chloroquine has been researched along with American Trypanosomiasis in 12 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with chronic Trypanosoma cruzi infections have peripheral auto-anti-idiotype (Id) T cells that proliferate on exposure to immunoaffinity-purified antibodies against T." | 1.28 | Two modes of idiotypic stimulation of T lymphocytes from patients with Chagas' disease: correlations with clinical forms of infection. ( Brener, Z; Cançado, JR; Cardoso, JE; Colley, DG; Gazzinelli, G; Gazzinelli, RT, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bollini, M | 1 |
| Casal, JJ | 1 |
| Alvarez, DE | 1 |
| Boiani, L | 1 |
| González, M | 1 |
| Cerecetto, H | 1 |
| Bruno, AM | 1 |
| Long, TE | 1 |
| Lu, X | 1 |
| Galizzi, M | 1 |
| Docampo, R | 1 |
| Gut, J | 1 |
| Rosenthal, PJ | 1 |
| Patrick, DA | 1 |
| Ismail, MA | 1 |
| Arafa, RK | 1 |
| Wenzler, T | 1 |
| Zhu, X | 1 |
| Pandharkar, T | 1 |
| Jones, SK | 1 |
| Werbovetz, KA | 1 |
| Brun, R | 2 |
| Boykin, DW | 1 |
| Tidwell, RR | 1 |
| Parra, LLL | 1 |
| Bertonha, AF | 1 |
| Severo, IRM | 1 |
| Aguiar, ACC | 1 |
| de Souza, GE | 1 |
| Oliva, G | 1 |
| Guido, RVC | 1 |
| Grazzia, N | 1 |
| Costa, TR | 1 |
| Miguel, DC | 1 |
| Gadelha, FR | 1 |
| Ferreira, AG | 1 |
| Hajdu, E | 1 |
| Romo, D | 1 |
| Berlinck, RGS | 1 |
| Saccoliti, F | 1 |
| Madia, VN | 1 |
| Tudino, V | 1 |
| De Leo, A | 1 |
| Pescatori, L | 1 |
| Messore, A | 1 |
| De Vita, D | 1 |
| Scipione, L | 1 |
| Kaiser, M | 2 |
| Mäser, P | 1 |
| Calvet, CM | 1 |
| Jennings, GK | 1 |
| Podust, LM | 1 |
| Costi, R | 1 |
| Di Santo, R | 1 |
| Wang, X | 1 |
| Cal, M | 1 |
| Buckner, FS | 1 |
| Lepesheva, GI | 1 |
| Sanford, AG | 1 |
| Wallick, AI | 1 |
| Davis, PH | 1 |
| Vennerstrom, JL | 1 |
| Pandey, RP | 1 |
| Nascimento, MS | 1 |
| Franco, CH | 1 |
| Bortoluci, K | 1 |
| Silva, MN | 1 |
| Zingales, B | 1 |
| Gibaldi, D | 1 |
| Castaño Barrios, L | 1 |
| Lannes-Vieira, J | 1 |
| Cariste, LM | 1 |
| Vasconcelos, JR | 1 |
| Moraes, CB | 1 |
| Freitas-Junior, LH | 1 |
| Kalil, J | 1 |
| Alcântara, L | 1 |
| Cunha-Neto, E | 1 |
| da Cruz Filho, IJ | 1 |
| Duarte, DMFA | 1 |
| da Conceição Alves de Lima, D | 1 |
| Marques, DSC | 1 |
| Dos Santos, FAB | 1 |
| Alves, LC | 1 |
| de Lima Aires, A | 1 |
| Nogueira, F | 1 |
| do Carmo Alves de Lima, M | 1 |
| Min-Oo, G | 1 |
| Ayi, K | 1 |
| Bongfen, SE | 1 |
| Tam, M | 1 |
| Radovanovic, I | 1 |
| Gauthier, S | 1 |
| Santiago, H | 1 |
| Rothfuchs, AG | 1 |
| Roffê, E | 1 |
| Sher, A | 1 |
| Mullick, A | 1 |
| Fortin, A | 1 |
| Stevenson, MM | 1 |
| Kain, KC | 1 |
| Gros, P | 1 |
| TELLA, A | 1 |
| Gazzinelli, RT | 1 |
| Gazzinelli, G | 1 |
| Cançado, JR | 1 |
| Cardoso, JE | 1 |
| Brener, Z | 1 |
| Colley, DG | 1 |
| Bruce-Chwatt, LJ | 1 |
1 review available for chloroquine and American Trypanosomiasis
| Article | Year |
|---|---|
Transfusion associated parasitic infections.
Topics: Animals; Babesiosis; Blood Donors; Blood Transfusion; Carrier State; Chagas Disease; Chloroquine; He | 1985 |
11 other studies available for chloroquine and American Trypanosomiasis
| Article | Year |
|---|---|
New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships.
Topics: Animals; Chagas Disease; DNA, Protozoan; Dose-Response Relationship, Drug; Glutathione; HeLa Cells; | 2009 |
Phosphonium lipocations as antiparasitic agents.
Topics: Animals; Antiparasitic Agents; Cations; Chagas Disease; Chlorocebus aethiops; Humans; Inhibitory Con | 2012 |
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
Topics: Animals; Antiprotozoal Agents; Benzene; Chagas Disease; Female; Leishmania donovani; Mice; Mice, Inb | 2013 |
Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.
Topics: Alkaloids; Animals; Antimalarials; Antiparasitic Agents; Antiprotozoal Agents; Chagas Disease; Leish | 2018 |
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Female; Humans; Imidazoles; Inhibitory Con | 2018 |
A new chemotype with promise against Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Humans; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma c | 2020 |
Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi
Topics: Animals; Chagas Disease; Chloroquine; Drug Repositioning; Mice; Nitroimidazoles; Trypanocidal Agents | 2022 |
In vitro evaluation of alkaline lignins as antiparasitic agents and their use as an excipient in the release of benznidazole.
Topics: Animals; Antioxidants; Antiparasitic Agents; Chagas Disease; Chloroquine; Excipients; Lignin; Trypan | 2023 |
Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.
Topics: Amidohydrolases; Animals; Antimalarials; Candidiasis; Chagas Disease; Chloroquine; Cysteamine; Cytok | 2010 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
Two modes of idiotypic stimulation of T lymphocytes from patients with Chagas' disease: correlations with clinical forms of infection.
Topics: Adult; Animals; Antibodies, Anti-Idiotypic; Antibodies, Protozoan; Antigen-Presenting Cells; Antigen | 1990 |