chloroquine has been researched along with Aging in 24 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine and hydroxychloroquine are quinoline derivatives used to treat malaria." | 5.05 | Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection. ( Cook, J; Joshi, A; Nicol, MR; Rizk, ML; Sabato, PE; Savic, RM; Wesche, D; Zheng, JH, 2020) |
| "Chloroquine treatment in vivo does not seem to have any demonstrable effect on testosterone secretion stimulated by hCG or PGE 1 in prepubertal as well as in the postpubertal rats." | 1.27 | Effect of acute chloroquine treatment on prostaglandin- and gonadotropin-stimulated testosterone secretion of rat testis. ( Dada, OA; Nduka, EU, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (62.50) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Osama El-Gendy, A | 1 |
| Saeed, H | 1 |
| Ali, AMA | 1 |
| Zawbaa, HM | 1 |
| Gomaa, D | 1 |
| Harb, HS | 1 |
| Madney, YM | 1 |
| Osama, H | 1 |
| Abdelrahman, MA | 1 |
| Abdelrahim, MEA | 1 |
| Nicol, MR | 1 |
| Joshi, A | 1 |
| Rizk, ML | 1 |
| Sabato, PE | 1 |
| Savic, RM | 1 |
| Wesche, D | 1 |
| Zheng, JH | 1 |
| Cook, J | 1 |
| Yamagiwa, Y | 1 |
| Takei, Y | 1 |
| Koizumi, H | 1 |
| Nemoto, S | 1 |
| Kurata, M | 1 |
| Satoh, H | 1 |
| Li, J | 1 |
| Cui, X | 1 |
| Ma, X | 1 |
| Li, C | 1 |
| Wang, Z | 1 |
| Betuela, I | 1 |
| Bassat, Q | 1 |
| Kiniboro, B | 1 |
| Robinson, LJ | 1 |
| Rosanas-Urgell, A | 1 |
| Stanisic, D | 1 |
| Siba, PM | 1 |
| Alonso, PL | 1 |
| Mueller, I | 1 |
| Bendiske, J | 2 |
| Caba, E | 1 |
| Brown, QB | 1 |
| Bahr, BA | 2 |
| Neubauer, AS | 1 |
| Samari-Kermani, K | 1 |
| Schaller, U | 1 |
| Welge-Lübetaen, U | 1 |
| Rudolph, G | 1 |
| Berninger, T | 1 |
| HAUSS, WH | 1 |
| JUNGE-HUELSING, G | 1 |
| JACOBSON, B | 1 |
| BOSTROEM, H | 1 |
| Kanju, PM | 1 |
| Parameshwaran, K | 1 |
| Vaithianathan, T | 1 |
| Sims, CM | 1 |
| Huggins, K | 1 |
| Ryzhikov, S | 1 |
| Suppiramaniam, V | 1 |
| Flint, DJ | 1 |
| Gardner, MJ | 1 |
| Nduka, EU | 1 |
| Dada, OA | 1 |
| van Zon, AA | 1 |
| Eling, WM | 1 |
| Rosenberg, R | 1 |
| Maheswary, NP | 1 |
| Lot, TY | 1 |
| Bennett, T | 1 |
| Wildenthal, K | 1 |
| Crie, JS | 1 |
| Karmazyn, M | 1 |
| Horrobin, DF | 1 |
| Oka, M | 1 |
| Manku, MS | 1 |
| Ally, AI | 1 |
| Karmali, RA | 1 |
| Morgan, RO | 1 |
| Cunnane, SC | 1 |
| Petruzzella, V | 1 |
| Fracasso, F | 1 |
| Gadaleta, MN | 1 |
| Cantatore, P | 1 |
| Fülöp, T | 1 |
| Varga, Z | 1 |
| Csongor, J | 1 |
| Fóris, G | 1 |
| Leövey, A | 1 |
| Karey, KP | 1 |
| Rothstein, M | 1 |
| Fredman, P | 1 |
| Klinghardt, GW | 1 |
| Svennerholm, L | 1 |
| Hochschild, R | 1 |
| Percival, SP | 1 |
| Behrman, J | 1 |
| Reizenstein, P | 1 |
1 review available for chloroquine and Aging
| Article | Year |
|---|---|
Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection.
Topics: Age Factors; Aging; Antiviral Agents; Chloroquine; Clinical Trials, Phase II as Topic; Clinical Tria | 2020 |
23 other studies available for chloroquine and Aging
| Article | Year |
|---|---|
Bacillus Calmette-Guérin vaccine, antimalarial, age and gender relation to COVID-19 spread and mortality.
Topics: Aging; Antiviral Agents; BCG Vaccine; Chemoprevention; Chloroquine; Coronavirus Infections; COVID-19 | 2020 |
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone.
Topics: Administration, Ophthalmic; Aging; Amiodarone; Animals; Chloroquine; Cornea; Disease Models, Animal; | 2019 |
Recombinant Buckwheat Trypsin Inhibitor Improves the Protein and Mitochondria Homeostasis in Caenorhabditis elegans Model of Aging and Age-Related Disease.
Topics: Adenosine Triphosphate; Aging; Amebicides; Animals; Autophagy; Caenorhabditis elegans; Caenorhabditi | 2019 |
Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.
Topics: Aging; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Cohort Studies | 2012 |
Intracellular deposition, microtubule destabilization, and transport failure: an "early" pathogenic cascade leading to synaptic decline.
Topics: Aging; Animals; Antimalarials; Calpain; Cell Death; Chloroquine; Dendrites; Hippocampus; Horseradish | 2002 |
Detecting chloroquine retinopathy: electro-oculogram versus colour vision.
Topics: Aging; Antirheumatic Agents; Chloroquine; Color Perception; Cornea; Electrooculography; Epidemiologi | 2003 |
[Changes in connective tissue metabolism by toxic, infectious and allergic influences].
Topics: Aging; Chloroquine; Chondroitin; Communicable Diseases; Connective Tissue; Cortisone; Humans; Thyrox | 1961 |
STUDIES ON THE BIOCHEMISTRY OF HEART VALVES. II. THE EFFECT OF AGING AND ANTI-INFLAMMATORY DRUGS ON THE SYNTHESIS OF GLUCOSAMINE 6-PHOSPHATE AND PHOSPHOADENOSINE PHOSPHOSULFATE BY BOVINE HEART VALVES.
Topics: Adenine Nucleotides; Aging; Animals; Anti-Inflammatory Agents; Aortic Valve; Benzoates; Cattle; Chlo | 1964 |
Lysosomal dysfunction produces distinct alterations in synaptic alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid and N-methyl-D-aspartate receptor currents in hippocampus.
Topics: Aging; Animals; Biomarkers; Blotting, Western; Cathepsin D; Chloroquine; Electric Conductivity; Exci | 2007 |
Effects of cell volume on insulin binding, internalization and degradation in rat adipocytes.
Topics: Adipose Tissue; Aging; Animals; Bacitracin; Chloroquine; Dose-Response Relationship, Drug; Female; I | 1984 |
Effect of acute chloroquine treatment on prostaglandin- and gonadotropin-stimulated testosterone secretion of rat testis.
Topics: Aging; Alprostadil; Animals; Chloroquine; Chorionic Gonadotropin; In Vitro Techniques; Male; Prostag | 1984 |
Depressed malarial immunity in pregnant mice.
Topics: Aging; Animals; Chloroquine; Female; Immunity; Malaria; Mice; Mice, Inbred Strains; Plasmodium bergh | 1980 |
Forest malaria in Bangladesh. I. Parasitology.
Topics: Adolescent; Adult; Aging; Bangladesh; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; | 1982 |
Comparison of the effects of chronic chloroquine treatment and denervation on noradrenergic mechanisms.
Topics: Aging; Animals; Body Weight; Chickens; Chloroquine; Dose-Response Relationship, Drug; Electric Stimu | 1982 |
The role of lysosomes and lysosomal enzymes in cardiac protein turnover.
Topics: Aging; Animals; Cathepsins; Chloroquine; In Vitro Techniques; Insulin; Leupeptins; Lysosomes; Mice; | 1980 |
Changes in coronary vascular resistance associated with prolonged hypoxia in isolated rat hearts: a possible role of prostaglandins.
Topics: Aging; Animals; Aspirin; Chloroquine; Coronary Circulation; Coronary Disease; In Vitro Techniques; I | 1979 |
Age-dependent structural variations in rat brain mitochondrial DNA.
Topics: Aging; Animals; Brain; Chloroquine; Densitometry; DNA, Mitochondrial; Electrophoresis, Agar Gel; Nuc | 1992 |
Age related impairment in phosphatidylinositol breakdown of polymorphonuclear granulocytes.
Topics: Adult; Aged; Aging; Aluminum; Aluminum Compounds; Chloroquine; Fluorides; GTP-Binding Proteins; Guan | 1989 |
Evidence for the lack of lysosomal involvement in the age-related slowing of protein breakdown in Turbatrix aceti.
Topics: Aging; Animals; Aspartic Acid Endopeptidases; Cell Survival; Chloroquine; Endopeptidases; Hydrolysis | 1986 |
Effect of chloroquine on the activity of some lysosomal enzymes involved in ganglioside degradation.
Topics: Aging; Animals; Brain; Chloroquine; Gangliosides; Glycoside Hydrolases; Kinetics; Liver; Lysosomes; | 1987 |
Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster.
Topics: Adrenal Cortex Hormones; Aging; Analgesics; Animals; Cell Membrane; Central Nervous System Stimulant | 1971 |
Ophthalmological safety of chloroquine.
Topics: Adult; Aged; Aging; Chloroquine; Electrooculography; Female; Fundus Oculi; Humans; Macula Lutea; Mal | 1969 |
Errors and artefacts in serum folic-acid assays. Effects of age, food, drugs and radiation.
Topics: Aging; Anti-Bacterial Agents; Biological Assay; Blood Chemical Analysis; Busulfan; Chloroquine; Diet | 1965 |