chloroquine has been researched along with Ataxia Telangiectasia Syndrome in 4 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that chloroquine ameliorates atherosclerosis and stabilizes plaque by modulating Tregs differentiation through the regulation of the ATM/AMPK/mTOR pathway." | 8.31 | Chloroquine Alleviates Atherosclerosis by Modulating Regulatory T Cells Through the ATM/AMPK/mTOR Signaling Pathway in ApoE -/- Mice. ( Gao, J; Huang, Q; Li, S; Liu, D; Meng, W; Mo, X; Tian, H; Zhang, Y, 2023) |
| "These findings suggest that chloroquine ameliorates atherosclerosis and stabilizes plaque by modulating Tregs differentiation through the regulation of the ATM/AMPK/mTOR pathway." | 4.31 | Chloroquine Alleviates Atherosclerosis by Modulating Regulatory T Cells Through the ATM/AMPK/mTOR Signaling Pathway in ApoE -/- Mice. ( Gao, J; Huang, Q; Li, S; Liu, D; Meng, W; Mo, X; Tian, H; Zhang, Y, 2023) |
| " Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53 tumor-suppressor pathway, preferentially enhances the death of Myc oncogene-overexpressing primary mouse B cells and mouse embryonic fibroblasts (MEFs) and impairs Myc-induced lymphomagenesis in a transgenic mouse model of human Burkitt lymphoma." | 3.74 | Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. ( Cleveland, JL; Dorsey, FC; Kastan, MB; Maclean, KH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dou, X | 1 |
| Sun, X | 1 |
| Huang, H | 1 |
| Jiang, L | 1 |
| Jin, Z | 1 |
| Liu, Y | 1 |
| Zou, Y | 1 |
| Li, Z | 1 |
| Zhu, G | 1 |
| Jin, H | 1 |
| Jiao, N | 1 |
| Zhang, L | 2 |
| Liu, Z | 1 |
| Liu, D | 1 |
| Zhang, Y | 2 |
| Huang, Q | 1 |
| Meng, W | 1 |
| Gao, J | 1 |
| Mo, X | 1 |
| Tian, H | 1 |
| Li, S | 1 |
| Dang, CV | 1 |
| Maclean, KH | 1 |
| Dorsey, FC | 1 |
| Cleveland, JL | 1 |
| Kastan, MB | 1 |
4 other studies available for chloroquine and Ataxia Telangiectasia Syndrome
| Article | Year |
|---|---|
Discovery of novel ataxia telangiectasia mutated (ATM) kinase modulators: Computational simulation, biological evaluation and cancer combinational chemotherapy study.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor | 2022 |
Chloroquine Alleviates Atherosclerosis by Modulating Regulatory T Cells Through the ATM/AMPK/mTOR Signaling Pathway in ApoE -/- Mice.
Topics: AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Ataxia Telangiectasia; Atherosclerosis; C | 2023 |
Antimalarial therapy prevents Myc-induced lymphoma.
Topics: Animals; Antimalarials; Apoptosis; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Au | 2008 |
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
Topics: Animals; Antirheumatic Agents; Apoptosis; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Prote | 2008 |