chloroquine has been researched along with Brain Edema in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Excerpt | Relevance | Reference |
---|---|---|
"Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal." | 1.51 | Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria. ( Azevedo-Quintanilha, IG; Bozza, PT; Campbell, RA; Castro-Faria-Neto, HC; Estato, V; Ferreira, AC; Nascimento, DO; Reis, PA; Silva, TI; Vieira-de-Abreu, A; Weyrich, AS; Zimmerman, GA, 2019) |
"In a man who had been in a coma for 24 hours with cerebral malaria dexamethasone had a dramatic, and probably life-saving, effect." | 1.25 | Use of dexamethasone in cerebral malaria. ( Dickinson, CJ; Woodruff, AW, 1968) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (33.33) | 18.7374 |
1990's | 1 (16.67) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Azevedo-Quintanilha, IG | 1 |
Vieira-de-Abreu, A | 1 |
Ferreira, AC | 1 |
Reis, PA | 1 |
Silva, TI | 1 |
Nascimento, DO | 1 |
Campbell, RA | 1 |
Estato, V | 1 |
Weyrich, AS | 1 |
Bozza, PT | 1 |
Zimmerman, GA | 1 |
Castro-Faria-Neto, HC | 1 |
Liu, YY | 1 |
Zhang, TY | 1 |
Xue, X | 1 |
Liu, DM | 1 |
Zhang, HT | 1 |
Yuan, LL | 1 |
Liu, YL | 1 |
Yang, HL | 1 |
Sun, SB | 1 |
Zhang, C | 1 |
Xu, HS | 1 |
Wu, CF | 1 |
Yang, JY | 1 |
Cui, CM | 1 |
Gao, JL | 1 |
Cui, Y | 1 |
Sun, LQ | 1 |
Wang, YC | 1 |
Wang, KJ | 1 |
Li, R | 1 |
Tian, YX | 1 |
Cui, JZ | 1 |
Holmin, S | 1 |
Mathiesen, T | 1 |
Havens, PL | 1 |
Splaingard, ML | 1 |
Bousounis, D | 1 |
Hoffman, GM | 1 |
Woodruff, AW | 1 |
Dickinson, CJ | 1 |
6 other studies available for chloroquine and Brain Edema
Article | Year |
---|---|
Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; CD11 Antigens; Chloroquine; Disease Models, Animal | 2019 |
Pseudoginsenoside-F11 attenuates cerebral ischemic injury by alleviating autophagic/lysosomal defects.
Topics: Animals; Apoptosis; Autophagy; Brain; Brain Edema; Brain Ischemia; Chloroquine; Disease Models, Anim | 2017 |
Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic death.
Topics: Animals; Antigens, Nuclear; Autophagy; Biomarkers; Brain Edema; Brain Injuries; Chloroquine; Disease | 2015 |
Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Concussion; Brain Damage, Chronic; Brain Edema; Chlo | 1996 |
Survival after chloroquine ingestion in a child.
Topics: Brain Edema; Chloroquine; Coma; Electroencephalography; Evoked Potentials; Humans; Infant; Male; Ner | 1988 |
Use of dexamethasone in cerebral malaria.
Topics: Adult; Brain Edema; Chloroquine; Coma; Dexamethasone; Humans; Malaria; Male | 1968 |