chloroquine has been researched along with Cancer of Colon in 30 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug." | 5.91 | Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023) |
| " We demonstrated the combinations of doxorubicin (DOX) + artesunate, DOX + chloroquine, paclitaxel (PTX) + fluoxetine, PTX + fluphenazine, and PTX + benztropine induce significant cytotoxicity in Michigan Cancer Foundation-7 (MCF-7) breast cancer cells." | 4.12 | Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action. ( Duarte, D; Nunes, M; Ricardo, S; Vale, N, 2022) |
| " Here, we aimed to investigate the role of CQ in potentiating the effect of 5-fluorouracil (5-FU), the chemotherapeutic agent of first choice for the treatment of colorectal cancer, in an animal model of colon cancer." | 3.78 | Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study. ( Hiyoshi, M; Hongo, K; Kaneko, M; Kawai, K; Kitayama, J; Murono, K; Nirei, T; Sasaki, K; Sunami, E; Tada, N; Takahashi, K; Tsuno, NH, 2012) |
| "Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug." | 1.91 | Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023) |
| " mRIP3 overexpression in combination with CQ markedly increased the inhibition rate relative to that observed in the CQ-treatment group." | 1.46 | Killing colon cancer cells through PCD pathways by a novel hyaluronic acid-modified shell-core nanoparticle loaded with RIP3 in combination with chloroquine. ( Cao, H; Gong, C; Guo, G; Hou, X; Hu, T; Li, R; Sun, D; Tong, A; Yang, C; Yang, F; Zhang, L; Zhang, X; Zheng, Y, 2017) |
| "Autophagy was induced in colon cancer models by exposure to both hypoxia and oxaliplatin." | 1.39 | Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy. ( Amaravadi, RK; O'Dwyer, PJ; Selvakumaran, M; Vasilevskaya, IA, 2013) |
| "Human colon cancer DLD-1 cells were treated with 5-FU (10 μΜ) or chloroquine (100 μΜ), or a combination of both." | 1.38 | Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration. ( Choi, JH; Lee, YY; Park, BB; Won, YW; Yoon, JS, 2012) |
| "In a patient with acute myelogenous leukemia infected with Plasmodium vivax, neither his underlying disease nor intensive cytotoxic chemotherapy appeared to ameliorate or worsen the clinical course of his infection." | 1.26 | Malaria complicating neoplastic disease. ( Armstrong, D; Tapper, ML, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.00) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Gochfeld, DJ | 1 |
| Hamann, MT | 1 |
| Matsuno, Y | 1 |
| Deguchi, J | 1 |
| Hirasawa, Y | 1 |
| Ohyama, K | 1 |
| Toyoda, H | 1 |
| Hirobe, C | 1 |
| Ekasari, W | 1 |
| Widyawaruyanti, A | 1 |
| Zaini, NC | 1 |
| Morita, H | 1 |
| See, CS | 1 |
| Kitagawa, M | 1 |
| Liao, PJ | 1 |
| Lee, KH | 1 |
| Wong, J | 1 |
| Lee, SH | 1 |
| Dymock, BW | 1 |
| Duarte, D | 1 |
| Nunes, M | 1 |
| Ricardo, S | 1 |
| Vale, N | 1 |
| Kang, C | 2 |
| Ju, S | 2 |
| Kim, J | 2 |
| Jung, Y | 2 |
| Zhang, L | 3 |
| Liu, S | 2 |
| Liu, H | 1 |
| Yang, C | 2 |
| Jiang, A | 1 |
| Wei, H | 1 |
| Sun, D | 2 |
| Cai, Z | 1 |
| Zheng, Y | 3 |
| Lu, S | 1 |
| Gao, J | 1 |
| Jia, H | 1 |
| Li, Y | 1 |
| Duan, Y | 1 |
| Song, F | 1 |
| Liu, Z | 1 |
| Ma, S | 1 |
| Wang, M | 1 |
| Zhao, T | 1 |
| Zhong, J | 1 |
| Fu, W | 1 |
| Li, X | 1 |
| Lu, X | 1 |
| Li, R | 2 |
| Zhang, N | 1 |
| Yang, X | 1 |
| Wang, Y | 1 |
| Zhao, Y | 1 |
| Meng, X | 1 |
| Zhu, WG | 1 |
| Selvakumaran, M | 1 |
| Amaravadi, RK | 1 |
| Vasilevskaya, IA | 1 |
| O'Dwyer, PJ | 1 |
| Ragusa, S | 1 |
| Cheng, J | 1 |
| Ivanov, KI | 1 |
| Zangger, N | 1 |
| Ceteci, F | 1 |
| Bernier-Latmani, J | 1 |
| Milatos, S | 1 |
| Joseph, JM | 1 |
| Tercier, S | 1 |
| Bouzourene, H | 1 |
| Bosman, FT | 1 |
| Letovanec, I | 1 |
| Marra, G | 1 |
| Gonzalez, M | 1 |
| Cammareri, P | 1 |
| Sansom, OJ | 1 |
| Delorenzi, M | 1 |
| Petrova, TV | 1 |
| Mei, L | 1 |
| Chen, Y | 1 |
| Wang, Z | 1 |
| Wang, J | 1 |
| Wan, J | 1 |
| Yu, C | 1 |
| Liu, X | 1 |
| Li, W | 1 |
| Pal, I | 1 |
| Parida, S | 1 |
| Prashanth Kumar, BN | 1 |
| Banik, P | 1 |
| Kumar Dey, K | 1 |
| Chakraborty, S | 1 |
| Bhutia, SK | 1 |
| Mandal, M | 1 |
| Chaachouay, H | 1 |
| Fehrenbacher, B | 1 |
| Toulany, M | 1 |
| Schaller, M | 1 |
| Multhoff, G | 1 |
| Rodemann, HP | 1 |
| Hou, X | 1 |
| Hu, T | 1 |
| Cao, H | 1 |
| Yang, F | 1 |
| Guo, G | 1 |
| Gong, C | 1 |
| Zhang, X | 1 |
| Tong, A | 1 |
| Zhao, YL | 1 |
| Deng, X | 1 |
| Yang, S | 1 |
| Mao, Y | 1 |
| Li, Z | 1 |
| Jiang, P | 1 |
| Zhao, X | 1 |
| Wei, Y | 1 |
| Carew, JS | 1 |
| Medina, EC | 1 |
| Esquivel, JA | 1 |
| Mahalingam, D | 1 |
| Swords, R | 1 |
| Kelly, K | 1 |
| Zhang, H | 1 |
| Huang, P | 1 |
| Mita, AC | 1 |
| Mita, MM | 1 |
| Giles, FJ | 1 |
| Nawrocki, ST | 1 |
| Ding, WX | 1 |
| Ni, HM | 1 |
| Gao, W | 1 |
| Chen, X | 1 |
| Kang, JH | 1 |
| Stolz, DB | 1 |
| Liu, J | 1 |
| Yin, XM | 1 |
| Sasaki, K | 2 |
| Tsuno, NH | 2 |
| Sunami, E | 2 |
| Tsurita, G | 1 |
| Kawai, K | 2 |
| Okaji, Y | 1 |
| Nishikawa, T | 1 |
| Shuno, Y | 1 |
| Hongo, K | 2 |
| Hiyoshi, M | 2 |
| Kaneko, M | 2 |
| Kitayama, J | 2 |
| Takahashi, K | 2 |
| Nagawa, H | 1 |
| Murono, K | 1 |
| Tada, N | 1 |
| Nirei, T | 1 |
| Choi, JH | 1 |
| Yoon, JS | 1 |
| Won, YW | 1 |
| Park, BB | 1 |
| Lee, YY | 1 |
| Pelisek, J | 1 |
| Gaedtke, L | 1 |
| DeRouchey, J | 1 |
| Walker, GF | 1 |
| Nikol, S | 1 |
| Wagner, E | 1 |
| Houri, JJ | 1 |
| Ogier-Denis, E | 1 |
| Trugnan, G | 1 |
| Codogno, P | 1 |
| Anderson, DC | 1 |
| Nichols, E | 1 |
| Manger, R | 1 |
| Woodle, D | 1 |
| Barry, M | 1 |
| Fritzberg, AR | 1 |
| Orlandi, PA | 1 |
| Curran, PK | 1 |
| Fishman, PH | 1 |
| Matroule, JY | 1 |
| Carthy, CM | 1 |
| Granville, DJ | 1 |
| Jolois, O | 1 |
| Hunt, DW | 1 |
| Piette, J | 1 |
| Tapper, ML | 1 |
| Armstrong, D | 1 |
| Guéant, JL | 1 |
| Masson, C | 1 |
| Schohn, H | 1 |
| Girr, M | 1 |
| Saunier, M | 1 |
| Nicolas, JP | 1 |
| Huang, Y | 1 |
| Hui, DY | 1 |
| Iwahashi, T | 1 |
| Tone, Y | 1 |
| Usui, J | 1 |
| Watanabe, H | 1 |
| Sugawara, I | 1 |
| Mori, S | 1 |
| Okazaki, H | 1 |
| Johnston, GS | 1 |
| Jones, AE | 1 |
30 other studies available for chloroquine and Cancer of Colon
| Article | Year |
|---|---|
Isolation and biological evaluation of filiformin, plakortide F, and plakortone G from the Caribbean sponge Plakortis sp.
Topics: Animals; Antimalarials; Bromobenzenes; Chromatography, High Pressure Liquid; Colonic Neoplasms; Diox | 2001 |
Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida.
Topics: Animals; Antimalarials; Carcinoma; Cell Line, Tumor; Chemistry, Pharmaceutical; Colonic Neoplasms; D | 2008 |
Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131).
Topics: Acrylonitrile; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplas | 2018 |
Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action.
Topics: Adenosine Diphosphate; Antimalarials; Antineoplastic Agents; Artesunate; ATP Binding Cassette Transp | 2022 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo | 2023 |
Versatile cationic liposomes for RIP3 overexpression in colon cancer therapy and RIP3 downregulation in acute pancreatitis therapy.
Topics: Animals; Antimalarials; Arginine; Cell Line; Chemotherapy, Adjuvant; Chloroquine; Colonic Neoplasms; | 2020 |
PD-1-siRNA Delivered by Attenuated
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chloroquine; Colonic Neoplasms; Humans; Imm | 2021 |
A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells.
Topics: Acridines; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Chloroquine; Colonic Neop | 2017 |
Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosi | 2013 |
PROX1 promotes metabolic adaptation and fuels outgrowth of Wnt(high) metastatic colon cancer cells.
Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Chloroquine; Colo | 2014 |
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Benzylisoquinolines; | 2015 |
Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Benzimidazoles; Cell Cycle; Cell Survival; Chloroquine; | 2015 |
AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cel | 2015 |
Killing colon cancer cells through PCD pathways by a novel hyaluronic acid-modified shell-core nanoparticle loaded with RIP3 in combination with chloroquine.
Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Cell Line, Tumor; Chloroquine; Coloni | 2017 |
Chloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chloroquine; Colonic Neoplasms; Mice; Mice | 2009 |
Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Boronic Acids; Bortezomib; Carcinoma; Cell Lin | 2010 |
Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy.
Topics: Animals; Antimalarials; Apoptosis; Autophagy; Blotting, Western; Boronic Acids; Bortezomib; Cell Lin | 2009 |
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
Topics: Antimalarials; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apop | 2010 |
Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; | 2012 |
Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration.
Topics: Antimalarials; Antimetabolites, Antineoplastic; Autophagy; Blotting, Western; Cell Cycle; Cell Line, | 2012 |
Optimized lipopolyplex formulations for gene transfer to human colon carcinoma cells under in vitro conditions.
Topics: Carcinoma; Chloroquine; Colonic Neoplasms; Deoxyribonuclease I; Gene Transfer Techniques; Genetic Ve | 2006 |
Autophagic degradation of N-linked glycoproteins is downregulated in differentiated human colon adenocarcinoma cells.
Topics: Adenine; Adenocarcinoma; Asparagine; Autophagy; Carbon Radioisotopes; Carcinogens; Cell Differentiat | 1993 |
Tumor cell retention of antibody Fab fragments is enhanced by an attached HIV TAT protein-derived peptide.
Topics: Amino Acid Sequence; Biological Transport; Carbon Radioisotopes; Cell Membrane; Chloroquine; Colonic | 1993 |
Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action.
Topics: Adenocarcinoma; Adenylyl Cyclases; Animals; Biological Transport; Brefeldin A; Cell Line; Chloroquin | 1993 |
Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization.
Topics: Acetylcysteine; Adenocarcinoma; Antioxidants; Apoptosis; Caspase 3; Caspases; Ceramides; Chloroquine | 2001 |
Malaria complicating neoplastic disease.
Topics: Adult; Antibodies; Antibody Formation; Chloroquine; Colonic Neoplasms; Female; Hemostasis, Surgical; | 1976 |
Receptor-mediated endocytosis of the intrinsic factor-cobalamin complex in HT 29, a human colon carcinoma cell line.
Topics: Chloroquine; Chromatography, Gel; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Endocytosi | 1992 |
Metabolic fate of pancreas-derived cholesterol esterase in intestine: an in vitro study using Caco-2 cells.
Topics: Adenocarcinoma; Animals; Bile; Biological Transport; Chloroquine; Cholesterol Esters; Colonic Neopla | 1990 |
Selective killing of carcinoembryonic-antigen (CEA)-producing cells in vitro by the immunoconjugate cytorhodin-S and CEA-reactive cytorhodin-S antibody CA208.
Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Carcinoembryonic Antig | 1989 |
Sequential liver scanning.
Topics: Adult; Breast Neoplasms; Chloroquine; Colonic Neoplasms; Dactinomycin; Emetine; Estrogens; Female; F | 1969 |