chloroquine has been researched along with Colorectal Cancer in 20 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU)-based chemotherapy is the first-line treatment for colorectal cancer (CRC) but is hampered by chemoresistance." | 8.02 | The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy. ( Chen, C; Chen, J; Fan, G; Liu, X; Lu, H; Na, R; Peng, Z; Song, G; Tang, H; Wang, X; Wang, Y; Xiao, C; Yan, D; Zhuang, G, 2021) |
| "To evaluate the antitumor effect of sinoporphyrin sodium mediated photodynamic therapy (DVDMS-PDT) against human colorectal cancer (CRC) and to investigate the role of autophagy in its effect." | 7.91 | Inhibition of Autophagy with Chloroquine Enhanced Sinoporphyrin Sodium Mediated Photodynamic Therapy-induced Apoptosis in Human Colorectal Cancer Cells. ( Han, Z; Hou, J; Hou, X; Hu, W; Li, S; Sheng, D; Wei, L; Wu, Y; Yu, L; Zhang, L; Zhao, N; Zhu, B, 2019) |
| " The aim of the present study was to investigate whether the combination of temsirolimus (TEM), an mTOR inhibitor, and chloroquine (CQ), an autophagy inhibitor, can increase radiosensitivity in colorectal cancer (CRC) cells." | 7.91 | The combination of temsirolimus and chloroquine increases radiosensitivity in colorectal cancer cells. ( Emoto, S; Hata, K; Kaneko, M; Kawai, K; Murono, K; Nishikawa, T; Nozawa, H; Otani, K; Sasaki, K; Shiratori, H; Sonoda, H; Tanaka, T, 2019) |
| "Temsirolimus (TEM) is a novel, water-soluble mammalian target of rapamycin (mTOR) inhibitor that has shown activity against a wide range of cancers in preclinical models, but its efficacy against colorectal cancer (CRC) has not been fully explored." | 7.80 | Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells. ( Emoto, S; Hiyoshi, M; Iida, Y; Kaneko, M; Kishikawa, J; Kitayama, J; Murono, K; Nirei, T; Nozawa, H; Sunami, E; Tada, N; Takahashi, K; Tsuno, NH; Watanabe, T, 2014) |
| "We observed that bortezomib-induced protective autophagy in cultured PANC-1 pancreatic cancer cells and HT-29 colorectal cancer cells." | 7.80 | Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells. ( Chen, ZR; Huang, M; Min, H; Xu, M; Zheng, K; Zhou, JD; Zou, XP, 2014) |
| " In the present study, we found that, in human colorectal cancer cells, low-dose camptothecin (CPT) simultaneously induced autophagy and premature senescence through AMPK-TSC2-mTOR pathway and ATM-Chk2-p53-p21 pathway respectively." | 7.80 | Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. ( Li, R; Liu, WT; Song, JR; Sun, K; Wei, LX; Wu, MC; Zhang, JW; Zhang, SS; Zhao, QD; Zong, C, 2014) |
| "The regimens on colorectal cancer (CRC) are clinically limited due to the ignorance of tumor-supportive microenvironments." | 5.91 | Dual-targeting of artesunate and chloroquine to tumor cells and tumor-associated macrophages by a biomimetic PLGA nanoparticle for colorectal cancer treatment. ( Chen, Y; Du, Q; Gong, Z; Pan, D; Peng, J; Sun, R; Wang, Q; Zhou, J, 2023) |
| "5-Fluorouracil (5-FU)-based chemotherapy is the first-line treatment for colorectal cancer (CRC) but is hampered by chemoresistance." | 4.02 | The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy. ( Chen, C; Chen, J; Fan, G; Liu, X; Lu, H; Na, R; Peng, Z; Song, G; Tang, H; Wang, X; Wang, Y; Xiao, C; Yan, D; Zhuang, G, 2021) |
| "To evaluate the antitumor effect of sinoporphyrin sodium mediated photodynamic therapy (DVDMS-PDT) against human colorectal cancer (CRC) and to investigate the role of autophagy in its effect." | 3.91 | Inhibition of Autophagy with Chloroquine Enhanced Sinoporphyrin Sodium Mediated Photodynamic Therapy-induced Apoptosis in Human Colorectal Cancer Cells. ( Han, Z; Hou, J; Hou, X; Hu, W; Li, S; Sheng, D; Wei, L; Wu, Y; Yu, L; Zhang, L; Zhao, N; Zhu, B, 2019) |
| " The aim of the present study was to investigate whether the combination of temsirolimus (TEM), an mTOR inhibitor, and chloroquine (CQ), an autophagy inhibitor, can increase radiosensitivity in colorectal cancer (CRC) cells." | 3.91 | The combination of temsirolimus and chloroquine increases radiosensitivity in colorectal cancer cells. ( Emoto, S; Hata, K; Kaneko, M; Kawai, K; Murono, K; Nishikawa, T; Nozawa, H; Otani, K; Sasaki, K; Shiratori, H; Sonoda, H; Tanaka, T, 2019) |
| "Temsirolimus (TEM) is a novel, water-soluble mammalian target of rapamycin (mTOR) inhibitor that has shown activity against a wide range of cancers in preclinical models, but its efficacy against colorectal cancer (CRC) has not been fully explored." | 3.80 | Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells. ( Emoto, S; Hiyoshi, M; Iida, Y; Kaneko, M; Kishikawa, J; Kitayama, J; Murono, K; Nirei, T; Nozawa, H; Sunami, E; Tada, N; Takahashi, K; Tsuno, NH; Watanabe, T, 2014) |
| "We observed that bortezomib-induced protective autophagy in cultured PANC-1 pancreatic cancer cells and HT-29 colorectal cancer cells." | 3.80 | Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells. ( Chen, ZR; Huang, M; Min, H; Xu, M; Zheng, K; Zhou, JD; Zou, XP, 2014) |
| " In the present study, we found that, in human colorectal cancer cells, low-dose camptothecin (CPT) simultaneously induced autophagy and premature senescence through AMPK-TSC2-mTOR pathway and ATM-Chk2-p53-p21 pathway respectively." | 3.80 | Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. ( Li, R; Liu, WT; Song, JR; Sun, K; Wei, LX; Wu, MC; Zhang, JW; Zhang, SS; Zhao, QD; Zong, C, 2014) |
| " Here, we aimed to investigate the role of CQ in potentiating the effect of 5-fluorouracil (5-FU), the chemotherapeutic agent of first choice for the treatment of colorectal cancer, in an animal model of colon cancer." | 3.78 | Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study. ( Hiyoshi, M; Hongo, K; Kaneko, M; Kawai, K; Kitayama, J; Murono, K; Nirei, T; Sasaki, K; Sunami, E; Tada, N; Takahashi, K; Tsuno, NH, 2012) |
| "Using as in vitro models the colorectal cancer cell lines HCT116, HT29, and CT26, and as triple-negative breast cancer models the 4T1, M-406, and MDA-MB-231 cell lines, we evaluated the effect of the drugs combination on the viability, apoptosis, clonogenicity, and cellular migratory capacity." | 1.91 | Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers. ( Anselmino, LE; Baglioni, MV; Menacho-Márquez, M; Reynoso, G; Rico, MJ; Rozados, VR; Scharovsky, OG, 2023) |
| "The regimens on colorectal cancer (CRC) are clinically limited due to the ignorance of tumor-supportive microenvironments." | 1.91 | Dual-targeting of artesunate and chloroquine to tumor cells and tumor-associated macrophages by a biomimetic PLGA nanoparticle for colorectal cancer treatment. ( Chen, Y; Du, Q; Gong, Z; Pan, D; Peng, J; Sun, R; Wang, Q; Zhou, J, 2023) |
| "Its role in tumorigenesis is more controversial and both the presence and the absence of autophagy have been implicated." | 1.42 | Autophagy is upregulated during colorectal carcinogenesis, and in DNA microsatellite stable carcinomas. ( Benincasa, M; Magnani, G; Mancini, S; Mariani, F; Palumbo, C; Pedroni, M; Roncucci, L; Sena, P, 2015) |
| "In this study, CSCs were isolated from colorectal cancer cells using PROM1/CD133 (prominin 1) expression, which is a surface marker commonly found on stem cells of various tissues." | 1.40 | Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. ( Chen, KC; Chen, MW; Hsiao, M; Hung, SC; Lin, SY; Lou, PJ; Shieh, MJ; Wei, MF; Yao, CJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (75.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anselmino, LE | 1 |
| Baglioni, MV | 1 |
| Reynoso, G | 1 |
| Rozados, VR | 1 |
| Scharovsky, OG | 1 |
| Rico, MJ | 1 |
| Menacho-Márquez, M | 1 |
| Peng, J | 1 |
| Zhou, J | 1 |
| Sun, R | 1 |
| Chen, Y | 2 |
| Pan, D | 1 |
| Wang, Q | 1 |
| Gong, Z | 1 |
| Du, Q | 1 |
| Wang, J | 1 |
| Liang, D | 1 |
| Zhang, XP | 1 |
| He, CF | 1 |
| Cao, L | 1 |
| Zhang, SQ | 1 |
| Xiao, X | 1 |
| Li, SJ | 1 |
| Cao, YX | 1 |
| Huang, XM | 1 |
| Huang, JJ | 1 |
| Du, JJ | 1 |
| Zhang, N | 1 |
| Long, Z | 1 |
| Yang, Y | 1 |
| Zhong, FF | 1 |
| Zheng, BW | 1 |
| Shen, YF | 1 |
| Huang, Z | 1 |
| Qin, X | 1 |
| Chen, JH | 1 |
| Lin, QY | 1 |
| Lin, WJ | 1 |
| Ma, WZ | 1 |
| Chen, J | 2 |
| Na, R | 1 |
| Xiao, C | 1 |
| Wang, X | 2 |
| Wang, Y | 3 |
| Yan, D | 1 |
| Song, G | 1 |
| Liu, X | 1 |
| Lu, H | 1 |
| Chen, C | 1 |
| Tang, H | 1 |
| Zhuang, G | 1 |
| Fan, G | 1 |
| Peng, Z | 1 |
| Mazouffre, C | 1 |
| Geyl, S | 1 |
| Perraud, A | 1 |
| Blondy, S | 1 |
| Jauberteau, MO | 1 |
| Mathonnet, M | 1 |
| Verdier, M | 1 |
| Huang, YH | 1 |
| Lei, J | 1 |
| Yi, GH | 1 |
| Huang, FY | 1 |
| Li, YN | 1 |
| Wang, CC | 1 |
| Sun, Y | 1 |
| Dai, HF | 1 |
| Tan, GH | 1 |
| Cheng, X | 1 |
| Feng, H | 1 |
| Wu, H | 1 |
| Jin, Z | 1 |
| Shen, X | 1 |
| Kuang, J | 1 |
| Huo, Z | 1 |
| Chen, X | 1 |
| Gao, H | 1 |
| Ye, F | 1 |
| Ji, X | 1 |
| Jing, X | 1 |
| Zhang, Y | 1 |
| Zhang, T | 1 |
| Qiu, W | 1 |
| Zhao, R | 1 |
| Zhu, B | 1 |
| Li, S | 1 |
| Yu, L | 1 |
| Hu, W | 1 |
| Sheng, D | 1 |
| Hou, J | 1 |
| Zhao, N | 1 |
| Hou, X | 1 |
| Wu, Y | 1 |
| Han, Z | 1 |
| Wei, L | 1 |
| Zhang, L | 1 |
| Shiratori, H | 1 |
| Kawai, K | 2 |
| Hata, K | 1 |
| Tanaka, T | 1 |
| Nishikawa, T | 1 |
| Otani, K | 1 |
| Sasaki, K | 2 |
| Kaneko, M | 3 |
| Murono, K | 3 |
| Emoto, S | 2 |
| Sonoda, H | 1 |
| Nozawa, H | 2 |
| Pan, H | 1 |
| Na, K | 1 |
| Wang, L | 1 |
| Li, Z | 1 |
| Guo, C | 1 |
| Guo, D | 1 |
| Hiyoshi, M | 2 |
| Tada, N | 2 |
| Nirei, T | 2 |
| Kishikawa, J | 1 |
| Iida, Y | 1 |
| Sunami, E | 2 |
| Tsuno, NH | 2 |
| Kitayama, J | 2 |
| Takahashi, K | 2 |
| Watanabe, T | 1 |
| Min, H | 1 |
| Xu, M | 1 |
| Chen, ZR | 1 |
| Zhou, JD | 1 |
| Huang, M | 1 |
| Zheng, K | 1 |
| Zou, XP | 1 |
| Zhang, JW | 1 |
| Zhang, SS | 1 |
| Song, JR | 1 |
| Sun, K | 1 |
| Zong, C | 1 |
| Zhao, QD | 1 |
| Liu, WT | 1 |
| Li, R | 1 |
| Wu, MC | 1 |
| Wei, LX | 1 |
| Wei, MF | 1 |
| Chen, MW | 1 |
| Chen, KC | 1 |
| Lou, PJ | 1 |
| Lin, SY | 1 |
| Hung, SC | 1 |
| Hsiao, M | 1 |
| Yao, CJ | 1 |
| Shieh, MJ | 1 |
| Sena, P | 1 |
| Mariani, F | 1 |
| Mancini, S | 1 |
| Benincasa, M | 1 |
| Magnani, G | 1 |
| Pedroni, M | 1 |
| Palumbo, C | 1 |
| Roncucci, L | 1 |
| Xiong, L | 1 |
| Liu, Z | 1 |
| Ouyang, G | 1 |
| Lin, L | 1 |
| Huang, H | 1 |
| Kang, H | 1 |
| Chen, W | 1 |
| Miao, X | 1 |
| Wen, Y | 1 |
| Chen, P | 1 |
| Luo, X | 1 |
| Nie, P | 1 |
| Wu, B | 1 |
| Xu, W | 1 |
| Shi, X | 1 |
| Chang, H | 1 |
| Li, B | 1 |
| Yu, X | 1 |
| Zou, Z | 1 |
| Hongo, K | 1 |
| Kauppila, JH | 1 |
| Karttunen, TJ | 1 |
| Saarnio, J | 1 |
| Nyberg, P | 1 |
| Salo, T | 1 |
| Graves, DE | 1 |
| Lehenkari, PP | 1 |
| Selander, KS | 1 |
20 other studies available for chloroquine and Colorectal Cancer
| Article | Year |
|---|---|
Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chloroquine; Colorectal Neoplasms; Humans; | 2023 |
Dual-targeting of artesunate and chloroquine to tumor cells and tumor-associated macrophages by a biomimetic PLGA nanoparticle for colorectal cancer treatment.
Topics: Animals; Artesunate; Biomimetics; Cell Line, Tumor; Chloroquine; Colorectal Neoplasms; Mice; Nanopar | 2023 |
Novel PI3K/Akt/mTOR signaling inhibitor, W922, prevents colorectal cancer growth via the regulation of autophagy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Chloroquine; Colorectal Neoplasm | 2021 |
Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin.
Topics: Animals; Antimetabolites; Autophagy; Cell Survival; Chloroquine; Colorectal Neoplasms; Deoxyglucose; | 2021 |
The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy.
Topics: Animals; Antimalarials; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Cell Line, Tumor; Cel | 2021 |
Dual inhibition of BDNF/TrkB and autophagy: a promising therapeutic approach for colorectal cancer.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Autopha | 2017 |
Coroglaucigenin induces senescence and autophagy in colorectal cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Products; Calotropis; Cardenolides; Cell Cycl | 2018 |
Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer.
Topics: Apoptosis; Autophagy; Cell Proliferation; Cell Survival; Chloroquine; Colorectal Neoplasms; Drug Res | 2018 |
Inhibition of Autophagy with Chloroquine Enhanced Sinoporphyrin Sodium Mediated Photodynamic Therapy-induced Apoptosis in Human Colorectal Cancer Cells.
Topics: Apoptosis; Blotting, Western; Chloroquine; Colorectal Neoplasms; Flow Cytometry; HCT116 Cells; Human | 2019 |
The combination of temsirolimus and chloroquine increases radiosensitivity in colorectal cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cel | 2019 |
Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagosomes; Autophagy; Cell Survival; Chloroquine; Co | 2019 |
Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Chloroquine; C | 2014 |
Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; | 2014 |
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Muta | 2014 |
Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells.
Topics: AC133 Antigen; Animals; Antigens, CD; Apoptosis; Autophagy; Carcinogenesis; Chloroquine; Colorectal | 2014 |
Autophagy is upregulated during colorectal carcinogenesis, and in DNA microsatellite stable carcinomas.
Topics: Apoptosis; Autophagy; Bevacizumab; Carcinogenesis; Chloroquine; Colorectal Neoplasms; Fluorouracil; | 2015 |
Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; A | 2017 |
CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk.
Topics: Animals; Apoptosis; Autophagy; Camptothecin; Cell Line, Tumor; Cell Survival; Chloroquine; Colorecta | 2017 |
Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; | 2012 |
Short DNA sequences and bacterial DNA induce esophageal, gastric, and colorectal cancer cell invasion.
Topics: Base Sequence; Caco-2 Cells; Chloroquine; Colorectal Neoplasms; Dipeptides; DNA, Bacterial; Enzyme A | 2013 |