chloroquine has been researched along with Cortical Lewy Body Disease in 1 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The autophagy-lysosome pathway (ALP) regulates intracellular homeostasis of the cytosolic protein SNCA/alpha-synuclein and is impaired in synucleinopathies, including Parkinson disease and dementia with Lewy bodies (DLB)." | 3.88 | Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype. ( Adame, A; Barkovits, K; Bergmann, A; Buzás, EI; Emmanouilidou, E; Galasko, D; Kittel, A; Klucken, J; Lie, DC; Marcus, K; Marxreiter, F; Masliah, E; Menges, S; Minakaki, G; Mollenhauer, B; Rockenstein, E; Schaeffner, I; Schlötzer-Schrehardt, U; Vekrellis, K; Winkler, J; Xiang, W, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Minakaki, G | 1 |
| Menges, S | 1 |
| Kittel, A | 1 |
| Emmanouilidou, E | 1 |
| Schaeffner, I | 1 |
| Barkovits, K | 1 |
| Bergmann, A | 1 |
| Rockenstein, E | 1 |
| Adame, A | 1 |
| Marxreiter, F | 1 |
| Mollenhauer, B | 1 |
| Galasko, D | 1 |
| Buzás, EI | 1 |
| Schlötzer-Schrehardt, U | 1 |
| Marcus, K | 1 |
| Xiang, W | 1 |
| Lie, DC | 1 |
| Vekrellis, K | 1 |
| Masliah, E | 1 |
| Winkler, J | 1 |
| Klucken, J | 1 |
1 other study available for chloroquine and Cortical Lewy Body Disease
| Article | Year |
|---|---|
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.
Topics: alpha-Synuclein; Animals; Autophagosomes; Autophagy; Biomarkers; Cells, Cultured; Chloroquine; Exoso | 2018 |