytochrome P-450 and the response to antimalarial drugs].
    Revista panamericana de salud publica = Pan American journal of public health, 2006, Volume: 19, Issue:1

    Topics: Administration, Oral; Adult; Amodiaquine; Animals; Antimalarials; Biotransformation; Child; Chloroqu

2006
Porphyria cutanea tarda, or the uroporphyrinogen decarboxylase deficiency diseases.
    Clinical biochemistry, 1986, Volume: 19, Issue:1

    Topics: Animals; Bloodletting; Carboxy-Lyases; Chloroquine; Chromatography, High Pressure Liquid; Disease Mo

1986
Animal models of osteoarthritis: implication for pathogenesis and treatment.
    Rational drug therapy, 1985, Volume: 19, Issue:1

    Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Aspirin; Chloroquine; Disease Models, An

1985

Trials

2 trials available for chloroquine and Disease Models, Animal

ArticleYear
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats.
    Malaria journal, 2016, Apr-21, Volume: 15

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Malaria; Male; Mice; Parasitemia; Penta

2016

Other Studies

289 other studies available for chloroquine and Disease Models, Animal

ArticleYear
Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
    European journal of medicinal chemistry, 2007, Volume: 42, Issue:4

    Topics: Animals; Antiparasitic Agents; Disease Models, Animal; Guanidines; Leishmania; Mice; Molecular Struc

2007
Synthesis and evaluation of naphthyridine compounds as antimalarial agents.
    Bioorganic & medicinal chemistry letters, 2007, Nov-15, Volume: 17, Issue:22

    Topics: Animals; Antimalarials; Disease Models, Animal; Inhibitory Concentration 50; Malaria; Molecular Stru

2007
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
    Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7

    Topics: Animals; Antimalarials; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Dr

2008
Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Animals; Animals, Newborn; Antiprotozoal Agents; Cell Line; Cryptosporidiosis; Cryptosporidium parvu

2008
Kinetic studies and bioactivity of potential manzamine prodrugs.
    Journal of natural products, 2008, Volume: 71, Issue:7

    Topics: Administration, Oral; Animals; Antimalarials; Candida albicans; Carbolines; Chlorocebus aethiops; Cr

2008
New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Aminoquinolines; Animals; Antimalarials; Binding Sites; Disease Models, Animal; Dose-Response Relati

2008
Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Animals; Antiprotozoal Agents; Benzofurans; Cations; Disease Models, Animal; Leishmania; Mice; Molec

2008
Semisynthesis and antiplasmodial activity of the quinoline alkaloid aurachin E.
    Journal of natural products, 2008, Volume: 71, Issue:11

    Topics: Alkaloids; Animals; Antimalarials; Disease Models, Animal; Mice; Mitochondria; Molecular Structure;

2008
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity.
    Bioorganic & medicinal chemistry letters, 2009, Jan-15, Volume: 19, Issue:2

    Topics: Animals; Antimalarials; Astemizole; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclinica

2009
Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa.
    Journal of natural products, 2009, Volume: 72, Issue:1

    Topics: Animals; Anti-Infective Agents; Antiparasitic Agents; Aspergillus fumigatus; Brain; Candida albicans

2009
Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Disease Models, Animal; Erythrocytes;

2009
Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.
    Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1

    Topics: Amidines; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Disease Models, Animal; Female; L

2010
Dialkylaminoalkyl derivatives of bicyclic compounds with antiplasmodial activity.
    Bioorganic & medicinal chemistry, 2010, Sep-15, Volume: 18, Issue:18

    Topics: Animals; Antimalarials; Azabicyclo Compounds; Bridged Bicyclo Compounds; Disease Models, Animal; Mic

2010
Potent antiprotozoal activity of a novel semi-synthetic berberine derivative.
    Bioorganic & medicinal chemistry letters, 2011, May-01, Volume: 21, Issue:9

    Topics: Animals; Antiprotozoal Agents; Berberine; Chlorocebus aethiops; Disease Models, Animal; Inhibitory C

2011
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
    Journal of medicinal chemistry, 2011, Jun-09, Volume: 54, Issue:11

    Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Drug Design; Drug Disc

2011
The anti-malarial activity of bivalent imidazolium salts.
    Bioorganic & medicinal chemistry, 2011, Nov-01, Volume: 19, Issue:21

    Topics: Animals; Antimalarials; Disease Models, Animal; Erythrocytes; Imidazoles; Magnetic Resonance Spectro

2011
Lead optimization of antimalarial propafenone analogues.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Administration, Oral; Animals; Antimalarials; Chloroquine; Cytochrome P-450 CYP2D6; Cytochrome P-450

2012
Short synthesis and antimalarial activity of fagaronine.
    Bioorganic & medicinal chemistry, 2012, Aug-01, Volume: 20, Issue:15

    Topics: Animals; Antimalarials; Benzophenanthridines; Chlorocebus aethiops; Chloroquine; Disease Models, Ani

2012
Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom.
    Bioorganic & medicinal chemistry, 2013, Sep-01, Volume: 21, Issue:17

    Topics: Animals; Antiprotozoal Agents; Bridged Bicyclo Compounds; Cell Line; Cell Survival; Disease Models,

2013
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
    Journal of medicinal chemistry, 2013, Nov-14, Volume: 56, Issue:21

    Topics: Administration, Oral; Aminopyridines; Animals; Antimalarials; CHO Cells; Cricetulus; Disease Models,

2013
Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines.
    European journal of medicinal chemistry, 2014, Jun-23, Volume: 81

    Topics: Animals; Antiparasitic Agents; Benzamides; Binding Sites; Cell Line; Cell Survival; Disease Models,

2014
Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites.
    Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3

    Topics: Animals; Antiprotozoal Agents; Cell Line, Tumor; Disease Models, Animal; HSP90 Heat-Shock Proteins;

2015
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
    Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3

    Topics: Animals; Antimalarials; Cell Line, Tumor; Dipeptides; Disease Models, Animal; Histone Deacetylase In

2015
Prodrugs of reverse fosmidomycin analogues.
    Journal of medicinal chemistry, 2015, Feb-26, Volume: 58, Issue:4

    Topics: Animals; Antimalarials; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Fos

2015
Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.
    Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7

    Topics: Administration, Oral; Animals; Antiprotozoal Agents; Azabicyclo Compounds; Disease Models, Animal; D

2015
Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents.
    European journal of medicinal chemistry, 2015, Volume: 96

    Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Chlorocebus aethiops; Disease Mo

2015
Discovery and optimisation studies of antimalarial phenotypic hits.
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Animals; Antimalarials; Cell Line; Cell Survival; Disease Models, Animal; Dose-Response Relationship

2015
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
    Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11

    Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Dose-Response Relation

2016
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
    Journal of medicinal chemistry, 2016, 11-10, Volume: 59, Issue:21

    Topics: Animals; Antimalarials; Disease Models, Animal; Dose-Response Relationship, Drug; Ether-A-Go-Go Pota

2016
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.
    Journal of medicinal chemistry, 2017, 02-09, Volume: 60, Issue:3

    Topics: Administration, Oral; Animals; Antimalarials; Disease Models, Animal; Mice; Plasmodium falciparum; Q

2017
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
    Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7

    Topics: Animals; Disease Models, Animal; Drug Design; Endoribonucleases; Enzyme Inhibitors; HEK293 Cells; Hu

2017
Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives.
    European journal of medicinal chemistry, 2018, May-10, Volume: 151

    Topics: Animals; Disease Models, Animal; Humans; Mice; Structure-Activity Relationship; Triazines; Tropolone

2018
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ
    Journal of medicinal chemistry, 2018, 05-10, Volume: 61, Issue:9

    Topics: Animals; Disease Models, Animal; Drug Discovery; Drug Stability; ERG1 Potassium Channel; Humans; Imi

2018
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
    Journal of medicinal chemistry, 2019, 01-24, Volume: 62, Issue:2

    Topics: Animals; Antimalarials; Benzimidazoles; Disease Models, Animal; Drug Design; ERG1 Potassium Channel;

2019
Efficacy of TLR7 agonistic imidazoquinoline as immunochemotherapeutic agent against P. Berghei ANKA infected rodent host.
    Bioorganic & medicinal chemistry letters, 2019, 05-01, Volume: 29, Issue:9

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Imidazoles; Interferon-gamma; Interleuk

2019
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
    Journal of medicinal chemistry, 2019, 04-11, Volume: 62, Issue:7

    Topics: Acridones; Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Hep G2 Cells; Humans; Mal

2019
4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides.
    Journal of medicinal chemistry, 2019, 04-11, Volume: 62, Issue:7

    Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Disease Models, Animal; Drug

2019
Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity.
    Bioorganic & medicinal chemistry, 2019, 05-15, Volume: 27, Issue:10

    Topics: Animals; Antimalarials; Cell Line; Cell Survival; Disease Models, Animal; Drug Resistance; Malaria;

2019
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights.
    European journal of medicinal chemistry, 2019, Oct-15, Volume: 180

    Topics: Animals; Anti-Bacterial Agents; Antimalarials; Benzimidazoles; Disease Models, Animal; Dose-Response

2019
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
    Journal of medicinal chemistry, 2020, 06-11, Volume: 63, Issue:11

    Topics: Acridones; Administration, Oral; Animals; Antimalarials; Cell Survival; Disease Models, Animal; Fema

2020
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and
    Journal of medicinal chemistry, 2020, 11-12, Volume: 63, Issue:21

    Topics: Animals; Antimalarials; Disease Models, Animal; Half-Life; Hemeproteins; Imidazoles; Life Cycle Stag

2020
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1
    Journal of medicinal chemistry, 2021, 05-27, Volume: 64, Issue:10

    Topics: Administration, Oral; Animals; Antimalarials; Cyclization; Disease Models, Animal; Ethers; Female; H

2021
Inhibition of autophagy rescues muscle atrophy in a LGMDD2 Drosophila model.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:10

    Topics: Animals; Animals, Genetically Modified; Autophagy; beta Karyopherins; Chloroquine; Disease Models, A

2021
Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic.
    Molecules (Basel, Switzerland), 2021, Sep-11, Volume: 26, Issue:18

    Topics: Animals; Antipruritics; Behavior, Animal; Chloroquine; Deoxycholic Acid; Disease Models, Animal; Dos

2021
Effects of autophagy inhibition by chloroquine on hepatic stellate cell activation in CCl4-induced acute liver injury mouse model.
    Journal of gastroenterology and hepatology, 2022, Volume: 37, Issue:1

    Topics: Animals; Autophagy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroquine; Disea

2022
Oxymatrine screened from Sophora flavescens by cell membrane immobilized chromatography relieves histamine-independent itch.
    The Journal of pharmacy and pharmacology, 2021, Dec-07, Volume: 73, Issue:12

    Topics: Alkaloids; Animals; Antipruritics; Cell Membrane; Chloroquine; Chromatography; Disease Models, Anima

2021
Apalutamide and autophagy inhibition in a xenograft mouse model of human prostate cancer.
    Journal of cancer research and clinical oncology, 2022, Volume: 148, Issue:12

    Topics: Androgen Receptor Antagonists; Animals; Apoptosis; Autophagy; Beclin-1; Caspase 3; Cell Line, Tumor;

2022
Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice.
    Acta neurobiologiae experimentalis, 2022, Volume: 82, Issue:2

    Topics: Animals; Anticonvulsants; Chloroquine; Disease Models, Animal; Electroshock; Mefloquine; Mice; Naltr

2022
Chloroquine alleviates the heat-induced to injure via autophagy and apoptosis mechanisms in skin cell and mouse models.
    PloS one, 2022, Volume: 17, Issue:8

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; beta Catenin; Burns; Chloroquine; Dise

2022
Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.
    eLife, 2022, 12-08, Volume: 11

    Topics: Animals; Behavior, Animal; Chloroquine; Deep Learning; Disease Models, Animal; Injections; Mice; Pru

2022
Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.
    eLife, 2022, 12-08, Volume: 11

    Topics: Animals; Behavior, Animal; Chloroquine; Deep Learning; Disease Models, Animal; Injections; Mice; Pru

2022
Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.
    eLife, 2022, 12-08, Volume: 11

    Topics: Animals; Behavior, Animal; Chloroquine; Deep Learning; Disease Models, Animal; Injections; Mice; Pru

2022
Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.
    eLife, 2022, 12-08, Volume: 11

    Topics: Animals; Behavior, Animal; Chloroquine; Deep Learning; Disease Models, Animal; Injections; Mice; Pru

2022
Neuroprotective role of chloroquine via modulation of autophagy and neuroinflammation in MPTP-induced Parkinson's disease.
    Inflammopharmacology, 2023, Volume: 31, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autophagy; Chloroquine; Disease Models, Anima

2023
Effect of liquiritigenin on chloroquine accumulation in digestive vacuole leading to apoptosis-like death of chloroquine-resistant P. falciparum.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 114

    Topics: Animals; Antimalarials; Apoptosis; Chloroquine; Chromatography, Liquid; Disease Models, Animal; Drug

2023
Integrating Pharmacokinetic-Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study.
    Antimicrobial agents and chemotherapy, 2023, 05-17, Volume: 67, Issue:5

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Humans; Malaria, Falciparum; Mice; Plas

2023
The superior efficacy of chloroquine over buparvaquone in reducing the chronic cerebral Toxoplasma gondii cysts load and improving the ultrastructural pathology in an immunocompromised murine model.
    Tropical biomedicine, 2023, Mar-01, Volume: 40, Issue:1

    Topics: Animals; Chloroquine; Cysts; Disease Models, Animal; Mice; Spiramycin; Toxoplasma; Toxoplasmosis, An

2023
Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis.
    Acta dermato-venereologica, 2023, 08-22, Volume: 103

    Topics: Animals; Calcium; Capsaicin; Chloroquine; Dermatitis, Atopic; Disease Models, Animal; Histamine; Neu

2023
Chloroquine inhibited Helicobacter pylori-related gastric carcinogenesis by YAP-β-catenin-autophagy axis.
    Microbial pathogenesis, 2023, Volume: 184

    Topics: Animals; Autophagy; Beclin-1; beta Catenin; Carcinogenesis; Chloroquine; Disease Models, Animal; Gas

2023
The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model.
    Investigative ophthalmology & visual science, 2019, 09-03, Volume: 60, Issue:12

    Topics: Animals; Antirheumatic Agents; Autophagy; Autophagy-Related Protein 5; Biomarkers; Chloroquine; Corn

2019
Chloroquine differentially modulates coronary vasodilation in control and diabetic mice.
    British journal of pharmacology, 2020, Volume: 177, Issue:2

    Topics: Animals; Antimalarials; Calcium Signaling; Chloroquine; Coronary Vessels; Diabetes Mellitus, Type 2;

2020
Intestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease.
    Cell death & disease, 2019, 09-30, Volume: 10, Issue:6

    Topics: Adult; Animals; Autophagy; Autophagy-Related Proteins; Cathepsin D; Chloroquine; Colon; Corticotropi

2019
Highly Sensitive and Rapid Characterization of the Development of Synchronized Blood Stage Malaria Parasites Via Magneto-Optical Hemozoin Quantification.
    Biomolecules, 2019, 10-07, Volume: 9, Issue:10

    Topics: Animals; Blood Chemical Analysis; Chloroquine; Disease Models, Animal; Early Diagnosis; Female; Heme

2019
Chloroquine pretreatment attenuates ischemia-reperfusion injury in the brain of ob/ob diabetic mice as well as wildtype mice.
    Brain research, 2020, 01-01, Volume: 1726

    Topics: Animals; Blood Glucose; Brain; Brain Ischemia; Cell Survival; Chloroquine; Diabetes Mellitus; Diseas

2020
Potential antimalarial activity of Coccinia barteri leaf extract and solvent fractions against Plasmodium berghei infected mice.
    Journal of ethnopharmacology, 2020, Feb-10, Volume: 248

    Topics: Animals; Antimalarials; Chloroquine; Cucurbitaceae; Disease Models, Animal; Female; Malaria; Male; M

2020
Curcumin-activated autophagy plays a negative role in its anti-osteoclastogenic effect.
    Molecular and cellular endocrinology, 2020, 01-15, Volume: 500

    Topics: Animals; Autophagy; Bone Resorption; Cells, Cultured; Chloroquine; Curcumin; Disease Models, Animal;

2020
Chloroquine and 3-Methyladenine Attenuates Periodontal Inflammation and Bone Loss in Experimental Periodontitis.
    Inflammation, 2020, Volume: 43, Issue:1

    Topics: Adenine; Alveolar Bone Loss; Alveolar Process; Animals; Anti-Inflammatory Agents; Autophagy; Autopha

2020
Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 12-10, Volume: 116, Issue:50

    Topics: Animals; Autophagy; Chloroquine; Disease Models, Animal; DNA-Binding Proteins; Drosophila; Drosophil

2019
Characterization of a chloroquine-induced canine model of pruritus and skin inflammation.
    Veterinary dermatology, 2020, Volume: 31, Issue:2

    Topics: Administration, Intravenous; Animals; Chloroquine; Cross-Over Studies; Disease Models, Animal; Dogs;

2020
Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria.
    PloS one, 2019, Volume: 14, Issue:12

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; CD11 Antigens; Chloroquine; Disease Models, Animal

2019
More than 80 clinical trials launch to test coronavirus treatments.
    Nature, 2020, Volume: 578, Issue:7795

    Topics: Adenosine Monophosphate; Alanine; Animals; Anti-HIV Agents; Betacoronavirus; China; Chloroquine; Cli

2020
Chloroquine attenuates lithium-induced NDI and proliferation of renal collecting duct cells.
    American journal of physiology. Renal physiology, 2020, 05-01, Volume: 318, Issue:5

    Topics: Animals; Aquaporin 2; Autophagy; beta Catenin; Cell Line; Cell Proliferation; Chloroquine; Diabetes

2020
Is GSK3β a molecular target of chloroquine treatment against COVID-19?
    Drug discoveries & therapeutics, 2020, May-06, Volume: 14, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; C

2020
Investigating the role of endogenous opioid system in chloroquine-induced phospholipidosis in rat liver by morphological, biochemical and molecular modelling studies.
    Clinical and experimental pharmacology & physiology, 2020, Volume: 47, Issue:9

    Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroquine; Disease Models, Animal; Fatty Liver; G

2020
Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus.
    The Journal of pharmacology and experimental therapeutics, 2020, Volume: 374, Issue:3

    Topics: Administration, Topical; Animals; Antipruritics; Chloroquine; Dermatitis, Atopic; Disease Models, An

2020
Autophagy-lysosome inhibitor chloroquine prevents CTLA-4 degradation of T cells and attenuates acute rejection in murine skin and heart transplantation.
    Theranostics, 2020, Volume: 10, Issue:18

    Topics: Animals; Autophagy; Cell Line; Chloroquine; CTLA-4 Antigen; Disease Models, Animal; Graft Rejection;

2020
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:21

    Topics: Animals; Apoptosis; Autophagy; Chloroquine; Decompression, Surgical; Disease Models, Animal; Female;

2020
Antileishmanial activity of a new chloroquine analog in an animal model of Leishmania panamensis infection.
    International journal for parasitology. Drugs and drug resistance, 2020, Volume: 14

    Topics: Animals; Antiprotozoal Agents; Chloroquine; Disease Models, Animal; Female; Leishmania; Leishmaniasi

2020
Autophagy inhibition protects from alveolar barrier dysfunction in LPS-induced ALI mice by targeting alveolar epithelial cells.
    Respiratory physiology & neurobiology, 2021, Volume: 283

    Topics: Acute Lung Injury; Adenine; Alveolar Epithelial Cells; Animals; Autophagy; Bronchoalveolar Lavage Fl

2021
The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension.
    Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:2

    Topics: Animals; Arterioles; Body Weight; Cell Line; Chloroquine; Disease Models, Animal; Hypoxia; Lung; Mal

2021
Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice.
    Biochemical and biophysical research communications, 2020, 12-17, Volume: 533, Issue:4

    Topics: Animals; Behavior, Animal; Chloroquine; Cyclopropanes; Disease Models, Animal; Histamine; Hypodermoc

2020
Cracking the Chloroquine Conundrum: The Application of Defective UiO-66 Metal-Organic Framework Materials to Prevent the Onset of Heart Defects-In Vivo and In Vitro.
    ACS applied materials & interfaces, 2021, Jan-13, Volume: 13, Issue:1

    Topics: Animals; Chloroquine; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Heart Diseases

2021
Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats.
    Journal of the American Heart Association, 2021, 04-06, Volume: 10, Issue:7

    Topics: Animals; Antirheumatic Agents; Chloroquine; Disease Models, Animal; Hypertension, Pulmonary; Male; M

2021
Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
    eLife, 2021, 05-18, Volume: 10

    Topics: Animals; Chloroquine; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins;

2021
In vivo antimalarial activity of a probiotic bacterium Lactobacillus sakei isolated from traditionally fermented milk in BALB/c mice infected with Plasmodium berghei ANKA.
    Journal of ethnopharmacology, 2021, Nov-15, Volume: 280

    Topics: Animals; Antimalarials; Cameroon; Chloroquine; Disease Models, Animal; Drug Combinations; Fermented

2021
Chloroquine and pyrimethamine inhibit the replication of human respiratory syncytial virus A.
    The Journal of general virology, 2021, Volume: 102, Issue:8

    Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chloroquine; Disease Models, Animal; Female; Hu

2021
TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms.
    Neuroscience bulletin, 2018, Volume: 34, Issue:1

    Topics: Animals; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Etanercept; Ganglia,

2018
Involvement of autophagy in connexin 40 reduction in the late phase of traumatic brain injury in rats.
    Brain research bulletin, 2017, Volume: 131

    Topics: Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Brain; Brain Injuries; Brain Injuries

2017
Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.
    Scientific reports, 2017, 04-11, Volume: 7

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu

2017
Long-term anti-itch effect of botulinum neurotoxin A is associated with downregulation of TRPV1 and TRPA1 in the dorsal root ganglia in mice.
    Neuroreport, 2017, Jun-14, Volume: 28, Issue:9

    Topics: Acetone; Animals; Botulinum Toxins, Type A; Chloroquine; Chronic Disease; Disease Models, Animal; Do

2017
The role of pharmacologic modulation of autophagy on anal cancer development in an HPV mouse model of carcinogenesis.
    Virology, 2017, Volume: 507

    Topics: Animals; Antiviral Agents; Anus Neoplasms; Autophagy; Carcinogenesis; Chloroquine; Disease Models, A

2017
Pseudoginsenoside-F11 attenuates cerebral ischemic injury by alleviating autophagic/lysosomal defects.
    CNS neuroscience & therapeutics, 2017, Volume: 23, Issue:7

    Topics: Animals; Apoptosis; Autophagy; Brain; Brain Edema; Brain Ischemia; Chloroquine; Disease Models, Anim

2017
Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.
    Experimental dermatology, 2017, Volume: 26, Issue:11

    Topics: Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricy

2017
Efficacy of Paromomycin-Chloroquine Combination Therapy in Experimental Cutaneous Leishmaniasis.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:8

    Topics: Amphotericin B; Animals; Antiprotozoal Agents; Chloroquine; Disease Models, Animal; Drug Combination

2017
Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model.
    Scientific reports, 2017, 07-27, Volume: 7, Issue:1

    Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Drug Synergism; Drug Ther

2017
Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 42, Issue:5

    Topics: Animals; Apoptosis; Autophagy; Brain Injuries, Traumatic; Calcitriol; Chloroquine; Disease Models, A

2017
Schwann cell dedifferentiation-associated demyelination leads to exocytotic myelin clearance in inflammatory segmental demyelination.
    Glia, 2017, Volume: 65, Issue:11

    Topics: Animals; Autophagy-Related Protein 7; Axotomy; Cell Dedifferentiation; Chloroquine; Demyelinating Di

2017
Pharmacological evidence of involvement of nitric oxide pathway in anti-pruritic effects of sumatriptan in chloroquine-induced scratching in mice.
    Fundamental & clinical pharmacology, 2018, Volume: 32, Issue:1

    Topics: Animals; Antipruritics; Behavior, Animal; Chloroquine; Disease Models, Animal; Dose-Response Relatio

2018
Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice.
    EBioMedicine, 2017, Volume: 24

    Topics: Animals; Cell Line; Chlorocebus aethiops; Chloroquine; Disease Models, Animal; Drug Approval; Drug E

2017
In vivo and in vitro Models for Scanning Drug Substances in Malaria: Prestudy.
    Turkiye parazitolojii dergisi, 2017, Volume: 41, Issue:3

    Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclini

2017
MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.
    Neuroreport, 2017, Dec-06, Volume: 28, Issue:17

    Topics: Acetone; Animals; Calcium; Cations, Divalent; Cells, Cultured; Chloroquine; Chronic Disease; Disease

2017
Potential of Nigella sativa seed aqueous extract in ameliorating quinine-induced thrombocytopenia in rats.
    Pakistan journal of pharmaceutical sciences, 2017, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Animals; Antioxidants; Blood Platelets; Case-Control Studies; Chloroquine; Diseas

2017
Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis.
    Scientific reports, 2017, Nov-17, Volume: 7, Issue:1

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Repositioning; Humans; Mice; Neura

2017
An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease.
    Antiviral research, 2018, Volume: 149

    Topics: Animals; Antiviral Agents; Chloroquine; Disease Models, Animal; Enterovirus A, Human; Hand, Foot and

2018
The Protective Effects of Κ-Opioid Receptor Stimulation in Hypoxic Pulmonary Hypertension Involve Inhibition of Autophagy Through the AMPK-MTOR Pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 44, Issue:5

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; AMP-Activa

2017
Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:6

    Topics: Animals; Antipruritics; Behavior, Animal; Capsaicin; Chloroquine; Chronic Disease; Cryotherapy; Dise

2018
Impaired autophagic flux is associated with the severity of trauma and the role of A
    Cell death & disease, 2018, 02-14, Volume: 9, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 12;

2018
In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis.
    British journal of pharmacology, 2018, Volume: 175, Issue:10

    Topics: Adult; Animals; Autophagy; Cell Proliferation; Cells, Cultured; Chloroquine; Disease Models, Animal;

2018
GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:8

    Topics: Animals; Cell Line; Chloroquine; Dermatitis, Contact; Dinitrochlorobenzene; Disease Models, Animal;

2018
Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity.
    European journal of immunology, 2018, Volume: 48, Issue:7

    Topics: Animals; Autoantigens; Cells, Cultured; Chloroquine; Dendritic Cells; Disease Models, Animal; Enceph

2018
Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection.
    Viruses, 2018, 05-17, Volume: 10, Issue:5

    Topics: Animals; Cells, Cultured; Chikungunya Fever; Chikungunya virus; Chloroquine; Cohort Studies; Disease

2018
Improved efficacy of doxycycline in liposomes against Plasmodium falciparum in culture and Plasmodium berghei infection in mice.
    Canadian journal of physiology and pharmacology, 2018, Volume: 96, Issue:11

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Doxycycline; Drug Carriers; Drug Resist

2018
The behavioral study on the interactive aggravation between pruritus and depression.
    Brain and behavior, 2018, Volume: 8, Issue:6

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Chloroquine; Depression; Depressive Disorder; Dise

2018
TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation.
    Cell death & disease, 2018, 08-28, Volume: 9, Issue:9

    Topics: Aged; Animals; Apoptosis; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Ch

2018
Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease.
    Acta biomaterialia, 2018, Volume: 82

    Topics: Administration, Oral; Animals; Chloroquine; Citrobacter rodentium; Cytokines; Disease Models, Animal

2018
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone.
    Toxicologic pathology, 2019, Volume: 47, Issue:1

    Topics: Administration, Ophthalmic; Aging; Amiodarone; Animals; Chloroquine; Cornea; Disease Models, Animal;

2019
Autophagy Activation in Asthma Airways Remodeling.
    American journal of respiratory cell and molecular biology, 2019, Volume: 60, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Airway Remodeling; Animals; Anti-Asthmatic Agents; Asthm

2019
Lupresan, a new drug that prevents or reverts the formation of nonbilayer phospholipid arrangements that trigger a murine lupus resembling human lupus.
    Biochemical and biophysical research communications, 2019, 01-29, Volume: 509, Issue:1

    Topics: Animals; Antibodies, Antiphospholipid; Antimalarials; Cell Line; Chloroquine; Disease Models, Animal

2019
Anti-cancer effects of CQBTO, a chloroquine, and benzo(e)triazine oxide conjugate.
    Chemical biology & drug design, 2019, Volume: 93, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal

2019
Resistance Exercise Improves Mitochondrial Quality Control in a Rat Model of Sporadic Inclusion Body Myositis.
    Gerontology, 2019, Volume: 65, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Apoptosis; Catalase; Chloroquine; Citrate (si)-Synthase; Disease Mod

2019
Is a combination of progesterone and chloroquine more effective than either alone in the treatment of cerebral ischemic injury?
    Restorative neurology and neuroscience, 2019, Volume: 37, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Cell Death; Chloroquine; Disease Models, Animal; Drug Therapy, Combi

2019
Low dosage chloroquine protects retinal ganglion cells against glutamate-induced cell death.
    Experimental eye research, 2019, Volume: 181

    Topics: Animals; Animals, Newborn; Antirheumatic Agents; Apoptosis; Blotting, Western; Cells, Cultured; Chlo

2019
Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells.
    Stem cells (Dayton, Ohio), 2019, Volume: 37, Issue:6

    Topics: Animals; Autophagy; Cartilage; Cell Differentiation; Chloroquine; Chondrogenesis; Disease Models, An

2019
Spinal somatostatin-positive interneurons transmit chemical itch.
    Pain, 2019, Volume: 160, Issue:5

    Topics: Action Potentials; Angiogenesis Inhibitors; Animals; Chloroquine; Disease Models, Animal; In Vitro T

2019
Honokiol post-treatment ameliorates myocardial ischemia/reperfusion injury by enhancing autophagic flux and reducing intracellular ROS production.
    Chemico-biological interactions, 2019, Jul-01, Volume: 307

    Topics: Animals; Apoptosis; Autophagy; Biphenyl Compounds; Chloroquine; Disease Models, Animal; Lignans; Mal

2019
Recombinant Buckwheat Trypsin Inhibitor Improves the Protein and Mitochondria Homeostasis in Caenorhabditis elegans Model of Aging and Age-Related Disease.
    Gerontology, 2019, Volume: 65, Issue:5

    Topics: Adenosine Triphosphate; Aging; Amebicides; Animals; Autophagy; Caenorhabditis elegans; Caenorhabditi

2019
Signal Transducer and Activator of Transcription 3 in Keratinocytes Regulates Histaminergic Itch but Not Nonhistaminergic Itch.
    Acta dermato-venereologica, 2019, 09-01, Volume: 99, Issue:10

    Topics: Animals; Chloroquine; Disease Models, Animal; Female; Histamine; Keratinocytes; Male; Mice, Knockout

2019
Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus.
    Antiviral research, 2019, Volume: 169

    Topics: Animals; Antimalarials; Autophagy; Cell Line; Chlorocebus aethiops; Chloroquine; Disease Models, Ani

2019
Immunohistochemical expression of autophagosome markers LC3 and p62 in preneoplastic liver foci in high fat diet-fed rats.
    The Journal of toxicological sciences, 2019, Volume: 44, Issue:8

    Topics: Amiodarone; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Chloroquine; Diet, High

2019
Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
    Circulation research, 2013, Apr-12, Volume: 112, Issue:8

    Topics: Animals; Autophagy; Bone Morphogenetic Protein Receptors, Type II; Cells, Cultured; Chloroquine; Dis

2013
CpG-oligodeoxynucleotide-induced TLR9 activation regulates macrophage TREM-1 expression and shedding.
    Innate immunity, 2013, Volume: 19, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Chloroquine; Disease Models, Animal; Gene

2013
An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines.
    The American journal of tropical medicine and hygiene, 2013, Volume: 88, Issue:6

    Topics: Acute Disease; Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Disease Mode

2013
Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys.
    Malaria journal, 2013, Apr-02, Volume: 12

    Topics: Administration, Oral; Animals; Antimalarials; Aotus trivirgatus; Benzylisoquinolines; Chloroquine; D

2013
Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis.
    Asian Pacific journal of tropical biomedicine, 2012, Volume: 2, Issue:4

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Malaria; Male; Mice; Orchitis; Parasite

2012
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
    The journal of pain, 2013, Volume: 14, Issue:6

    Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histam

2013
Cytoprotective and nonprotective autophagy in cancer therapy.
    Autophagy, 2013, Volume: 9, Issue:9

    Topics: Animals; Autophagy; Cell Line, Tumor; Chloroquine; Cytoprotection; Disease Models, Animal; Humans; N

2013
A novel chitosan based antimalarial drug delivery against Plasmodium berghei infection.
    Acta tropica, 2013, Volume: 128, Issue:3

    Topics: Animals; Antimalarials; Chitosan; Chloroquine; Disease Models, Animal; DNA Damage; Drug Carriers; Dr

2013
The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer.
    Scientific reports, 2013, Volume: 3

    Topics: Animals; Antibodies, Monoclonal, Humanized; Antimalarials; Antineoplastic Agents; Autophagy; Breast

2013
A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages.
    International journal of medical microbiology : IJMM, 2013, Volume: 303, Issue:8

    Topics: Animals; Antimalarials; Blood; Chimera; Chloroquine; Disease Models, Animal; Female; Liver; Malaria;

2013
Efficient delivery of siRNA by atelocollagen in a murine laser-induced choroidal neovascularization model.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2013, Volume: 230, Issue:4

    Topics: Animals; Antimalarials; Chloroquine; Choroidal Neovascularization; Collagen; Disease Models, Animal;

2013
Model system to define pharmacokinetic requirements for antimalarial drug efficacy.
    Science translational medicine, 2013, Oct-02, Volume: 5, Issue:205

    Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Humans; Malaria, Falcipar

2013
Antimalarial activity of plumbagin in vitro and in animal models.
    BMC complementary and alternative medicine, 2014, Jan-12, Volume: 14

    Topics: Animals; Antimalarials; Biological Availability; Body Weight; Chloroquine; Disease Models, Animal; F

2014
In vivo splenic clearance correlates with in vitro deformability of red blood cells from Plasmodium yoelii-infected mice.
    Infection and immunity, 2014, Volume: 82, Issue:6

    Topics: Anemia; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Erythrocyte Deformability; Fema

2014
Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord.
    Molecular brain, 2014, Apr-03, Volume: 7

    Topics: Animals; Butadienes; Chloroquine; Dinitrofluorobenzene; Disease Models, Animal; Enzyme Activation; E

2014
Antiplasmodial activity of synthetic ellipticine derivatives and an isolated analog.
    Bioorganic & medicinal chemistry letters, 2014, Jun-15, Volume: 24, Issue:12

    Topics: Animals; Antimalarials; Aspidosperma; Chloroquine; Disease Models, Animal; Ellipticines; Fibroblasts

2014
Therapeutic potential of chloroquine in a murine model of inflammatory bowel disease.
    International immunopharmacology, 2014, Volume: 21, Issue:2

    Topics: Animals; Body Weight; Cell Proliferation; Chloroquine; Colitis; Colon; Cytokines; Disease Models, An

2014
Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice.
    Acta dermato-venereologica, 2015, Volume: 95, Issue:2

    Topics: Animals; Antipruritics; Behavior, Animal; Chloroquine; Disease Models, Animal; Histamine; Ichthyosis

2015
Validation of a chloroquine-induced cell death mechanism for clinical use against malaria.
    Cell death & disease, 2014, Jun-26, Volume: 5

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Evaluation; Hemeproteins; Malaria;

2014
Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
    Journal of Huntington's disease, 2014, Volume: 3, Issue:2

    Topics: Animals; Antimalarials; Autophagy; Brain; Chloroquine; Disease Models, Animal; Gene Knock-In Techniq

2014
Protection against malaria by immunization with non-attenuated sporozoites under single-dose piperaquine-tetraphosphate chemoprophylaxis.
    Vaccine, 2014, Oct-14, Volume: 32, Issue:45

    Topics: Animals; CD8-Positive T-Lymphocytes; Chemoprevention; Chloroquine; Disease Models, Animal; Female; I

2014
Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:12

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Administration Schedule; Drug Ther

2014
Enhancing therapeutic effects of docetaxel-loaded dendritic copolymer nanoparticles by co-treatment with autophagy inhibitor on breast cancer.
    Theranostics, 2014, Volume: 4, Issue:11

    Topics: Animals; Antineoplastic Agents; Autophagy; Breast Neoplasms; Chloroquine; Dendrimers; Disease Models

2014
Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells.
    Molecular vision, 2014, Volume: 20

    Topics: Animals; Apoptosis; Autophagy; Caspase 3; Chloroquine; Cytomegalovirus Infections; Disease Models, A

2014
In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine.
    Malaria journal, 2014, Oct-21, Volume: 13

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Malaria; Male; Mice; Minocycline; Paras

2014
Early treatment with chloroquine inhibits the immune response against Plasmodium yoelii infection in mice.
    The Tohoku journal of experimental medicine, 2014, Volume: 234, Issue:4

    Topics: Animals; Antimalarials; Chloroquine; Dendritic Cells; Disease Models, Animal; Disease Progression; F

2014
Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors.
    Molecular pain, 2015, Jan-06, Volume: 11

    Topics: Animals; beta-Alanine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Chloroq

2015
[Inhibitory effect of chloroquine on airway hyperresponsiveness in asthmatic mice].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2015, Volume: 35, Issue:1

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Chloroquine; Dexamethasone; Dinoprost; Disease Models

2015
Enhanced nonpeptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch.
    The journal of pain, 2015, Volume: 16, Issue:4

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Cells, Cultured; Chloroquine; Disease Models, Ani

2015
Antiviral activity of chloroquine against dengue virus type 2 replication in Aotus monkeys.
    Viral immunology, 2015, Volume: 28, Issue:3

    Topics: Animals; Antiviral Agents; Aotidae; Chloroquine; Cytokines; Dengue; Dengue Virus; Disease Models, An

2015
Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic death.
    Molecular medicine reports, 2015, Volume: 12, Issue:2

    Topics: Animals; Antigens, Nuclear; Autophagy; Biomarkers; Brain Edema; Brain Injuries; Chloroquine; Disease

2015
Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem proteinopathy.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Animals; Apoptosis; Autophagy; Cell Cycle Proteins; Cell Line; Chloroquine; Disease Models, Animal;

2015
Lack of protection against ebola virus from chloroquine in mice and hamsters.
    Emerging infectious diseases, 2015, Volume: 21, Issue:6

    Topics: Animals; Antiviral Agents; Cell Line; Chloroquine; Cricetinae; Disease Models, Animal; Ebolavirus; H

2015
Effects of long-term chloroquine administration on the natural history of aortic aneurysms in mice.
    Canadian journal of physiology and pharmacology, 2015, Volume: 93, Issue:8

    Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Autophagy;

2015
Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:6

    Topics: Animals; Autophagy; Autophagy-Related Protein 7; Cells, Cultured; Chloroquine; Disease Models, Anima

2016
Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Jul-14, Volume: 112, Issue:28

    Topics: Amodiaquine; Animals; Behavior, Animal; Chloroquine; Disease Models, Animal; Ligands; Neurogenesis;

2015
Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats.
    Cardiovascular diabetology, 2015, Aug-11, Volume: 14

    Topics: Adamantane; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Chloroquine; Diabetes Melli

2015
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.
    Neuropharmacology, 2015, Volume: 99

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics

2015
Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress.
    Molecular carcinogenesis, 2016, Volume: 55, Issue:11

    Topics: Acids; Adenocarcinoma; Animals; Autophagy; Barrett Esophagus; Cell Line; Cell Survival; Chloroquine;

2016
In vivo efficacy and bioavailability of lumefantrine: Evaluating the application of Pheroid technology.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2015, Volume: 97, Issue:Pt A

    Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Chemistry, Pharmaceutical; Ch

2015
Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.
    Scientific reports, 2015, Oct-30, Volume: 5

    Topics: Amiodarone; Animals; Autophagy; Autophagy-Related Protein 7; Chloroquine; Disease Models, Animal; He

2015
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
    Brain research bulletin, 2016, Volume: 121

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease M

2016
Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model.
    Malaria journal, 2015, Dec-16, Volume: 14

    Topics: Animals; Antimalarials; Blood Chemical Analysis; Chloroquine; Chromatography, Liquid; Disease Models

2015
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.
    Scientific reports, 2016, Feb-02, Volume: 6

    Topics: Animals; Cathepsin D; Chloroquine; Collagen; Dipeptides; Disease Models, Animal; Extracellular Matri

2016
Impaired Autophagy in APOE4 Astrocytes.
    Journal of Alzheimer's disease : JAD, 2016, Volume: 51, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Apolipoprotein E3; Apolipoprotein E4; Astrocytes; Autophagy; Brain;

2016
Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model.
    Pharmaceutical biology, 2016, Volume: 54, Issue:10

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Drug Ther

2016
Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis.
    Scientific reports, 2016, 05-18, Volume: 6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Disease Models,

2016
Highly active ozonides selected against drug resistant malaria.
    Memorias do Instituto Oswaldo Cruz, 2016, Jun-07, Volume: 0

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Chloroquine; Disease Models, Animal; Female; Human

2016
Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents.
    Parasitology, 2016, Volume: 143, Issue:12

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Malaria; Mice; Organometallic Compounds

2016
Chloroquine Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats.
    American journal of hypertension, 2017, Volume: 30, Issue:2

    Topics: Animals; Blood Pressure; Blotting, Western; Chloroquine; Disease Models, Animal; Disease Progression

2017
Exploring the antimalarial potential of whole Cymbopogon citratus plant therapy.
    Journal of ethnopharmacology, 2016, Dec-04, Volume: 193

    Topics: Animals; Antimalarials; Chloroquine; Cymbopogon; Disease Models, Animal; Dose-Response Relationship,

2016
Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice.
    Acta dermato-venereologica, 2017, May-08, Volume: 97, Issue:5

    Topics: Animals; Behavior, Animal; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; En

2017
Anti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria.
    Malaria journal, 2017, 02-17, Volume: 16, Issue:1

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Female; Humans; Malaria; Malaria, Falci

2017
In vivo efficacy of top five surveyed Ghanaian herbal anti-malarial products.
    Malaria journal, 2017, 03-04, Volume: 16, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Female;

2017
Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation.
    Journal of vascular surgery, 2018, Volume: 67, Issue:3

    Topics: Aged; Animals; Autophagy; Blood Flow Velocity; Case-Control Studies; Caspase 1; Cell Line; Chloroqui

2018
The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias.
    Cell death and differentiation, 2008, Volume: 15, Issue:11

    Topics: Animals; Apoptosomes; Autophagy; Caspases; Cell Line, Tumor; Chloroquine; Cytoprotection; Disease Mo

2008
Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.
    Experimental parasitology, 2009, Volume: 122, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Disease Models, Animal; Drug Resista

2009
Enhanced antimalarial effects of chloroquine by aqueous Vernonia amygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasmodium berghei strains.
    African health sciences, 2008, Volume: 8, Issue:1

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Female; Malaria; Male;

2008
Antimalarial activity of the novel quinoline/6-thiopurine conjugate in Gallus gallus Linnaeus, infected experimentally by Plasmodium (Novyella) juxtanucleare.
    Chemical biology & drug design, 2009, Volume: 74, Issue:4

    Topics: Animals; Antimalarials; Chickens; Chloroquine; Disease Models, Animal; Malaria, Avian; Parasitemia;

2009
Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection.
    The Journal of general virology, 2010, Volume: 91, Issue:Pt 3

    Topics: Animals; Antiviral Agents; Chloroquine; Cricetinae; Disease Models, Animal; Drug Therapy, Combinatio

2010
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
    The Journal of cell biology, 2009, Dec-14, Volume: 187, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Animals; Autophagy; Biopsy; Case-Co

2009
Persistent cognitive and motor deficits after successful antimalarial treatment in murine cerebral malaria.
    Microbes and infection, 2010, Volume: 12, Issue:14-15

    Topics: Animals; Antimalarials; Chloroquine; Cognition Disorders; Disease Models, Animal; Female; Malaria, C

2010
Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes.
    The Journal of infectious diseases, 2011, Jan-15, Volume: 203, Issue:2

    Topics: Animals; Antimalarials; Chloroquine; Culicidae; Disease Models, Animal; Drug Resistance; Female; Mal

2011
Suppression of Plasmodium berghei parasitemia by LiCl in an animal infection model.
    Tropical biomedicine, 2010, Volume: 27, Issue:3

    Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Disease Models, Animal; Glycogen Synthase Kina

2010
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
    Nature neuroscience, 2011, Volume: 14, Issue:5

    Topics: Analysis of Variance; Animals; Animals, Newborn; Antirheumatic Agents; Calcium; Capsaicin; Cells, Cu

2011
Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:8

    Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Chromatography, High Pressure Liquid; Disease Mod

2011
Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta).
    Malaria journal, 2011, Jul-29, Volume: 10

    Topics: Aminoquinolines; Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Ch

2011
Interaction between ciprofloxacin and chloroquine in mice infected with chloroquine resistant Plasmodium berghei: interaction between ciprofloxacin and chloroqune.
    Parasitology research, 2012, Volume: 110, Issue:2

    Topics: Animals; Antimalarials; Chloroquine; Ciprofloxacin; Disease Models, Animal; Drug Resistance; Drug Th

2012
In vivo antiplasmodial activities of aqueous extract of Bridelia ferruginea stem bark against Plasmodium berghei berghei in mice.
    Pharmaceutical biology, 2012, Volume: 50, Issue:2

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Eupho

2012
Mosquito infection studies with Aotus monkeys and humans infected with the Chesson strain of Plasmodiun vivax.
    The American journal of tropical medicine and hygiene, 2012, Volume: 86, Issue:3

    Topics: Animals; Anopheles; Antimalarials; Aotidae; Chloroquine; Disease Management; Disease Models, Animal;

2012
Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C.
    Journal of ethnopharmacology, 2012, May-07, Volume: 141, Issue:1

    Topics: Animals; Antimalarials; Asteraceae; Cell Line; Chloroquine; Disease Models, Animal; Female; Humans;

2012
Chloroquine terminates stretch-induced atrial fibrillation more effectively than flecainide in the sheep heart.
    Circulation. Arrhythmia and electrophysiology, 2012, Jun-01, Volume: 5, Issue:3

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antirheumatic Agents; Atrial Fibrillation; Chlor

2012
Targeting Toll-like receptors by chloroquine protects mice from experimental cerebral malaria.
    International immunopharmacology, 2012, Volume: 13, Issue:4

    Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Cytokines; Dendritic Cells; Disease Models, An

2012
Synthesis, characterization of chitosan-tripolyphosphate conjugated chloroquine nanoparticle and its in vivo anti-malarial efficacy against rodent parasite: a dose and duration dependent approach.
    International journal of pharmaceutics, 2012, Sep-15, Volume: 434, Issue:1-2

    Topics: Animals; Antimalarials; Chitosan; Chloroquine; Disease Models, Animal; Dose-Response Relationship, D

2012
Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances.
    The American journal of tropical medicine and hygiene, 2012, Volume: 86, Issue:6

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclinical; Macaca mu

2012
Autophagy in proximal tubules protects against acute kidney injury.
    Kidney international, 2012, Volume: 82, Issue:12

    Topics: Acute Kidney Injury; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 7; Biomarkers; Blood U

2012
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine.
    Memorias do Instituto Oswaldo Cruz, 2012, Volume: 107, Issue:6

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhib

2012
Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization.
    Parasite immunology, 2012, Volume: 34, Issue:12

    Topics: Animals; Antimalarials; CD8-Positive T-Lymphocytes; Chloroquine; Disease Models, Animal; Gamma Rays;

2012
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
    Cell research, 2013, Volume: 23, Issue:2

    Topics: Animals; Antimalarials; Birds; Cell Line, Tumor; Cell Survival; Chloroquine; Disease Models, Animal;

2013
Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:3

    Topics: Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Cytoprotection; Disease Models,

2013
Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice.
    Journal of hepatology, 2013, Volume: 58, Issue:5

    Topics: Animals; Autophagy; Biomarkers; Carbamazepine; Cells, Cultured; Chloroquine; Dietary Fats; Disease M

2013
Plasmodium: assessment of the antimalarial potential of trifluralin and related compounds using a rat model of malaria, Rattus norvegicus.
    Experimental parasitology, 2002, Volume: 100, Issue:3

    Topics: Animals; Antimalarials; Cells, Cultured; Chloroquine; Dinitrobenzenes; Disease Models, Animal; Eryth

2002
Haem polymerase as a novel target of antimalarial action of cyproheptadine.
    Biochemical pharmacology, 2002, Nov-01, Volume: 64, Issue:9

    Topics: Animals; Antimalarials; Chloroquine; Cyproheptadine; Disease Models, Animal; Drug Resistance; Enzyme

2002
Prophylactic effect of multi-herbal extract 'Agbo-Iba' on malaria induced in mice.
    East African medical journal, 2002, Volume: 79, Issue:7

    Topics: Administration, Oral; Animals; Antimalarials; Cajanus; Cassia; Chloroquine; Cymbopogon; Disease Mode

2002
Renal function in a rat model of analgesic nephropathy: effect of chloroquine.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1

    Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Chloroquine; Dise

2003
Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease?
    Journal of neuropathology and experimental neurology, 2003, Volume: 62, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cathepsins; Chloroquine; Culture Techniq

2003
The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines.
    Annals of tropical medicine and parasitology, 2003, Volume: 97, Issue:3

    Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Drug

2003
Antimalarial effect of agmatine on Plasmodium berghei K173 strain.
    Acta pharmacologica Sinica, 2003, Volume: 24, Issue:9

    Topics: Agmatine; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Eflornithine

2003
Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection.
    Neuroscience, 2003, Volume: 121, Issue:3

    Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Antirheumatic Agents; Brain; Brain Injuries; Cell

2003
Sex ratios in the rodent malaria parasite, Plasmodium chabaudi.
    Parasitology, 2003, Volume: 127, Issue:Pt 5

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Female; Malaria; Male; Mice; Mice, Inbr

2003
Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release.
    International immunopharmacology, 2004, Volume: 4, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Cell Line; Chloroquine; Cytokines; Disease Models, Animal; DNA-Bind

2004
Inhibition of heme aggregation by chloroquine reduces Schistosoma mansoni infection.
    The Journal of infectious diseases, 2004, Aug-15, Volume: 190, Issue:4

    Topics: Animals; Cell Fractionation; Chloroquine; Cohort Studies; Disease Models, Animal; Drug Design; Femal

2004
Chloroquine enhances survival in Bacillus anthracis intoxication.
    The Journal of infectious diseases, 2004, Nov-01, Volume: 190, Issue:9

    Topics: Animals; Anthrax; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; Cell Death; Cell Surviv

2004
In vitro and in vivo antimalarial studies of Striga hermonthica and Tapinanthus sessilifolius extracts.
    African journal of medicine and medical sciences, 2004, Volume: 33, Issue:1

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; In Vi

2004
Enhanced anticryptococcal activity of chloroquine in phosphatidylserine-containing liposomes in a murine model.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 55, Issue:2

    Topics: Animals; Cell Line; Chloroquine; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Dr

2005
Prophylactic role of liposomized chloroquine against murine cryptococcosis less susceptible to fluconazole.
    Pharmaceutical research, 2004, Volume: 21, Issue:12

    Topics: Animals; Cell Line; Chloroquine; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Di

2004
An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi.
    Malaria journal, 2005, Feb-11, Volume: 4

    Topics: Alleles; Animals; Chloroquine; Chromosome Mapping; Chromosomes; Disease Models, Animal; DNA, Protozo

2005
Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum.
    Journal of ethnopharmacology, 2005, Apr-08, Volume: 98, Issue:1-2

    Topics: Alkaloids; Animals; Benzylisoquinolines; Chloroquine; Disease Models, Animal; Dose-Response Relation

2005
Plasmodium berghei: development of an irreversible experimental malaria model in Wistar rats.
    Experimental parasitology, 2006, Volume: 113, Issue:3

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Erythrocytes; Malaria; Parasitemia; Pla

2006
Carbenoxolone and mefloquine suppress tremor in the harmaline mouse model of essential tremor.
    Movement disorders : official journal of the Movement Disorder Society, 2006, Volume: 21, Issue:10

    Topics: 1-Octanol; Animals; Carbenoxolone; Central Nervous System Stimulants; Cerebellum; Chloroquine; Conne

2006
A clinical drug library screen identifies astemizole as an antimalarial agent.
    Nature chemical biology, 2006, Volume: 2, Issue:8

    Topics: Animals; Antimalarials; Astemizole; Chloroquine; Disease Models, Animal; Dose-Response Relationship,

2006
Tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 99, Issue:5

    Topics: Administration, Oral; Animals; Antioxidants; Chemoprevention; Chloroquine; Creatinine; Curcumin; Dis

2006
Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit.
    Journal of ethnopharmacology, 2007, May-22, Volume: 111, Issue:3

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Femal

2007
Chloroquine is therapeutic in murine experimental model of paracoccidioidomycosis.
    FEMS immunology and medical microbiology, 2007, Volume: 50, Issue:1

    Topics: Animals; Chloroquine; Disease Models, Animal; Hydrogen Peroxide; Interleukin-6; Iron; Macrophages, P

2007
Expression of autophagy-associated genes in skeletal muscle: an experimental model of chloroquine-induced myopathy.
    Pathobiology : journal of immunopathology, molecular and cellular biology, 2007, Volume: 74, Issue:3

    Topics: Animals; Antirheumatic Agents; Autophagy; Chloroquine; Disease Models, Animal; Injections, Intraperi

2007
Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys.
    The American journal of tropical medicine and hygiene, 2007, Volume: 77, Issue:2

    Topics: Animals; Antimalarials; Aotidae; Chloroquine; Cytochromes b; Dihydropteroate Synthase; Disease Model

2007
Retinal toxicity of chloroquine hydrochloride administered by intraperitoneal injection.
    Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:7

    Topics: Animals; Antimalarials; Chloroquine; Choroid; Disease Models, Animal; Injections, Intraperitoneal; M

2008
An investigation of the effect of anti-inflammatory and anti-rheumatoid drugs in cell-mediated immune arthritis in guinea-pigs by microfocal radiography.
    British journal of experimental pathology, 1980, Volume: 61, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chloroquine; Disease Models,

1980
Susceptibility of Guyanan Saimiri monkeys to a chloroquine-sensitive and a chloroquine-resistant strain of Plasmodium vivax from Papua New Guinea.
    The Journal of parasitology, 1995, Volume: 81, Issue:4

    Topics: Animals; Anopheles; Aotus trivirgatus; Chloroquine; Disease Models, Animal; Drug Resistance; Insect

1995
Chloroquine treated rat: a possible model for Alzheimer's disease.
    Muscle & nerve, 1995, Volume: 18, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Chloroquine; Dise

1995
Chloroquine-induced retardation of foetal lung maturation in rats.
    African journal of medicine and medical sciences, 1993, Volume: 22, Issue:2

    Topics: Animals; Body Weight; Chloroquine; Disease Models, Animal; Female; Fetal Growth Retardation; Fetal O

1993
Studies of a chloroquine-resistant strain of Plasmodium vivax from Papua New Guinea in Aotus and Anopheles farauti s.l.
    The Journal of parasitology, 1994, Volume: 80, Issue:5

    Topics: Animals; Anopheles; Aotus trivirgatus; Chloroquine; Disease Models, Animal; Drug Resistance; Insect

1994
[Studies on the establishment of malarial animal model of short-term relapse. IV. Short-term relapse in rhesus monkeys infected with sporozoites of Plasmodium cynomolgi].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1993, Volume: 11, Issue:4

    Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Disease Models, Animal; Drug Therapy,

1993
[Studies on the establishment of malarial animal model of short-term relapse. III. Combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1993, Volume: 11, Issue:3

    Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Disease Models, Animal; Drug Therapy,

1993
Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys.
    The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:1

    Topics: Animals; Aotus trivirgatus; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Cyproheptadine; D

1993
Modulation of cytokines and myocardial lesions by vitamin E and chloroquine in a Mg-deficient rat model.
    The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 1

    Topics: Animals; Cardiomyopathies; Chloroquine; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbe

1993
Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo.
    The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:3

    Topics: Animals; Antimalarials; Aotus trivirgatus; Artemether; Artemisinins; Chloroquine; Disease Models, An

1993
Co-localization of amyloid-associated proteins with amyloid beta in rat soleus muscle in chloroquine-induced myopathy: a possible model for amyloid beta formation in Alzheimer's disease.
    Brain research, 1995, Nov-20, Volume: 699, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antibodies; Chloroquine; Disease Models,

1995
The effect of hypertonic sodium bicarbonate on QRS duration in rats poisoned with chloroquine.
    Journal of toxicology. Clinical toxicology, 1996, Volume: 34, Issue:1

    Topics: Amebicides; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Electrocardiography; Heart

1996
Amyloid beta protein in rat soleus muscle in chloroquine-induced myopathy using end-specific antibodies for A beta 40 and A beta 42: immunohistochemical evidence for amyloid beta protein.
    Neuroscience letters, 1995, Dec-29, Volume: 202, Issue:1-2

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Antibody Spe

1995
Immunization of albino mice using chloroquine attenuated Plasmodium yoelli nigeriensis.
    East African medical journal, 1995, Volume: 72, Issue:11

    Topics: Animals; Chloroquine; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance; Immuniz

1995
Induction of chloroquine resistance in Plasmodium yoelii nigeriensis.
    East African medical journal, 1996, Volume: 73, Issue:10

    Topics: Animals; Antimalarials; Body Weight; Chloroquine; Disease Models, Animal; Drug Resistance; Female; M

1996
Biodistribution of 125I-MAb 425 in a human glioma xenograft model: effect of chloroquine.
    Hybridoma, 1997, Volume: 16, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Brain Neoplasms; Chloroquine; Disease Models, Animal; ErbB Receptor

1997
The pharmacokinetics of chloroquine in healthy and Plasmodium chabaudi-infected mice: implications for chronotherapy.
    Parasite (Paris, France), 1994, Volume: 1, Issue:3

    Topics: Animals; Antimalarials; Chloroquine; Circadian Rhythm; Disease Models, Animal; Injections, Intraperi

1994
Snake coiled fibres in rat soleus muscle in chloroquine induced myopathy share immunohistochemical characteristics with amyloid depositions in Alzheimer's disease brain tissue.
    International journal of experimental pathology, 1997, Volume: 78, Issue:1

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Brain; Chloroquine; Disease Mod

1997
Studies on a primaquine-tolerant strain of Plasmodium vivax from Brazil in Aotus and Saimiri monkeys.
    The Journal of parasitology, 1997, Volume: 83, Issue:4

    Topics: Animals; Anopheles; Antimalarials; Aotidae; Brazil; Chloroquine; Disease Models, Animal; Drug Resist

1997
Plasmodium berghei: in vivo efficacy of albendazole in different rodent models.
    Experimental parasitology, 1998, Volume: 88, Issue:2

    Topics: Albendazole; Animals; Anthelmintics; Antimalarials; Biomarkers; Chloroquine; Chromium Compounds; Dis

1998
In vitro and in vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine.
    The American journal of tropical medicine and hygiene, 1998, Volume: 58, Issue:5

    Topics: Adult; Animals; Antimalarials; Antipruritics; Aotidae; Aotus trivirgatus; Chloroquine; Disease Model

1998
Adaptation of a strain of Plasmodium vivax from Mauritania to New World monkeys and anopheline mosquitoes.
    The Journal of parasitology, 1998, Volume: 84, Issue:3

    Topics: Adaptation, Physiological; Animals; Anopheles; Antimalarials; Aotidae; Chloroquine; Disease Models,

1998
Therapy with a combination of low doses of interleukin 12 and chloroquine completely cures blood-stage malaria, prevents severe anemia, and induces immunity to reinfection.
    Infection and immunity, 1999, Volume: 67, Issue:2

    Topics: Anemia; Animals; Antibodies, Protozoan; Antimalarials; Chloroquine; Disease Models, Animal; Drug The

1999
Adaptation of the AMRU-1 strain of Plasmodium vivax to Aotus and Saimiri monkeys and to four species of anopheline mosquitoes.
    The Journal of parasitology, 1999, Volume: 85, Issue:4

    Topics: Adaptation, Biological; Animals; Anopheles; Aotus trivirgatus; Chloroquine; Disease Models, Animal;

1999
Plasmodium berghei: a new rat model for assessment of blood schizonticidal activity.
    Experimental parasitology, 1999, Volume: 93, Issue:2

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Eryth

1999
A simple and rapid evaluation of methemoglobin toxicity of 8-aminoquinolines and related compounds.
    Ecotoxicology and environmental safety, 2000, Volume: 45, Issue:3

    Topics: Administration, Cutaneous; Administration, Oral; Aminoquinolines; Animals; Antimalarials; Artemisini

2000
Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria.
    Biochemical pharmacology, 2000, May-01, Volume: 59, Issue:9

    Topics: Alkaloids; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Interactions; Drug Resi

2000
Adaptation of a chloroquine-resistant strain of Plasmodium vivax from Indonesia to New World monkeys.
    The American journal of tropical medicine and hygiene, 2000, Volume: 62, Issue:4

    Topics: Adaptation, Physiological; Adult; Amodiaquine; Animals; Antimalarials; Aotidae; Child; Chloroquine;

2000
Relationship of the CD22 immunotoxin dose and the tumour establishment in a SCID mice model.
    Leukemia & lymphoma, 2000, Volume: 39, Issue:5-6

    Topics: Animals; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Antineoplastic Agents; Burkitt Lymph

2000
Antimalarial drugs clear resistant parasites from partially immune hosts.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:10

    Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Immunization; Malaria;

2001
The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy.
    Journal of biochemistry, 2002, Volume: 131, Issue:5

    Topics: Animals; Autophagy; Blotting, Western; Chloroquine; COS Cells; Disease Models, Animal; Dose-Response

2002
Plasmodium falciparum and Plasmodium vivax infections in the owl monkey (Aotus trivirgatus). II. Responses to chloroquine, quinine, and pyrimethamine.
    The American journal of tropical medicine and hygiene, 1978, Volume: 27, Issue:4

    Topics: Animals; Aotus trivirgatus; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; F

1978
Plasmodium fragile and Macaca mulatta monkeys as a model system for the study of malaria vaccines.
    The American journal of tropical medicine and hygiene, 1979, Volume: 28, Issue:6

    Topics: Animals; Antibody Formation; Chloroquine; Disease Models, Animal; Haplorhini; Macaca mulatta; Malari

1979
Chemotherapy of Plasmodium vivax in Saimiri and Aotus models.
    The American journal of tropical medicine and hygiene, 1975, Volume: 24, Issue:2

    Topics: Administration, Oral; Animals; Chloroquine; Disease Models, Animal; Drug Combinations; Drug Evaluati

1975
Effect of Gingko biloba extract (EGb 761) on chloroquine induced retinal alterations.
    Lens and eye toxicity research, 1992, Volume: 9, Issue:3-4

    Topics: Animals; Chloroquine; Dark Adaptation; Disease Models, Animal; Electroretinography; Ginkgo biloba; P

1992
The carcinogenicity of some antimalarial drugs using the Egyptian toad Bufo regularis as a biological test animal.
    Nutrition and cancer, 1992, Volume: 18, Issue:2

    Topics: Animals; Antimalarials; Bufonidae; Chloroquine; Disease Models, Animal; Drug Combinations; Female; K

1992
Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization.
    Infection and immunity, 1992, Volume: 60, Issue:9

    Topics: Animals; Brain Diseases; Chloroquine; Colchicine; Cryptococcosis; Disease Models, Animal; Female; Mi

1992
Chronotherapy of malaria: identification of drug-sensitive stage of parasite and timing of drug delivery for improved therapy.
    Annales de parasitologie humaine et comparee, 1991, Volume: 66, Issue:1

    Topics: Animals; Chloroquine; Disease Models, Animal; Injections, Subcutaneous; Malaria; Male; Mice; Periodi

1991
Pattern of relapses in sporozoite induced Plasmodium cynomolgi B infection in rhesus monkeys.
    The Journal of communicable diseases, 1990, Volume: 22, Issue:2

    Topics: Animals; Chloroquine; Disease Models, Animal; Macaca mulatta; Malaria; Recurrence; Time Factors

1990
Protective cardiovascular effects of diazepam in experimental acute chloroquine poisoning.
    Intensive care medicine, 1988, Volume: 14, Issue:6

    Topics: Animals; Chloroquine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiog

1988
Adaptation of the Indochina I/CDC strain of Plasmodium falciparum to the squirrel monkey (Saimiri sciureus).
    The American journal of tropical medicine and hygiene, 1986, Volume: 35, Issue:3

    Topics: Animals; Aotus trivirgatus; Cebidae; Chloroquine; Disease Models, Animal; Drug Resistance; Malaria;

1986
Influence of chloroquine on the porphyrin metabolism.
    Archives of dermatological research, 1985, Volume: 277, Issue:2

    Topics: 7-Alkoxycoumarin O-Dealkylase; Aminolevulinic Acid; Aminopyrine N-Demethylase; Animals; Aryl Hydroca

1985
[Biochemical studies on experimental chloroquine myopathy].
    Rinsho shinkeigaku = Clinical neurology, 1985, Volume: 25, Issue:5

    Topics: Animals; Chloroquine; Disease Models, Animal; Lysosomes; Male; Microscopy, Electron; Muscle Proteins

1985
Infections with Plasmodium falciparum and Plasmodium vivax in the owl monkey--model systems for basic biological and chemotherapeutic studies.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1973, Volume: 67, Issue:4

    Topics: Animal Feed; Animals; Butylamines; Chlorobenzenes; Chloroquine; Colombia; Darkness; Disease Models,

1973
[Experimental lesions of the nervous and muscular systems due to chloroquine: models of various storage dystrophies (author's transl)].
    Acta neuropathologica, 1974, Volume: 28, Issue:2

    Topics: Animals; Chloroquine; Chromatography, Thin Layer; Disease Models, Animal; Germ-Free Life; Glycogen S

1974
[Experimental studies on the etiology of nitrofurane-induced polyneuropathy and histopathology of chlorochindiphosphate (Resochin) neuro-myopathy].
    Beitrage zur Neurochirurgie, 1970, Volume: 16

    Topics: Animals; Chloroquine; Disease Models, Animal; Muscle Spindles; Muscular Diseases; Nitrofurans; Polyn

1970
A drug-induced cerebrospinal lipodystrophy in the domestic chicken (Gallus domesticus).
    Canadian journal of comparative medicine : Revue canadienne de medecine comparee, 1971, Volume: 35, Issue:3

    Topics: Animals; Brain; Cat Diseases; Cats; Central Nervous System Diseases; Chickens; Chinchilla; Chloroqui

1971
A modification of rat adjuvant arthritis for testing antirheumatic drugs.
    The Journal of pharmacy and pharmacology, 1972, Volume: 24, Issue:10

    Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthr

1972
The molecular basis of the action of chloroquine in porphyria cutanea tarda.
    The Journal of investigative dermatology, 1973, Volume: 61, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Animals; Chemical Phenomena; Chemistry; Chloroquine; Chromatography, G

1973
Immunity to exoerythrocytic forms of malaria. I. Course of infection of Plasmodium fallax in turkeys.
    Experimental parasitology, 1973, Volume: 34, Issue:3

    Topics: Animals; Blood; Body Weight; Brain; Cells, Cultured; Chick Embryo; Chloroquine; Culture Media; Disea

1973
Malaria research at the National Institute of Allergy and Infectious Diseases.
    The Journal of infectious diseases, 1969, Volume: 120, Issue:4

    Topics: Animals; Chloroquine; Disease Models, Animal; Haplorhini; Humans; Malaria; National Institutes of He

1969
Antimicrobial activity of the leprostatic drug 3-(p-chloranilino)-10-(p-chlorphenyl-2,10-dihydro-2-(isopropylimino)-phenazine (G 30'320, B. 663).
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:5

    Topics: Animals; Antitubercular Agents; Aspergillosis; Candidiasis; Chloroquine; Cricetinae; Disease Models,

1970
Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity.
    Science (New York, N.Y.), 1970, Jul-17, Volume: 169, Issue:3942

    Topics: Animals; Carbon Isotopes; Chloroquine; Disease Models, Animal; Drug Resistance, Microbial; Erythrocy

1970
Observations on the relapse activity of Plasmodium fieldi in the rhesus monkey.
    The Journal of parasitology, 1971, Volume: 57, Issue:1

    Topics: Aedes; Animals; Chloroquine; Chronic Disease; Disease Models, Animal; Haplorhini; Insect Vectors; Ma

1971