chloroquine and Brain Diseases studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

Research Excerpts

Excerpt	Relevance	Reference
"There is no information and therefore no consensus on how chloroquine should be administered to persons with severe malaria."	9.06	Parenteral chloroquine for treating falciparum malaria. ( Bergqvist, Y; Njelesani, EK; Watt, G; White, NJ, 1987)
"Data concerning 11 cases of cerebral malaria treated with high doses of chloroquine base (18mg/kg/day) are reported."	7.66	Cerebral malaria treated with high doses of chloroquine. ( Nuti, S; Savioli, L, 1983)
"There is no information and therefore no consensus on how chloroquine should be administered to persons with severe malaria."	5.06	Parenteral chloroquine for treating falciparum malaria. ( Bergqvist, Y; Njelesani, EK; Watt, G; White, NJ, 1987)
"Data concerning 11 cases of cerebral malaria treated with high doses of chloroquine base (18mg/kg/day) are reported."	3.66	Cerebral malaria treated with high doses of chloroquine. ( Nuti, S; Savioli, L, 1983)
"Cerebral malaria is an acute diffuse encephalopathy associated only with Plasmodium falciparum."	2.35	Cerebral Malaria. ( Bruce-Chwatt, LJ; Marsden, PD, 1975)
"falciparum malaria and unrousable coma)."	1.28	Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. ( Borgstein, A; Molyneux, ME; Taylor, TE; Wirima, JJ, 1989)
" Reappraisal of quinine therapy has led to important modifications in dosage recommendations and recognition of a major complication of severe malaria associated with its use--hypoglycaemia."	1.27	Management of Plasmodium falciparum malaria. ( Phillips, RE, 1984)

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (87.50)	18.7374
1990's	5 (12.50)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
SPILLANE, JD	1
MIZUNO, T	1
Maguire, MJ	1
Nuti, S	1
Savioli, L	1
Phillips, RE	1
Weniger, BG	1
Blumberg, RS	1
Campbell, CC	1
Jones, TC	1
Mount, DL	1
Friedman, SM	1
Flici, O	1
Tadjerouni, A	1
Leroy, F	1
Teys, JP	1
Hubinont, PO	1
Poltera, AA	1
Hochmann, A	1
Lambert, PH	1
Holt, PA	1
Ghosh, SK	1
Santucci, A	1
Aguglia, F	1
Federico, M	1
De Mattia, G	1
Frisch, W	1
Lüllmann-Rauch, R	1
Blasi, E	2
Barluzzi, R	2
Mazzolla, R	2
Bistoni, F	2
Singh, PS	1
Putintsev, VI	1
Son, EA	1
Marsden, PD	1
Bruce-Chwatt, LJ	1
Berner, H	1
Mosci, P	1
Brewster, DR	1
Kwiatkowski, D	1
White, NJ	2
Endeshaw, Y	1
Assefa, D	1
Okeahialam, BN	1
Okeke, EN	1
Molyneux, ME	1
Taylor, TE	1
Wirima, JJ	1
Borgstein, A	1
Nathwani, DN	1
Smith, CC	1
Khaund, RR	1
Gopinathan, VP	1
Subramanian, AR	1
Olweny, CL	1
Chauhan, SS	1
Simooya, OO	1
Bulsara, MK	1
Njelesani, EK	2
Van Thuc, H	1
Watt, G	1
Bergqvist, Y	1
Devakul, K	1
Harinasuta, T	1
Reid, HA	1
Fischer, VW	1
Nelson, JS	1
Charters, AD	1
Davis, RE	1
Mitchell, AD	1
Gyr, K	1
Speck, B	1
Ritz, R	1
Cornu, P	1
Buckner, CD	1
Eales, L	1
Podos, SM	1
Enoch, JM	1
Berger, R	1
Birns, R	1
Jelliffe, DB	1
Blount, RE	1
Beale, PJ	1
Coni, NK	1
Newman, M	1
Verdrager, J	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819]				256 participants (Anticipated)	Observational	2021-01-02	Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Malaria in pregnant women. Presentation of 2 cases and review of the literature]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1982, Volume: 11, Issue:8 Topics: Abortion, Spontaneous; Acute Kidney Injury; Adult; Anemia, Hemolytic; Antimalarials; Brain Diseases;	1982
Cerebral Malaria. Contemporary neurology series, 1975, Volume: 12 Topics: Adolescent; Adult; Antimalarials; Brain Diseases; Capillaries; Cerebral Cortex; Cerebral Hemorrhage;	1975
Neurological sequelae of cerebral malaria in children. Lancet (London, England), 1990, Oct-27, Volume: 336, Issue:8722 Topics: Adolescent; Animals; Antimalarials; Brain Diseases; Child; Chloroquine; Coma; Follow-Up Studies; Gam	1990

Article	Year
IATROGENIC NEUROLOGICAL DISEASES. DRUG-INDUCED NEUROLOGICAL DISORDERS. Proceedings of the Royal Society of Medicine, 1964, Volume: 57 Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antihypertensive Agents	1964
[DIAGNOSIS AND THERAPY OF CONVULSIVE DISEASES IN CHILDHOOD]. [Chiryo] [Therapy], 1964, Volume: 46 Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Amino Acids; Barbiturates; Brain Diseases; C	1964
The management of cerebral malaria in African children. East African medical journal, 1983, Volume: 60, Issue:4 Topics: Africa; Brain Diseases; Child, Preschool; Chloroquine; Drug Administration Schedule; Female; Humans;	1983
Cerebral malaria treated with high doses of chloroquine. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1983, Volume: 77, Issue:6 Topics: Adolescent; Adult; Brain Diseases; Child; Chloroquine; Female; Humans; Malaria; Male; Plasmodium fal	1983
Management of Plasmodium falciparum malaria. The Medical journal of Australia, 1984, Oct-13, Volume: 141, Issue:8 Topics: Amodiaquine; Anemia; Antimalarials; Brain Diseases; Chloroquine; Drug Resistance; Female; Humans; Hy	1984
High-level chloroquine resistance of Plasmodium falciparum malaria acquired in Kenya. The New England journal of medicine, 1982, Dec-16, Volume: 307, Issue:25 Topics: Adult; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Female; Humans; Kenya; Malaria; Plas	1982
Trypanosoma brucei brucei: the response to Melarsoprol in mice with cerebral trypanosomiasis. An immunopathological study. Clinical and experimental immunology, 1981, Volume: 46, Issue:2 Topics: Animals; Antigen-Antibody Complex; Arsenicals; Brain; Brain Diseases; Chloroquine; Fluorescent Antib	1981
Malaria in the UK. Some observations on six years' experience in Leeds and Middlesbrough. The Practitioner, 1982, Volume: 226, Issue:1364 Topics: Adult; Brain Diseases; Chloroquine; England; Humans; Leukocyte Count; Malaria; Male; Middle Aged; Pl	1982
[Neuroendocrine syndromes with toxoplasmic origin: clinical and therapeutic considerations]. La Clinica terapeutica, 1980, Jul-15, Volume: 94, Issue:1 Topics: Adult; Brain Diseases; Child; Chloroquine; Female; Fenfluramine; Humans; Pyrimethamine; Sulfamethoxy	1980
Effects of several lipidosis-including drugs upon the area postrema and adjacent medullary nuclei of adult rats. I. Alterations is perikarya and dendrites. Acta neuropathologica, 1980, Volume: 52, Issue:3 Topics: Animals; Blood-Brain Barrier; Brain Diseases; Chloroquine; Chlorphentermine; Female; Lipidoses; Male	1980
Differential host susceptibility to intracerebral infections with Candida albicans and Cryptococcus neoformans. Infection and immunity, 1993, Volume: 61, Issue:8 Topics: Animals; Brain Diseases; Candidiasis; Chloroquine; Colchicine; Cryptococcosis; Disease Susceptibilit	1993
Coexistence of enteric fever with malaria. The Journal of the Association of Physicians of India, 1995, Volume: 43, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antimalarials; Brain Diseases; Chloroquine; Ciprofloxa	1995
[Hypothalamic syndrome as a consequence of years-long use of delagil]. Klinicheskaia meditsina, 1979, Volume: 57, Issue:9 Topics: Adult; Brain Diseases; Chloroquine; Consciousness Disorders; Humans; Hypothalamus; Male; Syndrome; T	1979
[Malaria in children, with special reference to cerebral malaria (author's transl)]. Klinische Padiatrie, 1975, Volume: 187, Issue:5 Topics: Age Factors; Anemia, Hemolytic; Brain Diseases; Cerebral Palsy; Child; Child, Preschool; Chloroquine	1975
Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization. Infection and immunity, 1992, Volume: 60, Issue:9 Topics: Animals; Brain Diseases; Chloroquine; Colchicine; Cryptococcosis; Disease Models, Animal; Female; Mi	1992
Cerebral malaria. Factors affecting outcome of treatment in a suboptimal clinical setting. The Journal of tropical medicine and hygiene, 1990, Volume: 93, Issue:1 Topics: Adult; Brain Diseases; Chloroquine; Ethiopia; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Co	1990
Chloroquine-resistant malaria in Jos, Nigeria. The Journal of tropical medicine and hygiene, 1989, Volume: 92, Issue:5 Topics: Adolescent; Animals; Brain Diseases; Chloroquine; Drug Resistance; Humans; Malaria; Male; Nigeria; P	1989
Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. The Quarterly journal of medicine, 1989, Volume: 71, Issue:265 Topics: Anemia; Animals; Blinking; Brain Diseases; Child; Child, Preschool; Chloroquine; Coma; Female; Human	1989
Cerebral malaria from West Africa: chloroquine-resistant Plasmodium falciparum? The Journal of infection, 1988, Volume: 17, Issue:2 Topics: Adult; Africa, Western; Animals; Brain Diseases; Chloroquine; Drug Resistance; Humans; Malaria; Male	1988
Childhood chloroquine poisonings--Wisconsin and Washington. MMWR. Morbidity and mortality weekly report, 1988, Jul-22, Volume: 37, Issue:28 Topics: Brain Diseases; Chloroquine; Diazepam; Drug Therapy, Combination; Epinephrine; Female; Humans; Infan	1988
Leads from the MMWR. Childhood chloroquine poisonings--Wisconsin and Washington. JAMA, 1988, Sep-09, Volume: 260, Issue:10 Topics: Brain Diseases; Chloroquine; Diazepam; Drug Therapy, Combination; Epinephrine; Female; Humans; Infan	1988
Vivax and falciparum malaria seen at an Indian service hospital. The Journal of tropical medicine and hygiene, 1986, Volume: 89, Issue:2 Topics: Adolescent; Adult; Anemia, Pernicious; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Huma	1986
Adult cerebral malaria in Zambia: preliminary report of clinical findings and treatment response. The Journal of tropical medicine and hygiene, 1986, Volume: 89, Issue:3 Topics: Adolescent; Adult; Brain Diseases; Child; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; P	1986
125-I-labelled fibrinogen in cerebral malaria. Lancet (London, England), 1966, Oct-22, Volume: 2, Issue:7469 Topics: Adolescent; Adult; Blood Coagulation; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Fibri	1966
Chloroquine-enhanced cerebellovascular changes in nutritionally imbalanced chicks. Acta neuropathologica, 1974, Volume: 29, Issue:1 Topics: Acid Phosphatase; Animals; Blood Vessels; Brain Diseases; Cerebellum; Chickens; Chloroquine; Endothe	1974
A survey of imported malaria in Western Australia including four cases of drug resistance. The Medical journal of Australia, 1974, Apr-06, Volume: 1, Issue:14 Topics: Adolescent; Adult; Australia; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Emigration an	1974
Recent experiences with severe and cerebral malaria. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Jun-09, Volume: 48, Issue:31 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Brain Diseases; Child; Child, Preschool; Chloroquine; Co	1974
[Cerebral tropical malaria with blackwater fever. A current diagnostic and therapeutic problem]. Schweizerische medizinische Wochenschrift, 1974, Nov-09, Volume: 104, Issue:45 Topics: Acute Kidney Injury; Adult; Blackwater Fever; Brain Diseases; Chloroquine; Disseminated Intravascula	1974
Acute falciparum malaria. Complications and treatment. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Jul-06, Volume: 48, Issue:32 Topics: Acute Kidney Injury; Brain Diseases; Chloroquine; Coma; Disseminated Intravascular Coagulation; Hepa	1974
Retinal pigmentary disease. International ophthalmology clinics, 1967,Winter, Volume: 7, Issue:4 Topics: Adolescent; Adult; Blindness; Brain Diseases; Chloroquine; Chorioretinitis; Choroid; Diagnosis, Diff	1967
A static perimetric technique believed to test receptive field properties: extension and verification of the analysis. Documenta ophthalmologica. Advances in ophthalmology, 1970, Dec-21, Volume: 29, Issue:1 Topics: Adenoma, Chromophobe; Adult; Amblyopia; Animals; Brain Diseases; Chloroquine; Color Vision Defects;	1970
The therapy of cerebral malaria in children. Editorial comment. The Journal of pediatrics, 1966, Volume: 69, Issue:3 Topics: Blood; Brain Diseases; Child; Child, Preschool; Chloroquine; Female; Humans; Malaria; Male; Plasmodi	1966
Management of chloroquine resistant falciparum malaria. Transactions of the American Clinical and Climatological Association, 1967, Volume: 78 Topics: Adult; Brain Diseases; Chloroquine; Dapsone; Dexamethasone; Drug Resistance, Microbial; Edema; Human	1967
Cerebral malaria. Annals of tropical medicine and parasitology, 1970, Volume: 64, Issue:2 Topics: Adult; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Quini	1970
Modern techniques in perimetry. International ophthalmology clinics, 1967,Winter, Volume: 7, Issue:4 Topics: Adaptation, Ocular; Adolescent; Adult; Amblyopia; Brain Diseases; Chloroquine; Chorioretinitis; Eye	1967
Cerebral malaria following blood transfusion. The Journal of tropical medicine and hygiene, 1969, Volume: 72, Issue:6 Topics: Adult; Brain Diseases; Chloroquine; Communicable Disease Control; Disease Reservoirs; Humans; Malari	1969

chloroquine and Brain Diseases

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