chloroquine has been researched along with Cystic Fibrosis in 9 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vasculitis is a well recognised complication of Cystic Fibrosis." | 5.36 | Treatment of cystic fibrosis associated cutaneous vasculitis with chloroquine. ( Molyneux, ID; Moon, T; Morice, AH; Webb, AK, 2010) |
| "Transforming growth factor beta (TGF-beta) has been implicated in pathophysiology of CF." | 5.33 | Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells. ( Deretic, V; Ornatowski, W; Perkett, EA; Poschet, JF, 2006) |
| "Vasculitis is a well recognised complication of Cystic Fibrosis." | 1.36 | Treatment of cystic fibrosis associated cutaneous vasculitis with chloroquine. ( Molyneux, ID; Moon, T; Morice, AH; Webb, AK, 2010) |
| "Transforming growth factor beta (TGF-beta) has been implicated in pathophysiology of CF." | 1.33 | Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells. ( Deretic, V; Ornatowski, W; Perkett, EA; Poschet, JF, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Pohl, K | 1 |
| Grimm, XA | 1 |
| Caceres, SM | 1 |
| Poch, KR | 1 |
| Rysavy, N | 1 |
| Saavedra, M | 1 |
| Nick, JA | 1 |
| Malcolm, KC | 1 |
| Molyneux, ID | 1 |
| Moon, T | 1 |
| Webb, AK | 1 |
| Morice, AH | 1 |
| Derleth, DP | 1 |
| Perkett, EA | 1 |
| Ornatowski, W | 1 |
| Poschet, JF | 1 |
| Deretic, V | 1 |
| Kollen, WJ | 2 |
| Midoux, P | 1 |
| Erbacher, P | 1 |
| Yip, A | 1 |
| Roche, AC | 1 |
| Monsigny, M | 1 |
| Glick, MC | 3 |
| Scanlin, TF | 3 |
| Schembri, FM | 1 |
| Gerwig, GJ | 1 |
| Vliegenthart, JF | 1 |
| Gibson, GA | 1 |
| Hill, WG | 1 |
| Weisz, OA | 1 |
| Klink, DT | 1 |
| Chao, S | 1 |
| Hermelin, B | 1 |
| Bertrand, F | 1 |
| Blivet, MJ | 1 |
| Picard, J | 1 |
9 other studies available for chloroquine and Cystic Fibrosis
| Article | Year |
|---|---|
Mycobacterium abscessus Clearance by Neutrophils Is Independent of Autophagy.
Topics: Adaptor Proteins, Signal Transducing; Anti-Bacterial Agents; Autophagy; Azithromycin; Case-Control S | 2020 |
Treatment of cystic fibrosis associated cutaneous vasculitis with chloroquine.
Topics: Adult; Antirheumatic Agents; Chloroquine; Cystic Fibrosis; Exanthema; Humans; Male; Skin; Vasculitis | 2010 |
A possible antiinflammatory treatment for cystic fibrosis.
Topics: Chloroquine; Clinical Trials as Topic; Cystic Fibrosis; Female; Humans; Male; Research; Sensitivity | 2003 |
Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Cells, Cultured; Chloroquine; Culture Media, Condi | 2006 |
Gluconoylated and glycosylated polylysines as vectors for gene transfer into cystic fibrosis airway epithelial cells.
Topics: Cell Count; Cells, Cultured; Chloroquine; Cystic Fibrosis; Epithelium; Gene Expression; Gene Transfe | 1996 |
Enhanced efficiency of lactosylated poly-L-lysine-mediated gene transfer into cystic fibrosis airway epithelial cells.
Topics: Amino Acid Sequence; Cell Line, Transformed; Chloroquine; Cystic Fibrosis; Gene Expression Regulatio | 1999 |
Evidence against the acidification hypothesis in cystic fibrosis.
Topics: Acids; Adenocarcinoma; Adenoviridae; Animals; Biological Transport; Cell Compartmentation; Cell Line | 2000 |
Nuclear translocation of lactosylated poly-L-lysine/cDNA complex in cystic fibrosis airway epithelial cells.
Topics: Cell Line, Transformed; Cell Nucleus; Chloroquine; Cystic Fibrosis; DNA, Complementary; Epithelial C | 2001 |
Change in activities of lysosomal glycosidases in skin fibroblasts from controls and patients with cystic fibrosis.
Topics: alpha-L-Fucosidase; alpha-Mannosidase; beta-N-Acetylhexosaminidases; Chloroquine; Culture Media; Cys | 1987 |