chloroquine has been researched along with Cancer of Ovary in 22 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested a panel of 28 epithelial ovarian cancer (EOC) cell lines with itraconazole to define its spectrum of activity." | 5.72 | Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer. ( Bowering, V; Bruce, JP; Cabanero, M; Chen, EX; Colombo, I; Dhani, NC; Garg, S; Gill, S; Joshua, AM; Ketela, T; Koritzinsky, M; Lheureux, S; Li, X; Li, ZJ; Madariaga, A; Mandilaras, V; Marastoni, S; Nair, SN; Oza, AM; Pesic, A; Pintilie, M; Rottapel, R; Shalev, Z; Wang, L; Wouters, BG; Zhang, W, 2022) |
| "Metastatic ovarian cancer spheroids exhibit cancer stem like properties and undergo a metabolic reprogramming when they disseminate from the primary tumor." | 1.72 | Metabolic Reprogramming and Lipophagy Mediates Survival of Ascites Derived Metastatic Ovarian Cancer Cells. ( Devaraj, VR; Gawari, R; N Swamy, S; Pallavi, VR; Premalatha, CS; S, SK; Sagar, BC; Shinde, DD, 2022) |
| "We tested a panel of 28 epithelial ovarian cancer (EOC) cell lines with itraconazole to define its spectrum of activity." | 1.72 | Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer. ( Bowering, V; Bruce, JP; Cabanero, M; Chen, EX; Colombo, I; Dhani, NC; Garg, S; Gill, S; Joshua, AM; Ketela, T; Koritzinsky, M; Lheureux, S; Li, X; Li, ZJ; Madariaga, A; Mandilaras, V; Marastoni, S; Nair, SN; Oza, AM; Pesic, A; Pintilie, M; Rottapel, R; Shalev, Z; Wang, L; Wouters, BG; Zhang, W, 2022) |
| "LBH and CQ inhibited ovarian cancer cell proliferation and induced apoptosis, and a strong synergistic effect was observed when combined." | 1.62 | Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair. ( González-Sarmiento, R; Herrero, AB; Ovejero-Sánchez, M, 2021) |
| "Treatment with olaparib increased phosphorylation of ATM and PTEN while decreasing the phosphorylation of AKT and mTOR and inducing autophagy." | 1.56 | Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. ( Amaravadi, RK; Bast, RC; Becker, SE; Heinzen, EP; Hou, X; Llombart-Cussac, A; Lu, Z; Matias-Guiu, X; Maurer, MJ; Oberg, AL; Pang, L; Poveda, A; Rask, P; Romero, I; Rubio, MJ; Santacana, M; Santiago-O'Farrill, JM; Weroha, SJ, 2020) |
| "Overexpression of PBK decreased ovarian cancer responsiveness to cisplatin treatment through inducing autophagy in vivo." | 1.51 | PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma. ( Gao, M; Kong, B; Li, R; Li, Y; Ma, H; Qi, G; Wang, X; Wu, H; Yan, S; Yang, N; Yuan, C, 2019) |
| " Lastly, doses of proteasome inhibitors that are inadequate to block the activity of the proteasomes, caused cell death when combined with mifepristone; this phenotype was accompanied by accumulation of poly-ubiquitinated proteins denoting proteasome inhibition." | 1.43 | Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors. ( Callegari, EA; Chien, J; Drappeau, DD; Eyster, KM; Gamarra-Luques, CD; Goyeneche, AA; Hapon, MB; Knapp, JR; Pan, B; Srinivasan, R; Telleria, CM; Terpstra, EJ; Wang, X; Zhang, L, 2016) |
| "In this study, ARHI-induced ovarian cancer cell death in culture has been found to depend upon autophagy and has been linked to G1 cell-cycle arrest, enhanced reactive oxygen species (ROS) activity, RIP1/RIP3 activation and necrosis." | 1.42 | ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts. ( Atkinson, N; Bast, RC; Liao, W; Lu, Z; Mao, W; Millward, S; Ornelas, A; Orozco, AF; Suh, G; Sutton, MN; Wang, Y; Washington, MN; Yang, H, 2015) |
| "Clinically, from the largest ovarian cancer data set (GSE 9899, n = 285) available in GEO, high levels of expression of both PTP4A3 and autophagy genes significantly predict poor prognosis of ovarian cancer patients." | 1.40 | A role of autophagy in PTP4A3-driven cancer progression. ( Al-Aidaroos, AQ; Gupta, A; Huang, YH; Lin, YB; McCrudden, CM; Murray, JT; Rozycka, E; Shen, HM; Tergaonkar, V; Thiery, JP; Yuen, HF; Zeng, Q; Zhang, SD, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 11 (50.00) | 24.3611 |
| 2020's | 7 (31.82) | 2.80 |
| Authors | Studies |
|---|---|
| S, SK | 1 |
| N Swamy, S | 1 |
| Devaraj, VR | 1 |
| Premalatha, CS | 1 |
| Pallavi, VR | 1 |
| Sagar, BC | 1 |
| Shinde, DD | 1 |
| Gawari, R | 1 |
| Ovejero-Sánchez, M | 2 |
| Rubio-Heras, J | 1 |
| Vicente de la Peña, MDC | 1 |
| San-Segundo, L | 1 |
| Pérez-Losada, J | 1 |
| González-Sarmiento, R | 2 |
| Herrero, AB | 2 |
| Marastoni, S | 1 |
| Madariaga, A | 1 |
| Pesic, A | 1 |
| Nair, SN | 1 |
| Li, ZJ | 1 |
| Shalev, Z | 1 |
| Ketela, T | 1 |
| Colombo, I | 1 |
| Mandilaras, V | 1 |
| Cabanero, M | 1 |
| Bruce, JP | 1 |
| Li, X | 1 |
| Garg, S | 1 |
| Wang, L | 1 |
| Chen, EX | 1 |
| Gill, S | 1 |
| Dhani, NC | 1 |
| Zhang, W | 2 |
| Pintilie, M | 1 |
| Bowering, V | 1 |
| Koritzinsky, M | 1 |
| Rottapel, R | 1 |
| Wouters, BG | 1 |
| Oza, AM | 1 |
| Joshua, AM | 1 |
| Lheureux, S | 1 |
| Santiago-O'Farrill, JM | 1 |
| Weroha, SJ | 1 |
| Hou, X | 1 |
| Oberg, AL | 1 |
| Heinzen, EP | 1 |
| Maurer, MJ | 1 |
| Pang, L | 1 |
| Rask, P | 1 |
| Amaravadi, RK | 2 |
| Becker, SE | 1 |
| Romero, I | 1 |
| Rubio, MJ | 1 |
| Matias-Guiu, X | 1 |
| Santacana, M | 1 |
| Llombart-Cussac, A | 1 |
| Poveda, A | 1 |
| Lu, Z | 3 |
| Bast, RC | 3 |
| Zhang, D | 1 |
| Reyes, RM | 1 |
| Osta, E | 1 |
| Kari, S | 1 |
| Gupta, HB | 1 |
| Padron, AS | 1 |
| Kornepati, AVR | 1 |
| Kancharla, A | 1 |
| Sun, X | 1 |
| Deng, Y | 1 |
| Wu, B | 1 |
| Vadlamudi, R | 1 |
| Li, R | 2 |
| Svatek, RS | 1 |
| Curiel, TJ | 1 |
| Pan, Y | 1 |
| Zhou, J | 1 |
| Yan, L | 1 |
| Lu, M | 1 |
| Dai, Y | 1 |
| Zhou, H | 1 |
| Zhang, S | 1 |
| Yang, J | 1 |
| Shao, M | 1 |
| Zhu, W | 1 |
| Lv, X | 1 |
| Yang, Q | 1 |
| Liu, X | 1 |
| Xie, Y | 1 |
| Tang, P | 1 |
| Sun, L | 1 |
| Ma, H | 1 |
| Li, Y | 1 |
| Wang, X | 2 |
| Wu, H | 2 |
| Qi, G | 1 |
| Yang, N | 1 |
| Gao, M | 1 |
| Yan, S | 1 |
| Yuan, C | 1 |
| Kong, B | 1 |
| Correa, RJ | 1 |
| Valdes, YR | 1 |
| Peart, TM | 1 |
| Fazio, EN | 1 |
| Bertrand, M | 1 |
| McGee, J | 1 |
| Préfontaine, M | 1 |
| Sugimoto, A | 1 |
| DiMattia, GE | 1 |
| Shepherd, TG | 1 |
| Huang, YH | 1 |
| Al-Aidaroos, AQ | 1 |
| Yuen, HF | 1 |
| Zhang, SD | 1 |
| Shen, HM | 1 |
| Rozycka, E | 1 |
| McCrudden, CM | 1 |
| Tergaonkar, V | 1 |
| Gupta, A | 1 |
| Lin, YB | 1 |
| Thiery, JP | 1 |
| Murray, JT | 1 |
| Zeng, Q | 1 |
| Lang, F | 1 |
| Qin, Z | 1 |
| Li, F | 1 |
| Zhang, H | 1 |
| Fang, Z | 1 |
| Hao, E | 1 |
| Washington, MN | 1 |
| Suh, G | 1 |
| Orozco, AF | 1 |
| Sutton, MN | 1 |
| Yang, H | 1 |
| Wang, Y | 1 |
| Mao, W | 1 |
| Millward, S | 1 |
| Ornelas, A | 1 |
| Atkinson, N | 1 |
| Liao, W | 1 |
| Zhang, L | 2 |
| Hapon, MB | 1 |
| Goyeneche, AA | 1 |
| Srinivasan, R | 1 |
| Gamarra-Luques, CD | 1 |
| Callegari, EA | 1 |
| Drappeau, DD | 1 |
| Terpstra, EJ | 1 |
| Pan, B | 1 |
| Knapp, JR | 1 |
| Chien, J | 1 |
| Eyster, KM | 1 |
| Telleria, CM | 1 |
| Wang, YF | 1 |
| Xu, YL | 1 |
| Tang, ZH | 1 |
| Li, T | 1 |
| Zhang, LL | 1 |
| Chen, X | 1 |
| Lu, JH | 1 |
| Leung, CH | 1 |
| Ma, DL | 1 |
| Qiang, WA | 1 |
| Wang, YT | 1 |
| Lu, JJ | 1 |
| Serikawa, T | 1 |
| Kikuchi, H | 1 |
| Oite, T | 1 |
| Tanaka, K | 1 |
| Luo, RZ | 1 |
| Lu, Y | 1 |
| Zhang, X | 1 |
| Yu, Q | 1 |
| Khare, S | 1 |
| Kondo, S | 1 |
| Kondo, Y | 1 |
| Yu, Y | 1 |
| Mills, GB | 1 |
| Liao, WS | 1 |
| Zhang, Y | 1 |
| Cheng, Y | 1 |
| Ren, X | 1 |
| Yap, KL | 1 |
| Patel, R | 1 |
| Liu, D | 1 |
| Qin, ZH | 1 |
| Shih, IM | 1 |
| Yang, JM | 1 |
| Adar, Y | 1 |
| Stark, M | 1 |
| Bram, EE | 1 |
| Nowak-Sliwinska, P | 1 |
| van den Bergh, H | 1 |
| Szewczyk, G | 1 |
| Sarna, T | 1 |
| Skladanowski, A | 1 |
| Griffioen, AW | 1 |
| Assaraf, YG | 1 |
| Kandala, PK | 1 |
| Srivastava, SK | 1 |
| Peoples, GE | 1 |
| Goedegebuure, PS | 1 |
| Andrews, JV | 1 |
| Schoof, DD | 1 |
| Eberlein, TJ | 1 |
22 other studies available for chloroquine and Cancer of Ovary
| Article | Year |
|---|---|
Metabolic Reprogramming and Lipophagy Mediates Survival of Ascites Derived Metastatic Ovarian Cancer Cells.
Topics: Ascites; Autophagy; Chloroquine; Female; Genital Neoplasms, Male; Humans; Lipids; Male; Ovarian Neop | 2022 |
Chloroquine-Induced DNA Damage Synergizes with Nonhomologous End Joining Inhibition to Cause Ovarian Cancer Cell Cytotoxicity.
Topics: Carcinoma, Ovarian Epithelial; Chloroquine; DNA Breaks, Double-Stranded; DNA Damage; DNA End-Joining | 2022 |
Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer.
Topics: Antifungal Agents; Antineoplastic Agents; Carcinoma, Ovarian Epithelial; Chloroquine; Drug Repositio | 2022 |
Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Chloroquine; Drug Resistance | 2020 |
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Autophagy; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation | 2021 |
Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival | 2021 |
The Sonic Hedgehog signaling pathway regulates autophagy and migration in ovarian cancer.
Topics: Animals; Autophagic Cell Death; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Chlo | 2021 |
Encapsulation of chloroquine and doxorubicin by MPEG-PLA to enhance anticancer effects by lysosomes inhibition in ovarian cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chlo | 2018 |
PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Movement; Chloroquine; Cisplatin | 2019 |
Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability.
Topics: Allosteric Regulation; Antineoplastic Agents; Ascites; Autophagy; Benzylamines; Cell Line, Tumor; Ce | 2014 |
A role of autophagy in PTP4A3-driven cancer progression.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy; Biocatalysis; Cell Cycle Proteins; Cell Me | 2014 |
Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Autophagy-Related Protein 5; Caspase 3; Cel | 2015 |
ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.
Topics: Antineoplastic Agents; Autophagy; Caspase 3; Cell Line, Tumor; Chloroquine; Cisplatin; Drug Resistan | 2015 |
Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.
Topics: Activating Transcription Factor 4; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chlor | 2016 |
Baicalein Induces Beclin 1- and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells.
Topics: Antimalarials; Autophagy; Beclin-1; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Su | 2017 |
Enhancement of gene expression efficiency using cationic liposomes on ovarian cancer cells.
Topics: Ammonium Chloride; Cations; Cell Line, Tumor; Chloroquine; Colchicine; Female; Gene Expression; Gene | 2008 |
Autophagy-induced tumor dormancy in ovarian cancer.
Topics: Animals; Antibiotics, Antineoplastic; Antirheumatic Agents; Autophagy; Cell Line, Tumor; Cell Surviv | 2008 |
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; Antirheumatic Agents; Autophagy; Cell Line, Tumor; Cell Surviv | 2008 |
NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Antineoplastic Agents, Alkylating; Autophagy; Cell | 2012 |
Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers.
Topics: Acridones; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, | 2012 |
Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinase Kinases; Autophagy; Autophagy-Rel | 2012 |
HLA-A2 presents shared tumor-associated antigens derived from endogenous proteins in ovarian cancer.
Topics: Antigen Presentation; Antigens, Neoplasm; Brefeldin A; Chloroquine; Cyclopentanes; Cytotoxicity, Imm | 1993 |