chloroquine has been researched along with Blood Poisoning in 15 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is caused by an overwhelming immune response to bacterial infection." | 5.39 | Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis. ( Cao, L; Kang, R; Tang, D; Xie, M; Yang, L; Yang, M; Yu, Y; Zhao, M, 2013) |
| "Mortality from sepsis has remained high despite recent advances in supportive and targeted therapies." | 5.35 | Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. ( Childs, R; Dear, JW; Doi, K; Hu, X; Ito, S; Klinman, DM; Leelahavanichkul, A; Star, RA; Takahashi, Y; Tsunoda, S; Yasuda, H; Yuen, PS; Zhou, H, 2008) |
| " The children had persistent fever (5 or more days) despite treatment with chloroquine and were admitted to the Department of Child Health of the University of Ghana Medical School in Accra with severe malaria (Plasmodium falciparum)." | 3.69 | Persistent fever in severe malaria in children. ( Agyepong, I; Commey, J; Quarm-Goka, B, 1994) |
| "The exact treatment of sepsis is still the subject of considerable debate." | 2.58 | Sepsis: The Involvement of Platelets and the Current Treatments. ( Ganaes, JOF; Lopes-Pires, ME; Naime, ACA, 2018) |
| "We report a case of dual infection of scrub typhus and malaria in a 48-year-old woman." | 1.40 | Scrub typhus and malaria co-infection causing severe sepsis. ( Kaushik, M; Mahajan, SK; Raina, R; Thakur, P, 2014) |
| "Sepsis was induced by cecal ligation and puncture (CLP)." | 1.40 | Complete activation of autophagic process attenuates liver injury and improves survival in septic mice. ( Chang, YF; Hsieh, YC; Kuo, PL; Lee, PH; Lin, CW; Lo, S; Perng, DS; Wu, DB; Yu, ML; Yuan, SS, 2014) |
| "Sepsis is caused by an overwhelming immune response to bacterial infection." | 1.39 | Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis. ( Cao, L; Kang, R; Tang, D; Xie, M; Yang, L; Yang, M; Yu, Y; Zhao, M, 2013) |
| "Mortality from sepsis has remained high despite recent advances in supportive and targeted therapies." | 1.35 | Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. ( Childs, R; Dear, JW; Doi, K; Hu, X; Ito, S; Klinman, DM; Leelahavanichkul, A; Star, RA; Takahashi, Y; Tsunoda, S; Yasuda, H; Yuen, PS; Zhou, H, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naime, ACA | 1 |
| Ganaes, JOF | 1 |
| Lopes-Pires, ME | 1 |
| Unuma, K | 1 |
| Aki, T | 1 |
| Funakoshi, T | 1 |
| Yoshida, K | 1 |
| Uemura, K | 1 |
| Molad, Y | 1 |
| Pokroy-Shapira, E | 1 |
| Carmon, V | 1 |
| Yang, M | 1 |
| Cao, L | 1 |
| Xie, M | 1 |
| Yu, Y | 1 |
| Kang, R | 1 |
| Yang, L | 1 |
| Zhao, M | 1 |
| Tang, D | 1 |
| Mahajan, SK | 1 |
| Kaushik, M | 1 |
| Raina, R | 1 |
| Thakur, P | 1 |
| Lin, CW | 1 |
| Lo, S | 1 |
| Perng, DS | 1 |
| Wu, DB | 1 |
| Lee, PH | 1 |
| Chang, YF | 1 |
| Kuo, PL | 1 |
| Yu, ML | 1 |
| Yuan, SS | 1 |
| Hsieh, YC | 1 |
| Cho, HI | 1 |
| Kim, SJ | 1 |
| Choi, JW | 1 |
| Lee, SM | 1 |
| Leelahavanichkul, A | 3 |
| Yasuda, H | 2 |
| Doi, K | 3 |
| Hu, X | 3 |
| Zhou, H | 2 |
| Yuen, PS | 3 |
| Star, RA | 3 |
| Eisner, C | 1 |
| Schnermann, J | 1 |
| Ablett, DJ | 1 |
| Del Punta, V | 1 |
| Gulletta, M | 1 |
| Matteelli, A | 1 |
| Spinoni, V | 1 |
| Regazzoli, A | 1 |
| Castelli, F | 1 |
| Wittebole, X | 1 |
| Castanares-Zapatero, D | 1 |
| Laterre, PF | 1 |
| Hong, Z | 1 |
| Jiang, Z | 1 |
| Liangxi, W | 1 |
| Guofu, D | 1 |
| Ping, L | 1 |
| Yongling, L | 1 |
| Wendong, P | 1 |
| Minghai, W | 1 |
| Tsunoda, S | 1 |
| Dear, JW | 1 |
| Takahashi, Y | 1 |
| Ito, S | 1 |
| Childs, R | 1 |
| Klinman, DM | 1 |
| Commey, J | 1 |
| Quarm-Goka, B | 1 |
| Agyepong, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury[NCT02530359] | Phase 4 | 90 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chloroquine and Blood Poisoning
| Article | Year |
|---|---|
Sepsis: The Involvement of Platelets and the Current Treatments.
Topics: Acetylcysteine; Animals; Blood Platelets; Capsaicin; Chloroquine; Disseminated Intravascular Coagula | 2018 |
Toll-like receptor 4 modulation as a strategy to treat sepsis.
Topics: Analgesics; Analgesics, Opioid; Animals; Antibodies; Antirheumatic Agents; Chloroquine; Cholecalcife | 2010 |
13 other studies available for chloroquine and Blood Poisoning
| Article | Year |
|---|---|
Cobalt protoporphyrin accelerates TFEB activation and lysosome reformation during LPS-induced septic insults in the rat heart.
Topics: Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Nucleus; Chlor | 2013 |
CpG-oligodeoxynucleotide-induced TLR9 activation regulates macrophage TREM-1 expression and shedding.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Chloroquine; Disease Models, Animal; Gene | 2013 |
Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis.
Topics: Animals; Antimalarials; Cell Line; Chloroquine; HMGB1 Protein; Inflammation Mediators; Macrophages; | 2013 |
Scrub typhus and malaria co-infection causing severe sepsis.
Topics: Animals; Anti-Bacterial Agents; Azithromycin; Chloroquine; Coinfection; Doxycycline; Enzyme-Linked I | 2014 |
Complete activation of autophagic process attenuates liver injury and improves survival in septic mice.
Topics: Adenine; Amebicides; Animals; Anticonvulsants; Autophagy; Carbamazepine; Chloroquine; Liver; Lysosom | 2014 |
Genipin alleviates sepsis-induced liver injury by restoring autophagy.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Autophagy; Autophagy-Related Proteins; C | 2016 |
Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice.
Topics: Acrylates; Animals; Cecum; Chloroquine; Inflammation; Kidney; Kidney Function Tests; Kinetics; Ligat | 2008 |
Reduced production of creatinine limits its use as marker of kidney injury in sepsis.
Topics: Animals; Antimalarials; Biomarkers; Chloroquine; Creatinine; Male; Mice; Nephrectomy; Renal Insuffic | 2009 |
Case study and subsequent audit.
Topics: Afghan Campaign 2001-; Afghanistan; Animals; Antimalarials; Cellulitis; Chloroquine; Diagnosis, Diff | 2009 |
Congenital Plasmodium vivax malaria mimicking neonatal sepsis: a case report.
Topics: Anti-Bacterial Agents; Antimalarials; Chloroquine; Diagnosis, Differential; Female; Humans; Incident | 2010 |
Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release.
Topics: Adjuvants, Immunologic; Animals; Cell Line; Chloroquine; Cytokines; Disease Models, Animal; DNA-Bind | 2004 |
Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury.
Topics: Acute Disease; Acute Kidney Injury; Animals; Antimalarials; Apoptosis; Blood Urea Nitrogen; Chloroqu | 2008 |
Persistent fever in severe malaria in children.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Chloroquine; Chronic Disease; Drug Resistance; Femal | 1994 |