chloroquine has been researched along with Carcinoma, Pancreatic Ductal in 11 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Approaches to improve pancreatic cancer therapy are essential as this disease has a very bleak outcome." | 1.91 | Effects of chloroquine and hydroxychloroquine on the sensitivity of pancreatic cancer cells to targeted therapies. ( Abrams, SL; Cervello, M; Follo, MY; Manzoli, L; Martelli, AM; McCubrey, JA; Ratti, S, 2023) |
| "Pterostilbene is a stilbenoid chemically related to resveratrol, and has potential for the treatment of cancers." | 1.62 | Chloroquine Potentiates the Anticancer Effect of Pterostilbene on Pancreatic Cancer by Inhibiting Autophagy and Downregulating the RAGE/STAT3 Pathway. ( Chen, RJ; Chen, YY; Ho, YS; Lee, YC; Lyu, YJ; Pan, MH; Wang, YJ, 2021) |
| "Here we show that pancreatic cancers have a distinct dependence on autophagy." | 1.37 | Pancreatic cancers require autophagy for tumor growth. ( Bardeesy, N; Bause, A; Contino, G; Dell'antonio, G; Doglioni, C; Haigis, M; Kimmelman, AC; Li, Y; Liesa, M; Mautner, J; Sahin, E; Shirihai, OS; Stommel, JM; Tonon, G; Wang, X; Yang, S; Ying, H, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 6 (54.55) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, RJ | 1 |
| Lyu, YJ | 1 |
| Chen, YY | 1 |
| Lee, YC | 1 |
| Pan, MH | 1 |
| Ho, YS | 1 |
| Wang, YJ | 1 |
| Stalnecker, CA | 1 |
| Coleman, MF | 1 |
| Bryant, KL | 1 |
| McCubrey, JA | 1 |
| Abrams, SL | 1 |
| Follo, MY | 1 |
| Manzoli, L | 1 |
| Ratti, S | 1 |
| Martelli, AM | 1 |
| Cervello, M | 1 |
| Silvis, MR | 1 |
| Silva, D | 1 |
| Rohweder, R | 1 |
| Schuman, S | 1 |
| Gudipaty, S | 1 |
| Truong, A | 1 |
| Yap, J | 1 |
| Affolter, K | 1 |
| McMahon, M | 1 |
| Kinsey, C | 1 |
| Pan, H | 1 |
| Zhu, S | 1 |
| Gong, T | 1 |
| Wu, D | 1 |
| Zhao, Y | 1 |
| Yan, J | 1 |
| Dai, C | 1 |
| Huang, Y | 1 |
| Yang, Y | 1 |
| Guo, Y | 1 |
| Yamamoto, K | 1 |
| Venida, A | 1 |
| Yano, J | 1 |
| Biancur, DE | 1 |
| Kakiuchi, M | 1 |
| Gupta, S | 1 |
| Sohn, ASW | 1 |
| Mukhopadhyay, S | 1 |
| Lin, EY | 1 |
| Parker, SJ | 1 |
| Banh, RS | 1 |
| Paulo, JA | 1 |
| Wen, KW | 1 |
| Debnath, J | 1 |
| Kim, GE | 1 |
| Mancias, JD | 1 |
| Fearon, DT | 1 |
| Perera, RM | 1 |
| Kimmelman, AC | 3 |
| Elliott, IA | 1 |
| Dann, AM | 1 |
| Xu, S | 1 |
| Kim, SS | 1 |
| Abt, ER | 1 |
| Kim, W | 1 |
| Poddar, S | 1 |
| Moore, A | 1 |
| Zhou, L | 1 |
| Williams, JL | 1 |
| Capri, JR | 1 |
| Ghukasyan, R | 1 |
| Matsumura, C | 1 |
| Tucker, DA | 1 |
| Armstrong, WR | 1 |
| Cabebe, AE | 1 |
| Wu, N | 1 |
| Li, L | 1 |
| Le, TM | 1 |
| Radu, CG | 1 |
| Donahue, TR | 1 |
| Yan, Z | 1 |
| Ohuchida, K | 1 |
| Fei, S | 1 |
| Zheng, B | 1 |
| Guan, W | 1 |
| Feng, H | 1 |
| Kibe, S | 1 |
| Ando, Y | 1 |
| Koikawa, K | 1 |
| Abe, T | 1 |
| Iwamoto, C | 1 |
| Shindo, K | 1 |
| Moriyama, T | 1 |
| Nakata, K | 1 |
| Miyasaka, Y | 1 |
| Ohtsuka, T | 1 |
| Mizumoto, K | 1 |
| Hashizume, M | 1 |
| Nakamura, M | 1 |
| Balic, A | 1 |
| Sørensen, MD | 1 |
| Trabulo, SM | 1 |
| Sainz, B | 1 |
| Cioffi, M | 1 |
| Vieira, CR | 1 |
| Miranda-Lorenzo, I | 1 |
| Hidalgo, M | 1 |
| Kleeff, J | 1 |
| Erkan, M | 1 |
| Heeschen, C | 1 |
| Yang, S | 2 |
| Wang, X | 1 |
| Contino, G | 1 |
| Liesa, M | 1 |
| Sahin, E | 1 |
| Ying, H | 1 |
| Bause, A | 1 |
| Li, Y | 1 |
| Stommel, JM | 1 |
| Dell'antonio, G | 1 |
| Mautner, J | 1 |
| Tonon, G | 1 |
| Haigis, M | 1 |
| Shirihai, OS | 1 |
| Doglioni, C | 1 |
| Bardeesy, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Open-label, ExploRatory Platform Trial to EValuate ImmunOtherapy Combinations With Chemotherapy for the Treatment of Patients With PreviousLy UnTreated MetastatIc Pancreatic AdenOcarciNoma (REVOLUTION)[NCT04787991] | Phase 1 | 45 participants (Anticipated) | Interventional | 2021-08-09 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for chloroquine and Carcinoma, Pancreatic Ductal
| Article | Year |
|---|---|
Chloroquine Potentiates the Anticancer Effect of Pterostilbene on Pancreatic Cancer by Inhibiting Autophagy and Downregulating the RAGE/STAT3 Pathway.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Autophagy; Carcinoma, Pancreatic Ductal; Cell Proliferati | 2021 |
Susceptibility to autophagy inhibition is enhanced by dual IGF1R and MAPK/ERK inhibition in pancreatic cancer.
Topics: Autophagy; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Chloroquine; Humans; Pancreatic Neoplasms | 2022 |
Effects of chloroquine and hydroxychloroquine on the sensitivity of pancreatic cancer cells to targeted therapies.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Chloroquine; Hydroxychloroquine; Mice; Mito | 2023 |
MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition.
Topics: Carcinoma, Pancreatic Ductal; Chloroquine; Cyclin-Dependent Kinase 4; Humans; Hydroxychloroquine; Ly | 2023 |
Matrix stiffness triggers chemoresistance through elevated autophagy in pancreatic ductal adenocarcinoma.
Topics: Autophagy; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Chloroquine; Deoxycyt | 2023 |
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
Topics: Adenocarcinoma; Animals; Antigen Presentation; Autophagy; Carcinoma, Pancreatic Ductal; CD8-Positive | 2020 |
Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion.
Topics: Animals; Aspartic Acid; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Chloroquine; Female; Humans; | 2019 |
Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.
Topics: Animals; Autophagy; Carcinoma, Pancreatic Ductal; Cell Communication; Cell Line, Tumor; Cell Movemen | 2019 |
Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling.
Topics: Animals; Autophagy; Carcinoma, Pancreatic Ductal; Cell Movement; Cell Proliferation; Chloroquine; He | 2014 |
Pancreatic cancers require autophagy for tumor growth.
Topics: Animals; Antineoplastic Agents; Autophagy; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Chloroqui | 2011 |
A critical role for autophagy in pancreatic cancer.
Topics: Animals; Autophagy; Carcinoma, Pancreatic Ductal; Chloroquine; Humans; Models, Biological; Pancreati | 2011 |