chloroquine has been researched along with Diabetes Mellitus, Type 1 in 8 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 16-year old girl with insulin-dependent diabetes mellitus (8 years' duration) developed tropic malaria 7 weeks after her return from Kenya despite a longtime prophylaxis using pyrimethamine and sulfadoxine (Fansidar)." | 7.67 | [Chloroquine and pyrimethamine/sulfadoxine resistant malaria tropica in a child with diabetes mellitus]. ( Bienzle, U; Burger, W; Kroll, MH; Weber, B, 1984) |
| "A 16-year old girl with insulin-dependent diabetes mellitus (8 years' duration) developed tropic malaria 7 weeks after her return from Kenya despite a longtime prophylaxis using pyrimethamine and sulfadoxine (Fansidar)." | 3.67 | [Chloroquine and pyrimethamine/sulfadoxine resistant malaria tropica in a child with diabetes mellitus]. ( Bienzle, U; Burger, W; Kroll, MH; Weber, B, 1984) |
| "Chloroquine treatment delayed the spontaneous onset of diabetes in NOD mice, coincident with the decreased activation of PLN DCs." | 1.36 | TLR9 blockade inhibits activation of diabetogenic CD8+ T cells and delays autoimmune diabetes. ( Dutz, JP; Finegood, D; Geng, X; Lee, AS; Santamaria, P; Shameli, A; Zhang, Y, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 1 |
| Zhao, X | 1 |
| Cheng, R | 1 |
| Huang, Y | 1 |
| de Almeida Júnior, RF | 1 |
| de Souza, KSC | 1 |
| Galdino, OA | 1 |
| da Silva Junior, AA | 1 |
| Arrais, RF | 1 |
| Machado, PRL | 1 |
| Farias, KJS | 1 |
| de Rezende, AA | 1 |
| Kang, JM | 1 |
| Lee, HS | 1 |
| Kim, J | 2 |
| Yang, DH | 1 |
| Jeong, HY | 1 |
| Lee, YH | 1 |
| Kim, DJ | 1 |
| Park, SH | 1 |
| Sung, M | 1 |
| An, HJ | 1 |
| Lee, SH | 1 |
| Lee, SY | 1 |
| Liu, M | 1 |
| Peng, J | 1 |
| Tai, N | 1 |
| Pearson, JA | 1 |
| Hu, C | 1 |
| Guo, J | 1 |
| Hou, L | 1 |
| Zhao, H | 1 |
| Wong, FS | 1 |
| Wen, L | 1 |
| Zhang, Y | 1 |
| Lee, AS | 1 |
| Shameli, A | 1 |
| Geng, X | 1 |
| Finegood, D | 1 |
| Santamaria, P | 1 |
| Dutz, JP | 1 |
| Zipris, D | 1 |
| Lien, E | 1 |
| Nair, A | 1 |
| Xie, JX | 1 |
| Greiner, DL | 1 |
| Mordes, JP | 1 |
| Rossini, AA | 1 |
| Blazar, BR | 1 |
| Whitley, CB | 1 |
| Kitabchi, AE | 1 |
| Tsai, MY | 1 |
| Santiago, J | 1 |
| White, N | 1 |
| Stentz, FB | 1 |
| Brown, DM | 1 |
| Kroll, MH | 1 |
| Bienzle, U | 1 |
| Burger, W | 1 |
| Weber, B | 1 |
8 other studies available for chloroquine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells.
Topics: Animals; Autophagy; Cataract; Cells, Cultured; Chloroquine; Culture Media; Diabetes Mellitus, Experi | 2020 |
Chloroquine as a promising adjuvant therapy for type 1 Diabetes Mellitus.
Topics: Adolescent; Anti-Inflammatory Agents; Case-Control Studies; Cell Proliferation; Cell Survival; Chemo | 2020 |
Beneficial Effect of Chloroquine and Amodiaquine on Type 1 Diabetic Tubulopathy by Attenuating Mitochondrial Nox4 and Endoplasmic Reticulum Stress.
Topics: Amodiaquine; Animals; Apoptosis; Cells, Cultured; Chloroquine; Diabetes Mellitus, Experimental; Diab | 2020 |
Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes.
Topics: Animals; Chloroquine; Diabetes Mellitus, Type 1; Female; Flow Cytometry; Glucose Tolerance Test; Ins | 2018 |
TLR9 blockade inhibits activation of diabetogenic CD8+ T cells and delays autoimmune diabetes.
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Differentiation; Chloroquine; Clone Cells; CpG Islands; Di | 2010 |
TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.
Topics: Animals; B-Lymphocytes; Breeding; Cells, Cultured; Chloroquine; Diabetes Mellitus, Type 1; Disease S | 2007 |
In vivo chloroquine-induced inhibition of insulin degradation in a diabetic patient with severe insulin resistance.
Topics: Adipose Tissue; Adult; alpha-Galactosidase; beta-N-Acetylhexosaminidases; Biopsy; Chloroquine; Diabe | 1984 |
[Chloroquine and pyrimethamine/sulfadoxine resistant malaria tropica in a child with diabetes mellitus].
Topics: Adolescent; Chloroquine; Diabetes Mellitus, Type 1; Diagnosis, Differential; Doxycycline; Drug Resis | 1984 |