Page last updated: 2024-10-24

chloroquine and Asthma

chloroquine has been researched along with Asthma in 38 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"The object of this review was to assess the efficacy of adding chloroquine to oral corticosteroids in patients with chronic asthma who are dependent on oral corticosteroids with the intention of minimising or eventually eliminating the use of these oral steroids."8.82Chloroquine as a steroid sparing agent for asthma. ( Bara, A; Dean, T; Dewey, A; Lasserson, TJ; Walters, EH, 2003)
"To investigate the effect of chloroquine on airway hyperresponsiveness in asthmatic mice and explore the possible mechanism."7.81[Inhibitory effect of chloroquine on airway hyperresponsiveness in asthmatic mice]. ( Fu, Z; Hu, XY; Liu, EM; Sun, XC; Wang, LJ, 2015)
"The object of this review was to assess the efficacy of adding chloroquine to oral corticosteroids in patients with chronic asthma who are dependent on oral corticosteroids with the intention of minimising or eventually eliminating the use of these oral steroids."4.82Chloroquine as a steroid sparing agent for asthma. ( Bara, A; Dean, T; Dewey, A; Lasserson, TJ; Walters, EH, 2003)
"To investigate the effect of chloroquine on airway hyperresponsiveness in asthmatic mice and explore the possible mechanism."3.81[Inhibitory effect of chloroquine on airway hyperresponsiveness in asthmatic mice]. ( Fu, Z; Hu, XY; Liu, EM; Sun, XC; Wang, LJ, 2015)
"Current asthma therapies fail to target airway remodeling that correlates with asthma severity driving disease progression that ultimately leads to loss of lung function."1.51Autophagy Activation in Asthma Airways Remodeling. ( Deshpande, DA; Ghavami, S; Haghi, M; McAlinden, KD; Oliver, BG; Sharma, P; Sohal, SS; Xenaki, D, 2019)
"TAS2R agonists attenuated features of airway remodeling including smooth muscle mass, extracellular matrix deposition and pro-fibrotic signaling, and also prevented mucus accumulation and development of AHR in mice."1.46Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice. ( Deshpande, DA; Knight, MJ; Nayak, AP; Oliver, B; Pan, S; Sharma, P; Tang, F; Wang, N; Yi, R, 2017)
"Sixty-seven patients with bronchial asthma treated with the bronchodilator insanovin for 4 weeks were followed up."1.32[Insanovin aerosol therapy in the treatment of bronchial asthma]. ( Insanov, AB; Mustafaeva, LI, 2004)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199029 (76.32)18.7374
1990's1 (2.63)18.2507
2000's2 (5.26)29.6817
2010's4 (10.53)24.3611
2020's2 (5.26)2.80

Authors

AuthorsStudies
Wang, J1
Zhao, Y1
Zhang, X1
Tu, W1
Wan, R1
Shen, Y1
Zhang, Y1
Trivedi, R1
Gao, P1
Senna, G1
Caminati, M1
Castells, M1
Sharma, P2
Yi, R1
Nayak, AP1
Wang, N1
Tang, F1
Knight, MJ1
Pan, S1
Oliver, B1
Deshpande, DA2
McAlinden, KD1
Ghavami, S1
Xenaki, D1
Sohal, SS1
Oliver, BG1
Haghi, M1
Sun, XC1
Hu, XY1
Wang, LJ1
Liu, EM1
Fu, Z1
Zhu, MS1
ENGESET, A1
JUUL-MOLLER, O1
BENDA, R1
MOSSE, A1
DE AGUILAR, R2
AGARWAL, SL1
DESHMANKAR, BS1
BHARGAVA, V1
ORINSTEIN, E1
GEOFFROY, H1
ALAMEL, P1
BERRADA, A1
DAOUDI, A1
HIRAKI, H1
KIMURA, I4
MORIYA, K2
TSUCHIDA, K1
MATSUURA, Y2
SHIBUYA, K1
KOTANI, H1
KRAMMER, H1
MORITANI, Y1
TSUCHIDA, J1
MATSUURA, R1
TIODA, J1
Dean, T1
Dewey, A1
Bara, A1
Lasserson, TJ1
Walters, EH1
Insanov, AB1
Mustafaeva, LI1
Mandour, AM1
Omran, LA1
Karapata, AP1
Yan, GT1
Rudyk, BI1
Ayitey-Smith, E1
Boye, GL1
Furkert, K1
Aviado, DM1
Sadavongvivad, C1
Cambar, P1
Jäger, L1
Pecherek, K1
Sadowski, M1
Narasaki, N1
Suematsu, T1
Ciszek, J2
Walczak, J2
Voog, R1
Chouteau, J1
Marchal, A1
Cabanel, G1
Isomaki, H1
Kreus, KE1
Jirkal, J1
Salavec, M1
Tennenbaum, JI1
Smith, RE1
Moriya, Y1
Nishizaki, Y1
Kudriavtsev, GV1

Reviews

3 reviews available for chloroquine and Asthma

ArticleYear
Chloroquine as a steroid sparing agent for asthma.
    The Cochrane database of systematic reviews, 2003, Issue:4

    Topics: Adrenal Cortex Hormones; Asthma; Chloroquine; Humans; Hydroxychloroquine; Randomized Controlled Tria

2003
[Antiasthmatics. 12].
    Pharmazeutische Praxis, 1967, Volume: 9

    Topics: Adrenal Cortex Hormones; Aminophylline; Anti-Bacterial Agents; Asthma; Atropine; Barbiturates; Bronc

1967
[Progress in the symptomatic treatment of bronchial asthma].
    Zeitschrift fur Erkrankungen der Atmungsorgane mit Folia bronchologica, 1972, Volume: 136, Issue:2

    Topics: Adrenergic beta-Agonists; Aerosols; Animals; Antimalarials; Asthma; Chloroquine; Diethylcarbamazine;

1972

Trials

1 trial available for chloroquine and Asthma

ArticleYear
Chloroquine in the treatment of bronchial asthma.
    Annals of allergy, 1968, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Aged; Asthma; Child; Chloroquine; Eye Diseases; Female; Humans; Male; Middle Aged

1968

Other Studies

34 other studies available for chloroquine and Asthma

ArticleYear
Type II alveolar epithelial cell aryl hydrocarbon receptor protects against allergic airway inflammation through controlling cell autophagy.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Allergens; Alveolar Epithelial Cells; Animals; Asthma; Autophagy; Basic Helix-Loop-Helix Transcripti

2022
Editorial: Reconsidering anaphylaxis at the time of COVID-19 pandemic.
    Current opinion in allergy and clinical immunology, 2020, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Anaphylaxis; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents,

2020
Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.
    Scientific reports, 2017, 04-11, Volume: 7

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu

2017
Autophagy Activation in Asthma Airways Remodeling.
    American journal of respiratory cell and molecular biology, 2019, Volume: 60, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Airway Remodeling; Animals; Anti-Asthmatic Agents; Asthm

2019
[Inhibitory effect of chloroquine on airway hyperresponsiveness in asthmatic mice].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2015, Volume: 35, Issue:1

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Chloroquine; Dexamethasone; Dinoprost; Disease Models

2015
A "bitter" end to asthma revealed.
    Protein & cell, 2011, Volume: 2, Issue:6

    Topics: Adrenergic beta-2 Receptor Agonists; Anti-Inflammatory Agents; Asthma; Chloroquine; Humans; Myocytes

2011
[Quinacrine & chloroquine in asthma therapy].
    Nordisk medicin, 1957, Oct-03, Volume: 58, Issue:40

    Topics: Asthma; Chloroquine; Disease; Peritoneal Diseases; Peritoneum; Quinacrine

1957
[Bronchial asthma treated with chloroquine].
    Ugeskrift for laeger, 1961, Jan-20, Volume: 123

    Topics: Asthma; Chloroquine

1961
[Synthetic antimalarials in the treatment of asthma].
    La Semaine des hopitaux: therapeutique, 1962, Volume: 38

    Topics: Antimalarials; Asthma; Chloroquine

1962
[Preliminary considerations on a new treatment for infantile asthma. Hypotelencephaly of growth].
    La Semana medica, 1961, Dec-04, Volume: 119

    Topics: Asthma; Biological Phenomena; Child; Chloroquine; Humans; Infant; Physiological Phenomena

1961
[Treatment of infantile asthma with chloroquine].
    Hispalis medica; revista sevillana de medicina y cirugia, 1962, Volume: 19

    Topics: Asthma; Child; Chloroquine; Humans; Infant

1962
CHLOROQUINE IN BRONCHIAL ASTHMA.
    The Journal of pharmacy and pharmacology, 1963, Volume: 15

    Topics: Asthma; Chloroquine; Histamine Release; Lung; Pharmacology; Rats; Research; Stomach

1963
[PROTECTIVE SERUMS IN COMBINATION WITH CORTICOIDS AND GAMMA GLOBULINS].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1963, Sep-10, Volume: 39

    Topics: Adrenal Cortex Hormones; Anti-Allergic Agents; Asthma; Chloroquine; gamma-Globulins; Histamine; Hist

1963
[A CASE OF HIGHLY EVOLUTIVE AND CACHEXIA-CAUSING POLYNEURITIC FORM OF PERIARTERITIS NODOSA].
    Maroc medical, 1963, Volume: 42

    Topics: Asthma; Biopsy; Blood Chemical Analysis; Cachexia; Chloroquine; Eosinophilia; Fundus Oculi; Gastroen

1963
[LECTURES ON NEW METHODS OF TREATING BRONCHIAL ASTHMA, WITH SPECIAL REFERENCE TO THE PROLONGED ADMINISTRATION OF CHLOROQUINE PHOSPHATE. (2)].
    [Sogo rinsho] Clinic all-round, 1964, Volume: 13

    Topics: Adolescent; Asthma; Child; Chloroquine; Humans; Japan; Statistics as Topic

1964
[Asthma therapy with resochin].
    Die Medizinische Welt, 1960, Feb-27, Volume: 9

    Topics: Asthma; Chloroquine

1960
[Prolonged quinoline derivative (chloroquine) therapy of bronchial asthma].
    Arerugi = [Allergy], 1962, Volume: 11

    Topics: Asthma; Chloroquine; Quinolines

1962
[Studies on bronchial asthma therapy using quinoline derivatives. On results of orotic acid-chloroquine therapy].
    [Chiryo] [Therapy], 1961, Volume: 43

    Topics: Anti-Infective Agents, Local; Asthma; Chloroquine; Dermatologic Agents; Hydroxychloroquine; Hydroxyq

1961
[Insanovin aerosol therapy in the treatment of bronchial asthma].
    Problemy tuberkuleza i boleznei legkikh, 2004, Issue:7

    Topics: Adult; Aerosols; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchod

2004
An authentic case of pulmonary malaria caused by Plasmodium falciparum.
    Journal of the Egyptian Society of Parasitology, 1981, Volume: 11, Issue:2

    Topics: Adult; Anemia; Asthma; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum

1981
[Ambulatory treatment of bronchial asthma patients with immunosuppressive agensts].
    Sovetskaia meditsina, 1977, Issue:4

    Topics: Adult; Ambulatory Care; Asthma; Chloroquine; Female; Humans; Immunosuppressive Agents; Male

1977
[Changes in activity of phospholipase A2 and its metabolic production of prostaglandins in lung tissue of asthmatic guinea pigs].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1992, Volume: 15, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Albumins; Animals; Asthma; Chloroquine; Dinoprost; Dinoprostone; Guine

1992
[Comparative evaluation of various methods of immunosuppressive therapy in severe bronchial asthma].
    Terapevticheskii arkhiv, 1985, Volume: 57, Issue:5

    Topics: Adolescent; Adult; Aged; Aminocaproic Acid; Asthma; Autoimmune Diseases; Azathioprine; Chloroquine;

1985
Effect of chloroquine on histamine-induced bronchial asthma in the guinea-pig.
    The Journal of pharmacy and pharmacology, 1974, Volume: 26, Issue:3

    Topics: Animals; Asthma; Chloroquine; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Lung; Male

1974
Cardiopulmonary effects of antimalarial drugs. 1. 4-Aminoquinolines: chloroquine quinetholate.
    Toxicology and applied pharmacology, 1970, Volume: 17, Issue:1

    Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Asthma; Blood Pressure; Chloroform; Chloroquine; Dopamin

1970
[Chloroquine in treatment of asthma in children].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1973, Oct-01, Volume: 28, Issue:40

    Topics: Adolescent; Age Factors; Asthma; Child; Child, Preschool; Chloroquine; Female; Humans; Male; Optic N

1973
[Therapy of bronchial asthma].
    Iryo, 1971, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Aged; Allergens; Asthma; Child; Chloroquine; Desensitization, Immunologic; Dust;

1971
Treatment of bronchial asthma with chloroquine.
    Polish medical journal, 1971, Volume: 10, Issue:5

    Topics: Administration, Oral; Adult; Asthma; Chloroquine; Dexamethasone; Drug Tolerance; Female; Humans; Mal

1971
[Asthma therapy with a combination of synthetic antimalarials (83 cases)].
    La Presse medicale, 1969, Dec-13, Volume: 77, Issue:53

    Topics: Adolescent; Adult; Aged; Asthma; Chloroquine; Drug Synergism; Electrocardiography; Eosinophilia; Eye

1969
[Treatment of bronchial asthma with arechin].
    Gruzlica i choroby pluc; tuberculosis et pneumonologia, 1970, Volume: 38, Issue:11

    Topics: Acute Disease; Adult; Asthma; Chloroquine; Dexamethasone; Drug Synergism; Drug Tolerance; Female; Hu

1970
[Antimalarials in the treatment of bronchial asthma].
    Vnitrni lekarstvi, 1968, Volume: 14, Issue:8

    Topics: Adolescent; Adult; Aged; Antimalarials; Asthma; Chloroquine; Female; Humans; Hypersensitivity; Infec

1968
Antimalarial therapy for resistant asthma.
    Annals of allergy, 1966, Volume: 24, Issue:1

    Topics: Adult; Asthma; Chloroquine; Female; Humans

1966
[Study on allergens of bronchial asthma].
    Arerugi = [Allergy], 1966, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Allergens; Asthma; Child; Child, Preschool; Chloroquine; Female; Humans; Ma

1966
[On the treatment of bronchial asthma with resoquine and delagyl in view of remote results].
    Sovetskaia meditsina, 1966, Volume: 29, Issue:6

    Topics: Adult; Aged; Asthma; Chloroquine; Female; Humans; Male; Middle Aged

1966