chloroquine has been researched along with Bone Cancer in 11 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated the combined effect of the autophagy inhibitor chloroquine and the mTOR inhibitor rapamycin on MG63 osteosarcoma cells." | 3.91 | Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells. ( Fukuoka, N; Ishibashi, Y; Nakamura, O; Nishimura, H; Yamagami, Y; Yamamoto, T, 2019) |
| " We previously reported that in human melanoma and osteosarcoma cells, autophagy inhibitors, such as 3‑methyladenine and chloroquine increased the sensitivity to apoptosis induced by tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL)." | 3.91 | Autophagy inhibitors regulate TRAIL sensitivity in human malignant cells by targeting the mitochondrial network and calcium dynamics. ( Ochiai, T; Onoe-Takahashi, A; Suzuki-Karasaki, M; Suzuki-Karasaki, Y, 2019) |
| " Ten chondrosarcoma cell lines were treated with the metabolic compounds CB-849, metformin, phenformin (lipophilic analogue of metformin) and chloroquine." | 3.88 | Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation. ( Addie, RD; Bovée, JVMG; Cleton-Jansen, AM; Cleven, AHG; de Jong, Y; Kruisselbrink, AB; Molenaar, RJ; Niessen, B; Peterse, EFP; van den Akker, BEWM, 2018) |
| "Chordoma is a rare tumor of the bone derived from remnants of the notochord with pronounced chemoresistance." | 1.48 | Characterization of the endolysosomal system in human chordoma cell lines: is there a role of lysosomes in chemoresistance of this rare bone tumor? ( Fuchs, R; Groselj-Strele, A; Heitzer, E; Kolb-Lenz, D; Leithner, A; Liegl-Atzwanger, B; Lohberger, B; Meditz, K; Pernitsch, D; Pritz, E; Rinner, B, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, SC | 1 |
| Chen, HY | 1 |
| Chuang, WL | 1 |
| Wang, HC | 1 |
| Hsieh, CP | 1 |
| Huang, YF | 1 |
| Feng, H | 1 |
| Zhang, Q | 1 |
| Zhao, Y | 1 |
| Zhao, L | 1 |
| Shan, B | 1 |
| Liu, Z | 2 |
| Wang, H | 1 |
| Hu, C | 1 |
| Wu, C | 1 |
| Wang, J | 1 |
| Hu, F | 1 |
| Fu, Y | 1 |
| Wen, J | 1 |
| Zhang, W | 1 |
| Chen, C | 1 |
| Zhang, H | 1 |
| Yu, Y | 1 |
| Huang, Q | 1 |
| Wang, W | 1 |
| Niu, J | 1 |
| Lou, J | 1 |
| Ren, T | 1 |
| Huang, Y | 1 |
| Guo, W | 1 |
| Tandon, M | 1 |
| Othman, AH | 1 |
| Ashok, V | 1 |
| Stein, GS | 1 |
| Pratap, J | 1 |
| Zhang, G | 1 |
| Chen, Y | 1 |
| Zhang, Y | 1 |
| Peterse, EFP | 1 |
| Niessen, B | 1 |
| Addie, RD | 1 |
| de Jong, Y | 1 |
| Cleven, AHG | 1 |
| Kruisselbrink, AB | 1 |
| van den Akker, BEWM | 1 |
| Molenaar, RJ | 1 |
| Cleton-Jansen, AM | 1 |
| Bovée, JVMG | 1 |
| Kolb-Lenz, D | 1 |
| Fuchs, R | 1 |
| Lohberger, B | 1 |
| Heitzer, E | 1 |
| Meditz, K | 1 |
| Pernitsch, D | 1 |
| Pritz, E | 1 |
| Groselj-Strele, A | 1 |
| Leithner, A | 1 |
| Liegl-Atzwanger, B | 1 |
| Rinner, B | 1 |
| Ishibashi, Y | 1 |
| Nakamura, O | 1 |
| Yamagami, Y | 1 |
| Nishimura, H | 1 |
| Fukuoka, N | 1 |
| Yamamoto, T | 1 |
| Onoe-Takahashi, A | 1 |
| Suzuki-Karasaki, M | 2 |
| Ochiai, T | 1 |
| Suzuki-Karasaki, Y | 1 |
| Wang, CK | 1 |
| Yu, XD | 1 |
| Li, Q | 1 |
| Xie, G | 1 |
| Teng, Y | 1 |
11 other studies available for chloroquine and Bone Cancer
| Article | Year |
|---|---|
Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines.
Topics: Antineoplastic Agents, Phytogenic; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Surviv | 2022 |
Leptin acts on mesenchymal stem cells to promote chemoresistance in osteosarcoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Carcinogenesis; Chloroquine; Cisplatin; D | 2020 |
Targeting autophagy enhances atezolizumab-induced mitochondria-related apoptosis in osteosarcoma.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosi | 2021 |
Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3.
Topics: Adult; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Bone Neoplasms; Cell Proliferation; Ch | 2021 |
The role of Runx2 in facilitating autophagy in metastatic breast cancer cells.
Topics: Acetylation; Animals; Antineoplastic Agents; Autophagosomes; Autophagy; Bone Neoplasms; Breast Neopl | 2018 |
High Serum HDGF Levels Are Predictive of Bone Metastasis and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
Topics: A549 Cells; Aged; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Chloroquine; Cohort Studies; Femal | 2017 |
Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation.
Topics: Antineoplastic Agents; Benzeneacetamides; Bone Neoplasms; Chloroquine; Chondrosarcoma; Drug Screenin | 2018 |
Characterization of the endolysosomal system in human chordoma cell lines: is there a role of lysosomes in chemoresistance of this rare bone tumor?
Topics: Antineoplastic Agents; Autophagy; Bone Neoplasms; Cell Proliferation; Cell Survival; Chloroquine; Ch | 2018 |
Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Autophagy; Bone Neoplasms; Cell Line, Tumor; Cell Proliferat | 2019 |
Autophagy inhibitors regulate TRAIL sensitivity in human malignant cells by targeting the mitochondrial network and calcium dynamics.
Topics: Autophagy; Biomarkers, Tumor; Bone Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Su | 2019 |
Chloroquine and valproic acid combined treatment in vitro has enhanced cytotoxicity in an osteosarcoma cell line.
Topics: Anticonvulsants; Antimalarials; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, | 2013 |