chloroquine has been researched along with African Sleeping Sickness in 21 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This work describes the optimization of the pharmacokinetic properties of a previously published family of triazine lead compounds." | 1.48 | Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives. ( Augustyns, K; Baán, A; Caljon, G; Kiekens, F; Maes, L; Matheeussen, A; Salado, IG; Van der Veken, P; Verdeyen, T, 2018) |
| " rhodesiense in vivo, curing three of four infected mice dosed intraperitoneally at 5 mg/kg x 4 days." | 1.35 | Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. ( Bakunov, SA; Bakunova, SM; Barzcz, T; Brun, R; Chen, H; Jones, SK; Kumar, EV; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (38.10) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodríguez, F | 1 |
| Rozas, I | 1 |
| Kaiser, M | 6 |
| Brun, R | 6 |
| Nguyen, B | 1 |
| Wilson, WD | 1 |
| García, RN | 1 |
| Dardonville, C | 2 |
| Patrick, DA | 2 |
| Bakunov, SA | 2 |
| Bakunova, SM | 2 |
| Kumar, EV | 1 |
| Chen, H | 1 |
| Jones, SK | 1 |
| Wenzler, T | 2 |
| Barzcz, T | 1 |
| Werbovetz, KA | 1 |
| Tidwell, RR | 2 |
| Ferrins, L | 1 |
| Rahmani, R | 1 |
| Sykes, ML | 1 |
| Jones, AJ | 1 |
| Avery, VM | 1 |
| Teston, E | 1 |
| Almohaywi, B | 1 |
| Yin, J | 1 |
| Smith, J | 1 |
| Hyland, C | 1 |
| White, KL | 1 |
| Ryan, E | 1 |
| Campbell, M | 1 |
| Charman, SA | 1 |
| Baell, JB | 1 |
| Ronga, L | 1 |
| Del Favero, M | 1 |
| Cohen, A | 1 |
| Soum, C | 1 |
| Le Pape, P | 1 |
| Savrimoutou, S | 1 |
| Pinaud, N | 1 |
| Mullié, C | 1 |
| Daulouede, S | 1 |
| Vincendeau, P | 1 |
| Farvacques, N | 1 |
| Agnamey, P | 1 |
| Pagniez, F | 1 |
| Hutter, S | 1 |
| Azas, N | 1 |
| Sonnet, P | 1 |
| Guillon, J | 1 |
| Ríos Martínez, CH | 1 |
| Lagartera, L | 1 |
| Sola, I | 1 |
| Castellà, S | 1 |
| Viayna, E | 1 |
| Galdeano, C | 1 |
| Taylor, MC | 1 |
| Gbedema, SY | 1 |
| Pérez, B | 1 |
| Clos, MV | 1 |
| Jones, DC | 1 |
| Fairlamb, AH | 1 |
| Wright, CW | 1 |
| Kelly, JM | 1 |
| Muñoz-Torrero, D | 1 |
| Seebacher, W | 1 |
| Wolkinger, V | 1 |
| Faist, J | 1 |
| Saf, R | 1 |
| Bucar, F | 1 |
| Gröblacher, B | 1 |
| Brantner, A | 1 |
| Merino, V | 1 |
| Kalia, Y | 1 |
| Scapozza, L | 1 |
| Perozzo, R | 1 |
| Weis, R | 1 |
| Karaaslan, C | 1 |
| Göker, H | 1 |
| Previti, S | 1 |
| Ettari, R | 1 |
| Cosconati, S | 1 |
| Amendola, G | 1 |
| Chouchene, K | 1 |
| Wagner, A | 1 |
| Hellmich, UA | 1 |
| Ulrich, K | 1 |
| Krauth-Siegel, RL | 1 |
| Wich, PR | 1 |
| Schmid, I | 1 |
| Schirmeister, T | 1 |
| Gut, J | 1 |
| Rosenthal, PJ | 1 |
| Grasso, S | 1 |
| Zappalà, M | 1 |
| Salado, IG | 1 |
| Baán, A | 1 |
| Verdeyen, T | 1 |
| Matheeussen, A | 1 |
| Caljon, G | 1 |
| Van der Veken, P | 1 |
| Kiekens, F | 1 |
| Maes, L | 1 |
| Augustyns, K | 1 |
| Saccoliti, F | 1 |
| Madia, VN | 1 |
| Tudino, V | 1 |
| De Leo, A | 1 |
| Pescatori, L | 1 |
| Messore, A | 1 |
| De Vita, D | 1 |
| Scipione, L | 1 |
| Mäser, P | 1 |
| Calvet, CM | 1 |
| Jennings, GK | 1 |
| Podust, LM | 1 |
| Costi, R | 1 |
| Di Santo, R | 1 |
| TELLA, A | 1 |
| Poltera, AA | 2 |
| Hochmann, A | 1 |
| Lambert, PH | 1 |
| Coppens, I | 1 |
| Baudhuin, P | 1 |
| Opperdoes, FR | 1 |
| Courtoy, PJ | 1 |
| Buyst, H | 2 |
| Otigbuo, IN | 1 |
| Woo, PT | 1 |
| Geddes, AM | 1 |
| Woodruff, AW | 1 |
21 other studies available for chloroquine and African Sleeping Sickness
| Article | Year |
|---|---|
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.
Topics: Animals; Antimalarials; Cell Line; DNA; Female; Guanidines; Hemeproteins; Hemin; Imidazolines; Malar | 2008 |
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
Topics: Animals; Antiprotozoal Agents; Benzene; Cell Survival; Leishmania donovani; Mice; Myoblasts; Naphtha | 2009 |
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.
Topics: Anilides; Animals; Humans; Mice; Myoblasts, Skeletal; Rats; Species Specificity; Structure-Activity | 2013 |
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
Topics: Animals; Antiprotozoal Agents; Isoxazoles; Mice; Molecular Structure; Plasmodium falciparum; Prodrug | 2014 |
Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents--part III.
Topics: Animals; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Female; Hep G2 Cells; Hu | 2014 |
Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines.
Topics: Animals; Antiparasitic Agents; Benzamides; Binding Sites; Cell Line; Cell Survival; Disease Models, | 2014 |
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Topics: Aminoquinolines; Animals; Antimalarials; Brain; Cell Line; Dimerization; Hemeproteins; Humans; Malar | 2015 |
Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Azabicyclo Compounds; Disease Models, Animal; D | 2015 |
Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.
Topics: Aniline Compounds; Animals; Antiprotozoal Agents; Benzimidazoles; Cell Line; Humans; Malaria, Falcip | 2016 |
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
Topics: Antimalarials; Carbamates; Cathepsin L; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dip | 2017 |
Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives.
Topics: Animals; Disease Models, Animal; Humans; Mice; Structure-Activity Relationship; Triazines; Tropolone | 2018 |
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Female; Humans; Imidazoles; Inhibitory Con | 2018 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
Chemotherapy, relapses and CNS in experimental African trypanosomiasis.
Topics: Animals; Central Nervous System; Chlorocebus aethiops; Chloroquine; Melarsoprol; Mice; Recurrence; T | 1983 |
Trypanosoma brucei brucei: the response to Melarsoprol in mice with cerebral trypanosomiasis. An immunopathological study.
Topics: Animals; Antigen-Antibody Complex; Arsenicals; Brain; Brain Diseases; Chloroquine; Fluorescent Antib | 1981 |
Role of acidic compartments in Trypanosoma brucei, with special reference to low-density lipoprotein processing.
Topics: Acids; Animals; Chloroquine; Endocytosis; Lipoproteins, LDL; Microscopy, Electron; Rats; Rats, Wista | 1993 |
Sleeping sickness in children.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chloroquine; Humans; Infant; Infant, Newbor | 1977 |
The treatment of T. rhodesiense sleeping sickness, with special reference to its physio-pathological and epidemiological basis.
Topics: Arsenicals; Chloroquine; Humans; Melarsoprol; Proguanil; Suramin; Trypanosomiasis, African; Zambia | 1975 |
The in vitro and in vivo effects of metronidazole and chloroquine on Trypanosoma brucei brucei.
Topics: Animals; Chloroquine; Drug Therapy, Combination; Female; Metronidazole; Mice; Trypanosoma brucei bru | 1988 |
Imported infections. Unexplained fever.
Topics: Africa; Asia; Brucellosis; Chloramphenicol; Chloroquine; Fever; Humans; Leishmaniasis, Visceral; Liv | 1974 |
Current practice in tropical medicine.
Topics: Acute Kidney Injury; Amebiasis; Amebicides; Chloroquine; Cholera; Drug Resistance, Microbial; Hepati | 1969 |