chloroquine has been researched along with Cell Transformation, Neoplastic in 14 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53 tumor-suppressor pathway, preferentially enhances the death of Myc oncogene-overexpressing primary mouse B cells and mouse embryonic fibroblasts (MEFs) and impairs Myc-induced lymphomagenesis in a transgenic mouse model of human Burkitt lymphoma." | 3.74 | Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. ( Cleveland, JL; Dorsey, FC; Kastan, MB; Maclean, KH, 2008) |
| "A different murine erythroleukemia cell line which does not differentiate in response to EP was found to have only the lower affinity binding sites for the hormone." | 1.27 | Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells. ( Goldwasser, E; Krantz, SB; Sawyer, ST, 1987) |
| "The immunotoxin bound to all Burkitt's lymphoma cell lines that were tested but not to human peripheral blood T cells." | 1.27 | Immunotoxin-mediated elimination of clonogenic tumor cells in the presence of human bone marrow. ( Houston, LL; Ramakrishnan, S; Uckun, FM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Saini, H | 3 |
| Choudhary, M | 3 |
| Sharma, H | 3 |
| Chowdhury, S | 3 |
| Mukherjee, S | 3 |
| Chowdhury, R | 3 |
| Sun, K | 1 |
| Guo, XL | 1 |
| Zhao, QD | 1 |
| Jing, YY | 1 |
| Kou, XR | 1 |
| Xie, XQ | 1 |
| Zhou, Y | 1 |
| Cai, N | 1 |
| Gao, L | 1 |
| Zhao, X | 1 |
| Zhang, SS | 1 |
| Song, JR | 1 |
| Li, D | 1 |
| Deng, WJ | 1 |
| Li, R | 1 |
| Wu, MC | 1 |
| Wei, LX | 1 |
| Parkhitko, AA | 1 |
| Priolo, C | 1 |
| Coloff, JL | 1 |
| Yun, J | 1 |
| Wu, JJ | 1 |
| Mizumura, K | 1 |
| Xu, W | 1 |
| Malinowska, IA | 1 |
| Yu, J | 1 |
| Kwiatkowski, DJ | 1 |
| Locasale, JW | 1 |
| Asara, JM | 1 |
| Choi, AM | 1 |
| Finkel, T | 1 |
| Henske, EP | 1 |
| Margalef, P | 1 |
| Colomer, C | 1 |
| Villanueva, A | 1 |
| Montagut, C | 1 |
| Iglesias, M | 1 |
| Bellosillo, B | 1 |
| Salazar, R | 1 |
| Martínez-Iniesta, M | 1 |
| Bigas, A | 1 |
| Espinosa, L | 1 |
| Eng, CH | 1 |
| Wang, Z | 1 |
| Tkach, D | 1 |
| Toral-Barza, L | 1 |
| Ugwonali, S | 1 |
| Liu, S | 1 |
| Fitzgerald, SL | 1 |
| George, E | 1 |
| Frias, E | 1 |
| Cochran, N | 1 |
| De Jesus, R | 1 |
| McAllister, G | 1 |
| Hoffman, GR | 1 |
| Bray, K | 1 |
| Lemon, L | 1 |
| Lucas, J | 1 |
| Fantin, VR | 1 |
| Abraham, RT | 1 |
| Murphy, LO | 1 |
| Nyfeler, B | 1 |
| Ding, WX | 1 |
| Ni, HM | 1 |
| Gao, W | 1 |
| Chen, X | 1 |
| Kang, JH | 1 |
| Stolz, DB | 1 |
| Liu, J | 1 |
| Yin, XM | 1 |
| Dang, CV | 1 |
| Maclean, KH | 1 |
| Dorsey, FC | 1 |
| Cleveland, JL | 1 |
| Kastan, MB | 1 |
| Baldwin, D | 1 |
| Prince, M | 1 |
| Marshall, S | 1 |
| Davies, P | 1 |
| Olefsky, JM | 1 |
| Pear, WS | 1 |
| Nolan, GP | 1 |
| Scott, ML | 1 |
| Baltimore, D | 1 |
| Jiang, LW | 1 |
| Maher, VM | 1 |
| McCormick, JJ | 1 |
| Schindler, M | 1 |
| Wakshull, E | 1 |
| Kraemer, PM | 1 |
| Wharton, W | 1 |
| Sawyer, ST | 1 |
| Krantz, SB | 1 |
| Goldwasser, E | 1 |
| Uckun, FM | 1 |
| Ramakrishnan, S | 1 |
| Houston, LL | 1 |
14 other studies available for chloroquine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP.
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Transform | 2023 |
Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats.
Topics: Animals; Antioxidants; Autophagy; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation | 2013 |
Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
Topics: 6-Aminonicotinamide; Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; | 2014 |
BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neopla | 2015 |
Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy.
Topics: Antineoplastic Agents; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Cell Proliferation; | 2016 |
Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy.
Topics: Animals; Antimalarials; Apoptosis; Autophagy; Blotting, Western; Boronic Acids; Bortezomib; Cell Lin | 2009 |
Antimalarial therapy prevents Myc-induced lymphoma.
Topics: Animals; Antimalarials; Apoptosis; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Au | 2008 |
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
Topics: Animals; Antirheumatic Agents; Apoptosis; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Prote | 2008 |
Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway.
Topics: Cadaverine; Cell Transformation, Neoplastic; Cells, Cultured; Chloroquine; Endocytosis; Fibroblasts; | 1980 |
Production of high-titer helper-free retroviruses by transient transfection.
Topics: 3T3 Cells; Animals; beta-Galactosidase; Bone Marrow Transplantation; Cell Line; Cell Transformation, | 1993 |
Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chloroquine; Dextrans; Fibroblasts; Fluorescein | 1990 |
Multistep change in epidermal growth factor receptors during spontaneous neoplastic progression in Chinese hamster embryo fibroblasts.
Topics: Animals; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Chloroquine; Cricetinae; Cric | 1985 |
Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells.
Topics: Ammonium Chloride; Animals; Cell Line; Cell Transformation, Neoplastic; Chloroquine; Endocytosis; Er | 1987 |
Immunotoxin-mediated elimination of clonogenic tumor cells in the presence of human bone marrow.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Binding Sites, Antibody; Bone Marrow; Bone | 1985 |