chloroquine has been researched along with Autoimmune Disease in 41 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anti-rheumatoid drug D-penicillamine (D-pen) has a reactive sulfhydryl group capable of modifying self antigens, and can provoke typical autoantibody-mediated myasthenia gravis (MG), especially in DR1+ individuals." | 7.70 | T cell responses to D-penicillamine in drug-induced myasthenia gravis: recognition of modified DR1:peptide complexes. ( Hill, M; Moss, P; Newsom-Davis, J; Willcox, N; Wordsworth, P, 1999) |
| "Azathioprine, an immunosuppressive agent, was given to 38 patients presenting with intestinal cystitis." | 7.65 | Treatment of interstitial cystitis with immunosuppression and chloroquine derivatives. ( Alfthan, OS; Oravisto, KJ, 1976) |
| "The anti-rheumatoid drug D-penicillamine (D-pen) has a reactive sulfhydryl group capable of modifying self antigens, and can provoke typical autoantibody-mediated myasthenia gravis (MG), especially in DR1+ individuals." | 3.70 | T cell responses to D-penicillamine in drug-induced myasthenia gravis: recognition of modified DR1:peptide complexes. ( Hill, M; Moss, P; Newsom-Davis, J; Willcox, N; Wordsworth, P, 1999) |
| "Azathioprine, an immunosuppressive agent, was given to 38 patients presenting with intestinal cystitis." | 3.65 | Treatment of interstitial cystitis with immunosuppression and chloroquine derivatives. ( Alfthan, OS; Oravisto, KJ, 1976) |
| " Although these agents have largely revolutionized the treatment of the systemic autoimmune diseases, adverse reactions, which can be serious and life threatening, to the various immunosuppressive agents used in the treatment of CTD can occur." | 2.46 | Toxicity and monitoring of immunosuppressive therapy used in systemic autoimmune diseases. ( Baughman, R; Decker, C; Meyer, KC, 2010) |
| " Preliminary results seem to indicate, that the dosage used may be reduced slowly and therapy finally stopped after 3-4 years of treatment in most patients." | 2.36 | [Therapy of chronic hepatitis (author's transl)]. ( Arnold, W; Meyer zum Büschenfelde, KH, 1981) |
| "To evaluate the susceptibility to coronavirus disease 2019 (COVID-19) in patients with autoimmune conditions treated with antimalarials in a population-based study." | 1.62 | Susceptibility to COVID-19 in Patients Treated With Antimalarials: A Population-Based Study in Emilia-Romagna, Northern Italy. ( Bajocchi, G; Boiardi, L; Carrozzi, G; Cassone, G; Costantini, M; Croci, S; Galli, E; Giorgi Rossi, P; Gradellini, F; Mancuso, P; Marata, AM; Muratore, F; Pandolfi, P; Pipitone, N; Reta, M; Salvarani, C; Sandri, G; Viani, N, 2021) |
| "In untreated rheumatoid arthritis 20% of the patients has a EOG Lp/Dt ratio lower than the lower 5% limit calculated for normal patients." | 1.27 | The EOG in rheumatoid arthritis. ( Broekhuyse, RM; Pinckers, A, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (53.66) | 18.7374 |
| 1990's | 6 (14.63) | 18.2507 |
| 2000's | 3 (7.32) | 29.6817 |
| 2010's | 5 (12.20) | 24.3611 |
| 2020's | 5 (12.20) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, Z | 1 |
| Yang, X | 1 |
| Duan, Y | 1 |
| Han, J | 1 |
| Liao, C | 1 |
| Park, TY | 1 |
| Jang, Y | 1 |
| Kim, W | 1 |
| Shin, J | 1 |
| Toh, HT | 1 |
| Kim, CH | 1 |
| Yoon, HS | 1 |
| Leblanc, P | 1 |
| Kim, KS | 1 |
| Askanase, AD | 1 |
| Khalili, L | 1 |
| Buyon, JP | 1 |
| Martinez, GP | 1 |
| Zabaleta, ME | 1 |
| Di Giulio, C | 1 |
| Charris, JE | 1 |
| Mijares, MR | 1 |
| Nirk, EL | 1 |
| Reggiori, F | 1 |
| Mauthe, M | 1 |
| Salvarani, C | 1 |
| Mancuso, P | 1 |
| Gradellini, F | 1 |
| Viani, N | 1 |
| Pandolfi, P | 1 |
| Reta, M | 1 |
| Carrozzi, G | 1 |
| Sandri, G | 1 |
| Bajocchi, G | 1 |
| Galli, E | 1 |
| Muratore, F | 1 |
| Boiardi, L | 1 |
| Pipitone, N | 1 |
| Cassone, G | 1 |
| Croci, S | 1 |
| Marata, AM | 1 |
| Costantini, M | 1 |
| Giorgi Rossi, P | 1 |
| Lo, B | 1 |
| Zhang, K | 1 |
| Lu, W | 1 |
| Zheng, L | 1 |
| Zhang, Q | 1 |
| Kanellopoulou, C | 1 |
| Zhang, Y | 1 |
| Liu, Z | 1 |
| Fritz, JM | 1 |
| Marsh, R | 1 |
| Husami, A | 1 |
| Kissell, D | 1 |
| Nortman, S | 1 |
| Chaturvedi, V | 1 |
| Haines, H | 1 |
| Young, LR | 1 |
| Mo, J | 1 |
| Filipovich, AH | 1 |
| Bleesing, JJ | 1 |
| Mustillo, P | 1 |
| Stephens, M | 1 |
| Rueda, CM | 1 |
| Chougnet, CA | 1 |
| Hoebe, K | 1 |
| McElwee, J | 1 |
| Hughes, JD | 1 |
| Karakoc-Aydiner, E | 1 |
| Matthews, HF | 1 |
| Price, S | 1 |
| Su, HC | 1 |
| Rao, VK | 1 |
| Lenardo, MJ | 1 |
| Jordan, MB | 1 |
| McCarthy, CG | 1 |
| Wenceslau, CF | 1 |
| Goulopoulou, S | 1 |
| Ogbi, S | 1 |
| Matsumoto, T | 1 |
| Webb, RC | 1 |
| Lipka, D | 1 |
| Boratyński, J | 1 |
| Meyer, KC | 1 |
| Decker, C | 1 |
| Baughman, R | 1 |
| Leadbetter, EA | 1 |
| Rifkin, IR | 1 |
| Marshak-Rothstein, A | 1 |
| PRICE, L | 1 |
| RUGGIERO, HA | 1 |
| QUE, GS | 1 |
| MANDEMA, E | 1 |
| KUPCHINSKAS, IuK | 1 |
| KAUFMAN, HE | 1 |
| Arnold, W | 1 |
| Meyer zum Büschenfelde, KH | 1 |
| Killen, JA | 1 |
| Lindstrom, JM | 1 |
| Pinckers, A | 1 |
| Broekhuyse, RM | 1 |
| Oravisto, KJ | 2 |
| Mariani, L | 1 |
| Baratelli, M | 1 |
| Fox, R | 1 |
| Wallace, DJ | 1 |
| Hill, M | 1 |
| Moss, P | 1 |
| Wordsworth, P | 1 |
| Newsom-Davis, J | 1 |
| Willcox, N | 1 |
| Chen, W | 1 |
| Thoburn, CJ | 1 |
| Miura, Y | 1 |
| Sommer, M | 1 |
| Hruban, R | 1 |
| Qian, Z | 1 |
| Baldwin, W | 1 |
| Hess, AD | 1 |
| Alfthan, OS | 1 |
| Forsdyke, DR | 1 |
| Hara, Y | 1 |
| Caspi, RR | 1 |
| Wiggert, B | 1 |
| Dorf, M | 1 |
| Streilein, JW | 1 |
| Gergely, P | 1 |
| Sugai, S | 1 |
| Yasuda, Y | 1 |
| Shimizu, S | 1 |
| Sawada, M | 1 |
| Tachibana, J | 1 |
| Konda, S | 1 |
| Kitada, H | 1 |
| Nakaizumi, H | 1 |
| Tsukada, S | 1 |
| Tomec, RJ | 1 |
| Walsh, M | 1 |
| Garcia, JC | 1 |
| Jordan, PK | 1 |
| Müller, I | 1 |
| Maier, B | 1 |
| Brinkmann, V | 1 |
| Kaufmann, SH | 1 |
| Metcalfe, P | 1 |
| Minchinton, RM | 1 |
| Murphy, MF | 1 |
| Waters, AH | 1 |
| Rudyk, BI | 1 |
| Ito, S | 1 |
| Tamura, T | 1 |
| Nishikawa, M | 1 |
| Karaca, M | 1 |
| Akoğuz, O | 1 |
| Bölükoğlu, B | 1 |
| Minovich, AI | 1 |
| Waldorf, DS | 1 |
| Lipkin, G | 1 |
| Kreier, JP | 1 |
| Leste, J | 1 |
| Chandler, D | 1 |
| Nalbandian, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death[NCT00246857] | 5,000 participants (Anticipated) | Observational | 2007-02-12 | Recruiting | |||
| Phase 1/2 Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-lymphocyte Antigen 4 (CTLA4) Haploinsufficiency[NCT03733067] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2023-11-30 | Withdrawn (stopped due to No enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for chloroquine and Autoimmune Disease
| Article | Year |
|---|---|
Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases.
Topics: Animals; Autoimmune Diseases; Drug Discovery; Humans; Models, Molecular; Protein Kinase Inhibitors; | 2021 |
The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases.
Topics: Autoimmune Diseases; Betacoronavirus; Chloroquine; Coronavirus Infections; COVID-19; Humans; Hydroxy | 2020 |
Hydroxychloroquine in rheumatic autoimmune disorders and beyond.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Chloroquine; Humans; Hydroxychloroquine; Lupus Erythemat | 2020 |
[Metalloproteinases. Structure and function].
Topics: 4-Aminobenzoic Acid; Animals; Apoptosis; Arthritis; Autoimmune Diseases; Cell Movement; Chloroquine; | 2008 |
Toxicity and monitoring of immunosuppressive therapy used in systemic autoimmune diseases.
Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal; Antimetabolites; Autoimmune Diseases; Benzamides; C | 2010 |
Toll-like receptors and activation of autoreactive B cells.
Topics: Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Autoimmune Diseases; B-Lymphocyte Subset | 2003 |
[AUTOALLERGY IN CLINICAL INTERNAL MEDICINE].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Agranulocytosis; Anemia, Hemolytic; Anemia, He | 1964 |
OCULAR INFLAMMATORY DISEASE.
Topics: Adrenal Cortex Hormones; Antigen-Antibody Reactions; Arthritis; Arthritis, Rheumatoid; Autoimmune Di | 1964 |
[Therapy of chronic hepatitis (author's transl)].
Topics: Autoimmune Diseases; Azathioprine; Chloroquine; Chronic Disease; Diagnosis, Differential; Hepatitis; | 1981 |
Interstitial cystitis as an autoimmune disease. A review.
Topics: Adult; Animals; Antibodies, Antinuclear; Antibody Specificity; Autoimmune Diseases; Azathioprine; Ch | 1980 |
[Anti-inflammatory or antirheumatic agents? Pharmacological activity and therapeutic effectiveness of non-steroid anti-inflammatory drugs: comparative study. III].
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Chloro | 1980 |
Anti-malarial drugs: possible mechanisms of action in autoimmune disease and prospects for drug development.
Topics: Antigen Presentation; Antimalarials; Autoantigens; Autoimmune Diseases; Chloroquine; Drug Design; Hi | 1996 |
The use of chloroquine and hydroxychloroquine for non-infectious conditions other than rheumatoid arthritis or lupus: a critical review.
Topics: Antimalarials; Antiphospholipid Syndrome; Autoimmune Diseases; Chloroquine; Controlled Clinical Tria | 1996 |
28 other studies available for chloroquine and Autoimmune Disease
| Article | Year |
|---|---|
Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases.
Topics: Autoimmune Diseases; Autoimmunity; Cell Differentiation; Chloroquine; Cyclic AMP Response Element-Bi | 2019 |
Thoughts on COVID-19 and autoimmune diseases.
Topics: Antibodies, Monoclonal, Humanized; Autoimmune Diseases; Azetidines; Betacoronavirus; Chloroquine; Co | 2020 |
Susceptibility to COVID-19 in Patients Treated With Antimalarials: A Population-Based Study in Emilia-Romagna, Northern Italy.
Topics: Adult; Aged; Aged, 80 and over; Antimalarials; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, | 2021 |
AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.
Topics: Abatacept; Adaptor Proteins, Signal Transducing; Adolescent; Autoimmune Diseases; Child; Chloroquine | 2015 |
AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.
Topics: Abatacept; Adaptor Proteins, Signal Transducing; Adolescent; Autoimmune Diseases; Child; Chloroquine | 2015 |
AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.
Topics: Abatacept; Adaptor Proteins, Signal Transducing; Adolescent; Autoimmune Diseases; Child; Chloroquine | 2015 |
AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.
Topics: Abatacept; Adaptor Proteins, Signal Transducing; Adolescent; Autoimmune Diseases; Child; Chloroquine | 2015 |
Autoimmune therapeutic chloroquine lowers blood pressure and improves endothelial function in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Autoimmune Diseases; Blood Pressure; Chloroquine; E | 2016 |
Could chloroquine conquer autoimmune disorders and inflammation?
Topics: Animals; Autoimmune Diseases; Chloroquine; Humans; Inflammation | 2011 |
Retinopathy associated with chloroquine.
Topics: Arthritis; Arthritis, Rheumatoid; Autoimmune Diseases; Chloroquine; Humans; Lupus Erythematosus, Sys | 1961 |
[TREATMENT OF COLLAGEN DISEASES].
Topics: Arthritis; Arthritis, Rheumatoid; Autoimmune Diseases; Chloroquine; Collagen Diseases; Dermatomyosit | 1963 |
A CASE OF IDIOPATHIC RETROPERITONEAL FIBROSIS PRESENTING AS A SYSTEMIC COLLAGEN DISEASE.
Topics: Adolescent; Autoimmune Diseases; Blood Protein Disorders; Blood Transfusion; Chloroquine; Collagen D | 1964 |
Specific killing of lymphocytes that cause experimental autoimmune myasthenia gravis by ricin toxin-acetylcholine receptor conjugates.
Topics: Adjuvants, Immunologic; Animals; Autoimmune Diseases; B-Lymphocytes; Chloroquine; Cytotoxins; Lympho | 1984 |
The EOG in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Autoimmune Diseases; Chloroquine; Electrooculography; Female; Humans; H | 1983 |
T cell responses to D-penicillamine in drug-induced myasthenia gravis: recognition of modified DR1:peptide complexes.
Topics: Aged; Amino Acid Sequence; Antirheumatic Agents; Autoimmune Diseases; Base Sequence; Blood Proteins; | 1999 |
Autoimmune-mediated vasculopathy.
Topics: Adoptive Transfer; Animals; Antigens, Differentiation, B-Lymphocyte; Arteriosclerosis; Autoimmune Di | 2001 |
Treatment of interstitial cystitis with immunosuppression and chloroquine derivatives.
Topics: Autoimmune Diseases; Azathioprine; Chloroquine; Cystitis; Drug Administration Schedule; Humans; Urin | 1976 |
Evidence for a relationship between chloroquine and complement from studies with lymphocyte mitogens: possible implications for the mechanism of action of chloroquine in disease.
Topics: Animals; Autoimmune Diseases; Cells, Cultured; Chloroquine; Complement System Proteins; Concanavalin | 1975 |
Analysis of an in vitro-generated signal that induces systemic immune deviation similar to that elicited by antigen injected into the anterior chamber of the eye.
Topics: Animals; Anterior Chamber; Antigens; Autoimmune Diseases; Chloroquine; Formaldehyde; Hybridomas; Mac | 1992 |
Treatment of autoimmune patients.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Antineopl | 1991 |
DNA autosensitivity in two Japanese sisters.
Topics: Adult; Animals; Autoantibodies; Autoimmune Diseases; Cattle; Chloroquine; Deoxyribonucleases; DNA; F | 1990 |
Diagnosis of autoerythrocyte sensitization syndrome in the emergency department.
Topics: Adult; Autoimmune Diseases; Chloroquine; Diagnosis, Differential; Emergency Service, Hospital; Eryth | 1989 |
Autoreactive T cell clones from mice infected with Mycobacterium bovis, strain Bacillus Calmette-Guérin (BCG). I. Phenotype, specificity and in vitro function.
Topics: Animals; Antigen-Presenting Cells; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Autoi | 1986 |
Use of chloroquine-treated granulocytes and platelets in the diagnosis of immune cytopenias.
Topics: Adult; Antibodies; Autoantibodies; Autoimmune Diseases; Blood Platelets; Chloroquine; Female; Fever; | 1985 |
[Comparative evaluation of various methods of immunosuppressive therapy in severe bronchial asthma].
Topics: Adolescent; Adult; Aged; Aminocaproic Acid; Asthma; Autoimmune Diseases; Azathioprine; Chloroquine; | 1985 |
Effects of desiccated thyroid, prednisolone and chloroquine on goiter and antibody titer in chronic thyroiditis.
Topics: Agglutination Tests; Autoantibodies; Autoimmune Diseases; Chloroquine; Chronic Disease; Complement F | 1968 |
Autoerythrocyte sensitization syndrome.
Topics: Adult; Autoimmune Diseases; Blood Platelets; Chloroquine; Cortisone; Ecchymosis; Erythrocytes; Femal | 1973 |
[Immunological indices in diffuse glomerulonephritis during immunodepressive therapy].
Topics: Adolescent; Adult; Antistreptolysin; Autoantibodies; Autoimmune Diseases; Azathioprine; Child; Chlor | 1970 |
Sensitization to erythrocytes: a distinctive syndrome.
Topics: Adult; Autoimmune Diseases; Chloroquine; Cyproheptadine; Ecchymosis; Erythrocytes; Female; Humans; I | 1968 |
Parasitemia and erythrocyte destruction in Plasmodium berghei-infected rats. II. Effect of infected host globulin.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Chloroquine; Chromium Isotopes; Erythrocytes; Malaria; | 1968 |
DNA autosensitivity.
Topics: Autoimmune Diseases; Chloroquine; Diagnosis, Differential; DNA; Female; Humans; Lupus Erythematosus, | 1966 |