Page last updated: 2024-10-24

chloroquine and Aging

chloroquine has been researched along with Aging in 24 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Chloroquine and hydroxychloroquine are quinoline derivatives used to treat malaria."5.05Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection. ( Cook, J; Joshi, A; Nicol, MR; Rizk, ML; Sabato, PE; Savic, RM; Wesche, D; Zheng, JH, 2020)
"Chloroquine treatment in vivo does not seem to have any demonstrable effect on testosterone secretion stimulated by hCG or PGE 1 in prepubertal as well as in the postpubertal rats."1.27Effect of acute chloroquine treatment on prostaglandin- and gonadotropin-stimulated testosterone secretion of rat testis. ( Dada, OA; Nduka, EU, 1984)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199015 (62.50)18.7374
1990's1 (4.17)18.2507
2000's3 (12.50)29.6817
2010's3 (12.50)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Osama El-Gendy, A1
Saeed, H1
Ali, AMA1
Zawbaa, HM1
Gomaa, D1
Harb, HS1
Madney, YM1
Osama, H1
Abdelrahman, MA1
Abdelrahim, MEA1
Nicol, MR1
Joshi, A1
Rizk, ML1
Sabato, PE1
Savic, RM1
Wesche, D1
Zheng, JH1
Cook, J1
Yamagiwa, Y1
Takei, Y1
Koizumi, H1
Nemoto, S1
Kurata, M1
Satoh, H1
Li, J1
Cui, X1
Ma, X1
Li, C1
Wang, Z1
Betuela, I1
Bassat, Q1
Kiniboro, B1
Robinson, LJ1
Rosanas-Urgell, A1
Stanisic, D1
Siba, PM1
Alonso, PL1
Mueller, I1
Bendiske, J2
Caba, E1
Brown, QB1
Bahr, BA2
Neubauer, AS1
Samari-Kermani, K1
Schaller, U1
Welge-Lübetaen, U1
Rudolph, G1
Berninger, T1
HAUSS, WH1
JUNGE-HUELSING, G1
JACOBSON, B1
BOSTROEM, H1
Kanju, PM1
Parameshwaran, K1
Vaithianathan, T1
Sims, CM1
Huggins, K1
Ryzhikov, S1
Suppiramaniam, V1
Flint, DJ1
Gardner, MJ1
Nduka, EU1
Dada, OA1
van Zon, AA1
Eling, WM1
Rosenberg, R1
Maheswary, NP1
Lot, TY1
Bennett, T1
Wildenthal, K1
Crie, JS1
Karmazyn, M1
Horrobin, DF1
Oka, M1
Manku, MS1
Ally, AI1
Karmali, RA1
Morgan, RO1
Cunnane, SC1
Petruzzella, V1
Fracasso, F1
Gadaleta, MN1
Cantatore, P1
Fülöp, T1
Varga, Z1
Csongor, J1
Fóris, G1
Leövey, A1
Karey, KP1
Rothstein, M1
Fredman, P1
Klinghardt, GW1
Svennerholm, L1
Hochschild, R1
Percival, SP1
Behrman, J1
Reizenstein, P1

Reviews

1 review available for chloroquine and Aging

ArticleYear
Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection.
    Clinical pharmacology and therapeutics, 2020, Volume: 108, Issue:6

    Topics: Age Factors; Aging; Antiviral Agents; Chloroquine; Clinical Trials, Phase II as Topic; Clinical Tria

2020

Other Studies

23 other studies available for chloroquine and Aging

ArticleYear
Bacillus Calmette-Guérin vaccine, antimalarial, age and gender relation to COVID-19 spread and mortality.
    Vaccine, 2020, 07-31, Volume: 38, Issue:35

    Topics: Aging; Antiviral Agents; BCG Vaccine; Chemoprevention; Chloroquine; Coronavirus Infections; COVID-19

2020
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone.
    Toxicologic pathology, 2019, Volume: 47, Issue:1

    Topics: Administration, Ophthalmic; Aging; Amiodarone; Animals; Chloroquine; Cornea; Disease Models, Animal;

2019
Recombinant Buckwheat Trypsin Inhibitor Improves the Protein and Mitochondria Homeostasis in Caenorhabditis elegans Model of Aging and Age-Related Disease.
    Gerontology, 2019, Volume: 65, Issue:5

    Topics: Adenosine Triphosphate; Aging; Amebicides; Animals; Autophagy; Caenorhabditis elegans; Caenorhabditi

2019
Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:4

    Topics: Aging; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Cohort Studies

2012
Intracellular deposition, microtubule destabilization, and transport failure: an "early" pathogenic cascade leading to synaptic decline.
    Journal of neuropathology and experimental neurology, 2002, Volume: 61, Issue:7

    Topics: Aging; Animals; Antimalarials; Calpain; Cell Death; Chloroquine; Dendrites; Hippocampus; Horseradish

2002
Detecting chloroquine retinopathy: electro-oculogram versus colour vision.
    The British journal of ophthalmology, 2003, Volume: 87, Issue:7

    Topics: Aging; Antirheumatic Agents; Chloroquine; Color Perception; Cornea; Electrooculography; Epidemiologi

2003
[Changes in connective tissue metabolism by toxic, infectious and allergic influences].
    Zeitschrift fur Rheumaforschung, 1961, Volume: 20

    Topics: Aging; Chloroquine; Chondroitin; Communicable Diseases; Connective Tissue; Cortisone; Humans; Thyrox

1961
STUDIES ON THE BIOCHEMISTRY OF HEART VALVES. II. THE EFFECT OF AGING AND ANTI-INFLAMMATORY DRUGS ON THE SYNTHESIS OF GLUCOSAMINE 6-PHOSPHATE AND PHOSPHOADENOSINE PHOSPHOSULFATE BY BOVINE HEART VALVES.
    Biochimica et biophysica acta, 1964, Jul-07, Volume: 83

    Topics: Adenine Nucleotides; Aging; Animals; Anti-Inflammatory Agents; Aortic Valve; Benzoates; Cattle; Chlo

1964
Lysosomal dysfunction produces distinct alterations in synaptic alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid and N-methyl-D-aspartate receptor currents in hippocampus.
    Journal of neuropathology and experimental neurology, 2007, Volume: 66, Issue:9

    Topics: Aging; Animals; Biomarkers; Blotting, Western; Cathepsin D; Chloroquine; Electric Conductivity; Exci

2007
Effects of cell volume on insulin binding, internalization and degradation in rat adipocytes.
    Molecular and cellular endocrinology, 1984, Volume: 36, Issue:3

    Topics: Adipose Tissue; Aging; Animals; Bacitracin; Chloroquine; Dose-Response Relationship, Drug; Female; I

1984
Effect of acute chloroquine treatment on prostaglandin- and gonadotropin-stimulated testosterone secretion of rat testis.
    Toxicology letters, 1984, Volume: 23, Issue:3

    Topics: Aging; Alprostadil; Animals; Chloroquine; Chorionic Gonadotropin; In Vitro Techniques; Male; Prostag

1984
Depressed malarial immunity in pregnant mice.
    Infection and immunity, 1980, Volume: 28, Issue:2

    Topics: Aging; Animals; Chloroquine; Female; Immunity; Malaria; Mice; Mice, Inbred Strains; Plasmodium bergh

1980
Forest malaria in Bangladesh. I. Parasitology.
    The American journal of tropical medicine and hygiene, 1982, Volume: 31, Issue:2

    Topics: Adolescent; Adult; Aging; Bangladesh; Child; Child, Preschool; Chloroquine; Drug Resistance; Female;

1982
Comparison of the effects of chronic chloroquine treatment and denervation on noradrenergic mechanisms.
    Medical biology, 1982, Volume: 60, Issue:1

    Topics: Aging; Animals; Body Weight; Chickens; Chloroquine; Dose-Response Relationship, Drug; Electric Stimu

1982
The role of lysosomes and lysosomal enzymes in cardiac protein turnover.
    Federation proceedings, 1980, Volume: 39, Issue:1

    Topics: Aging; Animals; Cathepsins; Chloroquine; In Vitro Techniques; Insulin; Leupeptins; Lysosomes; Mice;

1980
Changes in coronary vascular resistance associated with prolonged hypoxia in isolated rat hearts: a possible role of prostaglandins.
    Life sciences, 1979, Dec-03, Volume: 25, Issue:23

    Topics: Aging; Animals; Aspirin; Chloroquine; Coronary Circulation; Coronary Disease; In Vitro Techniques; I

1979
Age-dependent structural variations in rat brain mitochondrial DNA.
    Annals of the New York Academy of Sciences, 1992, Dec-26, Volume: 673

    Topics: Aging; Animals; Brain; Chloroquine; Densitometry; DNA, Mitochondrial; Electrophoresis, Agar Gel; Nuc

1992
Age related impairment in phosphatidylinositol breakdown of polymorphonuclear granulocytes.
    FEBS letters, 1989, Mar-13, Volume: 245, Issue:1-2

    Topics: Adult; Aged; Aging; Aluminum; Aluminum Compounds; Chloroquine; Fluorides; GTP-Binding Proteins; Guan

1989
Evidence for the lack of lysosomal involvement in the age-related slowing of protein breakdown in Turbatrix aceti.
    Mechanisms of ageing and development, 1986, Volume: 35, Issue:2

    Topics: Aging; Animals; Aspartic Acid Endopeptidases; Cell Survival; Chloroquine; Endopeptidases; Hydrolysis

1986
Effect of chloroquine on the activity of some lysosomal enzymes involved in ganglioside degradation.
    Biochimica et biophysica acta, 1987, Jan-13, Volume: 917, Issue:1

    Topics: Aging; Animals; Brain; Chloroquine; Gangliosides; Glycoside Hydrolases; Kinetics; Liver; Lysosomes;

1987
Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster.
    Experimental gerontology, 1971, Volume: 6, Issue:2

    Topics: Adrenal Cortex Hormones; Aging; Analgesics; Animals; Cell Membrane; Central Nervous System Stimulant

1971
Ophthalmological safety of chloroquine.
    The British journal of ophthalmology, 1969, Volume: 53, Issue:2

    Topics: Adult; Aged; Aging; Chloroquine; Electrooculography; Female; Fundus Oculi; Humans; Macula Lutea; Mal

1969
Errors and artefacts in serum folic-acid assays. Effects of age, food, drugs and radiation.
    Acta medica Scandinavica, 1965, Volume: 178, Issue:2

    Topics: Aging; Anti-Bacterial Agents; Biological Assay; Blood Chemical Analysis; Busulfan; Chloroquine; Diet

1965