chloroquine has been researched along with Delayed Effects, Prenatal Exposure in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic use of chloroquine and hydroxychloroquine inthe treatment of rheumatic disease carries a small risk of sight-threatening pigmentary retinopathy." | 7.71 | Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases. ( Buncic, RJ; Ito, S; Klinger, G; Koren, G; Laskin, C; Morad, Y; Spitzer, KA; Westall, CA, 2001) |
| "The antimalarial drugs chloroquine (CQ) and hydroxychloroquine (HCQ) have been used for decades to treat rheumatic diseases." | 4.87 | Ocular toxicity in children exposed in utero to antimalarial drugs: review of the literature. ( Koren, G; Osadchy, A; Ratnapalan, T, 2011) |
| "Chloroquine (CQ), a drug that has been used extensively for the prevention and treatment of malaria, is currently considered safe for use during pregnancy." | 3.75 | In utero exposure to chloroquine alters sexual development in the male fetal rat. ( Andersen, ME; Clewell, RA; Pluta, L; Thomas, RS, 2009) |
| " Nineteen children over four years old were evaluated: nine were exposed to chloroquine diphosphate (CDP) during gestation and 10 were born from mothers that did not take this drug before conception or anytime during pregnancy (CONTROL)." | 3.72 | Chloroquine gestational use in systemic lupus erythematosus: assessing the risk of child ototoxicity by pure tone audiometry. ( Bertola, C; Bonfá, E; Borba, EF; Kuruma, KA; Lorenzi, MC; Pedalini, ME; Turrini-Filho, JR, 2004) |
| "Chronic use of chloroquine and hydroxychloroquine inthe treatment of rheumatic disease carries a small risk of sight-threatening pigmentary retinopathy." | 3.71 | Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases. ( Buncic, RJ; Ito, S; Klinger, G; Koren, G; Laskin, C; Morad, Y; Spitzer, KA; Westall, CA, 2001) |
| " Streptomycin, chloroquine and abortificients were used during early pregnancy." | 3.68 | Deafness in children--an analysis. ( Ganga, N; Padmanabhan, AS; Rajagopal, B; Rajendran, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clewell, RA | 1 |
| Pluta, L | 1 |
| Thomas, RS | 1 |
| Andersen, ME | 1 |
| Osadchy, A | 1 |
| Ratnapalan, T | 1 |
| Koren, G | 2 |
| Borba, EF | 1 |
| Turrini-Filho, JR | 1 |
| Kuruma, KA | 1 |
| Bertola, C | 1 |
| Pedalini, ME | 1 |
| Lorenzi, MC | 1 |
| Bonfá, E | 1 |
| Klinger, G | 1 |
| Morad, Y | 1 |
| Westall, CA | 1 |
| Laskin, C | 1 |
| Spitzer, KA | 1 |
| Ito, S | 1 |
| Buncic, RJ | 1 |
| Reyes, S | 1 |
| Rembao, D | 1 |
| Sotelo, J | 1 |
| Ganga, N | 1 |
| Rajagopal, B | 1 |
| Rajendran, S | 1 |
| Padmanabhan, AS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hydroxychloroquine in Unexplained Recurrent Pregnancy Loss ,Double Blinded Randomized Controlled Trial .[NCT05237843] | Phase 1 | 70 participants (Anticipated) | Interventional | 2022-03-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chloroquine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Ocular toxicity in children exposed in utero to antimalarial drugs: review of the literature.
Topics: Antimalarials; Child; Chloroquine; Databases, Factual; Eye; Eye Diseases; Female; Humans; Hydroxychl | 2011 |
5 other studies available for chloroquine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
In utero exposure to chloroquine alters sexual development in the male fetal rat.
Topics: Animals; Chloroquine; Female; Fetal Development; Male; Pregnancy; Prenatal Exposure Delayed Effects; | 2009 |
Chloroquine gestational use in systemic lupus erythematosus: assessing the risk of child ototoxicity by pure tone audiometry.
Topics: Adult; Antimalarials; Audiometry, Pure-Tone; Auditory Threshold; Child; Child, Preschool; Chloroquin | 2004 |
Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases.
Topics: Antirheumatic Agents; Child; Child, Preschool; Chloroquine; Female; Humans; Hydroxychloroquine; Infa | 2001 |
The antimalarials quinacrine and chloroquine potentiate the transplacental carcinogenic effect of ethylnitrosourea on ependymal cells.
Topics: Animals; Antimalarials; Brain Neoplasms; Carcinogens; Chloroquine; Drug Synergism; Ependyma; Ependym | 2001 |
Deafness in children--an analysis.
Topics: Abortifacient Agents; Adolescent; Chickenpox; Child; Child, Preschool; Chloroquine; Deafness; Female | 1991 |