chloroquine and Arthritis, Juvenile Chronic studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Research Excerpts

Excerpt	Relevance	Reference
"We describe a patient with juvenile chronic arthritis who developed reactive angioimmunoblastic lymphadenopathy, induced by sulfasalazine."	7.70	Sulfasalazine-induced angioimmunoblastic lymphadenopathy developing in a patient with juvenile chronic arthritis. ( Can, C; Dinc, A; Erdem, H; Pay, S; Simsek, I, 2000)
"We describe a patient with juvenile chronic arthritis who developed reactive angioimmunoblastic lymphadenopathy, induced by sulfasalazine."	3.70	Sulfasalazine-induced angioimmunoblastic lymphadenopathy developing in a patient with juvenile chronic arthritis. ( Can, C; Dinc, A; Erdem, H; Pay, S; Simsek, I, 2000)
"To evaluate the susceptibility to coronavirus disease 2019 (COVID-19) in patients with autoimmune conditions treated with antimalarials in a population-based study."	1.62	Susceptibility to COVID-19 in Patients Treated With Antimalarials: A Population-Based Study in Emilia-Romagna, Northern Italy. ( Bajocchi, G; Boiardi, L; Carrozzi, G; Cassone, G; Costantini, M; Croci, S; Galli, E; Giorgi Rossi, P; Gradellini, F; Mancuso, P; Marata, AM; Muratore, F; Pandolfi, P; Pipitone, N; Reta, M; Salvarani, C; Sandri, G; Viani, N, 2021)
" The pharmacokinetics of MTX were also similar with the Cmax and AUC values being 455."	1.34	Comparative study of the pharmacokinetics of MTX in juvenile idiopathic arthritis patients receiving long-term MTX monotherapy or MTX plus chloroquine. ( Kimura, E; Oga, S; Pereira, RM, 2007)
"Prednisone (PRED) was discontinued in one case with systemic (JCA) and 0."	1.27	Steroid economising effects of a calf thymus extract in three patients with juvenile chronic arthritis. ( Fabricius, HA; Klingshirn, R; Pernice, W; Stahn, R, 1983)
"Children suffering from juvenile chronic arthritis need a longterm therapy and guidance for many years, in course of which drug therapy is only one part of the whole treatment regimen."	1.27	[Drug therapy of chronic juvenile arthritis]. ( Tulzer, W, 1987)
"Children suffering from juvenile chronic arthritis need a longterm therapy and guidance for many years."	1.27	[Chronic juvenile arthritis. Control of long-term therapy]. ( Tulzer, W, 1985)
"Drug therapy of juvenile rheumatoid arthritis is discussed."	1.26	[Drug therapy of juvenile chronic polyarthritis]. ( Suschke, HJ, 1980)
"The prognosis for children with juvenile rheumatoid arthritis is good."	1.26	Juvenile rheumatoid arthritis. ( Schaller, J, 1977)
"Surgical treatment of cataracts, band keratopathy, and glaucoma achieved uniformly discouraging results."	1.25	Ocular manifestations of juvenile rheumatoid arthritis. ( Bellows, AR; Bienfang, DC; Chylack, LT; Stillman, JS, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (86.05)	18.7374
1990's	2 (4.65)	18.2507
2000's	2 (4.65)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (4.65)	2.80

Authors	Studies
Licciardi, F	1
Giani, T	1
Baldini, L	1
Favalli, EG	1
Caporali, R	1
Cimaz, R	1
Salvarani, C	1
Mancuso, P	1
Gradellini, F	1
Viani, N	1
Pandolfi, P	1
Reta, M	1
Carrozzi, G	1
Sandri, G	1
Bajocchi, G	1
Galli, E	1
Muratore, F	1
Boiardi, L	1
Pipitone, N	1
Cassone, G	1
Croci, S	1
Marata, AM	1
Costantini, M	1
Giorgi Rossi, P	1
ZIVOJIN, J	1
DZEMAL, R	1
NEDELJKO, R	1
DRAGO, M	1
GERMAIN, G	1
ANSELL, BM	1
BYWATERS, EG	2
RIVAS, R	1
VALLE, E	1
SAIRANEN, E	1
LAAKSONEN, AL	6
LOESCHKE, A	1
Kimura, E	1
Oga, S	1
Pereira, RM	1
Stewart, AJ	1
Hill, RH	1
Pernice, W	1
Stahn, R	1
Fabricius, HA	1
Klingshirn, R	1
Calabro, JJ	3
Suschke, HJ	1
Pay, S	1
Dinc, A	1
Simsek, I	1
Can, C	1
Erdem, H	1
Sänger, L	1
Schaller, J	1
Siliato, F	1
Scarsi, MR	1
Bonioli, E	1
Patrone, P	1
Cambiaso, R	1
Gemme, G	2
Chiossi, FM	1
DeBenedetti, C	1
Chylack, LT	1
Bienfang, DC	1
Bellows, AR	1
Stillman, JS	1
Gonggryp, LA	1
Kalla, AA	1
Hoza, J	1
Kadlecová, T	1
Nĕmcová, D	1
Havelka, S	1
Dugowson, CE	1
Gilliland, BC	1
Tulzer, W	2
Henkind, P	1
Gold, DH	1
Böke, W	1
Boden, BF	1
Casanovas, J	1
Casanovas, R	1
Katz, RM	1
Maltz, BA	1
Kölle, G	1
Koskiahde, V	3
Juva, K	4
Wessinghage, D	1
Miehlke, K	1
Anttila, R	1
Mäkinen, E	1
Rönning, O	1
Iakovleva, AA	1
Stepanova, II	1
Smiley, WK	1
Sunell, JE	2
Bihari, M	1
Grossman, BJ	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis[NCT04169828]				176 participants (Anticipated)	Interventional	2019-08-02	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country. Pediatric rheumatology online journal, 2020, Apr-22, Volume: 18, Issue:1 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Juvenile; Beta	2020
Management of rheumatoid arthritis. Disease-a-month : DM, 1986, Volume: 32, Issue:1 Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Azathioprine; Chloroquine; Cyc	1986
Ocular manifestations of rheumatic disorders. Natural and iatrogenic. Rheumatology, 1973, Volume: 4, Issue:0 Topics: Adrenal Cortex Hormones; Arteritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Chloroquine; Conjunc	1973
A critical reappraisal of juvenile rheumatoid arthritis. Clinical orthopaedics and related research, 1971, Volume: 74 Topics: Agammaglobulinemia; Arthritis, Juvenile; Aspirin; Cardiomegaly; Child; Child, Preschool; Chloroquine	1971
Rheumatoid arthritis. JAMA, 1973, Apr-30, Volume: 224, Issue:5 Suppl Topics: Antigen-Antibody Reactions; Arthritis, Juvenile; Arthritis, Rheumatoid; Aspirin; Biopsy; Chloroquine	1973
[Chronic polyarthritis. Changes--surgical and conservative treatment]. Ergebnisse der inneren Medizin und Kinderheilkunde, 1974, Volume: 36 Topics: Adult; Antibody Formation; Antigen-Antibody Complex; Antineoplastic Agents; Arthritis, Juvenile; Art	1974
The eye in arthritis. Annals of physical medicine, 1969, Volume: 10, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Antimalarials; Arthritis; Arthritis, Juvenile; Arthritis, Reactive;	1969

Article	Year
Sulphasalazine and Delagil--a comparative study in patients with juvenile chronic arthritis. Acta Universitatis Carolinae. Medica, 1991, Volume: 37, Issue:1-2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Child; Chloroquine; Female; Humans; Ma	1991
Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine. Scandinavian journal of rheumatology, 1974, Volume: 3, Issue:2 Topics: Adolescent; Adult; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Clinical Trials as Top	1974
[Chloroquine in the therapy of infectious non-specific (rheumatoid) arthritis in children]. Pediatriia, 1966, Volume: 45, Issue:4 Topics: Adolescent; Arthritis, Infectious; Arthritis, Juvenile; Aspirin; Child; Child, Preschool; Chloroquin	1966

chloroquine and Arthritis, Juvenile Chronic

Research Excerpts

Research

Studies (43)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Susceptibility to COVID-19 in Patients Treated With Antimalarials: A Population-Based Study in Emilia-Romagna, Northern Italy. Arthritis & rheumatology (Hoboken, N.J.), 2021, Volume: 73, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antimalarials; Antirheumatic Agents; Arthritis, Juvenile; Arthritis,	2021
[Still's disease treated with chloroquine 2,5-dihydroxybenzoate]. Annales medicales de Nancy, 1963, Volume: 2 Topics: Adolescent; Arthritis; Arthritis, Juvenile; Benzoates; Chloroquine; Gentisates; Humans; Hydroxybenzo	1963
[CLINICAL STUDY OF A NEW CHLOROQUINE SALT AND OCULAR COMPLICATIONS OF ANTIMALARIALS]. L'union medicale du Canada, 1964, Volume: 93 Topics: Adolescent; Antimalarials; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Chloroquine	1964
RHEUMATOID ARTHRITIS (STILL'S DISEASE). Pediatric clinics of North America, 1963, Volume: 10 Topics: Adolescent; Adrenal Cortex Hormones; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Blood Se	1963
[RHEUMATOID ARTHRITIS IN INFANCY]. Revista chilena de pediatria, 1964, Volume: 35 Topics: Adolescent; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Chloroquine; Clinical Labo	1964
THE RESULTS OF GOLD THERAPY IN JUVENILE RHEUMATOID ARTHRITIS. Annales paediatriae Fenniae, 1964, Volume: 10 Topics: Adolescent; Arthritis; Arthritis, Juvenile; Biomedical Research; Child; Chloroquine; Drug Therapy; G	1964
CHILD CARE IN GENERAL PRACTICE. RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS. British medical journal, 1965, Jun-26, Volume: 1, Issue:5451 Topics: Adolescent; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Child Care; Chloroquine; D	1965
[PROGNOSIS AND THERAPY OF RHEUMATOID ARTHRITIS IN CHILDHOOD]. Revista chilena de pediatria, 1964, Volume: 35 Topics: Adolescent; Adrenal Cortex Hormones; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; C	1964
Comparative study of the pharmacokinetics of MTX in juvenile idiopathic arthritis patients receiving long-term MTX monotherapy or MTX plus chloroquine. Journal of clinical pharmacy and therapeutics, 2007, Volume: 32, Issue:6 Topics: Adolescent; Adult; Antirheumatic Agents; Area Under Curve; Arthritis, Juvenile; Child; Chloroquine;	2007
Ocular manifestations in juvenile rheumatoid arthritis. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1967, Volume: 2, Issue:1 Topics: Adolescent; Adult; Arthritis, Juvenile; Cataract; Child; Child, Preschool; Chloroquine; Cornea; Cort	1967
Steroid economising effects of a calf thymus extract in three patients with juvenile chronic arthritis. Klinische Wochenschrift, 1983, Apr-15, Volume: 61, Issue:8 Topics: Animals; Arthritis, Juvenile; Aspirin; Azathioprine; Cattle; Child; Child, Preschool; Chloroquine; D	1983
Management of juvenile rheumatoid arthritis. Comprehensive therapy, 1981, Volume: 7, Issue:2 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Arthritis, Juvenile; Aspirin; Child; Chloroquine; Chroni	1981
[Drug therapy of juvenile chronic polyarthritis]. Fortschritte der Medizin, 1980, May-29, Volume: 98, Issue:20 Topics: Arthritis, Juvenile; Azathioprine; Child; Chloroquine; Glucocorticoids; Gold; Humans; Penicillamine;	1980
Sulfasalazine-induced angioimmunoblastic lymphadenopathy developing in a patient with juvenile chronic arthritis. Rheumatology international, 2000, Volume: 20, Issue:1 Topics: Adult; Antirheumatic Agents; Arthritis, Juvenile; Chloroquine; Humans; Immunoblastic Lymphadenopathy	2000
[Therapy of juvenile chronic polyarthritis]. Deutsche medizinische Wochenschrift (1946), 1975, Oct-03, Volume: 100, Issue:40 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis, Juvenile; Azathioprine; Child; Chlo	1975
Juvenile rheumatoid arthritis. Postgraduate medicine, 1977, Volume: 61, Issue:1 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Antibodies, Antinuclear; Arthritis, Juvenile; Aspi	1977
[Ocular changes in rheumatoid arthritis]. Minerva pediatrica, 1978, Nov-30, Volume: 30, Issue:22 Topics: Adrenal Cortex Hormones; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Conjunctivitis;	1978
[Rheumatoid disease in children. Current acquisitions and considerations of the pediatrist]. Minerva pediatrica, 1978, Nov-30, Volume: 30, Issue:22 Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Anti-Inflammatory Agents; Arthritis, Juvenile; Asp	1978
[Therapy of juvenile rheumatoid arthritis. Personal experience]. Minerva pediatrica, 1978, Nov-30, Volume: 30, Issue:22 Topics: Adrenal Cortex Hormones; Age Factors; Arthritis, Juvenile; Aspirin; Azathioprine; Child; Child, Pres	1978
Juvenile rheumatoid arthritis. Comprehensive therapy, 1976, Volume: 2, Issue:10 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Arthritis, Juvenile; Aspirin;	1976
Ocular manifestations of juvenile rheumatoid arthritis. American journal of ophthalmology, 1975, Volume: 79, Issue:6 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Arthritis, Juvenile; Atropine; Cataract; Ch	1975
Chloroquine-induced vitiligo in a patient with juvenile onset rheumatoid arthritis. British journal of rheumatology, 1992, Volume: 31, Issue:11 Topics: Adult; Arthritis, Juvenile; Chloroquine; Humans; Male; Vitiligo	1992
[Drug therapy of chronic juvenile arthritis]. Padiatrie und Padologie, 1987, Volume: 22, Issue:2 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineop	1987
[Chronic juvenile arthritis. Control of long-term therapy]. Wiener medizinische Wochenschrift (1946), 1985, Jun-30, Volume: 135, Issue:12 Topics: Adrenal Cortex Hormones; Alopecia; Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Child, Pres	1985
[Eye findings in rheumatic diseases]. Der Internist, 1974, Volume: 15, Issue:10 Topics: Adolescent; Arthritis, Juvenile; Arthritis, Reactive; Arthritis, Rheumatoid; Behcet Syndrome; Catara	1974
[Ocular manifestations in rheumatic diseases (new contributions)]. Archives d'ophtalmologie et revue generale d'ophtalmologie, 1970, Volume: 30, Issue:12 Topics: Adrenal Cortex Hormones; Aged; Alkaptonuria; Arthritis, Juvenile; Arthritis, Rheumatoid; Behcet Synd	1970
[Long term therapy of rheumatoid arthritis in children]. Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:8 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis, Juvenile; Azathioprine; Child; Chlo	1970
[Special problems of juvenile rheumatoid arthritis]. Lakartidningen, 1974, Jun-05, Volume: 71, Issue:23 Topics: Adrenal Cortex Hormones; Amyloidosis; Arthritis, Juvenile; Bone Development; Child; Chloroquine; Dia	1974
[Chloroquine and hydroxychloroquine dosage in juvenile rheumatoid arthritis]. Duodecim; laaketieteellinen aikakauskirja, 1974, Volume: 90, Issue:2 Topics: Administration, Oral; Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Corneal	1974
Treatment of juvenile rheumatoid arthritis by antimalarial drugs. Dosage in syrup and tablets. Acta paediatrica Scandinavica. Supplement, 1970, Volume: 206 Topics: Administration, Oral; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Humans	1970
Management of juvenile rheumatoid arthritis. The Journal of pediatrics, 1970, Volume: 77, Issue:3 Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Aspirin; Child; Chloroquine; Exercise Therapy; Gold;	1970
[Treatment of juvenile rheumatoid arthritis with chloroquine phosphate and hydroxychloroquine sulphate. Dosage of syrup and tablets with determinations of serum concentrations]. Nordisk medicin, 1971, Mar-25, Volume: 85, Issue:12 Topics: Administration, Oral; Arthritis, Juvenile; Child; Child, Preschool; Chloroquine; Female; Humans; Hyd	1971
Posterior subcapsular cataracts. Related to long-term corticosteroid treatment in children. American journal of diseases of children (1960), 1968, Volume: 116, Issue:6 Topics: Adolescent; Arthritis, Juvenile; Cataract; Child; Child, Preschool; Chloroquine; Colitis, Ulcerative	1968