chloroquine has been researched along with Disease Exacerbation in 35 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment Failure with chloroquine is one of the challenges that faced the dedicated efforts to eradicate malaria This study aims at investigating the impact of treatment failure with chloroquine on the progression of the disease-induced histo-pathogenic and immunogenic outcomes." | 7.96 | Progression of malaria induced pathogenicity during chloroquine therapy. ( Abd Majid, R; Abd Rachman-Isnadi, MF; Basir, R; Bello, RO; Chin, VK; Noor, SM; Sidek, HM; Zaid, OI, 2020) |
| "Chloroquine diphosphate has been used in the treatment of various rheumatic diseases, including rheumatoid arthritis." | 7.74 | Chloroquine-induced bull's eye maculopathy in rheumatoid arthritis: related to disease duration? ( Kochen, JA; Laurindo, IM; Maia, OO; Morita, C; Shinjo, SK; Takahashi, WY; Tizziani, VA, 2007) |
| "Chloroquine treatment increased whole lung and PASMC p62 protein levels consistent with inhibition of autophagy, and increased levels of BMPR-II protein." | 5.39 | Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. ( Dunmore, BJ; Long, L; Lu, J; Marciniak, SJ; Morrell, NW; Southwood, M; Yang, X, 2013) |
| "Progression of radiographic damage and association of radiographic damage and genetic predisposition were compared in two cohorts, one treated according to the delayed treatment strategy (initial treatment with analgesics), the other treated according to the early treatment strategy (treatment with disease modifying antirheumatic drugs (DMARDs) chloroquine or sulfasalazine)." | 5.11 | Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis. ( Breedveld, FC; Hazes, JM; Huizinga, TW; Lard, LR; le Cessie, S; van Aken, J, 2004) |
| "Between 1993 and 1995, 109 patients diagnosed with probable or definite rheumatoid arthritis of recent onset were initially treated with analgesics; if they had persistent active disease, they were treated subsequently with the disease-modifying drugs chloroquine or salazopyrine (delayed treatment)." | 5.09 | Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies. ( Breedveld, FC; Hazes, JM; Lard, LR; Speyer, I; vander Horst-Bruinsma, IE; Visser, H; Zwinderman, AH, 2001) |
| "Treatment Failure with chloroquine is one of the challenges that faced the dedicated efforts to eradicate malaria This study aims at investigating the impact of treatment failure with chloroquine on the progression of the disease-induced histo-pathogenic and immunogenic outcomes." | 3.96 | Progression of malaria induced pathogenicity during chloroquine therapy. ( Abd Majid, R; Abd Rachman-Isnadi, MF; Basir, R; Bello, RO; Chin, VK; Noor, SM; Sidek, HM; Zaid, OI, 2020) |
| "Chloroquine (CQ), a well-known anti-malarial drug, has long been used for the treatment of autoimmune diseases because of its profound immunomodulatory effects." | 3.80 | Early treatment with chloroquine inhibits the immune response against Plasmodium yoelii infection in mice. ( Cao, Y; Chen, G; Du, Y; Feng, Y; Pang, W; Qi, Z; Qin, X; Zhu, X, 2014) |
| " They were monitored for development of Plasmodium falciparum malaria, which was treated with chloroquine (CQ) + sulfadoxine-pyrimethamine (SP) and the children followed up for 28 days." | 3.76 | Prolonged elevation of viral loads in HIV-1-infected children in a region of intense malaria transmission in Northern Uganda: a prospective cohort study. ( Egwang, TG; Kiyingi, HS; Nannyonga, M, 2010) |
| "Chloroquine diphosphate has been used in the treatment of various rheumatic diseases, including rheumatoid arthritis." | 3.74 | Chloroquine-induced bull's eye maculopathy in rheumatoid arthritis: related to disease duration? ( Kochen, JA; Laurindo, IM; Maia, OO; Morita, C; Shinjo, SK; Takahashi, WY; Tizziani, VA, 2007) |
| "Disease progression was observed in 18 patients (16." | 1.62 | Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital. ( Angkasekwinai, N; Assanasen, S; Chayakulkeeree, M; Chierakul, N; Horthongkham, N; Jitmuang, A; Kantakamalakul, W; Koomanachai, P; Ratanarat, R; Rattanaumpawan, P; Rongrungruang, Y; Sirijatuphat, R; Suputtamongkol, Y; Wangchinda, W, 2021) |
| "Chloroquine-induced maculopathy may progress years after drug cessation and an apparent period of visual stability." | 1.46 | Delayed progression of bull's eye maculopathy. ( Jain, NG; Jain, S, 2017) |
| "Clinically, from the largest ovarian cancer data set (GSE 9899, n = 285) available in GEO, high levels of expression of both PTP4A3 and autophagy genes significantly predict poor prognosis of ovarian cancer patients." | 1.40 | A role of autophagy in PTP4A3-driven cancer progression. ( Al-Aidaroos, AQ; Gupta, A; Huang, YH; Lin, YB; McCrudden, CM; Murray, JT; Rozycka, E; Shen, HM; Tergaonkar, V; Thiery, JP; Yuen, HF; Zeng, Q; Zhang, SD, 2014) |
| "Chloroquine treatment increased whole lung and PASMC p62 protein levels consistent with inhibition of autophagy, and increased levels of BMPR-II protein." | 1.39 | Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. ( Dunmore, BJ; Long, L; Lu, J; Marciniak, SJ; Morrell, NW; Southwood, M; Yang, X, 2013) |
| " In patients in whom the daily dosage of hydroxychloroquine could be estimated (12 of 13), when using actual body weight, 8 were taking 6." | 1.37 | Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy. ( Francis, PJ; Michaelides, M; Stover, NB; Weleber, RG, 2011) |
| "Twenty-two patients had some degree of renal failure; glomerular filtration rate (GFR) levels and albumin values were negatively associated to renal failure, while treatment with methylprednisolone decreased the probability of renal failure." | 1.35 | Prognostic factors in children with membranoproliferative glomerulonephritis type I. ( de Leon Bojorge, B; García-de la Puente, S; Orozco-Loza, IL; Zaltzman-Girshevich, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.71) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 17 (48.57) | 24.3611 |
| 2020's | 7 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guidon, AC | 1 |
| Amato, AA | 1 |
| Xu, CY | 1 |
| Lu, SD | 1 |
| Ye, X | 1 |
| Cao, MY | 1 |
| Xu, GD | 1 |
| Yu, Q | 1 |
| Qian, JX | 1 |
| Zeng, G | 1 |
| Gegúndez-Fernández, JA | 1 |
| Zarranz-Ventura, J | 1 |
| Garay-Aramburu, G | 1 |
| Muñoz-Negrete, FJ | 1 |
| Mendicute Del Barrio, J | 1 |
| Pablo-Júlvez, L | 1 |
| García-Delpech, S | 1 |
| López-Alemany, A | 1 |
| Arnalich-Montiel, F | 1 |
| Cordero-Coma, M | 1 |
| Cárceles, JA | 1 |
| Putman, M | 1 |
| Chock, YPE | 1 |
| Tam, H | 1 |
| Kim, AHJ | 1 |
| Sattui, SE | 1 |
| Berenbaum, F | 1 |
| Danila, MI | 1 |
| Korsten, P | 1 |
| Sanchez-Alvarez, C | 1 |
| Sparks, JA | 1 |
| Coates, LC | 1 |
| Palmerlee, C | 1 |
| Peirce, A | 1 |
| Jayatilleke, A | 1 |
| Johnson, SR | 1 |
| Kilian, A | 1 |
| Liew, J | 1 |
| Prokop, LJ | 1 |
| Murad, MH | 1 |
| Grainger, R | 1 |
| Wallace, ZS | 1 |
| Duarte-García, A | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
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| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
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| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
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| Li, J | 7 |
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| Wang, C | 3 |
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| Lv, B | 1 |
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| Zhuang, T | 1 |
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| Nakamura, M | 1 |
| Michaelides, M | 1 |
| Stover, NB | 1 |
| Francis, PJ | 1 |
| Weleber, RG | 1 |
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| Breedveld, FC | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Relevance of Monitoring Blood Levels Compared to Salivar Levels of Drugs Used in Rheumatic Autoimmune Diseases: Adherence and Understanding the Possible Underlying Mechanisms Involved in Effectiveness and in Adverse Effects[NCT03122431] | Phase 4 | 93 participants (Actual) | Interventional | 2017-06-05 | Completed | ||
| The Effect of Tocilizumab (Anti-interleukin-6) Treatment on microRNA Expression and Adipokine Levels in Rheumatoid Arthritis Patients[NCT03149796] | 80 participants (Actual) | Observational | 2011-03-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Serum levels of hydroxycloroquine by LCMS (NCT03122431)
Timeframe: 12 months
| Intervention | ng/mL (Mean) |
|---|---|
| Inactive SLE With Standard Dose of HCQ | 991.6 |
| Inactive SLE With Reduced Dose of HCQ | 569.0 |
Serum levels of thalidomide by liquid chromatography and tandem mass spectrometry (HPLC-MS/MS) (NCT03122431)
Timeframe: 12 months
| Intervention | ng/mL (Mean) |
|---|---|
| SLE/Cutaneous Lupus With Thalidomide | 415.1 |
5 reviews available for chloroquine and Disease Exacerbation
| Article | Year |
|---|---|
COVID-19 and neuromuscular disorders.
Topics: Antiviral Agents; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Vaccines; Delivery of Heal | 2020 |
Combined treatment of tocilizumab and chloroquine on severe COVID-19: a case report.
Topics: Antibodies, Monoclonal, Humanized; Chloroquine; Clinical Laboratory Techniques; Coronavirus Infectio | 2020 |
Recommendations for eye care during the alarm state by the coronavirus disease pandemic COVID-19.
Topics: Antimalarials; Asymptomatic Diseases; Betacoronavirus; Blood Safety; Chloroquine; Contact Lenses; Co | 2020 |
Antirheumatic Disease Therapies for the Treatment of COVID-19: A Systematic Review and Meta-Analysis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Azetidines; Bias; C | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
4 trials available for chloroquine and Disease Exacerbation
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Disease Progression; Epitopes | 2004 |
Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases.
Topics: Adult; Aged; Alkaline Phosphatase; Antirheumatic Agents; Chloroquine; Diagnosis, Differential; Disea | 1997 |
Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies.
Topics: Activities of Daily Living; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antir | 2001 |
27 other studies available for chloroquine and Disease Exacerbation
| Article | Year |
|---|---|
Progression of malaria induced pathogenicity during chloroquine therapy.
Topics: Animals; Antimalarials; Chloroquine; Disease Progression; Malaria; Mice, Inbred ICR; Parasitemia; Pl | 2020 |
Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital.
Topics: Adult; Aged; Aged, 80 and over; Amides; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treat | 2021 |
Delayed progression of bull's eye maculopathy.
Topics: Aftercare; Aged; Antirheumatic Agents; Chloroquine; Disease Progression; Electroretinography; Female | 2017 |
Methods for Monitoring Macroautophagy in Pancreatic Cancer Cells.
Topics: Animals; Autophagosomes; Autophagy; Autophagy-Related Proteins; Carcinogenesis; Cell Culture Techniq | 2019 |
Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
Topics: Animals; Autophagy; Bone Morphogenetic Protein Receptors, Type II; Cells, Cultured; Chloroquine; Dis | 2013 |
Cystoid macular oedema and epiretinal membrane formation during progression of chloroquine retinopathy after drug cessation.
Topics: Aged; Antirheumatic Agents; Chloroquine; Disease Progression; Electroretinography; Epiretinal Membra | 2014 |
Dynamic interplay between autophagic flux and Akt during melanoma progression in vitro.
Topics: Autophagy; Cell Line, Tumor; Chloroquine; Disease Progression; Humans; In Vitro Techniques; Melanocy | 2014 |
A role of autophagy in PTP4A3-driven cancer progression.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy; Biocatalysis; Cell Cycle Proteins; Cell Me | 2014 |
Early treatment with chloroquine inhibits the immune response against Plasmodium yoelii infection in mice.
Topics: Animals; Antimalarials; Chloroquine; Dendritic Cells; Disease Models, Animal; Disease Progression; F | 2014 |
Effects of long-term chloroquine administration on the natural history of aortic aneurysms in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Autophagy; | 2015 |
Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress.
Topics: Acids; Adenocarcinoma; Animals; Autophagy; Barrett Esophagus; Cell Line; Cell Survival; Chloroquine; | 2016 |
Long-term continuation of chloroquine-induced retinal toxicity in rheumatoid arthritis despite drug cessation.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Disease Progression; Humans; Male; Middle | 2016 |
Chloroquine Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats.
Topics: Animals; Blood Pressure; Blotting, Western; Chloroquine; Disease Models, Animal; Disease Progression | 2017 |
Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.
Topics: Animals; Autophagy; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chloroquine; Disease Progre | 2017 |
Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Chloroquine; Disease Progression; Drug Therapy | 2011 |
AACR highlights: promise for treating pancreatic cancer.
Topics: Albumin-Bound Paclitaxel; Albumins; Anilides; Animals; Antineoplastic Agents; Antineoplastic Combine | 2011 |
Prolonged elevation of viral loads in HIV-1-infected children in a region of intense malaria transmission in Northern Uganda: a prospective cohort study.
Topics: Antimalarials; CD4 Lymphocyte Count; Child; Child, Preschool; Chloroquine; Disease Progression; Drug | 2010 |
Morphea with discoid lupus erythematosus.
Topics: Antibodies, Bacterial; Arm; Atrophy; Borrelia burgdorferi; Chloroquine; Disease Progression; Doxycyc | 2011 |
Blocking the interleukin 2 (IL2)-induced systemic autophagic syndrome promotes profound antitumor effects and limits toxicity.
Topics: Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Chloroquine; Dendritic Cells; Disease P | 2012 |
Early treatment of childhood fevers with pre-packaged antimalarial drugs in the home reduces severe malaria morbidity in Burkina Faso.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Aspirin; Burkina Faso; Child, Preschool; Chl | 2003 |
Chloroquine-induced bull's eye maculopathy in rheumatoid arthritis: related to disease duration?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Disease Progression; Female; | 2007 |
Familial linear scleroderma (en coup de sabre) responsive to antimalarials and narrowband ultraviolet B therapy.
Topics: Adult; Antimalarials; Chloroquine; Colchicine; Disease Progression; Drug Therapy, Combination; Femal | 2007 |
Prognostic factors in children with membranoproliferative glomerulonephritis type I.
Topics: Adolescent; Alkylating Agents; Child; Child, Preschool; Chloroquine; Complement System Proteins; Cyc | 2008 |
Previous antimalarial therapy in patients diagnosed with lupus nephritis: influence on outcomes and survival.
Topics: Adolescent; Adult; Aged; Antimalarials; Biopsy; Child; Chloroquine; Disease Progression; Female; Fol | 2008 |
Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alopecia; Antimalarials; Biopsy; Chloroquine; Dermato | 1997 |
Autoimmune-mediated vasculopathy.
Topics: Adoptive Transfer; Animals; Antigens, Differentiation, B-Lymphocyte; Arteriosclerosis; Autoimmune Di | 2001 |
Disease activity during the premenopausal and postmenopausal periods in women with systemic lupus erythematosus.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Chloroquine; Cohort Studies; Disease Progression; Em | 2001 |