chloroquine has been researched along with Alzheimer Disease in 28 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Further drug-like property analysis demonstrated that the optimized compound, 8d (WI-1758), had liver microsomal metabolic stability, was well tolerated (>2000 mg/kg), and had a rational pharmacokinetic profile, as well as an oral bioavailability of 14." | 1.48 | Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease. ( Chan, ASC; Feng, X; Hu, J; Huang, L; Li, X; Wang, Z; Yang, X, 2018) |
| "Alzheimer's disease is the common cause of dementia characterized by the accumulation of amyloid-β produced by breakage of amyloid-β precursor protein (APP)." | 1.42 | Inhibitory effect of chloroquine derivatives on presenilin 1 and ubiquilin 1 expression in Alzheimer's disease. ( Li, J; Zhang, FF, 2015) |
| "Chloroquine treatment induced accumulation of GM1 ganglioside (GM1) in Rab5-positive enlarged early endosomes and on the cell surface." | 1.33 | Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Abeta fibrillogenesis in Alzheimer's disease. ( Yamamoto, N; Yanagisawa, K; Yuyama, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (39.29) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 12 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rao, KV | 1 |
| Donia, MS | 1 |
| Peng, J | 1 |
| Garcia-Palomero, E | 1 |
| Alonso, D | 1 |
| Martinez, A | 1 |
| Medina, M | 1 |
| Franzblau, SG | 1 |
| Tekwani, BL | 1 |
| Khan, SI | 1 |
| Wahyuono, S | 1 |
| Willett, KL | 1 |
| Hamann, MT | 1 |
| Lan, JS | 1 |
| Xie, SS | 1 |
| Li, SY | 1 |
| Pan, LF | 1 |
| Wang, XB | 2 |
| Kong, LY | 2 |
| Xie, S | 1 |
| Chen, J | 1 |
| Li, X | 3 |
| Su, T | 1 |
| Wang, Y | 1 |
| Wang, Z | 2 |
| Huang, L | 2 |
| Wang, J | 1 |
| Cai, P | 1 |
| Yang, XL | 1 |
| Li, F | 1 |
| Wu, JJ | 1 |
| Hu, J | 1 |
| Yang, X | 1 |
| Feng, X | 1 |
| Chan, ASC | 1 |
| Gay, M | 1 |
| Carato, P | 1 |
| Coevoet, M | 1 |
| Renault, N | 1 |
| Larchanché, PE | 1 |
| Barczyk, A | 1 |
| Yous, S | 1 |
| Buée, L | 1 |
| Sergeant, N | 1 |
| Melnyk, P | 1 |
| Fardet, L | 2 |
| Nazareth, I | 2 |
| Petersen, I | 2 |
| Lee, YH | 1 |
| Zhao, L | 1 |
| Zhao, Y | 1 |
| Tang, FL | 1 |
| Xiong, L | 1 |
| Su, C | 1 |
| Mei, L | 1 |
| Zhu, XJ | 1 |
| Xiong, WC | 1 |
| Wei, Y | 1 |
| Zhou, J | 2 |
| Wu, J | 1 |
| Huang, J | 1 |
| Zhang, FF | 1 |
| Li, J | 1 |
| Seo, BR | 1 |
| Lee, SJ | 1 |
| Cho, KS | 1 |
| Yoon, YH | 1 |
| Koh, JY | 1 |
| Bendiske, J | 1 |
| Bahr, BA | 1 |
| Hegde, ML | 1 |
| Anitha, S | 1 |
| Latha, KS | 1 |
| Mustak, MS | 1 |
| Stein, R | 1 |
| Ravid, R | 1 |
| Rao, KS | 1 |
| Yuyama, K | 1 |
| Yamamoto, N | 1 |
| Yanagisawa, K | 1 |
| Refolo, LM | 1 |
| Sambamurti, K | 1 |
| Efthimiopoulos, S | 1 |
| Pappolla, MA | 1 |
| Robakis, NK | 1 |
| Jensen, TG | 1 |
| Roses, AD | 1 |
| Jørgensen, AL | 1 |
| Fuller, SJ | 1 |
| Storey, E | 1 |
| Li, QX | 1 |
| Smith, AI | 1 |
| Beyreuther, K | 1 |
| Masters, CL | 1 |
| Murakami, N | 2 |
| Ihara, Y | 3 |
| Nonaka, I | 1 |
| Tsuzuki, K | 2 |
| Fukatsu, R | 2 |
| Takamaru, Y | 2 |
| Yoshida, T | 2 |
| Mafune, N | 1 |
| Kobayashi, K | 2 |
| Fujii, N | 2 |
| Takahata, N | 2 |
| Hayashi, Y | 1 |
| Oyama, F | 2 |
| Kouchi, Z | 1 |
| Kinouchi, T | 1 |
| Sorimachi, H | 1 |
| Ishiura, S | 1 |
| Suzuki, K | 1 |
| Bi, X | 1 |
| Lynch, G | 1 |
| Takeuchi, IK | 1 |
| Takeuchi, YK | 1 |
| Gu, YJ | 1 |
| Wolozin, B | 1 |
| Bacic, M | 1 |
| Merrill, MJ | 1 |
| Lesch, KP | 1 |
| Chen, C | 1 |
| Lebovics, RS | 1 |
| Sunderland, T | 1 |
1 review available for chloroquine and Alzheimer Disease
| Article | Year |
|---|---|
Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antimalarials; Brain; Chloroquine; Humans; Lysosomes; Muscles; Muscular | 1998 |
27 other studies available for chloroquine and Alzheimer Disease
| Article | Year |
|---|---|
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.
Topics: Alzheimer Disease; Animals; Female; Glycogen Synthase Kinase 3; HIV-1; Humans; Indole Alkaloids; Ind | 2006 |
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain B | 2014 |
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cations, Divalent; Cell Membrane Permeabilit | 2015 |
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzylamines; Blood-Retinal Barrier; | 2017 |
Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Proliferation; Drug Des | 2018 |
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.
Topics: Alzheimer Disease; Amodiaquine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compo | 2018 |
Chronic hydroxychloroquine/chloroquine exposure for connective tissue diseases and risk of Alzheimer's disease: a population-based cohort study.
Topics: Alzheimer Disease; Antirheumatic Agents; Chloroquine; Chronic Disease; Connective Tissue Diseases; D | 2019 |
Response to: 'Chronic hydroxychloroquine/chloroquine exposure for connective tissue diseases and risk of Alzheimer's disease' by Lee.
Topics: Alzheimer Disease; Chloroquine; Cohort Studies; Connective Tissue Diseases; Humans; Hydroxychloroqui | 2019 |
Chronic hydroxychloroquine/chloroquine exposure for connective tissue diseases and risk of Alzheimer's disease.
Topics: Alzheimer Disease; Chloroquine; Cohort Studies; Connective Tissue Diseases; Humans; Hydroxychloroqui | 2019 |
pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2019 |
ERβ promotes Aβ degradation via the modulation of autophagy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Autophagy-Related Protein 7; Cell Line | 2019 |
Inhibitory effect of chloroquine derivatives on presenilin 1 and ubiquilin 1 expression in Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Autophagy-Related Proteins; Blotting, Weste | 2015 |
The zinc ionophore clioquinol reverses autophagy arrest in chloroquine-treated ARPE-19 cells and in APP/mutant presenilin-1-transfected Chinese hamster ovary cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autophagy; Chloro | 2015 |
Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease?
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cathepsins; Chloroquine; Culture Techniq | 2003 |
First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: a new insight in understanding Alzheimer's disease.
Topics: Aged; Aluminum; Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Cell Nucleus; Chloroquine; DNA; | 2004 |
Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Abeta fibrillogenesis in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Chloroquine; Endocytosis; Endosomes; G(M | 2006 |
Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; As | 1995 |
Apolipoprotein E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low density lipoprotein receptor.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Cell Line, Transformed; Cells, Cultured; Chlorocebus | 1994 |
Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein.
Topics: Alzheimer Disease; Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid | 1995 |
Chloroquine treated rat: a possible model for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Chloroquine; Dise | 1995 |
Co-localization of amyloid-associated proteins with amyloid beta in rat soleus muscle in chloroquine-induced myopathy: a possible model for amyloid beta formation in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antibodies; Chloroquine; Disease Models, | 1995 |
Snake coiled fibres in rat soleus muscle in chloroquine induced myopathy share immunohistochemical characteristics with amyloid depositions in Alzheimer's disease brain tissue.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Brain; Chloroquine; Disease Mod | 1997 |
The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis.
Topics: Adenovirus Early Proteins; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biotinylation | 1998 |
Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Cathepsin B; Cathepsin L; Cathepsins; Chloroquine; Cysteine Endope | 1999 |
Transient accumulation of Gallyas-Braak-positive and phosphorylated tau-immunopositive substances in neuronal lipofuscin granules in the amygdala, hippocampus and entorhinal cortex of rats during long-term chloroquine intoxication.
Topics: Alzheimer Disease; Amygdala; Animals; Antimalarials; Body Weight; Chloroquine; Drug Administration S | 2001 |
Simultaneous quantification of APP and tau mRNA by RT-PCR.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Chloroquine; Male; Muscle, Skeletal; Rat | 1998 |
Differential expression of carboxyl terminal derivatives of amyloid precursor protein among cell lines.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Antimetabolites; Cell Line; Chloroquine; Humans; | 1992 |