chloroquine has been researched along with Anemia, Sickle Cell in 18 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy of monthly SP presumptive treatment, versus weekly chloroquine for malaria prophylaxis in children attending the Sickle Cell Clinic, Mulago Hospital." | 9.14 | Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial. ( Nakiboneka, D; Nakibuuka, V; Ndeezi, G; Ndugwa, CM; Tumwine, JK, 2009) |
| "To compare the efficacy of monthly SP presumptive treatment, versus weekly chloroquine for malaria prophylaxis in children attending the Sickle Cell Clinic, Mulago Hospital." | 5.14 | Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial. ( Nakiboneka, D; Nakibuuka, V; Ndeezi, G; Ndugwa, CM; Tumwine, JK, 2009) |
| " Low arginine and nitric oxide bioavailability are implicated in morbidity related to sickle-cell disease." | 1.48 | Ready-to-use food supplement, with or without arginine and citrulline, with daily chloroquine in Tanzanian children with sickle-cell disease: a double-blind, random order crossover trial. ( Cox, SE; Ellins, EA; Halcox, JP; Johnson, W; Kirkham, FJ; Luca Di Tanna, G; Makani, J; Marealle, AI; Newton, CR; Prentice, AM; Sasi, P; Soka, D, 2018) |
| "Chloroquine resistance has been associated with the Plasmodium falciparum multidrug resistance 1 (Pfmdr1) mutant gene." | 1.35 | High prevalence of Plasmodium falciparum Pfmdr1 86Y mutant gene in sickle cell disease in Nigeria. ( Agbonlahor, DE; Clarence, YS; Faith, O; Inoigbe, OP; Mirabeau, TY; Samuel, TK, 2008) |
| "Chloroquine resistance has been associated with the emergence of Pfcrt mutant genes." | 1.35 | Chloroquine prophylaxis associated with high prevalence of Plasmodium falciparum pfcrt K76T mutation in people with sickle-cell disease in Benin City, Nigeria. ( Adeolu, A; Agbonlahor, DE; Okodua, M; Omolu, PI; Tatfeng, YM; Tchounga, KS; Yah, CS, 2008) |
| "Intact erythrocytes from subjects with sickle cell anemia bound approximately 71 mumoles of chloroquine per kg with an apparent Kd of 10(-6) M." | 1.27 | Toxic heme in sickle cells: an explanation for death of malaria parasites. ( Chevli, R; Fitch, CD; Orjih, AU, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cox, SE | 1 |
| Ellins, EA | 1 |
| Marealle, AI | 1 |
| Newton, CR | 1 |
| Soka, D | 1 |
| Sasi, P | 1 |
| Luca Di Tanna, G | 1 |
| Johnson, W | 1 |
| Makani, J | 1 |
| Prentice, AM | 1 |
| Halcox, JP | 1 |
| Kirkham, FJ | 1 |
| Mongella, S | 1 |
| Enweji, N | 1 |
| Mnong'one, N | 1 |
| Minde, M | 1 |
| Kamugisha, E | 1 |
| Swedberg, G | 1 |
| Agbonlahor, DE | 2 |
| Mirabeau, TY | 1 |
| Faith, O | 1 |
| Inoigbe, OP | 1 |
| Samuel, TK | 1 |
| Clarence, YS | 1 |
| Nakibuuka, V | 1 |
| Ndeezi, G | 1 |
| Nakiboneka, D | 1 |
| Ndugwa, CM | 1 |
| Tumwine, JK | 1 |
| WARLEY, MA | 1 |
| HAMILTON, PJ | 1 |
| MARSDEN, PD | 1 |
| BROWN, RE | 1 |
| MERSELIS, JG | 1 |
| WILKS, N | 1 |
| LEWTHWAITE, CJ | 1 |
| Juwah, AI | 1 |
| Nlemadim, EU | 1 |
| Kaine, W | 1 |
| Iyamu, EW | 1 |
| Ekekezie, C | 1 |
| Woods, GM | 1 |
| Tatfeng, YM | 1 |
| Tchounga, KS | 1 |
| Omolu, PI | 1 |
| Okodua, M | 1 |
| Yah, CS | 1 |
| Adeolu, A | 1 |
| Massabi, M | 1 |
| Nurse, GT | 1 |
| Friedman, DF | 1 |
| Lukas, MB | 1 |
| Jawad, A | 1 |
| Larson, PJ | 1 |
| Ohene-Frempong, K | 1 |
| Manno, CS | 1 |
| MacIver, JE | 1 |
| Mankad, VN | 1 |
| Moore, RB | 1 |
| Orjih, AU | 2 |
| Chevli, R | 1 |
| Fitch, CD | 1 |
| Harrison, KA | 1 |
| Ibeziako, PA | 1 |
| Haddock, DR | 1 |
| Bonotey-Ahulu, FI | 1 |
| Janosi, M | 1 |
| Ankra-Badu, G | 1 |
| Reid, HA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of a Ready-to-use Nutraceutical Food for Patients With Sickle Cell Disease (SCD): Testing of Vascular Support Components[NCT01718054] | Phase 2/Phase 3 | 120 participants (Anticipated) | Interventional | 2012-08-31 | Active, not recruiting | ||
| Efficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral Malaria: a Randomized Clinical Trial[NCT00124267] | Phase 3 | 108 participants | Interventional | 2003-09-30 | Active, not recruiting | ||
| Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Children With Sickle Cell Anaemia in Eastern and Southern Africa: a Double Blind Randomised Trial (CHEMCHA)[NCT04844099] | Phase 3 | 723 participants (Actual) | Interventional | 2021-04-09 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for chloroquine and Anemia, Sickle Cell
16 other studies available for chloroquine and Anemia, Sickle Cell
| Article | Year |
|---|---|
Ready-to-use food supplement, with or without arginine and citrulline, with daily chloroquine in Tanzanian children with sickle-cell disease: a double-blind, random order crossover trial.
Topics: Anemia, Sickle Cell; Arginine; Child; Chloroquine; Citrulline; Cross-Over Studies; Dietary Supplemen | 2018 |
High prevalence of Plasmodium falciparum pfcrt K76T mutation in children with sickle cell disease at a tertiary hospital in north-western Tanzania.
Topics: Anemia, Sickle Cell; Child, Preschool; Chloroquine; Drug Resistance; Endemic Diseases; Female; Human | 2014 |
High prevalence of Plasmodium falciparum Pfmdr1 86Y mutant gene in sickle cell disease in Nigeria.
Topics: Analysis of Variance; Anemia, Sickle Cell; Animals; Antibiotic Prophylaxis; Antimalarials; Chi-Squar | 2008 |
CHEMOPROPHYLAXIS OF HOMOZYGOUS SICKLERS WITH ANTIMALARIALS AND LONG-ACTING PENICILLIN.
Topics: Adolescent; Anemia; Anemia, Sickle Cell; Antimalarials; Biomedical Research; Chemoprevention; Child; | 1965 |
A trial of chemoprophylaxis in sicklecell anaemia. Preliminary communication.
Topics: Anemia; Anemia, Sickle Cell; Chemoprevention; Chloroquine; Communication; Humans; Penicillins | 1962 |
Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria.
Topics: Adolescent; Anemia, Sickle Cell; Antimalarials; Bilirubin; Child; Child, Preschool; Chloroquine; Fem | 2004 |
In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes.
Topics: Adolescent; Anemia, Sickle Cell; Animals; Anti-Inflammatory Agents; Antimalarials; Arginase; Cattle; | 2007 |
Chloroquine prophylaxis associated with high prevalence of Plasmodium falciparum pfcrt K76T mutation in people with sickle-cell disease in Benin City, Nigeria.
Topics: Anemia, Sickle Cell; Animals; Antimalarials; Chemoprevention; Chloroquine; Drug Resistance; Humans; | 2008 |
Maternal chloroquine prophylaxis and sickle-cell anemia.
Topics: Anemia, Sickle Cell; Chloroquine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Matern | 1983 |
Maternal chloroquine prophylaxis and sickle-cell anaemia.
Topics: Anemia, Sickle Cell; Chloroquine; Female; Fetal Diseases; Humans; Maternal-Fetal Exchange; Pregnancy | 1983 |
Alloimmunization to platelets in heavily transfused patients with sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Antigens, Human Platelet; Blood Platelets; Blood Transfusion; Bone | 1996 |
Haematological problems in immigrants.
Topics: Adolescent; Adult; Anemia, Hypochromic; Anemia, Megaloblastic; Anemia, Sickle Cell; Child; Chloroqui | 1976 |
Reduction in morphological sickling of red cells incubated with quinine.
Topics: Anemia, Sickle Cell; Chloroquine; Cyanates; Drug Synergism; Erythrocytes, Abnormal; Humans; Quinine | 1987 |
Increased accumulation of chloroquine and desethylchloroquine in homozygous sickle cells.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Chloroquine; Erythrocytes, Abnormal | 1987 |
Toxic heme in sickle cells: an explanation for death of malaria parasites.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Animals; Chloroquine; Erythrocytes; Female; Heme; Hemin; Hum | 1985 |
Maternal anaemia and fetal birthweight.
Topics: Anemia; Anemia, Sickle Cell; Birth Weight; Blood Transfusion; Body Height; Chloroquine; Embryonic an | 1973 |