chloroquine has been researched along with Congenital Zika Syndrome in 8 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an optimal maternal/fetal dosing regimen to prevent ZIKV endocytosis in brain cells." | 5.51 | Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection. ( Badhan, RKS; Olafuyi, O, 2019) |
| " We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an optimal maternal/fetal dosing regimen to prevent ZIKV endocytosis in brain cells." | 1.51 | Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection. ( Badhan, RKS; Olafuyi, O, 2019) |
| "Chloroquine treatment significantly improved the survival of ZIKV-infected 1-day old suckling SCID Beige mice and reduced viremia in adult SCID Beige mice." | 1.51 | Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus. ( Chen, L; Feng, L; Guo, W; Li, C; Li, P; Liu, X; Niu, X; Pan, W; Peng, J; Qu, L; Wang, Q; Wu, M; Yan, Q; Ye, X; Yi, C; Zhang, F; Zhang, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernatchez, JA | 1 |
| Tran, LT | 1 |
| Li, J | 1 |
| Luan, Y | 1 |
| Siqueira-Neto, JL | 1 |
| Li, R | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, C | 2 |
| Zhu, X | 1 |
| Ji, X | 1 |
| Quanquin, N | 1 |
| Deng, YQ | 1 |
| Tian, M | 1 |
| Aliyari, R | 1 |
| Zuo, X | 1 |
| Yuan, L | 1 |
| Afridi, SK | 1 |
| Li, XF | 1 |
| Jung, JU | 1 |
| Nielsen-Saines, K | 1 |
| Qin, FX | 1 |
| Qin, CF | 1 |
| Xu, Z | 1 |
| Cheng, G | 1 |
| Shiryaev, SA | 1 |
| Mesci, P | 1 |
| Pinto, A | 1 |
| Fernandes, I | 1 |
| Sheets, N | 1 |
| Shresta, S | 1 |
| Farhy, C | 1 |
| Huang, CT | 1 |
| Strongin, AY | 1 |
| Muotri, AR | 1 |
| Terskikh, AV | 1 |
| Peng, H | 1 |
| Liu, B | 1 |
| Yves, TD | 1 |
| He, Y | 1 |
| Wang, S | 1 |
| Tang, H | 1 |
| Ren, H | 1 |
| Zhao, P | 1 |
| Qi, Z | 1 |
| Qin, Z | 1 |
| Olafuyi, O | 1 |
| Badhan, RKS | 1 |
| Zhang, S | 1 |
| Yi, C | 1 |
| Zhang, F | 1 |
| Peng, J | 1 |
| Wang, Q | 1 |
| Liu, X | 1 |
| Ye, X | 1 |
| Li, P | 1 |
| Wu, M | 1 |
| Yan, Q | 1 |
| Guo, W | 1 |
| Niu, X | 1 |
| Feng, L | 1 |
| Pan, W | 1 |
| Chen, L | 1 |
| Qu, L | 1 |
| Delvecchio, R | 1 |
| Higa, LM | 1 |
| Pezzuto, P | 1 |
| Valadão, AL | 1 |
| Garcez, PP | 1 |
| Monteiro, FL | 1 |
| Loiola, EC | 1 |
| Dias, AA | 1 |
| Silva, FJ | 1 |
| Aliota, MT | 1 |
| Caine, EA | 1 |
| Osorio, JE | 1 |
| Bellio, M | 1 |
| O'Connor, DH | 1 |
| Rehen, S | 1 |
| de Aguiar, RS | 1 |
| Savarino, A | 1 |
| Campanati, L | 1 |
| Tanuri, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hydroxychloroquine Post-Exposure Prophylaxis for Coronavirus Disease (COVID-19) Among Health-Care Workers: A Randomized-Controlled Trial[NCT04438837] | 582 participants (Anticipated) | Interventional | 2020-07-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chloroquine and Congenital Zika Syndrome
| Article | Year |
|---|---|
Drugs for the Treatment of Zika Virus Infection.
Topics: Animals; Antiviral Agents; Drug Development; Drug Discovery; Humans; Viral Vaccines; Zika Virus; Zik | 2020 |
7 other studies available for chloroquine and Congenital Zika Syndrome
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice.
Topics: Animals; Cell Line; Chlorocebus aethiops; Chloroquine; Disease Models, Animal; Drug Approval; Drug E | 2017 |
Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Repositioning; Humans; Mice; Neura | 2017 |
Zika Virus Induces Autophagy in Human Umbilical Vein Endothelial Cells.
Topics: Androstadienes; Animals; Autophagy; Chlorocebus aethiops; Chloroquine; Gene Knockout Techniques; Hum | 2018 |
Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.
Topics: Antimalarials; Arthritis, Rheumatoid; Chloroquine; Female; Gestational Age; Humans; Lupus Erythemato | 2019 |
Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus.
Topics: Animals; Antimalarials; Autophagy; Cell Line; Chlorocebus aethiops; Chloroquine; Disease Models, Ani | 2019 |
Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Chloroquine; Endocytosis; Humans; Mice; | 2016 |