chloroquine has been researched along with Chemical and Drug Induced Liver Injury in 32 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-dose chloroquine therapy for porphyria cutanea tarda is rarely used now because of its hepatic side-effects." | 7.74 | Porphyria cutanea tarda: effects and risk factors for hepatotoxicity from high-dose chloroquine treatment. ( Olsson, R; Rossmann-Ringdahl, I, 2007) |
| "Amodiaquine (AQ), an effective antimalarial drug for uncomplicated malaria, has been greatly restricted after cases of life-threatening agranulocytosis and hepatic toxicity during prophylactic use." | 5.13 | Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania. ( Akida, JA; Bygbjerg, IC; Chile, MM; Kitua, AY; Lemnge, MM; Lusingu, JP; Makunde, R; Malebo, HM; Massaga, JJ; Rønn, AM; Theander, TG, 2008) |
| "High-dose chloroquine therapy for porphyria cutanea tarda is rarely used now because of its hepatic side-effects." | 3.74 | Porphyria cutanea tarda: effects and risk factors for hepatotoxicity from high-dose chloroquine treatment. ( Olsson, R; Rossmann-Ringdahl, I, 2007) |
| "Itching is a common side effect of epidermal growth factor receptor inhibitors." | 2.53 | Drug-Induced Itch Management. ( Ebata, T, 2016) |
| "All drugs used for malaria prophylaxis have common adverse effects, in addition to rare and/or severe adverse effects." | 2.41 | Safety evaluation of the drugs available to prevent malaria. ( Beer, MD; Cook, GC; Croft, AM; Whitehouse, DP, 2002) |
| "Amiodarone is a widely used antiarrhythmic drug that can cause the development of steatohepatitis as well as liver fibrosis and cirrhosis." | 1.56 | Autophagy alleviates amiodarone-induced hepatotoxicity. ( Bantel, H; Frangež, Ž; John, K; Liebig, S; Pfeffer, TJ; Schulze-Osthoff, K; Shibolet, O; Simon, HU; Veltmann, C; Vondran, F; Wandrer, F; Wedemeyer, H, 2020) |
| "Chloroquine (CQ) is a widely prescribed anti-malarial agent and is also prescribed to treat autoimmune diseases." | 1.38 | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity. ( Arai, H; Hagihara, Y; Kono, N; Rotzoll, DE; Shichiri, M; Shimanaka, Y; Tamai, H; Tanito, M; Yoshida, Y, 2012) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "A woman with mixed connective tissue disease who developed a reversible acute hepatitis shortly after the initiation of low-dose HCQ is presented." | 1.34 | Severe acute hepatitis related to hydroxychloroquine in a woman with mixed connective tissue disease. ( Esteban, MJ; Giner Galvañ, V; Oltra, MR; Redón, J; Rueda, D, 2007) |
| "Tetrahydrocurcumin (THC) is an antioxidative substance, which is derived from curcumin, the component of turmeric." | 1.33 | Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats. ( Amali, DR; Pari, L, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (21.88) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 9 (28.13) | 24.3611 |
| 2020's | 8 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 4 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 2 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 4 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Chen, Y | 4 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 2 |
| Hu, C | 1 |
| Le, TV | 1 |
| Dinh, NBT | 1 |
| Dang, MT | 1 |
| Phan, NCL | 1 |
| Dang, LTT | 1 |
| Grassi, G | 1 |
| Holterman, AXL | 1 |
| Le, HM | 1 |
| Truong, NH | 1 |
| Malek, MR | 1 |
| Ahmadian, S | 1 |
| Dehpour, AR | 1 |
| Ebrahim-Habibi, A | 1 |
| Shafizadeh, M | 1 |
| Kashani-Amin, E | 1 |
| Wandrer, F | 1 |
| Frangež, Ž | 1 |
| Liebig, S | 1 |
| John, K | 1 |
| Vondran, F | 1 |
| Wedemeyer, H | 1 |
| Veltmann, C | 1 |
| Pfeffer, TJ | 1 |
| Shibolet, O | 1 |
| Schulze-Osthoff, K | 1 |
| Simon, HU | 1 |
| Bantel, H | 1 |
| Norinder, U | 1 |
| Tuck, A | 1 |
| Norgren, K | 1 |
| Munic Kos, V | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
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| Lekashvili, O | 1 |
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| Huang, W | 1 |
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| Wu, M | 2 |
| Ma, Q | 1 |
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| Xue, F | 1 |
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5 reviews available for chloroquine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19.
Topics: Anti-Inflammatory Agents; Antiviral Agents; Arrhythmias, Cardiac; Azithromycin; Betacoronavirus; Che | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Drug-Induced Itch Management.
Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Analgesics, Opioid; Antimalarials; Antineoplasti | 2016 |
Safety evaluation of the drugs available to prevent malaria.
Topics: Adult; Animals; Antimalarials; Chemical and Drug Induced Liver Injury; Chloroquine; Humans; Malaria, | 2002 |
2 trials available for chloroquine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania.
Topics: Adolescent; Adult; Agranulocytosis; Amodiaquine; Analysis of Variance; Animals; Antimalarials; Chemi | 2008 |
26 other studies available for chloroquine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Effects of autophagy inhibition by chloroquine on hepatic stellate cell activation in CCl4-induced acute liver injury mouse model.
Topics: Animals; Autophagy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroquine; Disea | 2022 |
Investigating the role of endogenous opioid system in chloroquine-induced phospholipidosis in rat liver by morphological, biochemical and molecular modelling studies.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroquine; Disease Models, Animal; Fatty Liver; G | 2020 |
Autophagy alleviates amiodarone-induced hepatotoxicity.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Chem | 2020 |
SARS-CoV-2 and hepatitis.
Topics: Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Betacoronavirus; Chemical and D | 2020 |
Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.
Topics: Abdominal Pain; Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agent | 2020 |
Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Autophagy; Chemical and D | 2021 |
A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity.
Topics: Animals; Antimalarials; Carrier Proteins; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; | 2012 |
[Adverse drug reactions (ADRs) to antimalarial drugs. Analysis of spontaneous report from the French pharmacovigilance database (1996-2000)].
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Antimalarials; Chemic | 2003 |
[Toxic hepatitis caused by resochin].
Topics: Chemical and Drug Induced Liver Injury; Chloroquine; Hepatitis; Hepatitis A; Humans | 1960 |
EFFECTS OF CHLOROQUINE ON PATIENTS WITH CUTANEOUS PORPHYRIA OF THE "SYMPTOMATIC" TYPE.
Topics: Amino Acids; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chloroquine; Class | 1965 |
Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroquine; Curcuma; Curcumin; Female; Liver Disea | 2005 |
Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil.
Topics: Adverse Drug Reaction Reporting Systems; Antimalarials; Chemical and Drug Induced Liver Injury; Chlo | 2005 |
Severe acute hepatitis related to hydroxychloroquine in a woman with mixed connective tissue disease.
Topics: Acute Disease; Adult; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Chloroquine; Fem | 2007 |
Porphyria cutanea tarda: effects and risk factors for hepatotoxicity from high-dose chloroquine treatment.
Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Antimalarials; Chemical and Drug Induced Liver | 2007 |
[Granulomatous hepatitis attributed to the combination pyrimethamine-chloroquine].
Topics: Antimalarials; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Chloroquine; Drug Combination | 1996 |
[Studies on lysosomes in hepatic disorders (author's transl)].
Topics: Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Chloroquine; Glucuronidase; Hexos | 1979 |
Effects of chronic chloroquine treatment on lysosomes of rat liver cells.
Topics: Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Chloroquine; Cytoplasmic Granules | 1970 |
Biochemical effects of chloroquine therapy in porphyria cutanea tarda.
Topics: Ascites; Body Temperature; Chemical and Drug Induced Liver Injury; Chloroquine; Chromatography; Fece | 1970 |
[On the toxicity of chloroquine].
Topics: Animals; Blood Vessels; Chemical and Drug Induced Liver Injury; Chloroquine; Guinea Pigs; Kidney; Li | 1967 |
[Effect of various antirheumatics on the biosynthesis of collagen].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroquine; Collagen; Indomethacin; Male; Mice; Ra | 1968 |