chloroquine has been researched along with Agranulocytosis in 8 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bone marrow was cultured in vitro for colonies of granulocytes and macrophages five months after a patient had recovered from amodiaquine induced agranulocytosis." | 7.67 | Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents. ( Ball, J; Franklin, IM; Rhodes, EG, 1986) |
| "Amodiaquine (AQ), an effective antimalarial drug for uncomplicated malaria, has been greatly restricted after cases of life-threatening agranulocytosis and hepatic toxicity during prophylactic use." | 5.13 | Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania. ( Akida, JA; Bygbjerg, IC; Chile, MM; Kitua, AY; Lemnge, MM; Lusingu, JP; Makunde, R; Malebo, HM; Massaga, JJ; Rønn, AM; Theander, TG, 2008) |
| " As he required further anti-malarial prophylaxis, his marrow was prospectively tested in vitro with proguanil and its metabolite cycloguanil." | 3.68 | Prospective in vitro testing for drug-induced neutropenia in a patient requiring anti-malarial prophylaxis: confirmation of findings on exposure of patient to drug. ( French, A; Humphrey, CA; Morris, TC, 1990) |
| "Bone marrow was cultured in vitro for colonies of granulocytes and macrophages five months after a patient had recovered from amodiaquine induced agranulocytosis." | 3.67 | Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents. ( Ball, J; Franklin, IM; Rhodes, EG, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Massaga, JJ | 1 |
| Lusingu, JP | 1 |
| Makunde, R | 1 |
| Malebo, HM | 1 |
| Chile, MM | 1 |
| Akida, JA | 1 |
| Lemnge, MM | 1 |
| Rønn, AM | 1 |
| Theander, TG | 1 |
| Bygbjerg, IC | 1 |
| Kitua, AY | 1 |
| KUPCHINSKAS, IuK | 1 |
| Jaremin, B | 1 |
| Felczak-Korzybska, I | 1 |
| Myjak, P | 1 |
| Humphrey, CA | 1 |
| French, A | 1 |
| Morris, TC | 1 |
| Rhodes, EG | 1 |
| Ball, J | 1 |
| Franklin, IM | 1 |
| Don, PC | 1 |
| Kahn, TA | 1 |
| Bickers, DR | 1 |
| Dale, DC | 1 |
| Wolff, SM | 1 |
| Sheehy, TW | 1 |
| Reba, RC | 1 |
| Parks, GR | 1 |
1 review available for chloroquine and Agranulocytosis
| Article | Year |
|---|---|
[AUTOALLERGY IN CLINICAL INTERNAL MEDICINE].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Agranulocytosis; Anemia, Hemolytic; Anemia, He | 1964 |
1 trial available for chloroquine and Agranulocytosis
| Article | Year |
|---|---|
Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania.
Topics: Adolescent; Adult; Agranulocytosis; Amodiaquine; Analysis of Variance; Animals; Antimalarials; Chemi | 2008 |
6 other studies available for chloroquine and Agranulocytosis
| Article | Year |
|---|---|
[A case of methemoglobinemia and agranulocytosis during the treatment of malaria (pl. ovale) with arequine and primaquine].
Topics: Adult; Agranulocytosis; Antimalarials; Chloroquine; Humans; Malaria; Male; Methemoglobinemia; Primaq | 1982 |
Prospective in vitro testing for drug-induced neutropenia in a patient requiring anti-malarial prophylaxis: confirmation of findings on exposure of patient to drug.
Topics: Agranulocytosis; Bone Marrow; Cells, Cultured; Chloroquine; Colony-Forming Units Assay; Humans; Mala | 1990 |
Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents.
Topics: Adult; Agranulocytosis; Amodiaquine; Antimalarials; Bone Marrow; Bone Marrow Cells; Cells, Cultured; | 1986 |
Chloroquine-induced neutropenia in a patient with dermatomyositis.
Topics: Adult; Agranulocytosis; Chloroquine; Dermatomyositis; Female; Humans; Neutropenia | 1987 |
Studies of the neutropenia of acute malaria.
Topics: Adult; Agranulocytosis; Bone Marrow Cells; Bone Marrow Examination; Chloroquine; Humans; Isofluropha | 1973 |
Combined pyrimethamine-quinine therapy for chloroquine-resistant P. falciparum infections.
Topics: Adolescent; Adult; Agranulocytosis; Anemia, Hemolytic; Chloroquine; Clinical Laboratory Techniques; | 1969 |