Page last updated: 2024-10-24

chloroquine and Brain Edema

chloroquine has been researched along with Brain Edema in 6 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

ExcerptRelevanceReference
"Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal."1.51Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria. ( Azevedo-Quintanilha, IG; Bozza, PT; Campbell, RA; Castro-Faria-Neto, HC; Estato, V; Ferreira, AC; Nascimento, DO; Reis, PA; Silva, TI; Vieira-de-Abreu, A; Weyrich, AS; Zimmerman, GA, 2019)
"In a man who had been in a coma for 24 hours with cerebral malaria dexamethasone had a dramatic, and probably life-saving, effect."1.25Use of dexamethasone in cerebral malaria. ( Dickinson, CJ; Woodruff, AW, 1968)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Azevedo-Quintanilha, IG1
Vieira-de-Abreu, A1
Ferreira, AC1
Reis, PA1
Silva, TI1
Nascimento, DO1
Campbell, RA1
Estato, V1
Weyrich, AS1
Bozza, PT1
Zimmerman, GA1
Castro-Faria-Neto, HC1
Liu, YY1
Zhang, TY1
Xue, X1
Liu, DM1
Zhang, HT1
Yuan, LL1
Liu, YL1
Yang, HL1
Sun, SB1
Zhang, C1
Xu, HS1
Wu, CF1
Yang, JY1
Cui, CM1
Gao, JL1
Cui, Y1
Sun, LQ1
Wang, YC1
Wang, KJ1
Li, R1
Tian, YX1
Cui, JZ1
Holmin, S1
Mathiesen, T1
Havens, PL1
Splaingard, ML1
Bousounis, D1
Hoffman, GM1
Woodruff, AW1
Dickinson, CJ1

Other Studies

6 other studies available for chloroquine and Brain Edema

ArticleYear
Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria.
    PloS one, 2019, Volume: 14, Issue:12

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; CD11 Antigens; Chloroquine; Disease Models, Animal

2019
Pseudoginsenoside-F11 attenuates cerebral ischemic injury by alleviating autophagic/lysosomal defects.
    CNS neuroscience & therapeutics, 2017, Volume: 23, Issue:7

    Topics: Animals; Apoptosis; Autophagy; Brain; Brain Edema; Brain Ischemia; Chloroquine; Disease Models, Anim

2017
Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic death.
    Molecular medicine reports, 2015, Volume: 12, Issue:2

    Topics: Animals; Antigens, Nuclear; Autophagy; Biomarkers; Brain Edema; Brain Injuries; Chloroquine; Disease

2015
Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion.
    Acta neurochirurgica, 1996, Volume: 138, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Concussion; Brain Damage, Chronic; Brain Edema; Chlo

1996
Survival after chloroquine ingestion in a child.
    Journal of toxicology. Clinical toxicology, 1988, Volume: 26, Issue:5-6

    Topics: Brain Edema; Chloroquine; Coma; Electroencephalography; Evoked Potentials; Humans; Infant; Male; Ner

1988
Use of dexamethasone in cerebral malaria.
    British medical journal, 1968, Jul-06, Volume: 3, Issue:5609

    Topics: Adult; Brain Edema; Chloroquine; Coma; Dexamethasone; Humans; Malaria; Male

1968