chloroquine and Arthritis, Juvenile studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Arthritis, Juvenile: Arthritis in children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.

Research Excerpts

Excerpt	Relevance	Reference
"We describe a patient with juvenile chronic arthritis who developed reactive angioimmunoblastic lymphadenopathy, induced by sulfasalazine."	7.70	Sulfasalazine-induced angioimmunoblastic lymphadenopathy developing in a patient with juvenile chronic arthritis. ( Can, C; Dinc, A; Erdem, H; Pay, S; Simsek, I, 2000)
"We describe a patient with juvenile chronic arthritis who developed reactive angioimmunoblastic lymphadenopathy, induced by sulfasalazine."	3.70	Sulfasalazine-induced angioimmunoblastic lymphadenopathy developing in a patient with juvenile chronic arthritis. ( Can, C; Dinc, A; Erdem, H; Pay, S; Simsek, I, 2000)
"To evaluate the susceptibility to coronavirus disease 2019 (COVID-19) in patients with autoimmune conditions treated with antimalarials in a population-based study."	1.62	Susceptibility to COVID-19 in Patients Treated With Antimalarials: A Population-Based Study in Emilia-Romagna, Northern Italy. ( Bajocchi, G; Boiardi, L; Carrozzi, G; Cassone, G; Costantini, M; Croci, S; Galli, E; Giorgi Rossi, P; Gradellini, F; Mancuso, P; Marata, AM; Muratore, F; Pandolfi, P; Pipitone, N; Reta, M; Salvarani, C; Sandri, G; Viani, N, 2021)
" The pharmacokinetics of MTX were also similar with the Cmax and AUC values being 455."	1.34	Comparative study of the pharmacokinetics of MTX in juvenile idiopathic arthritis patients receiving long-term MTX monotherapy or MTX plus chloroquine. ( Kimura, E; Oga, S; Pereira, RM, 2007)
"Prednisone (PRED) was discontinued in one case with systemic (JCA) and 0."	1.27	Steroid economising effects of a calf thymus extract in three patients with juvenile chronic arthritis. ( Fabricius, HA; Klingshirn, R; Pernice, W; Stahn, R, 1983)
"Children suffering from juvenile chronic arthritis need a longterm therapy and guidance for many years, in course of which drug therapy is only one part of the whole treatment regimen."	1.27	[Drug therapy of chronic juvenile arthritis]. ( Tulzer, W, 1987)
"Children suffering from juvenile chronic arthritis need a longterm therapy and guidance for many years."	1.27	[Chronic juvenile arthritis. Control of long-term therapy]. ( Tulzer, W, 1985)
"Drug therapy of juvenile rheumatoid arthritis is discussed."	1.26	[Drug therapy of juvenile chronic polyarthritis]. ( Suschke, HJ, 1980)
"The prognosis for children with juvenile rheumatoid arthritis is good."	1.26	Juvenile rheumatoid arthritis. ( Schaller, J, 1977)
"Surgical treatment of cataracts, band keratopathy, and glaucoma achieved uniformly discouraging results."	1.25	Ocular manifestations of juvenile rheumatoid arthritis. ( Bellows, AR; Bienfang, DC; Chylack, LT; Stillman, JS, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (86.05)	18.7374
1990's	2 (4.65)	18.2507
2000's	2 (4.65)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (4.65)	2.80

Authors	Studies
Licciardi, F	1
Giani, T	1
Baldini, L	1
Favalli, EG	1
Caporali, R	1
Cimaz, R	1
Salvarani, C	1
Mancuso, P	1
Gradellini, F	1
Viani, N	1
Pandolfi, P	1
Reta, M	1
Carrozzi, G	1
Sandri, G	1
Bajocchi, G	1
Galli, E	1
Muratore, F	1
Boiardi, L	1
Pipitone, N	1
Cassone, G	1
Croci, S	1
Marata, AM	1
Costantini, M	1
Giorgi Rossi, P	1
ZIVOJIN, J	1
DZEMAL, R	1
NEDELJKO, R	1
DRAGO, M	1
GERMAIN, G	1
ANSELL, BM	1
BYWATERS, EG	2
RIVAS, R	1
VALLE, E	1
SAIRANEN, E	1
LAAKSONEN, AL	6
LOESCHKE, A	1
Kimura, E	1
Oga, S	1
Pereira, RM	1
Stewart, AJ	1
Hill, RH	1
Pernice, W	1
Stahn, R	1
Fabricius, HA	1
Klingshirn, R	1
Calabro, JJ	3
Suschke, HJ	1
Pay, S	1
Dinc, A	1
Simsek, I	1
Can, C	1
Erdem, H	1
Sänger, L	1
Schaller, J	1
Siliato, F	1
Scarsi, MR	1
Bonioli, E	1
Patrone, P	1
Cambiaso, R	1
Gemme, G	2
Chiossi, FM	1
DeBenedetti, C	1
Chylack, LT	1
Bienfang, DC	1
Bellows, AR	1
Stillman, JS	1
Gonggryp, LA	1
Kalla, AA	1
Hoza, J	1
Kadlecová, T	1
Nĕmcová, D	1
Havelka, S	1
Dugowson, CE	1
Gilliland, BC	1
Tulzer, W	2
Henkind, P	1
Gold, DH	1
Böke, W	1
Boden, BF	1
Casanovas, J	1
Casanovas, R	1
Katz, RM	1
Maltz, BA	1
Kölle, G	1
Koskiahde, V	3
Juva, K	4
Wessinghage, D	1
Miehlke, K	1
Anttila, R	1
Mäkinen, E	1
Rönning, O	1
Iakovleva, AA	1
Stepanova, II	1
Smiley, WK	1
Sunell, JE	2
Bihari, M	1
Grossman, BJ	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis[NCT04169828]				176 participants (Anticipated)	Interventional	2019-08-02	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country. Pediatric rheumatology online journal, 2020, Apr-22, Volume: 18, Issue:1 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Juvenile; Beta	2020
Management of rheumatoid arthritis. Disease-a-month : DM, 1986, Volume: 32, Issue:1 Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Azathioprine; Chloroquine; Cyc	1986
Ocular manifestations of rheumatic disorders. Natural and iatrogenic. Rheumatology, 1973, Volume: 4, Issue:0 Topics: Adrenal Cortex Hormones; Arteritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Chloroquine; Conjunc	1973
A critical reappraisal of juvenile rheumatoid arthritis. Clinical orthopaedics and related research, 1971, Volume: 74 Topics: Agammaglobulinemia; Arthritis, Juvenile; Aspirin; Cardiomegaly; Child; Child, Preschool; Chloroquine	1971
Rheumatoid arthritis. JAMA, 1973, Apr-30, Volume: 224, Issue:5 Suppl Topics: Antigen-Antibody Reactions; Arthritis, Juvenile; Arthritis, Rheumatoid; Aspirin; Biopsy; Chloroquine	1973
[Chronic polyarthritis. Changes--surgical and conservative treatment]. Ergebnisse der inneren Medizin und Kinderheilkunde, 1974, Volume: 36 Topics: Adult; Antibody Formation; Antigen-Antibody Complex; Antineoplastic Agents; Arthritis, Juvenile; Art	1974
The eye in arthritis. Annals of physical medicine, 1969, Volume: 10, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Antimalarials; Arthritis; Arthritis, Juvenile; Arthritis, Reactive;	1969

Article	Year
Sulphasalazine and Delagil--a comparative study in patients with juvenile chronic arthritis. Acta Universitatis Carolinae. Medica, 1991, Volume: 37, Issue:1-2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Child; Chloroquine; Female; Humans; Ma	1991
Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine. Scandinavian journal of rheumatology, 1974, Volume: 3, Issue:2 Topics: Adolescent; Adult; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Clinical Trials as Top	1974
[Chloroquine in the therapy of infectious non-specific (rheumatoid) arthritis in children]. Pediatriia, 1966, Volume: 45, Issue:4 Topics: Adolescent; Arthritis, Infectious; Arthritis, Juvenile; Aspirin; Child; Child, Preschool; Chloroquin	1966

chloroquine and Arthritis, Juvenile

Research Excerpts

Research

Studies (43)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Susceptibility to COVID-19 in Patients Treated With Antimalarials: A Population-Based Study in Emilia-Romagna, Northern Italy. Arthritis & rheumatology (Hoboken, N.J.), 2021, Volume: 73, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antimalarials; Antirheumatic Agents; Arthritis, Juvenile; Arthritis,	2021
[Still's disease treated with chloroquine 2,5-dihydroxybenzoate]. Annales medicales de Nancy, 1963, Volume: 2 Topics: Adolescent; Arthritis; Arthritis, Juvenile; Benzoates; Chloroquine; Gentisates; Humans; Hydroxybenzo	1963
[CLINICAL STUDY OF A NEW CHLOROQUINE SALT AND OCULAR COMPLICATIONS OF ANTIMALARIALS]. L'union medicale du Canada, 1964, Volume: 93 Topics: Adolescent; Antimalarials; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Chloroquine	1964
RHEUMATOID ARTHRITIS (STILL'S DISEASE). Pediatric clinics of North America, 1963, Volume: 10 Topics: Adolescent; Adrenal Cortex Hormones; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Blood Se	1963
[RHEUMATOID ARTHRITIS IN INFANCY]. Revista chilena de pediatria, 1964, Volume: 35 Topics: Adolescent; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Chloroquine; Clinical Labo	1964
THE RESULTS OF GOLD THERAPY IN JUVENILE RHEUMATOID ARTHRITIS. Annales paediatriae Fenniae, 1964, Volume: 10 Topics: Adolescent; Arthritis; Arthritis, Juvenile; Biomedical Research; Child; Chloroquine; Drug Therapy; G	1964
CHILD CARE IN GENERAL PRACTICE. RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS. British medical journal, 1965, Jun-26, Volume: 1, Issue:5451 Topics: Adolescent; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Child Care; Chloroquine; D	1965
[PROGNOSIS AND THERAPY OF RHEUMATOID ARTHRITIS IN CHILDHOOD]. Revista chilena de pediatria, 1964, Volume: 35 Topics: Adolescent; Adrenal Cortex Hormones; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; C	1964
Comparative study of the pharmacokinetics of MTX in juvenile idiopathic arthritis patients receiving long-term MTX monotherapy or MTX plus chloroquine. Journal of clinical pharmacy and therapeutics, 2007, Volume: 32, Issue:6 Topics: Adolescent; Adult; Antirheumatic Agents; Area Under Curve; Arthritis, Juvenile; Child; Chloroquine;	2007
Ocular manifestations in juvenile rheumatoid arthritis. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1967, Volume: 2, Issue:1 Topics: Adolescent; Adult; Arthritis, Juvenile; Cataract; Child; Child, Preschool; Chloroquine; Cornea; Cort	1967
Steroid economising effects of a calf thymus extract in three patients with juvenile chronic arthritis. Klinische Wochenschrift, 1983, Apr-15, Volume: 61, Issue:8 Topics: Animals; Arthritis, Juvenile; Aspirin; Azathioprine; Cattle; Child; Child, Preschool; Chloroquine; D	1983
Management of juvenile rheumatoid arthritis. Comprehensive therapy, 1981, Volume: 7, Issue:2 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Arthritis, Juvenile; Aspirin; Child; Chloroquine; Chroni	1981
[Drug therapy of juvenile chronic polyarthritis]. Fortschritte der Medizin, 1980, May-29, Volume: 98, Issue:20 Topics: Arthritis, Juvenile; Azathioprine; Child; Chloroquine; Glucocorticoids; Gold; Humans; Penicillamine;	1980
Sulfasalazine-induced angioimmunoblastic lymphadenopathy developing in a patient with juvenile chronic arthritis. Rheumatology international, 2000, Volume: 20, Issue:1 Topics: Adult; Antirheumatic Agents; Arthritis, Juvenile; Chloroquine; Humans; Immunoblastic Lymphadenopathy	2000
[Therapy of juvenile chronic polyarthritis]. Deutsche medizinische Wochenschrift (1946), 1975, Oct-03, Volume: 100, Issue:40 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis, Juvenile; Azathioprine; Child; Chlo	1975
Juvenile rheumatoid arthritis. Postgraduate medicine, 1977, Volume: 61, Issue:1 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Antibodies, Antinuclear; Arthritis, Juvenile; Aspi	1977
[Ocular changes in rheumatoid arthritis]. Minerva pediatrica, 1978, Nov-30, Volume: 30, Issue:22 Topics: Adrenal Cortex Hormones; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Conjunctivitis;	1978
[Rheumatoid disease in children. Current acquisitions and considerations of the pediatrist]. Minerva pediatrica, 1978, Nov-30, Volume: 30, Issue:22 Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Anti-Inflammatory Agents; Arthritis, Juvenile; Asp	1978
[Therapy of juvenile rheumatoid arthritis. Personal experience]. Minerva pediatrica, 1978, Nov-30, Volume: 30, Issue:22 Topics: Adrenal Cortex Hormones; Age Factors; Arthritis, Juvenile; Aspirin; Azathioprine; Child; Child, Pres	1978
Juvenile rheumatoid arthritis. Comprehensive therapy, 1976, Volume: 2, Issue:10 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Arthritis, Juvenile; Aspirin;	1976
Ocular manifestations of juvenile rheumatoid arthritis. American journal of ophthalmology, 1975, Volume: 79, Issue:6 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Arthritis, Juvenile; Atropine; Cataract; Ch	1975
Chloroquine-induced vitiligo in a patient with juvenile onset rheumatoid arthritis. British journal of rheumatology, 1992, Volume: 31, Issue:11 Topics: Adult; Arthritis, Juvenile; Chloroquine; Humans; Male; Vitiligo	1992
[Drug therapy of chronic juvenile arthritis]. Padiatrie und Padologie, 1987, Volume: 22, Issue:2 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineop	1987
[Chronic juvenile arthritis. Control of long-term therapy]. Wiener medizinische Wochenschrift (1946), 1985, Jun-30, Volume: 135, Issue:12 Topics: Adrenal Cortex Hormones; Alopecia; Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Child, Pres	1985
[Eye findings in rheumatic diseases]. Der Internist, 1974, Volume: 15, Issue:10 Topics: Adolescent; Arthritis, Juvenile; Arthritis, Reactive; Arthritis, Rheumatoid; Behcet Syndrome; Catara	1974
[Ocular manifestations in rheumatic diseases (new contributions)]. Archives d'ophtalmologie et revue generale d'ophtalmologie, 1970, Volume: 30, Issue:12 Topics: Adrenal Cortex Hormones; Aged; Alkaptonuria; Arthritis, Juvenile; Arthritis, Rheumatoid; Behcet Synd	1970
[Long term therapy of rheumatoid arthritis in children]. Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:8 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis, Juvenile; Azathioprine; Child; Chlo	1970
[Special problems of juvenile rheumatoid arthritis]. Lakartidningen, 1974, Jun-05, Volume: 71, Issue:23 Topics: Adrenal Cortex Hormones; Amyloidosis; Arthritis, Juvenile; Bone Development; Child; Chloroquine; Dia	1974
[Chloroquine and hydroxychloroquine dosage in juvenile rheumatoid arthritis]. Duodecim; laaketieteellinen aikakauskirja, 1974, Volume: 90, Issue:2 Topics: Administration, Oral; Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Corneal	1974
Treatment of juvenile rheumatoid arthritis by antimalarial drugs. Dosage in syrup and tablets. Acta paediatrica Scandinavica. Supplement, 1970, Volume: 206 Topics: Administration, Oral; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Humans	1970
Management of juvenile rheumatoid arthritis. The Journal of pediatrics, 1970, Volume: 77, Issue:3 Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Aspirin; Child; Chloroquine; Exercise Therapy; Gold;	1970
[Treatment of juvenile rheumatoid arthritis with chloroquine phosphate and hydroxychloroquine sulphate. Dosage of syrup and tablets with determinations of serum concentrations]. Nordisk medicin, 1971, Mar-25, Volume: 85, Issue:12 Topics: Administration, Oral; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Female; Humans; Hyd	1971
Posterior subcapsular cataracts. Related to long-term corticosteroid treatment in children. American journal of diseases of children (1960), 1968, Volume: 116, Issue:6 Topics: Adolescent; Arthritis, Juvenile; Cataract; Child; Child, Preschool; Chloroquine; Colitis, Ulcerative	1968