chloroquine has been researched along with Cystinosis in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Cystinosis: A metabolic disease characterized by the defective transport of CYSTINE across the lysosomal membrane due to mutation of a membrane protein cystinosin. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. In the KIDNEY, nephropathic cystinosis is a common cause of RENAL FANCONI SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study concerns the effect of the lysosomotropic drug chloroquine on the uptake and metabolism of [35S]cystine in vitro by normal human fibroblasts and those from patients suffering from the lysosomal storage disease cystinosis." | 3.66 | The effect of chloroquine on the metabolism of [35S]cystine in normal and cystinotic human skin fibroblasts. ( Danpure, CJ, 1981) |
| "Fibroblasts derived from patients with cystinosis, an autosomal recessive condition, accumulate the disulfide amino acid cystine within lysosomes." | 3.65 | Cystinotic fibroblasts accumulate cystine from intracellular protein degradation. ( Oshima, RG; Ritchie, DG; Schneider, JA; Thoene, JG, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| States, B | 1 |
| Lee, J | 1 |
| Segal, S | 1 |
| Danpure, CJ | 3 |
| Fyfe, DA | 2 |
| Thoene, JG | 2 |
| Oshima, RG | 1 |
| Ritchie, DG | 1 |
| Schneider, JA | 1 |
| Pisoni, RL | 1 |
| Christensen, HN | 1 |
| Jennings, PR | 1 |
6 other studies available for chloroquine and Cystinosis
| Article | Year |
|---|---|
Effect of chloroquine on handling of cystine by cystinotic fibroblasts.
Topics: Amino Acids; Child; Chloroquine; Cystine; Cystinosis; Fibroblasts; Humans | 1983 |
The effect of chloroquine on the metabolism of [35S]cystine in normal and cystinotic human skin fibroblasts.
Topics: Aminoquinolines; Cell Line; Chloroquine; Cystine; Cystinosis; Fibroblasts; Humans; Skin; Sulfur Radi | 1981 |
The effect of chloroquine on the intralysosomal accumulation of cystine in cystinotic and normal fibroblasts.
Topics: Biological Transport; Chloroquine; Cystine; Cystinosis; Fibroblasts; Humans; Lysosomes; Skin | 1980 |
Cystinotic fibroblasts accumulate cystine from intracellular protein degradation.
Topics: Biodegradation, Environmental; Cells, Cultured; Chloroquine; Cystine; Cystinosis; Fibroblasts; Gluta | 1977 |
Detection and characterization of carrier-mediated cationic amino acid transport in lysosomes of normal and cystinotic human fibroblasts. Role in therapeutic cystine removal?
Topics: Amino Acids; Biological Transport, Active; Cell Line; Chloroquine; Cysteamine; Cystinosis; Electroph | 1985 |
Further studies on the effect of chloroquine on the uptake, metabolism and intracellular translocation of [35S]cystine in cystinotic fibroblasts.
Topics: Biological Transport; Cells, Cultured; Chloroquine; Cysteamine; Cystine; Cystinosis; Fibroblasts; Hu | 1986 |