chloroquine has been researched along with Breast Cancer in 68 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A combination of chloroquine with taxane or taxane-like chemotherapy was efficacious in patients with locally advanced or metastatic breast cancer with prior anthracycline-based chemotherapy." | 9.41 | A Phase II Study of the Efficacy and Safety of Chloroquine in Combination With Taxanes in the Treatment of Patients With Advanced or Metastatic Anthracycline-refractory Breast Cancer. ( Anand, K; Boone, T; Chang, JC; Ensor, J; Niravath, P; Patel, T; Rodriguez, A; Wong, ST, 2021) |
| "Patients with newly diagnosed breast cancer were randomized 2:1 to chloroquine 500 mg daily or placebo for 2- to 6-weeks prior to their breast surgery." | 9.30 | A randomized, double-blind, window of opportunity trial evaluating the effects of chloroquine in breast cancer patients. ( Arnaout, A; Clemons, M; Coupland, S; Gottlieb, C; Hilton, J; Hurley, B; Ianni, L; Jeong, A; Kroeger, L; Lee, H; McCarthy, A; Pond, GR; Robertson, SJ, 2019) |
| "A series of chloroquine (CQ) analogs were designed and synthesized in a repositioning approach to develop compounds with high anti-breast cancer property." | 7.76 | Design and synthesis of chloroquine analogs with anti-breast cancer property. ( Hu, C; Lee, H; Solomon, VR, 2010) |
| "A hybrid pharmacophore approach was used to design and synthesize isatin-benzothiazole analogs to examine their anti-breast cancer activity." | 7.75 | Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity. ( Hu, C; Lee, H; Solomon, VR, 2009) |
| "Epidermal growth factor (EGF) may play a role in regulating growth of breast cancer cells in vivo." | 7.67 | Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture. ( Fitzpatrick, SL; LaChance, MP; Schultz, GS, 1984) |
| "Chloroquine (CQ) is an old antimalarial drug currently being investigated for its anti-tumor properties." | 5.51 | Chloroquine inhibits tumor-related Kv10.1 channel and decreases migration of MDA-MB-231 breast cancer cells in vitro. ( Morán-Zendejas, R; Rangel-Flores, JM; Rodríguez-Menchaca, AA; Valdés-Abadía, B, 2019) |
| "A combination of chloroquine with taxane or taxane-like chemotherapy was efficacious in patients with locally advanced or metastatic breast cancer with prior anthracycline-based chemotherapy." | 5.41 | A Phase II Study of the Efficacy and Safety of Chloroquine in Combination With Taxanes in the Treatment of Patients With Advanced or Metastatic Anthracycline-refractory Breast Cancer. ( Anand, K; Boone, T; Chang, JC; Ensor, J; Niravath, P; Patel, T; Rodriguez, A; Wong, ST, 2021) |
| "Chloroquine (CQ) is a 4-aminoquinoline drug used for the treatment of diverse diseases." | 5.38 | Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. ( Aryal, S; Cummings, CT; Maycotte, P; Morgan, MJ; Thorburn, A; Thorburn, J, 2012) |
| "Metastatic breast cancers are hard to treat and almost always fatal." | 5.36 | Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. ( Deng, XQ; Jiang, PD; Li, ZG; Mao, YQ; Shi, W; Tang, QQ; Wei, YQ; Yang, SY; Zhao, YL; Zheng, YZ, 2010) |
| "The chloroquine treatment decreased the viability of Bcap-37 cells in a concentration- and time-dependent manner, which correlated with G(2)/M phase cell cycle arrest." | 5.35 | Cell growth inhibition, G2/M cell cycle arrest, and apoptosis induced by chloroquine in human breast cancer cell line Bcap-37. ( Deng, XQ; Jiang, PD; Li, ZG; Mao, YQ; Shi, W; Wei, YQ; Xie, G; Yang, SY; Zhao, YL; Zheng, YZ, 2008) |
| "Patients with newly diagnosed breast cancer were randomized 2:1 to chloroquine 500 mg daily or placebo for 2- to 6-weeks prior to their breast surgery." | 5.30 | A randomized, double-blind, window of opportunity trial evaluating the effects of chloroquine in breast cancer patients. ( Arnaout, A; Clemons, M; Coupland, S; Gottlieb, C; Hilton, J; Hurley, B; Ianni, L; Jeong, A; Kroeger, L; Lee, H; McCarthy, A; Pond, GR; Robertson, SJ, 2019) |
| " We demonstrated the combinations of doxorubicin (DOX) + artesunate, DOX + chloroquine, paclitaxel (PTX) + fluoxetine, PTX + fluphenazine, and PTX + benztropine induce significant cytotoxicity in Michigan Cancer Foundation-7 (MCF-7) breast cancer cells." | 4.12 | Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action. ( Duarte, D; Nunes, M; Ricardo, S; Vale, N, 2022) |
| " To test this hypothesis, we treated breast cancer MDA-MB-231 cells with tamoxifen (TMX), which induces autophagy through an estrogen receptor-independent pathway." | 3.83 | Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells. ( Ann, DK; Chen, YR; Hu, S; Liu, X; Ma, H; Tsou, B; Yen, Y, 2016) |
| " 1 had improved cytotoxicity against BT-474 breast cancer cells compared to chloroquine, a clinically relevant autophagy inhibitor." | 3.81 | Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy. ( De Mei, C; Ercolani, L; Ferrari, A; Grimaldi, B; Parodi, C; Scarpelli, R; Torrente, E, 2015) |
| "Chloroquine given immediately after tumor irradiation increased the cure rate of MCaK breast cancer in C3H mice." | 3.79 | Chloroquine engages the immune system to eradicate irradiated breast tumors in mice. ( Ratikan, JA; Sayre, JW; Schaue, D, 2013) |
| " Here, we determined the in vitro and in vivo activity of the combination of the pan-HDI panobinostat and the autophagy inhibitor chloroquine against human estrogen/progesterone receptor and HER2 (triple)-negative breast cancer (TNBC) cells." | 3.78 | Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells. ( Atadja, P; Balusu, R; Bhalla, KN; Chauhan, L; Fiskus, W; Ha, K; Hembruff, SL; Mudunuru, U; Rao, R; Smith, JE; Venkannagari, S, 2012) |
| " We therefore combined chloroquine (CQ), a pharmacological inhibitor of autophagy, with other drugs known to act as ERS aggravators (ERSA), namely nelfinavir (an HIV protease inhibitor) and celecoxib (a cyclooxygenase-2 inhibitor) or its non-coxib analog 2,5-dimethyl-celecoxib (DMC), and investigated combination drug effects in a variety of breast cancer cell lines." | 3.78 | Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. ( Agarwal, P; Chen, TC; Cho, H; Gaffney, KJ; Golden, EB; Hofman, FM; Louie, SG; Petasis, NA; Schönthal, AH; Sharma, N; Thomas, S, 2012) |
| " Previously, we showed that molecular Iodine (I(2)) induces apoptosis in hormone responsive MCF-7 breast cancer cells, and non-apoptotic cell death in ER(-ve)-p53 mutant MDA-MB231 cells (Shrivastava, 2006)." | 3.77 | Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors. ( Agarwal, G; Annarao, S; Godbole, M; Ingle, A; Mitra, K; Rao, G; Roy, R; Singh, P; Tiwari, S, 2011) |
| "A series of chloroquine (CQ) analogs were designed and synthesized in a repositioning approach to develop compounds with high anti-breast cancer property." | 3.76 | Design and synthesis of chloroquine analogs with anti-breast cancer property. ( Hu, C; Lee, H; Solomon, VR, 2010) |
| "A hybrid pharmacophore approach was used to design and synthesize isatin-benzothiazole analogs to examine their anti-breast cancer activity." | 3.75 | Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity. ( Hu, C; Lee, H; Solomon, VR, 2009) |
| "Epidermal growth factor (EGF) may play a role in regulating growth of breast cancer cells in vivo." | 3.67 | Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture. ( Fitzpatrick, SL; LaChance, MP; Schultz, GS, 1984) |
| "Cytotoxic therapy for breast cancer inhibits the growth of primary tumors, but promotes metastasis to the sentinel lymph nodes through the lymphatic system." | 1.51 | Paclitaxel induces lymphatic endothelial cells autophagy to promote metastasis. ( Alves, M; Chollet, C; Fougeray, T; Franchet, C; Garmy-Susini, B; Gomez-Brouchet, A; Guillermet-Guibert, J; Lacazette, E; Martinez, LO; Najib, S; Prats, AC; Tatin, F; Therville, N; Vaysse, C; Zamora, A, 2019) |
| "Chloroquine (CQ) is an old antimalarial drug currently being investigated for its anti-tumor properties." | 1.51 | Chloroquine inhibits tumor-related Kv10.1 channel and decreases migration of MDA-MB-231 breast cancer cells in vitro. ( Morán-Zendejas, R; Rangel-Flores, JM; Rodríguez-Menchaca, AA; Valdés-Abadía, B, 2019) |
| "Chloroquine (CQ) is an antimalarial and amebicidal drug that inhibits autophagy in mammalian cells and human tumors." | 1.48 | Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor-positive breast cancer. ( Demidenko, E; Hosford, SR; Liu, S; Miller, TW; Shee, K; Traphagen, NA; Yang, W, 2018) |
| "This is the first report showing that breast cancer cells chronically exposed to TRAIL exhibit upregulation of the autophagic activity, indicating that autophagy efficiently protects breast cancer cells from TRAIL." | 1.42 | Autophagy facilitates the development of resistance to the tumor necrosis factor superfamily member TRAIL in breast cancer. ( Li, Y; Lv, S; Qi, W; Sun, M; Wang, X; Yang, Q; Zhang, N, 2015) |
| "TAK1 phosphorylation in MDA-MB231 breast cancer cells was evaluated by western blotting." | 1.40 | Autophagy inhibition can overcome radioresistance in breast cancer cells through suppression of TAK1 activation. ( Chang, HW; Choi, JY; Han, MW; Kim, GC; Kim, SW; Kim, SY; Lee, JC; Nam, HY, 2014) |
| "Human mammary cancer cells and derived xenografts were used to examine whether hypoxia could exacerbate autophagy-mediated resistance to the mTOR inhibitor rapamycin." | 1.39 | Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours. ( Boidot, R; Bouzin, C; Feron, O; Gallez, B; Jordan, BF; Karroum, O; Machiels, JP; Seront, E, 2013) |
| "Chloroquine (CQ) is a 4-aminoquinoline drug used for the treatment of diverse diseases." | 1.38 | Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. ( Aryal, S; Cummings, CT; Maycotte, P; Morgan, MJ; Thorburn, A; Thorburn, J, 2012) |
| "Metastatic breast cancers are hard to treat and almost always fatal." | 1.36 | Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. ( Deng, XQ; Jiang, PD; Li, ZG; Mao, YQ; Shi, W; Tang, QQ; Wei, YQ; Yang, SY; Zhao, YL; Zheng, YZ, 2010) |
| "The chloroquine treatment decreased the viability of Bcap-37 cells in a concentration- and time-dependent manner, which correlated with G(2)/M phase cell cycle arrest." | 1.35 | Cell growth inhibition, G2/M cell cycle arrest, and apoptosis induced by chloroquine in human breast cancer cell line Bcap-37. ( Deng, XQ; Jiang, PD; Li, ZG; Mao, YQ; Shi, W; Wei, YQ; Xie, G; Yang, SY; Zhao, YL; Zheng, YZ, 2008) |
| "The survival curve of MDA-MB 231 breast cancer cells was establish in the presence or absence of CQ after irradiation by colongenic assay." | 1.33 | [Chloroquine increased radiosensitivity of radioresistant MDA-MB 231 cells and its molecular mechanism]. ( Cai, Y; Lee, H; Zhao, H, 2006) |
| "Chloroquine was most active in stimulating MCF-7 apoptosis, and quinine was most active in promoting MCF-7 cell differentiation." | 1.31 | Control of mammary tumor cell growth in vitro by novel cell differentiation and apoptosis agents. ( McCracken, MA; Strobl, JS; Zhou, Q, 2002) |
| "Cathepsin D secretion by the breast cancer cell lines MDA-MB-231, MDA-MB-435, MDA-MB-435s, MDA-MB-468, SK-Br-3, and MCF-7-ADRr was also measured." | 1.29 | The role of cathepsin D in the invasiveness of human breast cancer cells. ( Dickson, RB; Johnson, MD; Lippman, ME; Torri, JA, 1993) |
| "Two human breast cancer cell lines (T-47D and MCF-7) and one cell line derived from normal human milk (HBL-100) not only specifically bound but also degraded prolactin." | 1.26 | Processing of prolactin by human breast cancer cells in long term tissue culture. ( Shiu, RP, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.88) | 18.7374 |
| 1990's | 2 (2.94) | 18.2507 |
| 2000's | 11 (16.18) | 29.6817 |
| 2010's | 41 (60.29) | 24.3611 |
| 2020's | 10 (14.71) | 2.80 |
| Authors | Studies |
|---|---|
| Solomon, VR | 4 |
| Hu, C | 4 |
| Lee, H | 7 |
| Torrente, E | 1 |
| Parodi, C | 1 |
| Ercolani, L | 1 |
| De Mei, C | 1 |
| Ferrari, A | 1 |
| Scarpelli, R | 1 |
| Grimaldi, B | 1 |
| Gain, C | 1 |
| Sarkar, A | 1 |
| Bural, S | 1 |
| Rakshit, M | 1 |
| Banerjee, J | 1 |
| Dey, A | 1 |
| Biswas, N | 1 |
| Kar, GK | 1 |
| Saha, A | 1 |
| Rojas-Sanchez, G | 1 |
| García-Miranda, A | 1 |
| Montes-Alvarado, JB | 1 |
| Cotzomi-Ortega, I | 1 |
| Sarmiento-Salinas, FL | 1 |
| Jimenez-Ignacio, EE | 1 |
| Ramírez-Ramírez, D | 1 |
| Romo-Rodríguez, RE | 1 |
| Reyes-Leyva, J | 1 |
| Vallejo-Ruiz, V | 1 |
| Pazos-Salazar, NG | 1 |
| Maycotte, P | 3 |
| An, S | 1 |
| Hu, M | 1 |
| Gámez-Chiachio, M | 1 |
| Molina-Crespo, Á | 1 |
| Ramos-Nebot, C | 1 |
| Martinez-Val, J | 1 |
| Martinez, L | 1 |
| Gassner, K | 1 |
| Llobet, FJ | 1 |
| Soriano, M | 1 |
| Hernandez, A | 1 |
| Cordani, M | 1 |
| Bernadó-Morales, C | 1 |
| Diaz, E | 1 |
| Rojo-Sebastian, A | 1 |
| Triviño, JC | 1 |
| Sanchez, L | 1 |
| Rodríguez-Barrueco, R | 1 |
| Arribas, J | 1 |
| Llobet-Navás, D | 1 |
| Sarrió, D | 1 |
| Moreno-Bueno, G | 1 |
| Duarte, D | 1 |
| Nunes, M | 1 |
| Ricardo, S | 1 |
| Vale, N | 1 |
| Cheng, Y | 2 |
| Wang, C | 5 |
| Wang, H | 3 |
| Zhang, Z | 1 |
| Yang, X | 3 |
| Dong, Y | 2 |
| Ma, L | 1 |
| Luo, J | 1 |
| Arnaout, A | 1 |
| Robertson, SJ | 1 |
| Pond, GR | 1 |
| Jeong, A | 1 |
| Ianni, L | 1 |
| Kroeger, L | 1 |
| Hilton, J | 1 |
| Coupland, S | 1 |
| Gottlieb, C | 1 |
| Hurley, B | 1 |
| McCarthy, A | 1 |
| Clemons, M | 1 |
| Wang, X | 7 |
| Yin, X | 1 |
| Yang, Y | 3 |
| Zamora, A | 1 |
| Alves, M | 1 |
| Chollet, C | 1 |
| Therville, N | 1 |
| Fougeray, T | 1 |
| Tatin, F | 1 |
| Franchet, C | 1 |
| Gomez-Brouchet, A | 1 |
| Vaysse, C | 1 |
| Martinez, LO | 1 |
| Najib, S | 1 |
| Guillermet-Guibert, J | 1 |
| Lacazette, E | 1 |
| Prats, AC | 1 |
| Garmy-Susini, B | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 5 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 2 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 2 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 3 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, Y | 3 |
| Chen, L | 3 |
| Shan, A | 1 |
| Zhao, H | 4 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Wang, J | 4 |
| Zhang, E | 1 |
| Zhang, J | 3 |
| Li, Y | 6 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Wang, Y | 3 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
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| Rojas, A | 1 |
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| Li, J | 8 |
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| Hou, J | 1 |
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| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 1 |
| Zhu, J | 2 |
| Zhang, L | 2 |
| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
| Qu, Y | 1 |
| Yao, H | 1 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
| Zhao, Q | 2 |
| Hu, W | 1 |
| Zhang, Y | 6 |
| Wu, X | 1 |
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| Li, M | 1 |
| Li, W | 2 |
| Wu, W | 1 |
| Du, F | 1 |
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| Wan, L | 1 |
| Wen, Q | 1 |
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| Huang, H | 1 |
| Wei, Y | 2 |
| Gao, Y | 2 |
| Na, KJ | 1 |
| Choi, H | 1 |
| Oh, HR | 1 |
| Kim, YH | 1 |
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| Jung, YJ | 1 |
| Koh, J | 1 |
| Park, S | 1 |
| Lee, HJ | 1 |
| Jeon, YK | 1 |
| Chung, DH | 1 |
| Paeng, JC | 1 |
| Park, IK | 1 |
| Kang, CH | 1 |
| Cheon, GJ | 1 |
| Kang, KW | 1 |
| Lee, DS | 1 |
| Kim, YT | 1 |
| Pajuelo-Lozano, N | 1 |
| Alcalá, S | 1 |
| Sainz, B | 1 |
| Perona, R | 1 |
| Sanchez-Perez, I | 1 |
| Logotheti, S | 1 |
| Marquardt, S | 1 |
| Gupta, SK | 1 |
| Richter, C | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Study of Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer[NCT04011410] | Phase 2 | 20 participants (Actual) | Interventional | 2019-12-03 | Active, not recruiting | ||
| Preventing Invasive Breast Neoplasia With Chloroquine (PINC) Trial[NCT01023477] | Phase 1/Phase 2 | 12 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
One of the primary outcomes of this study was to measure the impact of weekly chloroquine on the amount of DCIS seen on MRI.The tumor response was evaluated by RECIST criteria. Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0) for target lesions and assessed by MRI: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR The longest diameter of the target lesion or primary area of non-mass enhancement was measured by digital calipers. For one patient, the longest diameter was difficult to measure due to the presence of a significant post biopsy resolving hematoma at the biopsy site. Further correlation was made based on the extent of the pre-treatment microcalcifications and post treatment areas of non-mass enhancement. (NCT01023477)
Timeframe: Immediately preceding study drug treatment and again after treatment prior to surgery. The total time interval was up to 8 weeks
| Intervention | percentage length change (Mean) |
|---|---|
| Chloroquine Standard Dose (500mg/Week) | 6 |
| Chloroquine Low Dose (250mg/Week) | 43 |
We evaluated the effect of therapy on cellular proliferation as measured by the change in proliferating cell nuclear antigen (PCNA) proliferation index. PCNA , which is elevated during the G1/S phase of the cell cycle, may be used as a marker of cellular proliferation. The PCNA proliferation index was measured as the number of PCNA positive stained cells in the DCIS lesion/ total number of cells in the lesion. The change in the PCNA index is equal to the mean PCNA proliferation index pre-treatment minus the mean PCNA proliferation index post-treatment. (NCT01023477)
Timeframe: At the time of breast biopsy and again at time of surgery.
| Intervention | Change in PCNA proliferation index (Mean) |
|---|---|
| Chloroquine Standard Dose (500mg/Week) | 50.4 |
| Chloroquine Low Dose (250mg/Week) | 56.71 |
One of the outcomes was to ensure the safety of weekly chloroquine. Patients were followed clinically during the treatment with chloroquine and during their surgery and postoperative period ( including radiation therapy). Patients were verbally assessed for additional symptoms or concerns. Patients were also examined by the provider during treatment and follow up visits to the surgeon. (NCT01023477)
Timeframe: The patients were monitored from the time of diagnosis through 6 months of surgical follow up.
| Intervention | Adverse Events (mortality, SAE, AE) (Number) |
|---|---|
| Chloroquine Standard Dose (500mg/Week) | 0 |
| Chloroquine Low Dose (250mg/Week) | 0 |
"The study evaluated the effect of chloroquine treatment on the proteomic signaling profiles of the DCIS lesions. Post treatment surgical specimens were evaluated by immunohistochemical staining to measure cell signaling kinase levels for CD68 and HMGB1. CD68 (Cluster Determinant 68) is a marker of macrophages/monocytes in the breast ducts. and HMGB1 (High Mobility Group Box 1) is involved in oxidative stress-mediated autophagy. HMGB1 is a non-histone DNA binding protein. The number of positive cells were quantified and recorded.~." (NCT01023477)
Timeframe: At the time of surgery
| Intervention | Positive cells (Mean) | |
|---|---|---|
| HMGB1 | CD68 | |
| Chloroquine Low Dose (250mg/Week) | 47.89 | 163.2 |
| Chloroquine Standard Dose (500mg/Week) | 33.9 | 318.3 |
1 review available for chloroquine and Breast Cancer
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
3 trials available for chloroquine and Breast Cancer
| Article | Year |
|---|---|
A randomized, double-blind, window of opportunity trial evaluating the effects of chloroquine in breast cancer patients.
Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers | 2019 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
A Phase II Study of the Efficacy and Safety of Chloroquine in Combination With Taxanes in the Treatment of Patients With Advanced or Metastatic Anthracycline-refractory Breast Cancer.
Topics: Adult; Aged; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Proto | 2021 |
65 other studies available for chloroquine and Breast Cancer
| Article | Year |
|---|---|
Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity.
Topics: Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Drug Design; Drug Screening Assays, Antitum | 2009 |
Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: a hybrid pharmacophore approach.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antit | 2010 |
Design and synthesis of chloroquine analogs with anti-breast cancer property.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Des | 2010 |
Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy.
Topics: Antineoplastic Agents; Autophagy; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitum | 2015 |
Identification of two novel thiophene analogues as inducers of autophagy mediated cell death in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; | 2021 |
Chloroquine Induces ROS-mediated Macrophage Migration Inhibitory Factor Secretion and Epithelial to Mesenchymal Transition in ER-positive Breast Cancer Cell Lines.
Topics: Breast Neoplasms; Cadherins; Cell Line; Cell Line, Tumor; Chloroquine; Epithelial-Mesenchymal Transi | 2021 |
Quercetin Promotes TFEB Nuclear Translocation and Activates Lysosomal Degradation of Ferritin to Induce Ferroptosis in Breast Cancer Cells.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Breast Neoplasms; Chloroquine; Female; | 2022 |
Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation.
Topics: Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Drug Resistance, Neoplasm; Fema | 2022 |
Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action.
Topics: Adenosine Diphosphate; Antimalarials; Antineoplastic Agents; Artesunate; ATP Binding Cassette Transp | 2022 |
Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy.
Topics: Adjuvants, Immunologic; Autophagy; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Female; Humans; | 2022 |
Rasal2 suppresses breast cancer cell proliferation modulated by secretory autophagy.
Topics: Autophagy; Breast Neoplasms; Cell Proliferation; Chloroquine; Exosomes; Female; GTPase-Activating Pr | 2019 |
Paclitaxel induces lymphatic endothelial cells autophagy to promote metastasis.
Topics: Autophagy; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cel | 2019 |
Proteolytic Targeting Chimeras with Specificity for Plasma Membrane and Intracellular Estrogen Receptors.
Topics: Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Chloroquine; Estro | 2021 |
PINK1/Parkin-mediated mitophagy inhibits warangalone-induced mitochondrial apoptosis in breast cancer cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Breast Neoplasms; Cel | 2021 |
The role of Runx2 in facilitating autophagy in metastatic breast cancer cells.
Topics: Acetylation; Animals; Antineoplastic Agents; Autophagosomes; Autophagy; Bone Neoplasms; Breast Neopl | 2018 |
S-Adenosylmethionine-mediated apoptosis is potentiated by autophagy inhibition induced by chloroquine in human breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; | 2018 |
Synthesis and Evaluation of Chloroquine-Containing DMAEMA Copolymers as Efficient Anti-miRNA Delivery Vectors with Improved Endosomal Escape and Antimigratory Activity in Cancer Cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chloroquine; E | 2018 |
Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor-positive breast cancer.
Topics: Animals; Antimalarials; Apoptosis; Autophagy; Breast Neoplasms; Cell Proliferation; Chloroquine; Fem | 2018 |
Suppression of eEF-2K-mediated autophagy enhances the cytotoxicity of raddeanin A against human breast cancer cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Down-R | 2018 |
Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis.
Topics: Animals; Apoptosis; Autophagy; beta-Transducin Repeat-Containing Proteins; Breast Neoplasms; Cell Li | 2018 |
Chloroquine inhibits tumor-related Kv10.1 channel and decreases migration of MDA-MB-231 breast cancer cells in vitro.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Movement; Chloroquine; Cytoplasm; Ether-A-Go | 2019 |
The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antimalarials; Antineoplastic Agents; Autophagy; Breast | 2013 |
Chloroquine engages the immune system to eradicate irradiated breast tumors in mice.
Topics: Animals; Antigen Presentation; Apoptosis; Autophagy; Breast Neoplasms; CD8-Positive T-Lymphocytes; C | 2013 |
Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Breast Neoplasms; Cell Hypoxia; | 2013 |
Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death.
Topics: Animals; Apoptosis; Autophagy; Breast Neoplasms; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proli | 2014 |
Autophagy inhibition can overcome radioresistance in breast cancer cells through suppression of TAK1 activation.
Topics: Antifungal Agents; Antimalarials; Autophagy; Blotting, Western; Breast Neoplasms; Cell Proliferation | 2014 |
Lactaptin induces p53-independent cell death associated with features of apoptosis and autophagy and delays growth of breast cancer cells in mouse xenografts.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Caseins; Caspases; Cell Deat | 2014 |
Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells.
Topics: Artemisia; Artemisinins; Breast Neoplasms; Cell Survival; Chlorogenic Acid; Chloroquine; Cisplatin; | 2014 |
Enhancing therapeutic effects of docetaxel-loaded dendritic copolymer nanoparticles by co-treatment with autophagy inhibitor on breast cancer.
Topics: Animals; Antineoplastic Agents; Autophagy; Breast Neoplasms; Chloroquine; Dendrimers; Disease Models | 2014 |
Autophagy facilitates the development of resistance to the tumor necrosis factor superfamily member TRAIL in breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Survival; Chloroquine; Chromones | 2015 |
Cytotoxicity of Ru(II) piano-stool complexes with chloroquine and chelating ligands against breast and lung tumor cells: Interactions with DNA and BSA.
Topics: Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cattle; Cell Line, Tumor; Chelating | 2015 |
Inhibition of Autophagy Increases Proliferation Inhibition and Apoptosis Induced by the PI3K/mTOR Inhibitor NVP-BEZ235 in Breast Cancer Cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Pro | 2015 |
Polyphosphazene vesicles for co-delivery of doxorubicin and chloroquine with enhanced anticancer efficacy by drug resistance reversal.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Chloroquine; Doxorubicin; Drug Delivery Systems; D | 2016 |
Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells.
Topics: Animals; Antimalarials; Antineoplastic Agents, Hormonal; Apoptosis; Autophagy; Benzamides; Blotting, | 2016 |
Chloroquine (CQ) exerts anti-breast cancer through modulating microenvironment and inducing apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; CD8-Positive T-Lymphocytes; Cell Line, | 2017 |
Cell growth inhibition, G2/M cell cycle arrest, and apoptosis induced by chloroquine in human breast cancer cell line Bcap-37.
Topics: Apoptosis; Breast Neoplasms; Caspase 3; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell P | 2008 |
Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells.
Topics: Acetylation; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferat | 2009 |
Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors.
Topics: Actins; Autophagy; Biomarkers, Tumor; Breast Neoplasms; Calcium-Binding Proteins; Calponins; Carcino | 2010 |
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.
Topics: Animals; Antirheumatic Agents; Apoptosis Regulatory Proteins; Autophagy; Breast Neoplasms; Caveolin | 2010 |
Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 9; Cell Cycle; Cell | 2010 |
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production.
Topics: Antimalarials; Apoptosis; Artemisinins; Artesunate; Breast Neoplasms; Cell Line, Tumor; Chloroquine; | 2011 |
Autophagy contributes to resistance of tumor cells to ionizing radiation.
Topics: Adenine; Autophagy; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell | 2011 |
A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D.
Topics: Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Breast Neoplasms; Carcinoma; Ce | 2011 |
Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Caspase 3; Caspase 9; Cathep | 2011 |
Akt and p53 are potential mediators of reduced mammary tumor growth by cloroquine and the mTOR inhibitor RAD001.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; | 2012 |
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy.
Topics: Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 12; Breast Neoplasms; Cell Line | 2012 |
Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Breast Neoplasms; Cel | 2012 |
The anticancer activity of chloroquine-gold nanoparticles against MCF-7 breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Proliferation; Cell Survival; Chloroquine; | 2012 |
Doxorubicin and chloroquine coencapsulated liposomes: preparation and improved cytotoxicity on human breast cancer cells.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Chemistry, Pharmaceutical; Chloroquine; Dose-Response | 2012 |
Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Breast Neoplasms; Cel | 2012 |
Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?
Topics: Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Cytoprotection; Disease Models, | 2013 |
Control of mammary tumor cell growth in vitro by novel cell differentiation and apoptosis agents.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Differentiation; Cell Division; Chloroquine | 2002 |
Cell-type specific targeting and gene expression using a variant of polyoma VP1 virus-like particles.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; beta-Galactosidase; Breast Neoplasms; Cap | 2003 |
Enhancement of the p27Kip1-mediated antiproliferative effect of trastuzumab (Herceptin) on HER2-overexpressing tumor cells.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimalarials; Antineoplastic Agents; Bre | 2004 |
Chloroquine-mediated radiosensitization is due to the destabilization of the lysosomal membrane and subsequent induction of cell death by necrosis.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Dose-Response Relationship, Drug; Dose-R | 2005 |
Inhibition of endosomal sequestration of basic anticancer drugs: influence on cytotoxicity and tissue penetration.
Topics: Animals; Antibiotics, Antineoplastic; Antimalarials; Antineoplastic Agents; Breast Neoplasms; Chloro | 2006 |
[Chloroquine increased radiosensitivity of radioresistant MDA-MB 231 cells and its molecular mechanism].
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Su | 2006 |
Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives.
Topics: Amines; Aminoquinolines; Amodiaquine; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chl | 2008 |
Unusual intensification of skin reactions by chloroquine use during breast radiotherapy.
Topics: Antimalarials; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Chloroquine; Drug Hypersensitivi | 2008 |
Processing of prolactin by human breast cancer cells in long term tissue culture.
Topics: Breast Neoplasms; Cell Line; Chloroquine; Female; Humans; Kinetics; Milk, Human; Pregnancy; Prolacti | 1980 |
Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture.
Topics: Breast Neoplasms; Cell Division; Cell Line; Chloroquine; Epidermal Growth Factor; ErbB Receptors; Fe | 1984 |
The role of cathepsin D in the invasiveness of human breast cancer cells.
Topics: Breast Neoplasms; Cathepsin D; Chloroquine; Diffusion Chambers, Culture; Female; Humans; Molecular W | 1993 |
A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery.
Topics: Ammonium Chloride; Animals; Anti-Bacterial Agents; Breast Neoplasms; Chloroquine; COS Cells; Diphthe | 1998 |
[On the value of chloroquine in the treatment of malignant tumor diseases].
Topics: Adenocarcinoma, Scirrhous; Adult; Aged; Animals; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, E | 1967 |
Sequential liver scanning.
Topics: Adult; Breast Neoplasms; Chloroquine; Colonic Neoplasms; Dactinomycin; Emetine; Estrogens; Female; F | 1969 |