chloroquine has been researched along with Carcinoma, Anaplastic in 19 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As an autophagy inhibitor, chloroquine (CQ) showed anti-tumor effect on several types of cancer and paclitaxel (PTX) is widely used in the treatment of esophageal carcinoma patients, but chemoresistance remains a major hurdle for PTX application due to the cytoprotective autophagy." | 8.31 | Chloroquine Sensitizes Esophageal Carcinoma EC109 Cells to Paclitaxel by Inhibiting Autophagy. ( Cai, J; Cai, Y; Du, Q; Guo, X; Ma, Q; Xu, L; Yuan, Z; Zhong, X, 2023) |
| "We investigated the effect of chloroquine, a known inhibitor of autophagy, on sensitization against radiation-induced apoptosis in a panel of five nasopharyngeal carcinoma cell lines and a SV40-transformed nasoepithelial cell line." | 7.83 | Chloroquine Sensitizes Nasopharyngeal Carcinoma Cells but Not Nasoepithelial Cells to Irradiation by Blocking Autophagy. ( Eble, M; Hoß, M; Kontny, U; Makowska, A; Prescher, K, 2016) |
| "A rat medullary thyroid carcinoma cell line, CA-77, was shown to express the cholecystokinin (CCK) gene." | 7.68 | Expression and processing of procholecystokinin in a rat medullary thyroid carcinoma cell line. ( Odum, L; Rehfeld, JF, 1990) |
| "Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug." | 5.91 | Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023) |
| "As an autophagy inhibitor, chloroquine (CQ) showed anti-tumor effect on several types of cancer and paclitaxel (PTX) is widely used in the treatment of esophageal carcinoma patients, but chemoresistance remains a major hurdle for PTX application due to the cytoprotective autophagy." | 4.31 | Chloroquine Sensitizes Esophageal Carcinoma EC109 Cells to Paclitaxel by Inhibiting Autophagy. ( Cai, J; Cai, Y; Du, Q; Guo, X; Ma, Q; Xu, L; Yuan, Z; Zhong, X, 2023) |
| "We investigated the effect of chloroquine, a known inhibitor of autophagy, on sensitization against radiation-induced apoptosis in a panel of five nasopharyngeal carcinoma cell lines and a SV40-transformed nasoepithelial cell line." | 3.83 | Chloroquine Sensitizes Nasopharyngeal Carcinoma Cells but Not Nasoepithelial Cells to Irradiation by Blocking Autophagy. ( Eble, M; Hoß, M; Kontny, U; Makowska, A; Prescher, K, 2016) |
| "The present study investigated the effect of valproic acid (VPA) on the inhibition of RET signaling and induction of apoptosis in human thyroid carcinoma cells." | 3.81 | Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA). ( Dong, JD; Xu, D; Xu, Y; Ye, B; Zhang, Y; Zhang, YL; Zhu, SJ, 2015) |
| "A rat medullary thyroid carcinoma cell line, CA-77, was shown to express the cholecystokinin (CCK) gene." | 3.68 | Expression and processing of procholecystokinin in a rat medullary thyroid carcinoma cell line. ( Odum, L; Rehfeld, JF, 1990) |
| "Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug." | 1.91 | Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuno, Y | 1 |
| Deguchi, J | 1 |
| Hirasawa, Y | 1 |
| Ohyama, K | 1 |
| Toyoda, H | 1 |
| Hirobe, C | 1 |
| Ekasari, W | 1 |
| Widyawaruyanti, A | 1 |
| Zaini, NC | 1 |
| Morita, H | 1 |
| Kang, C | 2 |
| Ju, S | 2 |
| Kim, J | 2 |
| Jung, Y | 2 |
| Yuan, Z | 1 |
| Cai, J | 1 |
| Du, Q | 1 |
| Ma, Q | 1 |
| Xu, L | 1 |
| Cai, Y | 1 |
| Zhong, X | 1 |
| Guo, X | 1 |
| Xiong, R | 1 |
| Shao, D | 1 |
| Do, S | 1 |
| Chan, WK | 1 |
| Zhou, ZR | 1 |
| Zhu, XD | 1 |
| Zhao, W | 1 |
| Qu, S | 1 |
| Su, F | 1 |
| Huang, ST | 1 |
| Ma, JL | 1 |
| Li, XY | 1 |
| Shteingauz, A | 1 |
| Boyango, I | 1 |
| Naroditsky, I | 1 |
| Hammond, E | 1 |
| Gruber, M | 1 |
| Doweck, I | 1 |
| Ilan, N | 1 |
| Vlodavsky, I | 1 |
| Xu, Y | 1 |
| Xu, D | 1 |
| Zhu, SJ | 1 |
| Ye, B | 1 |
| Dong, JD | 1 |
| Zhang, YL | 1 |
| Zhang, Y | 1 |
| Makowska, A | 1 |
| Eble, M | 1 |
| Prescher, K | 1 |
| Hoß, M | 1 |
| Kontny, U | 1 |
| Carew, JS | 1 |
| Medina, EC | 1 |
| Esquivel, JA | 1 |
| Mahalingam, D | 1 |
| Swords, R | 1 |
| Kelly, K | 1 |
| Zhang, H | 1 |
| Huang, P | 1 |
| Mita, AC | 1 |
| Mita, MM | 1 |
| Giles, FJ | 1 |
| Nawrocki, ST | 1 |
| Wilson, EN | 1 |
| Bristol, ML | 1 |
| Di, X | 1 |
| Maltese, WA | 1 |
| Koterba, K | 1 |
| Beckman, MJ | 1 |
| Gewirtz, DA | 1 |
| Kandala, PK | 1 |
| Srivastava, SK | 1 |
| Pelisek, J | 1 |
| Gaedtke, L | 1 |
| DeRouchey, J | 1 |
| Walker, GF | 1 |
| Nikol, S | 1 |
| Wagner, E | 1 |
| Seth, P | 2 |
| Fitzgerald, DJ | 1 |
| Willingham, MC | 2 |
| Pastan, I | 2 |
| Kim, H | 1 |
| Barroso, M | 1 |
| Samanta, R | 1 |
| Greenberger, L | 1 |
| Sztul, E | 1 |
| Odum, L | 1 |
| Rehfeld, JF | 1 |
| Peters, M | 1 |
| Frenzel, H | 1 |
| Kade, H | 1 |
| Poste, G | 1 |
| Kowalewski, K | 1 |
19 other studies available for chloroquine and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida.
Topics: Animals; Antimalarials; Carcinoma; Cell Line, Tumor; Chemistry, Pharmaceutical; Colonic Neoplasms; D | 2008 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine Sensitizes Esophageal Carcinoma EC109 Cells to Paclitaxel by Inhibiting Autophagy.
Topics: Apoptosis; Autophagy; Carcinoma; Cell Line, Tumor; Cell Proliferation; Chloroquine; Esophageal Neopl | 2023 |
Activation of Chaperone-Mediated Autophagy Inhibits the Aryl Hydrocarbon Receptor Function by Degrading This Receptor in Human Lung Epithelial Carcinoma A549 Cells.
Topics: A549 Cells; Autophagy; Carcinoma; Chaperone-Mediated Autophagy; Chloroquine; Humans; Ligands; Lung; | 2023 |
Poly(ADP-ribose) polymerase-1 regulates the mechanism of irradiation-induced CNE-2 human nasopharyngeal carcinoma cell autophagy and inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Benzamides; Carcinoma; Cell Line, Tumor; Cell Survival; | 2013 |
Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy.
Topics: Amino Acids; Animals; Antineoplastic Agents; Autophagy; Carcinoma; Cell Division; Cell Line, Tumor; | 2015 |
Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA).
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma; Cell Line, Tumor; Cell Proliferation; Chloro | 2015 |
Chloroquine Sensitizes Nasopharyngeal Carcinoma Cells but Not Nasoepithelial Cells to Irradiation by Blocking Autophagy.
Topics: Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Autophagy-Related Pr | 2016 |
Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Boronic Acids; Bortezomib; Carcinoma; Cell Lin | 2010 |
A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D.
Topics: Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Breast Neoplasms; Carcinoma; Ce | 2011 |
Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinase Kinases; Autophagy; Autophagy-Rel | 2012 |
Optimized lipopolyplex formulations for gene transfer to human colon carcinoma cells under in vitro conditions.
Topics: Carcinoma; Chloroquine; Colonic Neoplasms; Deoxyribonuclease I; Gene Transfer Techniques; Genetic Ve | 2006 |
Role of a low-pH environment in adenovirus enhancement of the toxicity of a Pseudomonas exotoxin-epidermal growth factor conjugate.
Topics: Adenoviruses, Human; Amines; Ammonium Chloride; Carcinoma; Cell Line; Chloroquine; Drug Synergism; E | 1984 |
Adenovirus-dependent release of 51Cr from KB cells at an acidic pH.
Topics: Adenoviruses, Human; ADP Ribose Transferases; Bacterial Toxins; Carcinoma; Cell Transformation, Vira | 1984 |
Experimentally induced changes in the endocytic traffic of P-glycoprotein alter drug resistance of cancer cells.
Topics: Adaptor Protein Complex alpha Subunits; Adaptor Proteins, Vesicular Transport; Antibodies; ATP Bindi | 1997 |
Expression and processing of procholecystokinin in a rat medullary thyroid carcinoma cell line.
Topics: Animals; Carcinoma; Chloroquine; Cholecystokinin; Chromatography, Gel; Colchicine; Dexamethasone; Ge | 1990 |
[Therapy of infections with clonorchis sinensis (author's transl)].
Topics: Adult; Anthelmintics; Benzenesulfonates; Carcinoma; Chloroquine; Clonorchiasis; Clonorchis sinensis; | 1973 |
Sub-lethal autolysis. Modification of cell periphery by lysosomal enzymes.
Topics: Acid Phosphatase; Animals; Autolysis; Carcinoma; Cell Line; Cell Membrane; Chloroquine; Complement S | 1971 |
Effect of chloroquine on tissue hydroxyproline and hexosamine in mice bearing Bashford carcinoma.
Topics: Animals; Carcinoma; Chloroquine; Hexosamines; Hydroxyproline; Male; Mice; Neoplasms, Connective Tiss | 1967 |