chloroquine has been researched along with Benign Neoplasms, Brain in 41 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the effect of adding chloroquine to conventional therapy for glioblastoma multiforme." | 9.12 | Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial. ( Briceño, E; López-González, MA; Sotelo, J, 2006) |
| " They studied the effects of chloroquine, an antimutagenic with an optimal pharmacological profile for human use, as adjuvant for the treatment of patients with glioblastoma multiforme (GBM)." | 9.10 | Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine. ( Briceño, E; Reyes, S; Sotelo, J, 2003) |
| "Chloroquine has been shown to increase the cellular retention and nuclear incorporation of 125I-labeled monoclonal antibody (MAb) 425, a murine anti-epidermal growth factor receptor monoclonal antibody, in human high-grade glioma cells in vitro." | 7.69 | Biodistribution of 125I-MAb 425 in a human glioma xenograft model: effect of chloroquine. ( Bender, H; Brady, LW; Class, R; Dilling, TJ; Emrich, JG; Hand, CM, 1997) |
| "Glioblastoma is the most common and aggressive primary brain tumor in adults." | 5.48 | Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma. ( Chen, X; Han, D; Hou, X; Liu, H; Liu, Z; Ma, J; Peng, F; Shen, C; Shu, M; Wang, K; Wang, L; Wang, X; Wu, J; Yang, G; Yin, Z; Zhang, D; Zhao, B; Zhao, S; Zhao, W; Zheng, Z; Zhong, C, 2018) |
| "Malignant glioma is the most aggressive brain tumor." | 5.46 | Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway. ( Chen, JT; Chen, RM; Cheng, BC; Chio, CC; Liu, SH; Yang, ST, 2017) |
| "Quercetin can inhibit cell viability and induce autophagy of U87 and U251 glioma cells in a dose-dependent manner." | 5.43 | Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells. ( Bi, Y; Gao, D; Hou, X; Li, C; Liu, H; Liu, Y; Liu, Z; Peng, F; Shen, C; Shi, C; Wang, K; Wang, X; Wu, J; Zhang, J; Zhao, B; Zhao, S; Zheng, Z; Zhong, C; Zou, H, 2016) |
| "Chloroquine (CQ) is an anti-malaria and immunomodulatory drug that may inhibit autophagy and increase the radiosensitivity of GBM." | 5.40 | FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma: first tolerability and feasibility results. ( Bilger, A; Bittner, MI; Firat, E; Grosu, AL; Meyer, PT; Milanović, D; Niedermann, G; Weber, WA; Wiedenmann, N, 2014) |
| "Pretreatment with chloroquine, an autophagy inhibitor, strongly augmented apoptosis in U373MG cells, indicating that quercetin induced protective autopagy in U373MG cells." | 5.39 | Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. ( Ahn, KS; Cho, SK; Kim, H; Moon, JY, 2013) |
| "To examine the effect of adding chloroquine to conventional therapy for glioblastoma multiforme." | 5.12 | Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial. ( Briceño, E; López-González, MA; Sotelo, J, 2006) |
| " They studied the effects of chloroquine, an antimutagenic with an optimal pharmacological profile for human use, as adjuvant for the treatment of patients with glioblastoma multiforme (GBM)." | 5.10 | Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine. ( Briceño, E; Reyes, S; Sotelo, J, 2003) |
| "These data suggest that the anti-proliferative activity of ADS-I in human glioma cells is associated with the activation of autophagy in addition to cell cycle arrest and apoptosis, and the antagonistic effect of chloroquine suggests an important role of autophagy in ADS-I-mediated cell death against tumor growth." | 3.80 | Stimulation of autophagic activity in human glioma cells by anti-proliferative ardipusilloside I isolated from Ardisia pusilla. ( Du, C; Guan, Q; Wang, L; Wang, PY; Wang, R; Wang, XJ; Xiao, X, 2014) |
| "Chloroquine has been shown to increase the cellular retention and nuclear incorporation of 125I-labeled monoclonal antibody (MAb) 425, a murine anti-epidermal growth factor receptor monoclonal antibody, in human high-grade glioma cells in vitro." | 3.69 | Biodistribution of 125I-MAb 425 in a human glioma xenograft model: effect of chloroquine. ( Bender, H; Brady, LW; Class, R; Dilling, TJ; Emrich, JG; Hand, CM, 1997) |
| "The progression-free survival of brain metastases (BMPFS) rates at one year were 83." | 2.78 | Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases. ( Arce-Salinas, C; Arrieta, O; Crismatt, A; Dorantes-Gallareta, Y; Gamboa-Vignolle, C; Gonzalez-Pinedo, M; Nuñez-Gomez, R; Ortega-Gomez, A; Rojas-Puentes, LL, 2013) |
| "To enhance the benefit of TMZ in the treatment of glioblastomas, effective combination strategies are needed to sensitize glioblastoma cells to TMZ." | 2.53 | Targeting autophagy to sensitive glioma to temozolomide treatment. ( Dai, S; Gong, Z; Qian, L; Sun, L; Xu, Z; Yan, Y, 2016) |
| "Treatment with Dabrafenib and Trametinib was started, and tumor size increased in size after 14 months of treatment." | 1.56 | Using personalized medicine in gliomas: a genomic approach to diagnosis and overcoming treatment resistance in a case with pleomorphic xanthoastrocytoma. ( Evernden, BR; Forsyth, P; Fusco, MJ; Macaulay, RJ; Peguero, E; Piña, Y; Smalley, KS; Walko, CM, 2020) |
| "Glioblastoma is a disease with high heterogeneity that has long been difficult for doctors to identify and treat." | 1.51 | Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma. ( Chen, X; Gao, M; Liu, Z; Shu, M; Wang, K; Wang, X; Ye, J; Yin, Z; Zhao, B; Zhao, H; Zhao, S; Zhao, W; Zheng, Z; Zhong, C, 2019) |
| "Glioblastoma is the most common and aggressive primary brain tumor in adults." | 1.48 | Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma. ( Chen, X; Han, D; Hou, X; Liu, H; Liu, Z; Ma, J; Peng, F; Shen, C; Shu, M; Wang, K; Wang, L; Wang, X; Wu, J; Yang, G; Yin, Z; Zhang, D; Zhao, B; Zhao, S; Zhao, W; Zheng, Z; Zhong, C, 2018) |
| "Treatment with chloroquine, or knockdown of the autophagy gene ATG5, inhibited the formation of VM and KDR phosphorylation in GSCs." | 1.46 | Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells. ( Bian, XW; Chen, Q; Fu, WJ; Niu, Q; Ping, YF; Wang, JM; Weng, HY; Wu, HB; Yang, S; Yao, XH; Zhang, X; Zhao, XL, 2017) |
| "Malignant glioma is the most aggressive brain tumor." | 1.46 | Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway. ( Chen, JT; Chen, RM; Cheng, BC; Chio, CC; Liu, SH; Yang, ST, 2017) |
| "Quercetin can inhibit cell viability and induce autophagy of U87 and U251 glioma cells in a dose-dependent manner." | 1.43 | Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells. ( Bi, Y; Gao, D; Hou, X; Li, C; Liu, H; Liu, Y; Liu, Z; Peng, F; Shen, C; Shi, C; Wang, K; Wang, X; Wu, J; Zhang, J; Zhao, B; Zhao, S; Zheng, Z; Zhong, C; Zou, H, 2016) |
| "Inhibition of early steps of autophagy by 3-MA or Beclin 1 knockdown decreased the toxic effect of arsenic trioxide (ATO) in GBM cell lines." | 1.42 | Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells. ( Bi, Y; Chen, X; Cho, K; Hou, X; Li, C; Liu, H; Liu, Y; Peng, F; Shen, C; Wang, K; Wang, X; Yang, Z; Zhang, J; Zhang, W; Zhang, X; Zhao, S; Zheng, Z; Zhong, C; Zou, H, 2015) |
| "Chloroquine (CQ) is an anti-malaria and immunomodulatory drug that may inhibit autophagy and increase the radiosensitivity of GBM." | 1.40 | FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma: first tolerability and feasibility results. ( Bilger, A; Bittner, MI; Firat, E; Grosu, AL; Meyer, PT; Milanović, D; Niedermann, G; Weber, WA; Wiedenmann, N, 2014) |
| "Pretreatment with chloroquine, an autophagy inhibitor, strongly augmented apoptosis in U373MG cells, indicating that quercetin induced protective autopagy in U373MG cells." | 1.39 | Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. ( Ahn, KS; Cho, SK; Kim, H; Moon, JY, 2013) |
| "Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating subpopulation." | 1.38 | Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression. ( Chin, BB; Dai, D; Greer, KL; Hjelemand, A; Lascola, C; McDougald, D; McLendon, R; Metzler, SD; Reiman, R; Rich, J; Song, H; Storms, R; Vaidyanathan, G, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.88) | 18.7374 |
| 1990's | 1 (2.44) | 18.2507 |
| 2000's | 8 (19.51) | 29.6817 |
| 2010's | 27 (65.85) | 24.3611 |
| 2020's | 3 (7.32) | 2.80 |
| Authors | Studies |
|---|---|
| Piña, Y | 1 |
| Fusco, MJ | 1 |
| Macaulay, RJ | 1 |
| Walko, CM | 1 |
| Peguero, E | 1 |
| Evernden, BR | 1 |
| Smalley, KS | 1 |
| Forsyth, P | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 5 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 3 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, Y | 3 |
| Chen, L | 3 |
| Shan, A | 1 |
| Zhao, H | 3 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Wang, J | 5 |
| Zhang, E | 1 |
| Zhang, J | 5 |
| Li, Y | 5 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Wang, Y | 2 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
| Verani, A | 1 |
| Du, L | 1 |
| Liu, X | 2 |
| Ren, Y | 1 |
| Li, J | 7 |
| Li, P | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 2 |
| Wang, YS | 1 |
| Wang, C | 3 |
| Zhou, X | 2 |
| Wang, W | 1 |
| Wang, S | 2 |
| Hou, J | 1 |
| Zhang, A | 1 |
| Lv, B | 1 |
| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 3 |
| Zhu, J | 2 |
| Zhang, L | 2 |
| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
| Qu, Y | 1 |
| Yao, H | 1 |
| Wang, X | 10 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
| Zhao, Q | 1 |
| Hu, W | 1 |
| Zhang, Y | 4 |
| Wu, X | 1 |
| Lu, J | 2 |
| Li, M | 1 |
| Li, W | 2 |
| Wu, W | 1 |
| Du, F | 1 |
| Ji, H | 1 |
| Yang, X | 2 |
| Xu, Z | 2 |
| Wan, L | 1 |
| Wen, Q | 1 |
| Cho, CH | 1 |
| Zou, C | 1 |
| Xiao, Z | 1 |
| Liao, J | 1 |
| Su, X | 1 |
| Bi, Z | 1 |
| Su, Q | 1 |
| Huang, H | 2 |
| Wei, Y | 2 |
| Gao, Y | 2 |
| Na, KJ | 1 |
| Choi, H | 1 |
| Oh, HR | 1 |
| Kim, YH | 1 |
| Lee, SB | 1 |
| Jung, YJ | 1 |
| Koh, J | 1 |
| Park, S | 1 |
| Lee, HJ | 1 |
| Jeon, YK | 1 |
| Chung, DH | 1 |
| Paeng, JC | 1 |
| Park, IK | 1 |
| Kang, CH | 1 |
| Cheon, GJ | 1 |
| Kang, KW | 1 |
| Lee, DS | 1 |
| Kim, YT | 1 |
| Pajuelo-Lozano, N | 1 |
| Alcalá, S | 1 |
| Sainz, B | 1 |
| Perona, R | 1 |
| Sanchez-Perez, I | 1 |
| Logotheti, S | 1 |
| Marquardt, S | 1 |
| Gupta, SK | 1 |
| Richter, C | 1 |
| Edelhäuser, BAH | 1 |
| Engelmann, D | 1 |
| Brenmoehl, J | 1 |
| Söhnchen, C | 1 |
| Murr, N | 1 |
| Alpers, M | 1 |
| Singh, KP | 1 |
| Wolkenhauer, O | 1 |
| Heckl, D | 1 |
| Spitschak, A | 1 |
| Pützer, BM | 1 |
| Liao, Y | 1 |
| Cheng, J | 1 |
| Kong, X | 1 |
| Li, S | 1 |
| Zhang, M | 4 |
| Zhang, H | 1 |
| Yang, T | 2 |
| Dong, Y | 1 |
| Xu, Y | 1 |
| Yuan, Z | 1 |
| Cao, J | 1 |
| Zheng, Y | 1 |
| Luo, Z | 1 |
| Mei, Z | 1 |
| Yao, Y | 1 |
| Liu, Z | 5 |
| Liang, C | 1 |
| Yang, H | 1 |
| Song, Y | 1 |
| Yu, K | 1 |
| Zhu, C | 1 |
| Huang, Z | 1 |
| Qian, J | 1 |
| Ge, J | 1 |
| Hu, J | 2 |
| Wang, H | 3 |
| Liu, Y | 6 |
| Mi, Y | 1 |
| Kong, H | 1 |
| Xi, D | 1 |
| Yan, W | 1 |
| Luo, X | 1 |
| Ning, Q | 1 |
| Chang, X | 2 |
| Zhang, T | 2 |
| Wang, Q | 2 |
| Rathore, MG | 1 |
| Reddy, K | 1 |
| Chen, H | 1 |
| Shin, SH | 1 |
| Ma, WY | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Mu, W | 1 |
| Liu, C | 3 |
| Gao, F | 1 |
| Qi, Y | 1 |
| Lu, H | 1 |
| Zhang, X | 7 |
| Cai, X | 1 |
| Ji, RY | 1 |
| Hou, Y | 3 |
| Tian, J | 2 |
| Shi, Y | 1 |
| Ying, S | 1 |
| Tan, M | 1 |
| Feng, G | 1 |
| Kuang, Y | 1 |
| Chen, D | 1 |
| Wu, D | 3 |
| Zhu, ZQ | 1 |
| Tang, HX | 1 |
| Shi, ZE | 1 |
| Kang, J | 1 |
| Liu, Q | 1 |
| Qi, J | 2 |
| Mu, J | 1 |
| Cong, Z | 1 |
| Chen, S | 2 |
| Fu, D | 1 |
| Li, Z | 2 |
| Celestrin, CP | 1 |
| Rocha, GZ | 1 |
| Stein, AM | 1 |
| Guadagnini, D | 1 |
| Tadelle, RM | 1 |
| Saad, MJA | 1 |
| Oliveira, AG | 1 |
| Bianconi, V | 1 |
| Bronzo, P | 1 |
| Banach, M | 1 |
| Sahebkar, A | 1 |
| Mannarino, MR | 1 |
| Pirro, M | 1 |
| Patsourakos, NG | 1 |
| Kouvari, M | 1 |
| Kotidis, A | 1 |
| Kalantzi, KI | 1 |
| Tsoumani, ME | 1 |
| Anastasiadis, F | 1 |
| Andronikos, P | 1 |
| Aslanidou, T | 1 |
| Efraimidis, P | 1 |
| Georgiopoulos, A | 1 |
| Gerakiou, K | 1 |
| Grigoriadou-Skouta, E | 1 |
| Grigoropoulos, P | 1 |
| Hatzopoulos, D | 1 |
| Kartalis, A | 1 |
| Lyras, A | 1 |
| Markatos, G | 1 |
| Mikrogeorgiou, A | 1 |
| Myroforou, I | 1 |
| Orkopoulos, A | 1 |
| Pavlidis, P | 1 |
| Petras, C | 1 |
| Riga, M | 1 |
| Skouloudi, M | 1 |
| Smyrnioudis, N | 1 |
| Thomaidis, K | 1 |
| Tsikouri, GE | 1 |
| Tsikouris, EI | 1 |
| Zisimos, K | 1 |
| Vavoulis, P | 1 |
| Vitali, MG | 1 |
| Vitsas, G | 1 |
| Vogiatzidis, C | 1 |
| Chantanis, S | 1 |
| Fousas, S | 1 |
| Panagiotakos, DB | 1 |
| Tselepis, AD | 1 |
| Jungen, C | 1 |
| Alken, FA | 1 |
| Eickholt, C | 1 |
| Scherschel, K | 1 |
| Kuklik, P | 1 |
| Klatt, N | 1 |
| Schwarzl, J | 1 |
| Moser, J | 1 |
| Jularic, M | 1 |
| Akbulak, RO | 1 |
| Schaeffer, B | 1 |
| Willems, S | 1 |
| Meyer, C | 1 |
| Nowak, JK | 1 |
| Szczepanik, M | 1 |
| Trypuć, M | 1 |
| Pogorzelski, A | 1 |
| Bobkowski, W | 1 |
| Grytczuk, M | 1 |
| Minarowska, A | 1 |
| Wójciak, R | 1 |
| Walkowiak, J | 1 |
| Lu, Y | 1 |
| Xi, J | 1 |
| Li, C | 4 |
| Chen, W | 2 |
| Hu, X | 1 |
| Zhang, F | 1 |
| Wei, H | 1 |
| Wang, Z | 1 |
| Gurzu, S | 1 |
| Jung, I | 1 |
| Sugimura, H | 2 |
| Stefan-van Staden, RI | 1 |
| Yamada, H | 1 |
| Natsume, H | 1 |
| Iwashita, Y | 1 |
| Szodorai, R | 1 |
| Szederjesi, J | 1 |
| Yari, D | 1 |
| Ehsanbakhsh, Z | 1 |
| Validad, MH | 1 |
| Langroudi, FH | 1 |
| Esfandiari, H | 1 |
| Prager, A | 1 |
| Hassanpour, K | 1 |
| Kurup, SP | 1 |
| Mets-Halgrimson, R | 1 |
| Yoon, H | 1 |
| Zeid, JL | 1 |
| Mets, MB | 1 |
| Rahmani, B | 1 |
| Araujo-Castillo, RV | 1 |
| Culquichicón, C | 1 |
| Solis Condor, R | 1 |
| Efendi, F | 1 |
| Sebayang, SK | 1 |
| Astutik, E | 1 |
| Hadisuyatmana, S | 1 |
| Has, EMM | 1 |
| Kuswanto, H | 1 |
| Foroutan, T | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitroglycerin Plus Whole Intracranial Radiotherapy for Brain Metastases in Non-small Cell Lung Cancer Patients: a Phase II Open Randomized Clinical Trial[NCT04338867] | Phase 2 | 96 participants (Actual) | Interventional | 2020-03-01 | Completed | ||
| Imaging Tumor Hypoxia With 18F-EF5 PET in Recurrent or Metastatic Clear Cell Ovarian Cancer[NCT01881451] | 5 participants (Actual) | Observational | 2013-08-31 | Terminated (stopped due to Due to slow accrual and access to the study drug.) | |||
| Chloroquine as Adjuvant to the Treatment of Glioblastoma Multiforme, A Randomized Trial[NCT00224978] | Phase 3 | 0 participants | Interventional | 2005-01-31 | Completed | ||
| A Phase II Randomized Controlled Trial for the Addition of Chloroquine, an Autophagy Inhibitor, to Concurrent Chemoradiation for Newly Diagnosed Glioblastoma[NCT02432417] | Phase 2 | 0 participants (Actual) | Interventional | 2023-11-10 | Withdrawn (stopped due to The study was withdrawn due to a lack of funding. The researchers were unable to secure the necessary financial support to continue and complete the trial.) | ||
| A Phase I Trial for the Addition of Chloroquine, an Autophagy Inhibitor, to Concurrent Chemoradiation for Newly Diagnosed Glioblastoma[NCT02378532] | Phase 1 | 13 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for chloroquine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Autophagy in glioma cells: An identity crisis with a clinical perspective.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Proteins; Brain Neoplasms; Cell Survival; Chloroqui | 2018 |
Targeting autophagy to sensitive glioma to temozolomide treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell S | 2016 |
Retina and optic nerve.
Topics: Adult; Aged; Angiography; Animals; Blood Circulation; Brain Neoplasms; Carcinogens; Cats; Chloroquin | 1968 |
5 trials available for chloroquine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases.
Topics: Adult; Aged; Brain Neoplasms; Chemoradiotherapy; Chloroquine; Cranial Irradiation; Disease-Free Surv | 2013 |
Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine.
Topics: Adolescent; Adult; Antimutagenic Agents; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuv | 2003 |
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
Diagnostic efficacy of a radioiodinated chloroquine analog in patients with malignant melanoma.
Topics: Brain Neoplasms; Chloroquine; Clinical Trials as Topic; Eye Neoplasms; Humans; Iodine Radioisotopes; | 1970 |
33 other studies available for chloroquine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Using personalized medicine in gliomas: a genomic approach to diagnosis and overcoming treatment resistance in a case with pleomorphic xanthoastrocytoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chloroquine; Drug Resi | 2020 |
Presumed Chloroquine Retinopathy With Short-term Therapy for Glioblastoma Multiforme.
Topics: Adult; Antirheumatic Agents; Brain Neoplasms; Chloroquine; Female; Fluorescein Angiography; Fundus O | 2020 |
Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.
Topics: Angiogenesis Inhibitors; Animals; Autophagy; Autophagy-Related Proteins; Bevacizumab; Brain Neoplasm | 2017 |
Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Bevacizumab; Brain Neoplasms; Cell Line, Tumor; Cel | 2017 |
TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells' invasion.
Topics: Animals; Autophagy; Brain Neoplasms; Cell Line, Tumor; Chloroquine; Epithelial-Mesenchymal Transitio | 2017 |
EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition.
Topics: Animals; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Resista | 2018 |
Autophagy inhibition potentiates SAHA‑mediated apoptosis in glioblastoma cells by accumulation of damaged mitochondria.
Topics: Autophagosomes; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Syner | 2018 |
Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma.
Topics: Animals; Antiprotozoal Agents; Apoptosis; Autophagy; Brain Neoplasms; Cell Cycle Checkpoints; Cell L | 2018 |
Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma.
Topics: Animals; Autophagy; Brain Neoplasms; Cell Line, Tumor; Chloroquine; Down-Regulation; Gene Expression | 2019 |
Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells.
Topics: Apoptosis; Autophagy; Brain Neoplasms; Cell Count; Cell Line, Tumor; Cell Proliferation; Chloroquine | 2013 |
Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors.
Topics: Antineoplastic Agents; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Central Ner | 2014 |
FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma: first tolerability and feasibility results.
Topics: Adult; Brain Neoplasms; Chloroquine; Feasibility Studies; Female; Glioblastoma; Humans; Male; Middle | 2014 |
Stimulation of autophagic activity in human glioma cells by anti-proliferative ardipusilloside I isolated from Ardisia pusilla.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Ardisia; Autophagy; Bec | 2014 |
Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors.
Topics: Antineoplastic Agents; Autophagy; Brain Neoplasms; Brain Stem; Central Nervous System Neoplasms; Chi | 2014 |
Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenica | 2015 |
Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta.
Topics: Brain Neoplasms; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Chemoradiotherapy; Ch | 2015 |
Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells.
Topics: Adenine; Animals; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; Gli | 2016 |
Inhibition of Autophagy by Chloroquine Enhances the Antitumor Efficacy of Sorafenib in Glioblastoma.
Topics: Animals; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; | 2016 |
Chloroquine, an autophagy inhibitor, potentiates the radiosensitivity of glioma initiating cells by inhibiting autophagy and activating apoptosis.
Topics: Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Chloroquine; Dose-Response Relationship, Dr | 2016 |
Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors.
Topics: Antineoplastic Agents; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Surviv | 2017 |
Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway.
Topics: Adenine; Antimutagenic Agents; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Cell Hypoxia; Cell | 2017 |
Vaccine therapy with dendritic cells transfected with Il13ra2 mRNA for glioma in mice.
Topics: Animals; Bone Marrow Cells; Brain Neoplasms; Cancer Vaccines; Cell Line, Tumor; Chloroquine; Dendrit | 2010 |
Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells.
Topics: Animals; Antimalarials; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Proliferation; Chloroqui | 2010 |
Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent.
Topics: Antineoplastic Agents; Autophagy; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Chloroquine; | 2010 |
Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Chlo | 2012 |
Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma.
Topics: Adaptation, Physiological; AMP-Activated Protein Kinases; Angiogenesis Inhibitors; Animals; Antibodi | 2012 |
Summaries for patients. Adding chloroquine to conventional chemotherapy and radiotherapy for glioblastoma multiforme.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Chemotherapy, Ad | 2006 |
New treatments for malignant gliomas: careful evaluation and cautious optimism required.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Chloroquine | 2006 |
Selective enhancement of cellular oxidative stress by chloroquine: implications for the treatment of glioblastoma multiforme.
Topics: Animals; Artemisinins; Brain Neoplasms; Chloroquine; Cyclic N-Oxides; Glioblastoma; Hemin; Humans; I | 2006 |
Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme.
Topics: Adult; Antimalarials; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Chloroquine; F | 2007 |
Biodistribution of 125I-MAb 425 in a human glioma xenograft model: effect of chloroquine.
Topics: Animals; Antibodies, Monoclonal; Brain Neoplasms; Chloroquine; Disease Models, Animal; ErbB Receptor | 1997 |
Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107.
Topics: Animals; Antibodies, Monoclonal; Bacterial Toxins; Brain Neoplasms; Cerebrovascular Circulation; Chl | 2000 |
The antimalarials quinacrine and chloroquine potentiate the transplacental carcinogenic effect of ethylnitrosourea on ependymal cells.
Topics: Animals; Antimalarials; Brain Neoplasms; Carcinogens; Chloroquine; Drug Synergism; Ependyma; Ependym | 2001 |