chloroquine has been researched along with Cardiac Diseases in 23 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment." | 3.96 | Concentration-dependent mortality of chloroquine in overdose. ( Baud, FJ; Clemessy, JL; Hoglund, RM; Megarbane, B; Tarning, J; Watson, JA; White, NJ, 2020) |
| "Cardiotoxicity is a well-known side effect of chloroquine." | 3.91 | Revisiting the Cardiotoxic Effect of Chloroquine. ( Blignaut, M; Dhanabalan, K; Espach, Y; Huisamen, B; van Vuuren, M, 2019) |
| "Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up." | 2.41 | Cardiac damage from chronic use of chloroquine: a case report and review of the literature. ( Benvenuti, LA; Costa, R; Martinelli Filho, M; Nishióka, SA; Pedrosa, AA; Teixeira, RA, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (34.78) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 8 (34.78) | 2.80 |
| Authors | Studies |
|---|---|
| Vouri, SM | 1 |
| Thai, TN | 1 |
| Winterstein, AG | 1 |
| Kamp, TJ | 1 |
| Hamdan, MH | 1 |
| January, CT | 1 |
| Dos Reis Neto, ET | 1 |
| Kakehasi, AM | 1 |
| de Medeiros Pinheiro, M | 1 |
| Ferreira, GA | 1 |
| Marques, CDL | 1 |
| da Mota, LMH | 1 |
| Dos Santos Paiva, E | 1 |
| Pileggi, GCS | 1 |
| Sato, EI | 1 |
| Reis, APMG | 1 |
| Xavier, RM | 1 |
| Provenza, JR | 1 |
| Watson, JA | 1 |
| Tarning, J | 1 |
| Hoglund, RM | 1 |
| Baud, FJ | 1 |
| Megarbane, B | 1 |
| Clemessy, JL | 1 |
| White, NJ | 1 |
| Halm, MA | 1 |
| Choi, SW | 1 |
| Shin, JS | 1 |
| Park, SJ | 1 |
| Jung, E | 1 |
| Park, YG | 1 |
| Lee, J | 1 |
| Kim, SJ | 1 |
| Park, HJ | 1 |
| Lee, JH | 1 |
| Park, SM | 1 |
| Moon, SH | 1 |
| Ban, K | 1 |
| Go, YY | 1 |
| Alkasir, A | 1 |
| Lippmann, S | 1 |
| Jodłowski, PJ | 1 |
| Kurowski, G | 1 |
| Kuterasiński, Ł | 1 |
| Sitarz, M | 1 |
| Jeleń, P | 1 |
| Jaśkowska, J | 1 |
| Kołodziej, A | 1 |
| Pajdak, A | 1 |
| Majka, Z | 1 |
| Boguszewska-Czubara, A | 1 |
| Chatre, C | 1 |
| Roubille, F | 1 |
| Vernhet, H | 1 |
| Jorgensen, C | 1 |
| Pers, YM | 1 |
| Blignaut, M | 1 |
| Espach, Y | 1 |
| van Vuuren, M | 1 |
| Dhanabalan, K | 1 |
| Huisamen, B | 1 |
| Vereckei, A | 1 |
| Fazakas, A | 1 |
| Baló, T | 1 |
| Fekete, B | 1 |
| Molnár, MJ | 1 |
| Karádi, I | 1 |
| Maeda, H | 1 |
| Nagai, H | 1 |
| Takemura, G | 1 |
| Shintani-Ishida, K | 1 |
| Komatsu, M | 1 |
| Ogura, S | 1 |
| Aki, T | 1 |
| Shirai, M | 1 |
| Kuwahira, I | 1 |
| Yoshida, K | 1 |
| Teixeira, RA | 1 |
| Martinelli Filho, M | 1 |
| Benvenuti, LA | 1 |
| Costa, R | 1 |
| Pedrosa, AA | 1 |
| Nishióka, SA | 1 |
| THIODET, J | 1 |
| ARROYO, H | 1 |
| SULLI, G | 1 |
| VARRONE, F | 1 |
| KUBASTA, M | 1 |
| VYKYDAL, M | 1 |
| BLAHOS, J | 1 |
| ZMESKAL, A | 1 |
| GIKALOVOVA, I | 1 |
| Costedoat-Chalumeau, N | 1 |
| Hulot, JS | 1 |
| Amoura, Z | 1 |
| Delcourt, A | 1 |
| Maisonobe, T | 1 |
| Dorent, R | 1 |
| Bonnet, N | 1 |
| Sablé, R | 1 |
| Lechat, P | 1 |
| Wechsler, B | 2 |
| Piette, JC | 2 |
| Meeran, K | 1 |
| Jacobs, MG | 1 |
| Belghiti, J | 1 |
| Belghiti, D | 1 |
| Amedome, A | 1 |
| Durand, H | 1 |
| Guillevin, L | 1 |
| Chapelon, C | 1 |
| Bletry, O | 1 |
| Godeau, P | 1 |
| Moccetti, T | 1 |
| Pittman, FE | 1 |
| Pittman, JC | 1 |
| James, DG | 1 |
| Bailey, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Double-Blind Placebo-Controlled Trial on the Safety and Efficacy of Imatinib for Hospitalized Adults With COVID-19[NCT04394416] | Phase 3 | 204 participants (Anticipated) | Interventional | 2020-06-02 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for chloroquine and Cardiac Diseases
| Article | Year |
|---|---|
Chloroquine or Hydroxychloroquine for COVID-19: Is Cardiotoxicity a Concern?
Topics: Betacoronavirus; Cardiotoxicity; Chloroquine; Coronavirus Infections; COVID-19; Global Health; Heart | 2020 |
Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases.
Topics: Antimalarials; Antiphospholipid Syndrome; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; | 2020 |
COVID-19 and Antimalarial Drugs: Harms Outweigh Benefits.
Topics: Antimalarials; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; Heart Diseases; Hospi | 2020 |
Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature.
Topics: Antimalarials; Cardiotoxicity; Chloroquine; Dose-Response Relationship, Drug; Female; Heart Diseases | 2018 |
Cardiac damage from chronic use of chloroquine: a case report and review of the literature.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Female; Heart Diseases; Humans; Male; Midd | 2002 |
[EXTRAMALARIAL THERAPUETIC APPLICATIONS OF ANTIMALARIAL DRUGS. 1. CLINICAL UTILIZATIONS].
Topics: Amodiaquine; Antimalarials; Chloroquine; Collagen Diseases; Dermatology; Drug Utilization; Epilepsy; | 1963 |
Cardiomyopathy related to antimalarial therapy with illustrative case report.
Topics: Antimalarials; Chloroquine; Female; Heart Block; Heart Diseases; Heart Failure; Heart Transplantatio | 2007 |
16 other studies available for chloroquine and Cardiac Diseases
| Article | Year |
|---|---|
An evaluation of co-use of chloroquine or hydroxychloroquine plus azithromycin on cardiac outcomes: A pharmacoepidemiological study to inform use during the COVID19 pandemic.
Topics: Adolescent; Adult; Aged; Azithromycin; Chloroquine; Cohort Studies; COVID-19; COVID-19 Drug Treatmen | 2021 |
Concentration-dependent mortality of chloroquine in overdose.
Topics: Adult; Antimalarials; Biotransformation; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Dru | 2020 |
Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes.
Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antimalarials; Antiviral Agents; Chlorocebus aeth | 2020 |
COVID-19 and Cardiac Concerns for Psychiatric Patients.
Topics: Antidepressive Agents; Antiviral Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrioventricular | 2020 |
Cracking the Chloroquine Conundrum: The Application of Defective UiO-66 Metal-Organic Framework Materials to Prevent the Onset of Heart Defects-In Vivo and In Vitro.
Topics: Animals; Chloroquine; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Heart Diseases | 2021 |
Revisiting the Cardiotoxic Effect of Chloroquine.
Topics: Animals; Antimalarials; Cardiotoxicity; Cell Survival; Chloroquine; Dose-Response Relationship, Drug | 2019 |
Chloroquine cardiotoxicity mimicking connective tissue disease heart involvement.
Topics: Chloroquine; Connective Tissue Diseases; Diagnosis, Differential; Female; Heart; Heart Diseases; Hum | 2013 |
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.
Topics: Adenine; Animals; Autophagy; Chloroquine; Heart Diseases; Heart Failure; Hypoxia; Lysosomes; Male; M | 2013 |
[Kussmaul disease of a cardiac form. Incomplete action of nivaquine].
Topics: Chloroquine; Heart; Heart Diseases; Medical Records; Polyarteritis Nodosa | 1960 |
[ELECTROCARDIOGRAPHIC CHANGES DURING CHLOROQUINE TREATMENT].
Topics: Chloroquine; Electrocardiography; Heart Diseases; Humans; Toxicology | 1965 |
Chloroquine poisoning. Rapidly fatal without treatment.
Topics: Adult; Chloroquine; Diazepam; Drug Therapy, Combination; Epinephrine; Female; Heart Diseases; Humans | 1993 |
[Letter: Intoxication with chloroquine with cardiac disorders. Effect of isoprenaline].
Topics: Adolescent; Chloroquine; Heart Diseases; Humans; Hypotension; Isoproterenol; Male; Shock, Cardiogeni | 1975 |
Chloroquine cardiotoxicity.
Topics: Chloroquine; Heart Diseases; Humans; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic | 1987 |
[Cardiotoxic drugs].
Topics: Adult; Angina Pectoris; Anti-Bacterial Agents; Antipsychotic Agents; Chloroquine; Contraceptives, Or | 1973 |
Amebic liver abscess following metronidazole therapy for amebic colitis.
Topics: Adult; Chloroquine; Dysentery, Amebic; Emetine; Entamoeba histolytica; Follow-Up Studies; Heart Dise | 1974 |
Management of sarcoidosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Aminobenzoates; Calcium; Child; Chloroquine; Chronic | 1969 |