chloroquine has been researched along with Bronchial Hyperreactivity in 2 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| "TAS2R agonists attenuated features of airway remodeling including smooth muscle mass, extracellular matrix deposition and pro-fibrotic signaling, and also prevented mucus accumulation and development of AHR in mice." | 1.46 | Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice. ( Deshpande, DA; Knight, MJ; Nayak, AP; Oliver, B; Pan, S; Sharma, P; Tang, F; Wang, N; Yi, R, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, P | 1 |
| Yi, R | 1 |
| Nayak, AP | 1 |
| Wang, N | 1 |
| Tang, F | 1 |
| Knight, MJ | 1 |
| Pan, S | 1 |
| Oliver, B | 1 |
| Deshpande, DA | 1 |
| Morishima, H | 1 |
| Kajiwara, K | 1 |
| Akiyama, K | 1 |
| Yanagihara, Y | 1 |
2 other studies available for chloroquine and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu | 2017 |
Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells.
Topics: 2-Aminopurine; Bronchial Hyperreactivity; Calcium Signaling; Cells, Cultured; Chloroquine; Colforsin | 2008 |