chloroquine has been researched along with Cherry Red Spot Myoclonus Syndrome in 5 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine treatment of normal human fibroblasts had three effects: (a) greatly enhanced secretion of newly synthesized acid hydrolases bearing the recognition marker for uptake, (b) depletion of enzyme-binding sites from the cell surface, and (c) inhibition of pinocytosis of exogenous enzyme." | 1.26 | Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling. ( Gonzalez-Noriega, A; Grubb, JH; Sly, WS; Talkad, V, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kogot-Levin, A | 1 |
| Zeigler, M | 1 |
| Ornoy, A | 1 |
| Bach, G | 1 |
| Garvin, AJ | 1 |
| Lyubsky, S | 1 |
| Poore, CM | 1 |
| Gonzalez-Noriega, A | 1 |
| Grubb, JH | 1 |
| Talkad, V | 1 |
| Sly, WS | 1 |
| Goldin, E | 1 |
| Cooney, A | 1 |
| Kaneski, CR | 1 |
| Brady, RO | 1 |
| Schiffmann, R | 1 |
| Braulke, T | 1 |
| Tippmer, S | 1 |
| Matzner, U | 1 |
| Gartung, C | 1 |
| von Figura, K | 1 |
5 other studies available for chloroquine and Cherry Red Spot Myoclonus Syndrome
| Article | Year |
|---|---|
Mucolipidosis type IV: the effect of increased lysosomal pH on the abnormal lysosomal storage.
Topics: Antimalarials; Cells, Cultured; Chloroquine; Fibroblasts; Humans; Hydrogen-Ion Concentration; Ionoph | 2009 |
A cytochemical study of GERL in cultured human fibroblasts.
Topics: Acid Phosphatase; Ammonium Chloride; Cells, Cultured; Centrioles; Chloroquine; Fibroblasts; Golgi Ap | 1981 |
Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.
Topics: Ammonium Chloride; Chloroquine; Fibroblasts; Glucuronidase; Hexosaminidases; Humans; Hydrogen-Ion Co | 1980 |
Mucolipidosis IV consists of one complementation group.
Topics: Amines; Cell Fusion; Cell Survival; Chloroquine; Coloring Agents; Fibroblasts; Genetic Complementati | 1999 |
Mannose 6-phosphate/insulin-like growth factor II receptor in I-cell disease fibroblasts: increased synthesis and defective regulation of cell surface expression.
Topics: Blotting, Northern; Cell Line; Cell Membrane; Chloroquine; Gene Expression Regulation; Humans; Kinet | 1992 |